Amino acid dipepetide frequency for Marssonina coronariae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.752AlaAla: 9.752 ± 0.066	1.013AlaCys: 1.013 ± 0.016	4.315AlaAsp: 4.315 ± 0.033	5.562AlaGlu: 5.562 ± 0.047	3.003AlaPhe: 3.003 ± 0.031	6.572AlaGly: 6.572 ± 0.046	1.854AlaHis: 1.854 ± 0.021	4.137AlaIle: 4.137 ± 0.033	4.274AlaLys: 4.274 ± 0.039	7.805AlaLeu: 7.805 ± 0.051	1.945AlaMet: 1.945 ± 0.023	2.897AlaAsn: 2.897 ± 0.03	5.453AlaPro: 5.453 ± 0.051	3.421AlaGln: 3.421 ± 0.031	5.657AlaArg: 5.657 ± 0.05	7.989AlaSer: 7.989 ± 0.054	5.407AlaThr: 5.407 ± 0.037	5.381AlaVal: 5.381 ± 0.042	1.133AlaTrp: 1.133 ± 0.019	2.054AlaTyr: 2.054 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.016	0.22CysCys: 0.22 ± 0.008	0.577CysAsp: 0.577 ± 0.013	0.599CysGlu: 0.599 ± 0.013	0.48CysPhe: 0.48 ± 0.012	0.897CysGly: 0.897 ± 0.016	0.299CysHis: 0.299 ± 0.008	0.611CysIle: 0.611 ± 0.013	0.479CysLys: 0.479 ± 0.013	1.131CysLeu: 1.131 ± 0.018	0.238CysMet: 0.238 ± 0.007	0.377CysAsn: 0.377 ± 0.01	0.655CysPro: 0.655 ± 0.014	0.404CysGln: 0.404 ± 0.01	0.728CysArg: 0.728 ± 0.015	0.9CysSer: 0.9 ± 0.017	0.656CysThr: 0.656 ± 0.012	0.719CysVal: 0.719 ± 0.014	0.184CysTrp: 0.184 ± 0.007	0.312CysTyr: 0.312 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.707AspAla: 4.707 ± 0.033	0.587AspCys: 0.587 ± 0.012	3.906AspAsp: 3.906 ± 0.042	4.506AspGlu: 4.506 ± 0.041	2.16AspPhe: 2.16 ± 0.025	4.217AspGly: 4.217 ± 0.035	1.152AspHis: 1.152 ± 0.017	2.814AspIle: 2.814 ± 0.028	2.202AspLys: 2.202 ± 0.025	4.965AspLeu: 4.965 ± 0.042	1.216AspMet: 1.216 ± 0.018	1.655AspAsn: 1.655 ± 0.021	3.242AspPro: 3.242 ± 0.029	1.782AspGln: 1.782 ± 0.023	3.002AspArg: 3.002 ± 0.03	4.147AspSer: 4.147 ± 0.031	2.72AspThr: 2.72 ± 0.024	3.58AspVal: 3.58 ± 0.029	0.785AspTrp: 0.785 ± 0.014	1.395AspTyr: 1.395 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.647GluAla: 5.647 ± 0.05	0.589GluCys: 0.589 ± 0.013	4.323GluAsp: 4.323 ± 0.04	5.758GluGlu: 5.758 ± 0.072	1.926GluPhe: 1.926 ± 0.021	4.133GluGly: 4.133 ± 0.034	1.344GluHis: 1.344 ± 0.019	3.211GluIle: 3.211 ± 0.031	4.0GluLys: 4.0 ± 0.041	5.109GluLeu: 5.109 ± 0.045	1.519GluMet: 1.519 ± 0.021	2.379GluAsn: 2.379 ± 0.025	2.791GluPro: 2.791 ± 0.034	2.405GluGln: 2.405 ± 0.026	4.263GluArg: 4.263 ± 0.039	4.484GluSer: 4.484 ± 0.036	3.401GluThr: 3.401 ± 0.029	3.71GluVal: 3.71 ± 0.035	0.861GluTrp: 0.861 ± 0.014	1.59GluTyr: 1.59 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.04PheAla: 3.04 ± 0.031	0.5PheCys: 0.5 ± 0.013	2.099PheAsp: 2.099 ± 0.022	2.153PheGlu: 2.153 ± 0.026	1.475PhePhe: 1.475 ± 0.023	2.837PheGly: 2.837 ± 0.032	0.817PheHis: 0.817 ± 0.013	1.57PheIle: 1.57 ± 0.025	1.539PheLys: 1.539 ± 0.02	3.238PheLeu: 3.238 ± 0.035	0.736PheMet: 0.736 ± 0.014	1.33PheAsn: 1.33 ± 0.02	1.939PhePro: 1.939 ± 0.023	1.307PheGln: 1.307 ± 0.017	1.858PheArg: 1.858 ± 0.024	2.999PheSer: 2.999 ± 0.026	2.045PheThr: 2.045 ± 0.027	2.297PheVal: 2.297 ± 0.025	0.582PheTrp: 0.582 ± 0.013	1.017PheTyr: 1.017 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.762GlyAla: 5.762 ± 0.045	0.845GlyCys: 0.845 ± 0.015	3.77GlyAsp: 3.77 ± 0.03	4.215GlyGlu: 4.215 ± 0.034	2.762GlyPhe: 2.762 ± 0.031	6.471GlyGly: 6.471 ± 0.065	1.659GlyHis: 1.659 ± 0.02	3.506GlyIle: 3.506 ± 0.033	3.704GlyLys: 3.704 ± 0.035	6.238GlyLeu: 6.238 ± 0.038	1.677GlyMet: 1.677 ± 0.024	2.585GlyAsn: 2.585 ± 0.028	3.553GlyPro: 3.553 ± 0.033	2.515GlyGln: 2.515 ± 0.027	4.665GlyArg: 4.665 ± 0.041	6.257GlySer: 6.257 ± 0.048	4.077GlyThr: 4.077 ± 0.03	4.51GlyVal: 4.51 ± 0.043	1.147GlyTrp: 1.147 ± 0.019	2.046GlyTyr: 2.046 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.894HisAla: 1.894 ± 0.02	0.292HisCys: 0.292 ± 0.009	1.237HisAsp: 1.237 ± 0.017	1.298HisGlu: 1.298 ± 0.016	0.835HisPhe: 0.835 ± 0.014	1.736HisGly: 1.736 ± 0.02	0.818HisHis: 0.818 ± 0.016	1.105HisIle: 1.105 ± 0.017	0.925HisLys: 0.925 ± 0.014	2.142HisLeu: 2.142 ± 0.021	0.449HisMet: 0.449 ± 0.011	0.782HisAsn: 0.782 ± 0.014	1.684HisPro: 1.684 ± 0.022	0.945HisGln: 0.945 ± 0.015	1.516HisArg: 1.516 ± 0.021	1.852HisSer: 1.852 ± 0.02	1.236HisThr: 1.236 ± 0.019	1.392HisVal: 1.392 ± 0.019	0.276HisTrp: 0.276 ± 0.007	0.609HisTyr: 0.609 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.111IleAla: 4.111 ± 0.032	0.675IleCys: 0.675 ± 0.013	2.669IleAsp: 2.669 ± 0.028	2.894IleGlu: 2.894 ± 0.028	1.895IlePhe: 1.895 ± 0.022	3.067IleGly: 3.067 ± 0.032	1.116IleHis: 1.116 ± 0.016	2.329IleIle: 2.329 ± 0.027	2.232IleLys: 2.232 ± 0.026	4.465IleLeu: 4.465 ± 0.038	0.997IleMet: 0.997 ± 0.016	1.705IleAsn: 1.705 ± 0.019	3.087IlePro: 3.087 ± 0.027	1.787IleGln: 1.787 ± 0.02	2.751IleArg: 2.751 ± 0.028	4.085IleSer: 4.085 ± 0.036	2.749IleThr: 2.749 ± 0.027	2.988IleVal: 2.988 ± 0.03	0.668IleTrp: 0.668 ± 0.013	1.301IleTyr: 1.301 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.451LysAla: 4.451 ± 0.042	0.468LysCys: 0.468 ± 0.012	2.752LysAsp: 2.752 ± 0.031	3.496LysGlu: 3.496 ± 0.037	1.508LysPhe: 1.508 ± 0.02	3.156LysGly: 3.156 ± 0.03	1.121LysHis: 1.121 ± 0.015	2.519LysIle: 2.519 ± 0.026	3.752LysLys: 3.752 ± 0.064	4.053LysLeu: 4.053 ± 0.037	1.098LysMet: 1.098 ± 0.017	1.862LysAsn: 1.862 ± 0.025	2.814LysPro: 2.814 ± 0.031	1.85LysGln: 1.85 ± 0.023	3.56LysArg: 3.56 ± 0.034	3.824LysSer: 3.824 ± 0.038	2.899LysThr: 2.899 ± 0.028	2.849LysVal: 2.849 ± 0.027	0.646LysTrp: 0.646 ± 0.014	1.342LysTyr: 1.342 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.027LeuAla: 8.027 ± 0.062	1.075LeuCys: 1.075 ± 0.018	4.931LeuAsp: 4.931 ± 0.042	5.594LeuGlu: 5.594 ± 0.046	3.107LeuPhe: 3.107 ± 0.031	6.084LeuGly: 6.084 ± 0.045	2.099LeuHis: 2.099 ± 0.022	3.681LeuIle: 3.681 ± 0.038	4.306LeuLys: 4.306 ± 0.038	8.034LeuLeu: 8.034 ± 0.069	1.679LeuMet: 1.679 ± 0.021	2.949LeuAsn: 2.949 ± 0.029	5.647LeuPro: 5.647 ± 0.04	3.644LeuGln: 3.644 ± 0.033	5.632LeuArg: 5.632 ± 0.044	7.323LeuSer: 7.323 ± 0.044	4.716LeuThr: 4.716 ± 0.036	5.308LeuVal: 5.308 ± 0.044	1.066LeuTrp: 1.066 ± 0.016	2.119LeuTyr: 2.119 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.234MetAla: 2.234 ± 0.022	0.23MetCys: 0.23 ± 0.007	1.222MetAsp: 1.222 ± 0.018	1.283MetGlu: 1.283 ± 0.021	0.709MetPhe: 0.709 ± 0.014	1.489MetGly: 1.489 ± 0.018	0.442MetHis: 0.442 ± 0.009	0.977MetIle: 0.977 ± 0.015	1.093MetLys: 1.093 ± 0.019	1.75MetLeu: 1.75 ± 0.022	0.553MetMet: 0.553 ± 0.011	0.763MetAsn: 0.763 ± 0.015	1.267MetPro: 1.267 ± 0.018	0.843MetGln: 0.843 ± 0.014	1.316MetArg: 1.316 ± 0.017	1.884MetSer: 1.884 ± 0.019	1.189MetThr: 1.189 ± 0.017	1.257MetVal: 1.257 ± 0.019	0.242MetTrp: 0.242 ± 0.008	0.478MetTyr: 0.478 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.011AsnAla: 3.011 ± 0.026	0.389AsnCys: 0.389 ± 0.009	1.763AsnAsp: 1.763 ± 0.02	1.944AsnGlu: 1.944 ± 0.022	1.351AsnPhe: 1.351 ± 0.021	2.919AsnGly: 2.919 ± 0.034	0.825AsnHis: 0.825 ± 0.015	1.971AsnIle: 1.971 ± 0.023	1.479AsnLys: 1.479 ± 0.018	3.159AsnLeu: 3.159 ± 0.029	0.768AsnMet: 0.768 ± 0.014	1.375AsnAsn: 1.375 ± 0.025	2.416AsnPro: 2.416 ± 0.025	1.279AsnGln: 1.279 ± 0.021	1.892AsnArg: 1.892 ± 0.02	2.897AsnSer: 2.897 ± 0.029	2.144AsnThr: 2.144 ± 0.022	2.15AsnVal: 2.15 ± 0.025	0.483AsnTrp: 0.483 ± 0.012	1.002AsnTyr: 1.002 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.131ProAla: 6.131 ± 0.049	0.537ProCys: 0.537 ± 0.011	3.016ProAsp: 3.016 ± 0.03	3.753ProGlu: 3.753 ± 0.036	2.016ProPhe: 2.016 ± 0.022	4.356ProGly: 4.356 ± 0.037	1.356ProHis: 1.356 ± 0.02	2.561ProIle: 2.561 ± 0.027	2.804ProLys: 2.804 ± 0.032	4.928ProLeu: 4.928 ± 0.038	1.036ProMet: 1.036 ± 0.018	2.101ProAsn: 2.101 ± 0.023	5.685ProPro: 5.685 ± 0.083	2.448ProGln: 2.448 ± 0.034	3.973ProArg: 3.973 ± 0.042	6.415ProSer: 6.415 ± 0.064	4.122ProThr: 4.122 ± 0.039	3.707ProVal: 3.707 ± 0.034	0.667ProTrp: 0.667 ± 0.012	1.425ProTyr: 1.425 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.495GlnAla: 3.495 ± 0.036	0.389GlnCys: 0.389 ± 0.011	1.989GlnAsp: 1.989 ± 0.021	2.398GlnGlu: 2.398 ± 0.027	1.198GlnPhe: 1.198 ± 0.017	2.323GlnGly: 2.323 ± 0.025	1.052GlnHis: 1.052 ± 0.019	1.872GlnIle: 1.872 ± 0.023	2.038GlnLys: 2.038 ± 0.024	3.149GlnLeu: 3.149 ± 0.027	0.888GlnMet: 0.888 ± 0.017	1.554GlnAsn: 1.554 ± 0.021	2.373GlnPro: 2.373 ± 0.033	2.275GlnGln: 2.275 ± 0.053	2.658GlnArg: 2.658 ± 0.024	3.13GlnSer: 3.13 ± 0.035	2.241GlnThr: 2.241 ± 0.021	2.136GlnVal: 2.136 ± 0.021	0.461GlnTrp: 0.461 ± 0.011	1.09GlnTyr: 1.09 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.34ArgAla: 5.34 ± 0.044	0.716ArgCys: 0.716 ± 0.014	3.486ArgAsp: 3.486 ± 0.028	4.207ArgGlu: 4.207 ± 0.035	2.053ArgPhe: 2.053 ± 0.023	4.428ArgGly: 4.428 ± 0.04	1.533ArgHis: 1.533 ± 0.022	2.944ArgIle: 2.944 ± 0.025	3.7ArgLys: 3.7 ± 0.034	5.384ArgLeu: 5.384 ± 0.043	1.371ArgMet: 1.371 ± 0.017	2.28ArgAsn: 2.28 ± 0.022	3.885ArgPro: 3.885 ± 0.035	2.573ArgGln: 2.573 ± 0.028	5.538ArgArg: 5.538 ± 0.056	5.213ArgSer: 5.213 ± 0.048	3.375ArgThr: 3.375 ± 0.024	3.453ArgVal: 3.453 ± 0.029	0.878ArgTrp: 0.878 ± 0.016	1.558ArgTyr: 1.558 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	7.324SerAla: 7.324 ± 0.05	0.88SerCys: 0.88 ± 0.016	4.108SerAsp: 4.108 ± 0.038	4.383SerGlu: 4.383 ± 0.037	2.978SerPhe: 2.978 ± 0.025	5.929SerGly: 5.929 ± 0.045	1.988SerHis: 1.988 ± 0.023	4.09SerIle: 4.09 ± 0.035	4.03SerLys: 4.03 ± 0.038	7.317SerLeu: 7.317 ± 0.05	1.737SerMet: 1.737 ± 0.023	3.008SerAsn: 3.008 ± 0.027	6.345SerPro: 6.345 ± 0.073	3.376SerGln: 3.376 ± 0.04	5.666SerArg: 5.666 ± 0.049	9.624SerSer: 9.624 ± 0.104	5.73SerThr: 5.73 ± 0.055	4.595SerVal: 4.595 ± 0.038	1.074SerTrp: 1.074 ± 0.015	2.037SerTyr: 2.037 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.291ThrAla: 5.291 ± 0.036	0.677ThrCys: 0.677 ± 0.012	2.673ThrAsp: 2.673 ± 0.025	3.002ThrGlu: 3.002 ± 0.028	2.105ThrPhe: 2.105 ± 0.022	4.229ThrGly: 4.229 ± 0.035	1.24ThrHis: 1.24 ± 0.016	3.015ThrIle: 3.015 ± 0.027	2.664ThrLys: 2.664 ± 0.029	5.12ThrLeu: 5.12 ± 0.039	1.131ThrMet: 1.131 ± 0.016	1.969ThrAsn: 1.969 ± 0.024	4.548ThrPro: 4.548 ± 0.05	1.991ThrGln: 1.991 ± 0.023	3.375ThrArg: 3.375 ± 0.031	5.601ThrSer: 5.601 ± 0.048	3.979ThrThr: 3.979 ± 0.043	3.519ThrVal: 3.519 ± 0.031	0.777ThrTrp: 0.777 ± 0.015	1.515ThrTyr: 1.515 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.37ValAla: 5.37 ± 0.041	0.759ValCys: 0.759 ± 0.014	3.552ValAsp: 3.552 ± 0.03	4.043ValGlu: 4.043 ± 0.034	2.291ValPhe: 2.291 ± 0.027	4.233ValGly: 4.233 ± 0.038	1.303ValHis: 1.303 ± 0.017	2.736ValIle: 2.736 ± 0.029	2.994ValLys: 2.994 ± 0.031	5.391ValLeu: 5.391 ± 0.046	1.267ValMet: 1.267 ± 0.016	2.073ValAsn: 2.073 ± 0.024	3.647ValPro: 3.647 ± 0.033	2.294ValGln: 2.294 ± 0.022	3.464ValArg: 3.464 ± 0.033	4.663ValSer: 4.663 ± 0.036	3.379ValThr: 3.379 ± 0.03	4.259ValVal: 4.259 ± 0.04	0.817ValTrp: 0.817 ± 0.017	1.578ValTyr: 1.578 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.065TrpAla: 1.065 ± 0.017	0.175TrpCys: 0.175 ± 0.006	0.837TrpAsp: 0.837 ± 0.014	0.831TrpGlu: 0.831 ± 0.015	0.473TrpPhe: 0.473 ± 0.012	0.928TrpGly: 0.928 ± 0.017	0.319TrpHis: 0.319 ± 0.008	0.671TrpIle: 0.671 ± 0.015	0.75TrpLys: 0.75 ± 0.013	1.191TrpLeu: 1.191 ± 0.018	0.353TrpMet: 0.353 ± 0.009	0.57TrpAsn: 0.57 ± 0.012	0.565TrpPro: 0.565 ± 0.012	0.505TrpGln: 0.505 ± 0.012	0.901TrpArg: 0.901 ± 0.017	0.968TrpSer: 0.968 ± 0.016	0.827TrpThr: 0.827 ± 0.015	0.817TrpVal: 0.817 ± 0.013	0.257TrpTrp: 0.257 ± 0.007	0.362TrpTyr: 0.362 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.063TyrAla: 2.063 ± 0.022	0.357TyrCys: 0.357 ± 0.009	1.511TyrAsp: 1.511 ± 0.021	1.522TyrGlu: 1.522 ± 0.019	1.055TyrPhe: 1.055 ± 0.016	1.958TyrGly: 1.958 ± 0.027	0.687TyrHis: 0.687 ± 0.014	1.25TyrIle: 1.25 ± 0.019	1.055TyrLys: 1.055 ± 0.016	2.454TyrLeu: 2.454 ± 0.026	0.563TyrMet: 0.563 ± 0.011	1.007TyrAsn: 1.007 ± 0.016	1.442TyrPro: 1.442 ± 0.023	1.066TyrGln: 1.066 ± 0.017	1.498TyrArg: 1.498 ± 0.017	1.967TyrSer: 1.967 ± 0.024	1.531TyrThr: 1.531 ± 0.02	1.486TyrVal: 1.486 ± 0.018	0.36TyrTrp: 0.36 ± 0.01	0.792TyrTyr: 0.792 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9355 proteins (4461638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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