Amino acid dipepetide frequency for Nyando virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.983AlaAla: 1.983 ± 1.788
1.487AlaCys: 1.487 ± 1.009
0.744AlaAsp: 0.744 ± 0.569
2.479AlaGlu: 2.479 ± 1.0
1.239AlaPhe: 1.239 ± 1.182
2.231AlaGly: 2.231 ± 2.537
0.992AlaHis: 0.992 ± 0.991
4.71AlaIle: 4.71 ± 1.304
4.214AlaLys: 4.214 ± 0.447
5.949AlaLeu: 5.949 ± 1.314
1.239AlaMet: 1.239 ± 0.471
1.983AlaAsn: 1.983 ± 0.93
0.496AlaPro: 0.496 ± 0.313
1.239AlaGln: 1.239 ± 1.182
3.223AlaArg: 3.223 ± 2.266
1.735AlaSer: 1.735 ± 0.514
1.983AlaThr: 1.983 ± 1.187
1.239AlaVal: 1.239 ± 0.691
0.248AlaTrp: 0.248 ± 0.156
2.231AlaTyr: 2.231 ± 0.748
0.0AlaXaa: 0.0 ± 0.0
Cys
1.487CysAla: 1.487 ± 0.392
0.0CysCys: 0.0 ± 0.0
0.744CysAsp: 0.744 ± 0.343
1.487CysGlu: 1.487 ± 1.352
1.239CysPhe: 1.239 ± 0.785
1.983CysGly: 1.983 ± 1.459
0.248CysHis: 0.248 ± 0.225
2.975CysIle: 2.975 ± 0.852
2.479CysLys: 2.479 ± 0.71
2.231CysLeu: 2.231 ± 1.028
0.992CysMet: 0.992 ± 0.325
2.231CysAsn: 2.231 ± 0.568
1.487CysPro: 1.487 ± 0.426
1.487CysGln: 1.487 ± 0.858
0.496CysArg: 0.496 ± 0.451
1.735CysSer: 1.735 ± 0.61
2.479CysThr: 2.479 ± 1.571
0.744CysVal: 0.744 ± 0.676
0.0CysTrp: 0.0 ± 0.0
0.744CysTyr: 0.744 ± 0.343
0.0CysXaa: 0.0 ± 0.0
Asp
1.983AspAla: 1.983 ± 0.331
1.239AspCys: 1.239 ± 1.085
2.479AspAsp: 2.479 ± 0.583
2.727AspGlu: 2.727 ± 0.685
2.975AspPhe: 2.975 ± 1.878
0.744AspGly: 0.744 ± 0.196
0.496AspHis: 0.496 ± 0.142
5.702AspIle: 5.702 ± 0.805
3.718AspLys: 3.718 ± 0.981
4.214AspLeu: 4.214 ± 0.92
2.479AspMet: 2.479 ± 0.609
3.966AspAsn: 3.966 ± 0.537
3.223AspPro: 3.223 ± 0.689
3.718AspGln: 3.718 ± 2.799
1.487AspArg: 1.487 ± 0.426
2.727AspSer: 2.727 ± 1.721
2.231AspThr: 2.231 ± 0.507
2.727AspVal: 2.727 ± 1.014
0.992AspTrp: 0.992 ± 0.284
2.975AspTyr: 2.975 ± 0.785
0.0AspXaa: 0.0 ± 0.0
Glu
1.735GluAla: 1.735 ± 0.428
0.744GluCys: 0.744 ± 0.343
3.223GluAsp: 3.223 ± 1.119
3.471GluGlu: 3.471 ± 0.879
4.214GluPhe: 4.214 ± 2.014
1.983GluGly: 1.983 ± 0.568
0.992GluHis: 0.992 ± 0.562
4.462GluIle: 4.462 ± 0.622
4.71GluLys: 4.71 ± 0.603
7.933GluLeu: 7.933 ± 2.052
2.479GluMet: 2.479 ± 0.96
3.966GluAsn: 3.966 ± 0.985
1.239GluPro: 1.239 ± 0.726
2.479GluGln: 2.479 ± 0.719
2.479GluArg: 2.479 ± 0.707
4.214GluSer: 4.214 ± 1.048
3.966GluThr: 3.966 ± 1.05
2.479GluVal: 2.479 ± 0.306
0.992GluTrp: 0.992 ± 0.325
3.223GluTyr: 3.223 ± 0.901
0.0GluXaa: 0.0 ± 0.0
Phe
1.735PheAla: 1.735 ± 0.433
1.239PheCys: 1.239 ± 0.471
2.975PheAsp: 2.975 ± 0.344
3.471PheGlu: 3.471 ± 0.879
1.735PhePhe: 1.735 ± 1.123
2.975PheGly: 2.975 ± 1.07
0.992PheHis: 0.992 ± 0.284
2.479PheIle: 2.479 ± 0.62
4.214PheLys: 4.214 ± 0.712
4.958PheLeu: 4.958 ± 1.154
0.496PheMet: 0.496 ± 0.142
2.975PheAsn: 2.975 ± 1.238
1.239PhePro: 1.239 ± 1.373
0.744PheGln: 0.744 ± 0.627
1.487PheArg: 1.487 ± 0.392
3.966PheSer: 3.966 ± 1.301
3.718PheThr: 3.718 ± 0.981
2.479PheVal: 2.479 ± 0.609
0.496PheTrp: 0.496 ± 0.142
1.735PheTyr: 1.735 ± 1.123
0.0PheXaa: 0.0 ± 0.0
Gly
0.992GlyAla: 0.992 ± 1.264
2.231GlyCys: 2.231 ± 0.568
2.975GlyAsp: 2.975 ± 0.735
2.231GlyGlu: 2.231 ± 0.794
1.487GlyPhe: 1.487 ± 0.841
0.248GlyGly: 0.248 ± 0.225
0.248GlyHis: 0.248 ± 0.156
3.718GlyIle: 3.718 ± 2.106
2.727GlyLys: 2.727 ± 1.672
5.454GlyLeu: 5.454 ± 1.172
1.983GlyMet: 1.983 ± 0.331
3.718GlyAsn: 3.718 ± 1.45
1.983GlyPro: 1.983 ± 0.568
0.744GlyGln: 0.744 ± 0.196
2.231GlyArg: 2.231 ± 1.008
3.223GlySer: 3.223 ± 2.44
3.966GlyThr: 3.966 ± 2.605
0.744GlyVal: 0.744 ± 0.196
0.496GlyTrp: 0.496 ± 0.142
0.992GlyTyr: 0.992 ± 0.512
0.0GlyXaa: 0.0 ± 0.0
His
0.992HisAla: 0.992 ± 0.902
1.239HisCys: 1.239 ± 0.785
1.239HisAsp: 1.239 ± 0.305
0.496HisGlu: 0.496 ± 0.313
0.744HisPhe: 0.744 ± 0.627
0.992HisGly: 0.992 ± 0.991
1.239HisHis: 1.239 ± 0.305
0.744HisIle: 0.744 ± 0.676
1.735HisLys: 1.735 ± 0.514
1.735HisLeu: 1.735 ± 0.812
0.744HisMet: 0.744 ± 0.343
1.487HisAsn: 1.487 ± 0.622
1.983HisPro: 1.983 ± 0.492
0.0HisGln: 0.0 ± 0.0
0.744HisArg: 0.744 ± 0.569
3.471HisSer: 3.471 ± 0.994
1.983HisThr: 1.983 ± 0.815
0.496HisVal: 0.496 ± 0.313
0.248HisTrp: 0.248 ± 0.156
0.496HisTyr: 0.496 ± 0.142
0.0HisXaa: 0.0 ± 0.0
Ile
5.949IleAla: 5.949 ± 1.63
2.479IleCys: 2.479 ± 1.246
2.975IleAsp: 2.975 ± 0.785
5.206IleGlu: 5.206 ± 1.407
2.727IlePhe: 2.727 ± 1.061
3.966IleGly: 3.966 ± 1.164
2.231IleHis: 2.231 ± 0.83
5.206IleIle: 5.206 ± 1.287
5.702IleLys: 5.702 ± 0.881
11.403IleLeu: 11.403 ± 2.179
2.479IleMet: 2.479 ± 0.807
6.693IleAsn: 6.693 ± 2.004
1.239IlePro: 1.239 ± 0.474
2.479IleGln: 2.479 ± 0.62
2.479IleArg: 2.479 ± 0.71
6.197IleSer: 6.197 ± 1.267
3.966IleThr: 3.966 ± 0.644
3.718IleVal: 3.718 ± 0.96
0.496IleTrp: 0.496 ± 0.313
5.454IleTyr: 5.454 ± 1.903
0.0IleXaa: 0.0 ± 0.0
Lys
3.718LysAla: 3.718 ± 1.45
1.735LysCys: 1.735 ± 0.61
5.949LysAsp: 5.949 ± 1.054
4.958LysGlu: 4.958 ± 0.701
2.727LysPhe: 2.727 ± 1.581
3.223LysGly: 3.223 ± 0.901
1.239LysHis: 1.239 ± 0.471
4.958LysIle: 4.958 ± 0.635
6.197LysLys: 6.197 ± 0.888
6.693LysLeu: 6.693 ± 1.719
3.223LysMet: 3.223 ± 0.707
4.214LysAsn: 4.214 ± 1.309
4.214LysPro: 4.214 ± 1.553
2.231LysGln: 2.231 ± 0.794
3.718LysArg: 3.718 ± 1.327
6.197LysSer: 6.197 ± 0.923
6.197LysThr: 6.197 ± 1.689
3.718LysVal: 3.718 ± 1.162
1.239LysTrp: 1.239 ± 0.691
2.479LysTyr: 2.479 ± 0.71
0.0LysXaa: 0.0 ± 0.0
Leu
4.71LeuAla: 4.71 ± 1.849
2.231LeuCys: 2.231 ± 0.748
7.189LeuAsp: 7.189 ± 2.479
9.172LeuGlu: 9.172 ± 1.062
4.958LeuPhe: 4.958 ± 2.029
3.966LeuGly: 3.966 ± 0.983
1.983LeuHis: 1.983 ± 0.568
7.437LeuIle: 7.437 ± 2.352
10.164LeuLys: 10.164 ± 0.368
9.42LeuLeu: 9.42 ± 1.369
0.992LeuMet: 0.992 ± 0.325
6.197LeuAsn: 6.197 ± 0.826
5.206LeuPro: 5.206 ± 0.941
3.718LeuGln: 3.718 ± 2.497
4.958LeuArg: 4.958 ± 1.241
6.693LeuSer: 6.693 ± 2.398
8.18LeuThr: 8.18 ± 1.342
4.214LeuVal: 4.214 ± 0.944
0.496LeuTrp: 0.496 ± 0.142
3.718LeuTyr: 3.718 ± 0.981
0.0LeuXaa: 0.0 ± 0.0
Met
0.744MetAla: 0.744 ± 0.469
1.487MetCys: 1.487 ± 0.426
2.727MetAsp: 2.727 ± 1.031
1.735MetGlu: 1.735 ± 0.775
0.992MetPhe: 0.992 ± 0.512
0.496MetGly: 0.496 ± 0.313
0.496MetHis: 0.496 ± 0.142
2.479MetIle: 2.479 ± 0.609
2.479MetLys: 2.479 ± 0.942
2.479MetLeu: 2.479 ± 0.719
0.744MetMet: 0.744 ± 1.528
1.735MetAsn: 1.735 ± 0.514
1.735MetPro: 1.735 ± 0.902
0.744MetGln: 0.744 ± 0.627
1.239MetArg: 1.239 ± 0.305
1.983MetSer: 1.983 ± 1.198
1.983MetThr: 1.983 ± 0.815
0.992MetVal: 0.992 ± 0.284
0.0MetTrp: 0.0 ± 0.0
0.992MetTyr: 0.992 ± 0.626
0.0MetXaa: 0.0 ± 0.0
Asn
2.231AsnAla: 2.231 ± 0.507
1.735AsnCys: 1.735 ± 1.234
3.223AsnAsp: 3.223 ± 1.707
4.214AsnGlu: 4.214 ± 1.074
3.718AsnPhe: 3.718 ± 0.392
1.487AsnGly: 1.487 ± 1.245
2.231AsnHis: 2.231 ± 0.291
5.949AsnIle: 5.949 ± 1.613
3.718AsnLys: 3.718 ± 1.162
7.685AsnLeu: 7.685 ± 1.105
1.735AsnMet: 1.735 ± 0.746
3.223AsnAsn: 3.223 ± 1.726
3.223AsnPro: 3.223 ± 0.384
1.487AsnGln: 1.487 ± 0.426
2.975AsnArg: 2.975 ± 0.551
4.71AsnSer: 4.71 ± 0.672
3.966AsnThr: 3.966 ± 0.8
2.231AsnVal: 2.231 ± 0.724
0.992AsnTrp: 0.992 ± 0.284
3.718AsnTyr: 3.718 ± 1.162
0.248AsnXaa: 0.248 ± 0.225
Pro
0.992ProAla: 0.992 ± 0.284
1.239ProCys: 1.239 ± 0.785
2.975ProAsp: 2.975 ± 0.888
2.479ProGlu: 2.479 ± 0.306
1.487ProPhe: 1.487 ± 0.426
2.727ProGly: 2.727 ± 1.061
0.496ProHis: 0.496 ± 0.451
3.471ProIle: 3.471 ± 0.834
1.735ProLys: 1.735 ± 2.361
4.214ProLeu: 4.214 ± 0.739
0.496ProMet: 0.496 ± 0.313
1.239ProAsn: 1.239 ± 0.474
0.248ProPro: 0.248 ± 0.156
0.248ProGln: 0.248 ± 0.156
1.239ProArg: 1.239 ± 0.474
2.479ProSer: 2.479 ± 0.609
1.983ProThr: 1.983 ± 0.568
2.479ProVal: 2.479 ± 0.609
0.496ProTrp: 0.496 ± 0.313
0.496ProTyr: 0.496 ± 0.313
0.0ProXaa: 0.0 ± 0.0
Gln
0.496GlnAla: 0.496 ± 0.313
0.744GlnCys: 0.744 ± 0.343
1.983GlnAsp: 1.983 ± 0.797
1.487GlnGlu: 1.487 ± 0.858
1.983GlnPhe: 1.983 ± 0.331
2.727GlnGly: 2.727 ± 1.061
0.992GlnHis: 0.992 ± 0.284
3.223GlnIle: 3.223 ± 0.285
3.223GlnLys: 3.223 ± 1.397
3.223GlnLeu: 3.223 ± 0.904
0.496GlnMet: 0.496 ± 0.451
1.735GlnAsn: 1.735 ± 0.61
0.744GlnPro: 0.744 ± 0.196
0.744GlnGln: 0.744 ± 0.627
1.487GlnArg: 1.487 ± 1.391
1.983GlnSer: 1.983 ± 3.488
1.239GlnThr: 1.239 ± 0.305
1.487GlnVal: 1.487 ± 0.622
0.496GlnTrp: 0.496 ± 1.349
1.487GlnTyr: 1.487 ± 1.896
0.0GlnXaa: 0.0 ± 0.0
Arg
1.735ArgAla: 1.735 ± 0.384
1.487ArgCys: 1.487 ± 0.426
1.239ArgAsp: 1.239 ± 0.726
2.479ArgGlu: 2.479 ± 1.24
1.487ArgPhe: 1.487 ± 0.841
0.992ArgGly: 0.992 ± 0.512
2.727ArgHis: 2.727 ± 0.685
3.471ArgIle: 3.471 ± 0.882
2.975ArgLys: 2.975 ± 0.988
4.462ArgLeu: 4.462 ± 1.279
0.496ArgMet: 0.496 ± 0.142
3.223ArgAsn: 3.223 ± 1.707
0.744ArgPro: 0.744 ± 0.718
0.496ArgGln: 0.496 ± 1.349
1.983ArgArg: 1.983 ± 0.331
2.727ArgSer: 2.727 ± 1.093
2.231ArgThr: 2.231 ± 0.748
1.487ArgVal: 1.487 ± 0.407
0.992ArgTrp: 0.992 ± 2.081
2.231ArgTyr: 2.231 ± 0.507
0.0ArgXaa: 0.0 ± 0.0
Ser
2.975SerAla: 2.975 ± 1.586
1.983SerCys: 1.983 ± 0.568
2.975SerAsp: 2.975 ± 0.815
4.71SerGlu: 4.71 ± 1.449
2.479SerPhe: 2.479 ± 0.306
4.958SerGly: 4.958 ± 1.404
1.983SerHis: 1.983 ± 0.492
6.445SerIle: 6.445 ± 1.089
5.702SerLys: 5.702 ± 1.397
7.437SerLeu: 7.437 ± 1.387
2.727SerMet: 2.727 ± 0.729
3.471SerAsn: 3.471 ± 0.513
0.992SerPro: 0.992 ± 0.284
2.727SerGln: 2.727 ± 0.695
2.727SerArg: 2.727 ± 0.75
4.958SerSer: 4.958 ± 3.598
6.941SerThr: 6.941 ± 1.166
3.966SerVal: 3.966 ± 0.801
0.496SerTrp: 0.496 ± 0.313
3.471SerTyr: 3.471 ± 1.219
0.0SerXaa: 0.0 ± 0.0
Thr
4.214ThrAla: 4.214 ± 0.964
1.487ThrCys: 1.487 ± 1.009
2.727ThrAsp: 2.727 ± 1.061
3.471ThrGlu: 3.471 ± 1.07
3.966ThrPhe: 3.966 ± 1.301
3.718ThrGly: 3.718 ± 0.886
0.744ThrHis: 0.744 ± 0.676
6.445ThrIle: 6.445 ± 1.761
4.958ThrLys: 4.958 ± 1.269
5.454ThrLeu: 5.454 ± 1.653
1.487ThrMet: 1.487 ± 1.048
5.454ThrAsn: 5.454 ± 1.562
1.983ThrPro: 1.983 ± 0.492
1.735ThrGln: 1.735 ± 0.433
1.983ThrArg: 1.983 ± 1.193
5.702ThrSer: 5.702 ± 1.403
4.462ThrThr: 4.462 ± 1.496
2.975ThrVal: 2.975 ± 0.551
0.992ThrTrp: 0.992 ± 1.444
2.975ThrTyr: 2.975 ± 0.785
0.248ThrXaa: 0.248 ± 0.225
Val
1.487ValAla: 1.487 ± 0.685
1.487ValCys: 1.487 ± 0.426
0.992ValAsp: 0.992 ± 0.938
1.983ValGlu: 1.983 ± 0.331
3.223ValPhe: 3.223 ± 0.845
1.487ValGly: 1.487 ± 0.392
1.487ValHis: 1.487 ± 0.685
3.966ValIle: 3.966 ± 1.164
3.223ValLys: 3.223 ± 0.285
4.214ValLeu: 4.214 ± 1.539
0.744ValMet: 0.744 ± 0.343
2.479ValAsn: 2.479 ± 1.0
0.496ValPro: 0.496 ± 0.142
1.983ValGln: 1.983 ± 1.046
1.239ValArg: 1.239 ± 0.305
4.958ValSer: 4.958 ± 0.619
2.479ValThr: 2.479 ± 0.71
3.223ValVal: 3.223 ± 0.805
0.0ValTrp: 0.0 ± 0.0
2.975ValTyr: 2.975 ± 0.785
0.0ValXaa: 0.0 ± 0.0
Trp
0.248TrpAla: 0.248 ± 0.225
0.248TrpCys: 0.248 ± 0.156
0.744TrpAsp: 0.744 ± 0.343
0.496TrpGlu: 0.496 ± 0.142
0.496TrpPhe: 0.496 ± 0.142
0.496TrpGly: 0.496 ± 0.659
0.248TrpHis: 0.248 ± 1.085
0.496TrpIle: 0.496 ± 0.142
0.248TrpLys: 0.248 ± 0.156
1.735TrpLeu: 1.735 ± 0.433
0.496TrpMet: 0.496 ± 0.659
0.744TrpAsn: 0.744 ± 0.469
0.0TrpPro: 0.0 ± 0.0
0.496TrpGln: 0.496 ± 0.313
0.496TrpArg: 0.496 ± 1.031
2.231TrpSer: 2.231 ± 1.912
0.496TrpThr: 0.496 ± 0.142
0.248TrpVal: 0.248 ± 0.225
0.0TrpTrp: 0.0 ± 0.0
0.248TrpTyr: 0.248 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.239TyrAla: 1.239 ± 0.305
0.744TyrCys: 0.744 ± 0.676
2.479TyrAsp: 2.479 ± 0.306
2.231TyrGlu: 2.231 ± 0.794
2.231TyrPhe: 2.231 ± 1.085
0.992TyrGly: 0.992 ± 0.592
0.744TyrHis: 0.744 ± 0.343
4.958TyrIle: 4.958 ± 1.062
4.71TyrLys: 4.71 ± 1.266
4.71TyrLeu: 4.71 ± 1.904
1.487TyrMet: 1.487 ± 0.392
3.966TyrAsn: 3.966 ± 0.985
0.744TyrPro: 0.744 ± 0.569
2.479TyrGln: 2.479 ± 1.24
0.992TyrArg: 0.992 ± 0.512
1.983TyrSer: 1.983 ± 0.568
2.727TyrThr: 2.727 ± 0.685
2.479TyrVal: 2.479 ± 0.609
0.744TyrTrp: 0.744 ± 0.196
1.239TyrTyr: 1.239 ± 0.474
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.248XaaAsp: 0.248 ± 0.225
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.248XaaSer: 0.248 ± 0.225
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (4035 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski