Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA261C02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.302AlaAla: 5.302 ± 0.222
0.675AlaCys: 0.675 ± 0.07
3.693AlaAsp: 3.693 ± 0.158
5.905AlaGlu: 5.905 ± 0.208
2.579AlaPhe: 2.579 ± 0.135
6.013AlaGly: 6.013 ± 0.216
1.265AlaHis: 1.265 ± 0.083
5.296AlaIle: 5.296 ± 0.209
4.603AlaLys: 4.603 ± 0.188
7.17AlaLeu: 7.17 ± 0.238
1.591AlaMet: 1.591 ± 0.101
1.958AlaAsn: 1.958 ± 0.131
2.531AlaPro: 2.531 ± 0.128
1.723AlaGln: 1.723 ± 0.114
4.742AlaArg: 4.742 ± 0.181
4.447AlaSer: 4.447 ± 0.179
3.217AlaThr: 3.217 ± 0.153
4.868AlaVal: 4.868 ± 0.171
0.813AlaTrp: 0.813 ± 0.079
1.922AlaTyr: 1.922 ± 0.107
0.0AlaXaa: 0.0 ± 0.0
Cys
0.663CysAla: 0.663 ± 0.072
0.102CysCys: 0.102 ± 0.028
0.464CysAsp: 0.464 ± 0.047
0.735CysGlu: 0.735 ± 0.072
0.295CysPhe: 0.295 ± 0.043
1.175CysGly: 1.175 ± 0.098
0.205CysHis: 0.205 ± 0.037
0.53CysIle: 0.53 ± 0.056
0.627CysLys: 0.627 ± 0.06
0.717CysLeu: 0.717 ± 0.065
0.211CysMet: 0.211 ± 0.037
0.277CysAsn: 0.277 ± 0.04
0.735CysPro: 0.735 ± 0.076
0.241CysGln: 0.241 ± 0.04
0.404CysArg: 0.404 ± 0.047
0.59CysSer: 0.59 ± 0.064
0.416CysThr: 0.416 ± 0.056
0.566CysVal: 0.566 ± 0.065
0.127CysTrp: 0.127 ± 0.03
0.301CysTyr: 0.301 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
3.657AspAla: 3.657 ± 0.153
0.464AspCys: 0.464 ± 0.056
2.476AspAsp: 2.476 ± 0.123
5.405AspGlu: 5.405 ± 0.208
2.368AspPhe: 2.368 ± 0.125
3.91AspGly: 3.91 ± 0.159
0.97AspHis: 0.97 ± 0.076
3.718AspIle: 3.718 ± 0.153
3.248AspLys: 3.248 ± 0.141
6.531AspLeu: 6.531 ± 0.235
1.301AspMet: 1.301 ± 0.077
1.597AspAsn: 1.597 ± 0.119
2.928AspPro: 2.928 ± 0.121
1.356AspGln: 1.356 ± 0.103
2.922AspArg: 2.922 ± 0.139
3.085AspSer: 3.085 ± 0.151
2.259AspThr: 2.259 ± 0.118
4.73AspVal: 4.73 ± 0.163
0.741AspTrp: 0.741 ± 0.07
1.946AspTyr: 1.946 ± 0.119
0.0AspXaa: 0.0 ± 0.0
Glu
6.393GluAla: 6.393 ± 0.19
0.693GluCys: 0.693 ± 0.078
5.664GluAsp: 5.664 ± 0.171
11.502GluGlu: 11.502 ± 0.401
3.236GluPhe: 3.236 ± 0.141
6.007GluGly: 6.007 ± 0.177
1.422GluHis: 1.422 ± 0.084
7.284GluIle: 7.284 ± 0.228
8.351GluLys: 8.351 ± 0.261
9.664GluLeu: 9.664 ± 0.306
2.061GluMet: 2.061 ± 0.099
3.989GluAsn: 3.989 ± 0.183
2.766GluPro: 2.766 ± 0.149
1.832GluGln: 1.832 ± 0.114
5.356GluArg: 5.356 ± 0.205
4.519GluSer: 4.519 ± 0.184
3.983GluThr: 3.983 ± 0.141
7.116GluVal: 7.116 ± 0.241
0.85GluTrp: 0.85 ± 0.077
2.326GluTyr: 2.326 ± 0.113
0.0GluXaa: 0.0 ± 0.0
Phe
2.223PheAla: 2.223 ± 0.115
0.337PheCys: 0.337 ± 0.047
2.079PheAsp: 2.079 ± 0.133
3.338PheGlu: 3.338 ± 0.161
1.446PhePhe: 1.446 ± 0.105
2.802PheGly: 2.802 ± 0.148
0.687PheHis: 0.687 ± 0.068
1.868PheIle: 1.868 ± 0.102
2.253PheLys: 2.253 ± 0.106
3.531PheLeu: 3.531 ± 0.179
0.777PheMet: 0.777 ± 0.069
1.241PheAsn: 1.241 ± 0.08
1.392PhePro: 1.392 ± 0.096
0.892PheGln: 0.892 ± 0.068
1.862PheArg: 1.862 ± 0.099
2.386PheSer: 2.386 ± 0.119
1.892PheThr: 1.892 ± 0.104
2.278PheVal: 2.278 ± 0.112
0.337PheTrp: 0.337 ± 0.046
0.904PheTyr: 0.904 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
5.501GlyAla: 5.501 ± 0.232
0.747GlyCys: 0.747 ± 0.058
4.091GlyAsp: 4.091 ± 0.165
7.357GlyGlu: 7.357 ± 0.225
2.82GlyPhe: 2.82 ± 0.127
5.766GlyGly: 5.766 ± 0.229
1.247GlyHis: 1.247 ± 0.095
5.525GlyIle: 5.525 ± 0.201
6.17GlyLys: 6.17 ± 0.182
7.164GlyLeu: 7.164 ± 0.244
1.862GlyMet: 1.862 ± 0.123
2.067GlyAsn: 2.067 ± 0.13
2.284GlyPro: 2.284 ± 0.121
1.561GlyGln: 1.561 ± 0.109
4.447GlyArg: 4.447 ± 0.182
3.886GlySer: 3.886 ± 0.178
3.934GlyThr: 3.934 ± 0.144
6.375GlyVal: 6.375 ± 0.207
0.874GlyTrp: 0.874 ± 0.071
2.422GlyTyr: 2.422 ± 0.121
0.0GlyXaa: 0.0 ± 0.0
His
1.326HisAla: 1.326 ± 0.093
0.229HisCys: 0.229 ± 0.034
1.109HisAsp: 1.109 ± 0.081
1.512HisGlu: 1.512 ± 0.101
0.639HisPhe: 0.639 ± 0.058
1.494HisGly: 1.494 ± 0.1
0.44HisHis: 0.44 ± 0.05
1.03HisIle: 1.03 ± 0.072
0.844HisLys: 0.844 ± 0.073
1.82HisLeu: 1.82 ± 0.113
0.277HisMet: 0.277 ± 0.037
0.404HisAsn: 0.404 ± 0.049
1.181HisPro: 1.181 ± 0.088
0.621HisGln: 0.621 ± 0.067
0.988HisArg: 0.988 ± 0.075
1.085HisSer: 1.085 ± 0.079
0.783HisThr: 0.783 ± 0.067
1.326HisVal: 1.326 ± 0.088
0.265HisTrp: 0.265 ± 0.038
0.609HisTyr: 0.609 ± 0.069
0.0HisXaa: 0.0 ± 0.0
Ile
5.338IleAla: 5.338 ± 0.208
0.807IleCys: 0.807 ± 0.073
4.218IleAsp: 4.218 ± 0.179
5.953IleGlu: 5.953 ± 0.182
2.284IlePhe: 2.284 ± 0.134
6.098IleGly: 6.098 ± 0.226
1.283IleHis: 1.283 ± 0.082
4.778IleIle: 4.778 ± 0.197
4.41IleLys: 4.41 ± 0.218
6.796IleLeu: 6.796 ± 0.213
1.386IleMet: 1.386 ± 0.099
2.163IleAsn: 2.163 ± 0.108
3.344IlePro: 3.344 ± 0.16
2.097IleGln: 2.097 ± 0.124
3.983IleArg: 3.983 ± 0.166
4.621IleSer: 4.621 ± 0.177
3.434IleThr: 3.434 ± 0.142
5.085IleVal: 5.085 ± 0.204
0.53IleTrp: 0.53 ± 0.058
1.765IleTyr: 1.765 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
5.146LysAla: 5.146 ± 0.194
0.729LysCys: 0.729 ± 0.077
3.549LysAsp: 3.549 ± 0.137
6.555LysGlu: 6.555 ± 0.207
2.38LysPhe: 2.38 ± 0.121
4.778LysGly: 4.778 ± 0.189
1.271LysHis: 1.271 ± 0.1
6.164LysIle: 6.164 ± 0.209
6.212LysLys: 6.212 ± 0.263
7.471LysLeu: 7.471 ± 0.266
1.633LysMet: 1.633 ± 0.106
2.494LysAsn: 2.494 ± 0.136
2.838LysPro: 2.838 ± 0.141
1.597LysGln: 1.597 ± 0.101
4.314LysArg: 4.314 ± 0.19
4.664LysSer: 4.664 ± 0.179
3.898LysThr: 3.898 ± 0.134
5.362LysVal: 5.362 ± 0.206
0.789LysTrp: 0.789 ± 0.073
1.934LysTyr: 1.934 ± 0.119
0.0LysXaa: 0.0 ± 0.0
Leu
7.773LeuAla: 7.773 ± 0.223
0.825LeuCys: 0.825 ± 0.075
6.477LeuAsp: 6.477 ± 0.24
9.857LeuGlu: 9.857 ± 0.283
3.073LeuPhe: 3.073 ± 0.172
7.471LeuGly: 7.471 ± 0.248
1.633LeuHis: 1.633 ± 0.103
6.369LeuIle: 6.369 ± 0.231
7.441LeuLys: 7.441 ± 0.253
7.929LeuLeu: 7.929 ± 0.278
1.928LeuMet: 1.928 ± 0.109
3.254LeuAsn: 3.254 ± 0.128
3.681LeuPro: 3.681 ± 0.148
2.47LeuGln: 2.47 ± 0.154
5.814LeuArg: 5.814 ± 0.221
6.29LeuSer: 6.29 ± 0.198
5.121LeuThr: 5.121 ± 0.197
6.555LeuVal: 6.555 ± 0.174
0.825LeuTrp: 0.825 ± 0.073
1.982LeuTyr: 1.982 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
1.404MetAla: 1.404 ± 0.095
0.157MetCys: 0.157 ± 0.034
1.193MetAsp: 1.193 ± 0.075
1.585MetGlu: 1.585 ± 0.092
0.506MetPhe: 0.506 ± 0.06
1.82MetGly: 1.82 ± 0.11
0.271MetHis: 0.271 ± 0.039
1.735MetIle: 1.735 ± 0.106
1.904MetLys: 1.904 ± 0.116
2.103MetLeu: 2.103 ± 0.119
0.542MetMet: 0.542 ± 0.061
0.916MetAsn: 0.916 ± 0.075
1.072MetPro: 1.072 ± 0.078
0.41MetGln: 0.41 ± 0.055
1.32MetArg: 1.32 ± 0.091
1.512MetSer: 1.512 ± 0.097
1.356MetThr: 1.356 ± 0.095
1.494MetVal: 1.494 ± 0.091
0.139MetTrp: 0.139 ± 0.029
0.307MetTyr: 0.307 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.284AsnAla: 2.284 ± 0.116
0.41AsnCys: 0.41 ± 0.052
1.344AsnAsp: 1.344 ± 0.095
2.434AsnGlu: 2.434 ± 0.135
1.289AsnPhe: 1.289 ± 0.082
1.874AsnGly: 1.874 ± 0.109
0.554AsnHis: 0.554 ± 0.062
2.024AsnIle: 2.024 ± 0.101
1.814AsnLys: 1.814 ± 0.109
4.194AsnLeu: 4.194 ± 0.151
0.615AsnMet: 0.615 ± 0.059
0.886AsnAsn: 0.886 ± 0.067
2.47AsnPro: 2.47 ± 0.118
1.072AsnGln: 1.072 ± 0.081
1.777AsnArg: 1.777 ± 0.095
2.024AsnSer: 2.024 ± 0.097
1.368AsnThr: 1.368 ± 0.112
2.434AsnVal: 2.434 ± 0.117
0.488AsnTrp: 0.488 ± 0.058
1.091AsnTyr: 1.091 ± 0.087
0.0AsnXaa: 0.0 ± 0.0
Pro
2.308ProAla: 2.308 ± 0.118
0.398ProCys: 0.398 ± 0.042
2.633ProAsp: 2.633 ± 0.12
4.332ProGlu: 4.332 ± 0.159
1.446ProPhe: 1.446 ± 0.092
3.145ProGly: 3.145 ± 0.155
0.97ProHis: 0.97 ± 0.078
2.892ProIle: 2.892 ± 0.146
2.886ProLys: 2.886 ± 0.129
3.561ProLeu: 3.561 ± 0.127
0.801ProMet: 0.801 ± 0.062
1.506ProAsn: 1.506 ± 0.085
1.874ProPro: 1.874 ± 0.115
1.332ProGln: 1.332 ± 0.092
2.175ProArg: 2.175 ± 0.121
2.952ProSer: 2.952 ± 0.131
2.356ProThr: 2.356 ± 0.115
2.886ProVal: 2.886 ± 0.141
0.452ProTrp: 0.452 ± 0.055
1.464ProTyr: 1.464 ± 0.092
0.0ProXaa: 0.0 ± 0.0
Gln
1.934GlnAla: 1.934 ± 0.11
0.145GlnCys: 0.145 ± 0.033
1.38GlnAsp: 1.38 ± 0.092
2.645GlnGlu: 2.645 ± 0.151
0.669GlnPhe: 0.669 ± 0.072
1.717GlnGly: 1.717 ± 0.105
0.47GlnHis: 0.47 ± 0.051
1.82GlnIle: 1.82 ± 0.1
1.874GlnLys: 1.874 ± 0.104
2.362GlnLeu: 2.362 ± 0.126
0.633GlnMet: 0.633 ± 0.067
0.856GlnAsn: 0.856 ± 0.074
0.964GlnPro: 0.964 ± 0.077
0.651GlnGln: 0.651 ± 0.066
1.5GlnArg: 1.5 ± 0.105
1.295GlnSer: 1.295 ± 0.095
1.229GlnThr: 1.229 ± 0.092
2.0GlnVal: 2.0 ± 0.12
0.235GlnTrp: 0.235 ± 0.04
0.651GlnTyr: 0.651 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
3.832ArgAla: 3.832 ± 0.165
0.548ArgCys: 0.548 ± 0.059
2.946ArgAsp: 2.946 ± 0.151
6.694ArgGlu: 6.694 ± 0.213
1.862ArgPhe: 1.862 ± 0.121
4.404ArgGly: 4.404 ± 0.176
0.922ArgHis: 0.922 ± 0.08
4.091ArgIle: 4.091 ± 0.154
5.26ArgLys: 5.26 ± 0.219
4.971ArgLeu: 4.971 ± 0.196
1.488ArgMet: 1.488 ± 0.082
1.699ArgAsn: 1.699 ± 0.085
1.982ArgPro: 1.982 ± 0.098
1.32ArgGln: 1.32 ± 0.1
4.151ArgArg: 4.151 ± 0.181
3.043ArgSer: 3.043 ± 0.156
2.898ArgThr: 2.898 ± 0.134
4.284ArgVal: 4.284 ± 0.179
0.765ArgTrp: 0.765 ± 0.08
1.663ArgTyr: 1.663 ± 0.099
0.0ArgXaa: 0.0 ± 0.0
Ser
4.091SerAla: 4.091 ± 0.152
0.548SerCys: 0.548 ± 0.06
3.374SerAsp: 3.374 ± 0.147
5.519SerGlu: 5.519 ± 0.178
2.145SerPhe: 2.145 ± 0.12
5.061SerGly: 5.061 ± 0.165
1.229SerHis: 1.229 ± 0.096
4.224SerIle: 4.224 ± 0.162
4.567SerLys: 4.567 ± 0.176
5.441SerLeu: 5.441 ± 0.189
1.44SerMet: 1.44 ± 0.101
1.705SerAsn: 1.705 ± 0.109
2.808SerPro: 2.808 ± 0.127
1.832SerGln: 1.832 ± 0.116
3.434SerArg: 3.434 ± 0.155
3.983SerSer: 3.983 ± 0.163
2.838SerThr: 2.838 ± 0.132
4.007SerVal: 4.007 ± 0.156
0.705SerTrp: 0.705 ± 0.064
1.567SerTyr: 1.567 ± 0.114
0.0SerXaa: 0.0 ± 0.0
Thr
3.724ThrAla: 3.724 ± 0.159
0.482ThrCys: 0.482 ± 0.052
2.35ThrAsp: 2.35 ± 0.139
3.543ThrGlu: 3.543 ± 0.149
1.609ThrPhe: 1.609 ± 0.097
3.989ThrGly: 3.989 ± 0.195
1.048ThrHis: 1.048 ± 0.075
3.784ThrIle: 3.784 ± 0.153
2.784ThrLys: 2.784 ± 0.159
5.14ThrLeu: 5.14 ± 0.15
0.856ThrMet: 0.856 ± 0.065
1.657ThrAsn: 1.657 ± 0.097
2.802ThrPro: 2.802 ± 0.141
1.265ThrGln: 1.265 ± 0.09
2.898ThrArg: 2.898 ± 0.145
3.145ThrSer: 3.145 ± 0.14
2.85ThrThr: 2.85 ± 0.127
3.332ThrVal: 3.332 ± 0.154
0.482ThrTrp: 0.482 ± 0.063
1.47ThrTyr: 1.47 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
4.905ValAla: 4.905 ± 0.196
0.681ValCys: 0.681 ± 0.075
4.441ValAsp: 4.441 ± 0.165
6.953ValGlu: 6.953 ± 0.199
2.374ValPhe: 2.374 ± 0.134
5.76ValGly: 5.76 ± 0.233
1.259ValHis: 1.259 ± 0.092
5.067ValIle: 5.067 ± 0.184
6.14ValLys: 6.14 ± 0.216
6.525ValLeu: 6.525 ± 0.203
1.47ValMet: 1.47 ± 0.082
2.404ValAsn: 2.404 ± 0.115
3.055ValPro: 3.055 ± 0.132
1.585ValGln: 1.585 ± 0.102
4.175ValArg: 4.175 ± 0.176
4.368ValSer: 4.368 ± 0.173
3.495ValThr: 3.495 ± 0.131
4.808ValVal: 4.808 ± 0.189
0.699ValTrp: 0.699 ± 0.073
1.741ValTyr: 1.741 ± 0.111
0.0ValXaa: 0.0 ± 0.0
Trp
0.711TrpAla: 0.711 ± 0.07
0.084TrpCys: 0.084 ± 0.025
0.53TrpAsp: 0.53 ± 0.06
0.85TrpGlu: 0.85 ± 0.075
0.434TrpPhe: 0.434 ± 0.053
0.675TrpGly: 0.675 ± 0.056
0.211TrpHis: 0.211 ± 0.032
0.807TrpIle: 0.807 ± 0.086
0.825TrpLys: 0.825 ± 0.063
0.946TrpLeu: 0.946 ± 0.08
0.283TrpMet: 0.283 ± 0.045
0.422TrpAsn: 0.422 ± 0.057
0.392TrpPro: 0.392 ± 0.061
0.331TrpGln: 0.331 ± 0.046
0.85TrpArg: 0.85 ± 0.076
0.771TrpSer: 0.771 ± 0.088
0.518TrpThr: 0.518 ± 0.065
0.657TrpVal: 0.657 ± 0.062
0.241TrpTrp: 0.241 ± 0.047
0.283TrpTyr: 0.283 ± 0.043
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.802TyrAla: 1.802 ± 0.107
0.319TyrCys: 0.319 ± 0.043
1.603TyrAsp: 1.603 ± 0.106
2.338TyrGlu: 2.338 ± 0.118
1.072TyrPhe: 1.072 ± 0.088
2.139TyrGly: 2.139 ± 0.117
0.621TyrHis: 0.621 ± 0.066
1.374TyrIle: 1.374 ± 0.106
1.567TyrLys: 1.567 ± 0.088
2.735TyrLeu: 2.735 ± 0.143
0.59TyrMet: 0.59 ± 0.056
0.952TyrAsn: 0.952 ± 0.084
1.271TyrPro: 1.271 ± 0.072
0.844TyrGln: 0.844 ± 0.07
1.705TyrArg: 1.705 ± 0.1
1.85TyrSer: 1.85 ± 0.125
1.362TyrThr: 1.362 ± 0.097
1.741TyrVal: 1.741 ± 0.114
0.464TyrTrp: 0.464 ± 0.054
0.94TyrTyr: 0.94 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 703 proteins (165970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski