Amino acid dipepetide frequency for Torque teno midi virus 15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.777AlaAla: 6.777 ± 3.288
0.0AlaCys: 0.0 ± 0.0
1.506AlaAsp: 1.506 ± 0.926
3.765AlaGlu: 3.765 ± 2.414
0.753AlaPhe: 0.753 ± 0.763
3.765AlaGly: 3.765 ± 1.449
2.259AlaHis: 2.259 ± 1.487
1.506AlaIle: 1.506 ± 0.574
2.259AlaLys: 2.259 ± 1.289
6.777AlaLeu: 6.777 ± 2.549
1.506AlaMet: 1.506 ± 0.926
0.0AlaAsn: 0.0 ± 0.0
2.259AlaPro: 2.259 ± 0.711
1.506AlaGln: 1.506 ± 0.574
6.777AlaArg: 6.777 ± 1.453
1.506AlaSer: 1.506 ± 0.65
3.765AlaThr: 3.765 ± 1.206
0.753AlaVal: 0.753 ± 0.463
3.012AlaTrp: 3.012 ± 1.055
0.753AlaTyr: 0.753 ± 0.463
0.0AlaXaa: 0.0 ± 0.0
Cys
0.753CysAla: 0.753 ± 0.463
0.0CysCys: 0.0 ± 0.0
1.506CysAsp: 1.506 ± 0.926
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
3.012CysGly: 3.012 ± 1.055
2.259CysHis: 2.259 ± 1.487
0.0CysIle: 0.0 ± 0.0
0.753CysLys: 0.753 ± 0.463
0.0CysLeu: 0.0 ± 0.0
0.753CysMet: 0.753 ± 0.463
0.753CysAsn: 0.753 ± 0.763
0.753CysPro: 0.753 ± 0.463
0.753CysGln: 0.753 ± 0.463
0.753CysArg: 0.753 ± 0.463
0.753CysSer: 0.753 ± 0.463
1.506CysThr: 1.506 ± 0.65
0.753CysVal: 0.753 ± 0.463
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.024AspAla: 6.024 ± 2.109
0.0AspCys: 0.0 ± 0.0
0.0AspAsp: 0.0 ± 0.0
7.53AspGlu: 7.53 ± 4.022
3.765AspPhe: 3.765 ± 0.664
2.259AspGly: 2.259 ± 0.711
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.753AspLys: 0.753 ± 0.463
6.024AspLeu: 6.024 ± 0.872
0.753AspMet: 0.753 ± 0.463
1.506AspAsn: 1.506 ± 0.926
4.518AspPro: 4.518 ± 0.445
1.506AspGln: 1.506 ± 0.926
0.753AspArg: 0.753 ± 0.463
5.271AspSer: 5.271 ± 2.536
5.271AspThr: 5.271 ± 0.761
2.259AspVal: 2.259 ± 1.487
0.0AspTrp: 0.0 ± 0.0
4.518AspTyr: 4.518 ± 2.777
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
1.506GluCys: 1.506 ± 0.65
6.777GluAsp: 6.777 ± 2.43
3.012GluGlu: 3.012 ± 1.055
0.753GluPhe: 0.753 ± 0.463
0.753GluGly: 0.753 ± 0.763
0.0GluHis: 0.0 ± 0.0
6.024GluIle: 6.024 ± 2.109
4.518GluLys: 4.518 ± 1.135
3.012GluLeu: 3.012 ± 1.055
0.0GluMet: 0.0 ± 0.434
7.53GluAsn: 7.53 ± 4.022
4.518GluPro: 4.518 ± 1.135
3.765GluGln: 3.765 ± 0.664
0.0GluArg: 0.0 ± 0.0
5.271GluSer: 5.271 ± 1.683
4.518GluThr: 4.518 ± 1.743
0.753GluVal: 0.753 ± 0.763
0.0GluTrp: 0.0 ± 0.0
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 1.558
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
0.753PheGlu: 0.753 ± 0.763
1.506PhePhe: 1.506 ± 0.926
0.753PheGly: 0.753 ± 0.463
2.259PheHis: 2.259 ± 1.268
1.506PheIle: 1.506 ± 0.926
2.259PheLys: 2.259 ± 0.711
6.024PheLeu: 6.024 ± 2.109
0.753PheMet: 0.753 ± 0.463
1.506PheAsn: 1.506 ± 0.926
1.506PhePro: 1.506 ± 0.926
0.753PheGln: 0.753 ± 0.463
1.506PheArg: 1.506 ± 0.574
1.506PheSer: 1.506 ± 0.926
2.259PheThr: 2.259 ± 1.487
1.506PheVal: 1.506 ± 0.926
0.0PheTrp: 0.0 ± 0.0
0.753PheTyr: 0.753 ± 0.463
0.0PheXaa: 0.0 ± 0.0
Gly
2.259GlyAla: 2.259 ± 0.711
3.012GlyCys: 3.012 ± 1.055
6.777GlyAsp: 6.777 ± 1.701
0.753GlyGlu: 0.753 ± 0.463
0.753GlyPhe: 0.753 ± 0.463
3.012GlyGly: 3.012 ± 1.851
0.753GlyHis: 0.753 ± 0.463
1.506GlyIle: 1.506 ± 0.65
8.283GlyLys: 8.283 ± 4.327
3.012GlyLeu: 3.012 ± 1.851
1.506GlyMet: 1.506 ± 0.734
3.012GlyAsn: 3.012 ± 1.851
2.259GlyPro: 2.259 ± 1.389
0.0GlyGln: 0.0 ± 0.0
0.753GlyArg: 0.753 ± 0.763
0.753GlySer: 0.753 ± 0.463
3.012GlyThr: 3.012 ± 1.851
0.753GlyVal: 0.753 ± 0.763
2.259GlyTrp: 2.259 ± 1.268
0.753GlyTyr: 0.753 ± 0.763
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.753HisCys: 0.753 ± 0.463
2.259HisAsp: 2.259 ± 1.487
0.753HisGlu: 0.753 ± 0.463
3.012HisPhe: 3.012 ± 1.055
1.506HisGly: 1.506 ± 0.574
2.259HisHis: 2.259 ± 1.487
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
1.506HisLeu: 1.506 ± 0.926
0.0HisMet: 0.0 ± 0.0
2.259HisAsn: 2.259 ± 1.389
3.012HisPro: 3.012 ± 1.234
3.765HisGln: 3.765 ± 2.257
3.012HisArg: 3.012 ± 1.196
2.259HisSer: 2.259 ± 0.871
2.259HisThr: 2.259 ± 0.711
0.0HisVal: 0.0 ± 0.0
2.259HisTrp: 2.259 ± 1.487
3.012HisTyr: 3.012 ± 1.998
0.0HisXaa: 0.0 ± 0.0
Ile
0.753IleAla: 0.753 ± 0.718
2.259IleCys: 2.259 ± 1.389
1.506IleAsp: 1.506 ± 0.926
4.518IleGlu: 4.518 ± 1.135
0.753IlePhe: 0.753 ± 0.463
0.753IleGly: 0.753 ± 0.463
1.506IleHis: 1.506 ± 0.926
8.283IleIle: 8.283 ± 1.423
0.753IleLys: 0.753 ± 0.463
5.271IleLeu: 5.271 ± 0.619
0.753IleMet: 0.753 ± 0.463
0.753IleAsn: 0.753 ± 0.463
3.765IlePro: 3.765 ± 0.664
5.271IleGln: 5.271 ± 0.756
3.012IleArg: 3.012 ± 1.196
4.518IleSer: 4.518 ± 0.445
5.271IleThr: 5.271 ± 0.961
1.506IleVal: 1.506 ± 0.574
0.753IleTrp: 0.753 ± 0.463
0.753IleTyr: 0.753 ± 0.763
0.0IleXaa: 0.0 ± 0.0
Lys
0.753LysAla: 0.753 ± 0.763
0.0LysCys: 0.0 ± 0.0
3.012LysAsp: 3.012 ± 1.055
4.518LysGlu: 4.518 ± 1.795
1.506LysPhe: 1.506 ± 0.574
0.753LysGly: 0.753 ± 0.463
4.518LysHis: 4.518 ± 0.972
5.271LysIle: 5.271 ± 1.817
8.283LysLys: 8.283 ± 2.021
5.271LysLeu: 5.271 ± 0.619
0.0LysMet: 0.0 ± 0.0
6.024LysAsn: 6.024 ± 1.994
3.765LysPro: 3.765 ± 1.449
9.036LysGln: 9.036 ± 0.758
9.789LysArg: 9.789 ± 3.589
4.518LysSer: 4.518 ± 1.951
7.53LysThr: 7.53 ± 1.769
3.012LysVal: 3.012 ± 1.053
3.012LysTrp: 3.012 ± 1.851
0.753LysTyr: 0.753 ± 0.463
0.0LysXaa: 0.0 ± 0.0
Leu
4.518LeuAla: 4.518 ± 0.445
0.753LeuCys: 0.753 ± 0.463
6.777LeuAsp: 6.777 ± 4.462
3.765LeuGlu: 3.765 ± 0.664
1.506LeuPhe: 1.506 ± 0.926
1.506LeuGly: 1.506 ± 0.926
2.259LeuHis: 2.259 ± 0.711
1.506LeuIle: 1.506 ± 0.926
9.789LeuLys: 9.789 ± 1.452
6.777LeuLeu: 6.777 ± 2.733
0.753LeuMet: 0.753 ± 0.463
3.012LeuAsn: 3.012 ± 1.234
6.777LeuPro: 6.777 ± 3.553
6.024LeuGln: 6.024 ± 2.978
3.765LeuArg: 3.765 ± 1.558
1.506LeuSer: 1.506 ± 0.65
3.765LeuThr: 3.765 ± 2.314
0.753LeuVal: 0.753 ± 0.463
3.012LeuTrp: 3.012 ± 1.055
6.024LeuTyr: 6.024 ± 0.672
0.0LeuXaa: 0.0 ± 0.0
Met
0.753MetAla: 0.753 ± 0.463
0.0MetCys: 0.0 ± 0.0
0.753MetAsp: 0.753 ± 0.463
0.753MetGlu: 0.753 ± 0.463
0.753MetPhe: 0.753 ± 0.763
0.753MetGly: 0.753 ± 0.463
0.753MetHis: 0.753 ± 0.463
0.0MetIle: 0.0 ± 0.0
0.753MetLys: 0.753 ± 0.463
2.259MetLeu: 2.259 ± 1.389
0.753MetMet: 0.753 ± 0.463
0.753MetAsn: 0.753 ± 0.463
3.012MetPro: 3.012 ± 1.055
4.518MetGln: 4.518 ± 1.059
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
0.753MetThr: 0.753 ± 0.463
1.506MetVal: 1.506 ± 0.65
0.0MetTrp: 0.0 ± 0.0
2.259MetTyr: 2.259 ± 1.389
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 1.558
0.753AsnCys: 0.753 ± 0.463
0.753AsnAsp: 0.753 ± 0.463
1.506AsnGlu: 1.506 ± 0.65
1.506AsnPhe: 1.506 ± 0.926
2.259AsnGly: 2.259 ± 1.389
0.0AsnHis: 0.0 ± 0.0
4.518AsnIle: 4.518 ± 1.898
6.024AsnLys: 6.024 ± 2.978
1.506AsnLeu: 1.506 ± 0.926
0.753AsnMet: 0.753 ± 0.65
0.753AsnAsn: 0.753 ± 0.463
4.518AsnPro: 4.518 ± 2.777
3.765AsnGln: 3.765 ± 1.449
3.012AsnArg: 3.012 ± 1.055
0.753AsnSer: 0.753 ± 0.718
3.765AsnThr: 3.765 ± 0.664
3.012AsnVal: 3.012 ± 1.998
0.753AsnTrp: 0.753 ± 0.463
2.259AsnTyr: 2.259 ± 1.389
0.0AsnXaa: 0.0 ± 0.0
Pro
3.765ProAla: 3.765 ± 1.449
0.753ProCys: 0.753 ± 0.463
0.753ProAsp: 0.753 ± 0.463
5.271ProGlu: 5.271 ± 0.761
3.765ProPhe: 3.765 ± 0.664
6.024ProGly: 6.024 ± 2.991
2.259ProHis: 2.259 ± 1.389
3.765ProIle: 3.765 ± 0.913
5.271ProLys: 5.271 ± 3.43
7.53ProLeu: 7.53 ± 2.115
0.753ProMet: 0.753 ± 0.463
1.506ProAsn: 1.506 ± 0.926
8.283ProPro: 8.283 ± 1.696
6.777ProGln: 6.777 ± 2.198
6.777ProArg: 6.777 ± 2.507
6.024ProSer: 6.024 ± 0.546
3.765ProThr: 3.765 ± 1.206
0.753ProVal: 0.753 ± 0.463
3.012ProTrp: 3.012 ± 1.998
3.012ProTyr: 3.012 ± 1.234
0.0ProXaa: 0.0 ± 0.0
Gln
1.506GlnAla: 1.506 ± 0.574
0.0GlnCys: 0.0 ± 0.0
5.271GlnAsp: 5.271 ± 0.761
5.271GlnGlu: 5.271 ± 0.756
0.0GlnPhe: 0.0 ± 0.0
0.753GlnGly: 0.753 ± 0.463
5.271GlnHis: 5.271 ± 2.536
2.259GlnIle: 2.259 ± 1.389
4.518GlnLys: 4.518 ± 0.815
8.283GlnLeu: 8.283 ± 0.532
3.012GlnMet: 3.012 ± 1.3
4.518GlnAsn: 4.518 ± 0.445
5.271GlnPro: 5.271 ± 1.749
8.283GlnGln: 8.283 ± 2.331
1.506GlnArg: 1.506 ± 0.574
3.012GlnSer: 3.012 ± 1.872
4.518GlnThr: 4.518 ± 1.743
0.753GlnVal: 0.753 ± 0.463
3.012GlnTrp: 3.012 ± 1.055
2.259GlnTyr: 2.259 ± 0.871
0.0GlnXaa: 0.0 ± 0.0
Arg
5.271ArgAla: 5.271 ± 2.347
2.259ArgCys: 2.259 ± 1.389
3.765ArgAsp: 3.765 ± 1.558
0.753ArgGlu: 0.753 ± 0.463
0.753ArgPhe: 0.753 ± 0.763
3.765ArgGly: 3.765 ± 0.664
0.753ArgHis: 0.753 ± 0.763
0.753ArgIle: 0.753 ± 0.463
9.789ArgLys: 9.789 ± 2.166
1.506ArgLeu: 1.506 ± 0.926
0.753ArgMet: 0.753 ± 0.463
4.518ArgAsn: 4.518 ± 1.135
4.518ArgPro: 4.518 ± 1.721
4.518ArgGln: 4.518 ± 1.898
12.801ArgArg: 12.801 ± 5.204
2.259ArgSer: 2.259 ± 0.587
3.765ArgThr: 3.765 ± 0.976
0.753ArgVal: 0.753 ± 0.463
0.753ArgTrp: 0.753 ± 0.463
2.259ArgTyr: 2.259 ± 1.389
0.0ArgXaa: 0.0 ± 0.0
Ser
3.765SerAla: 3.765 ± 1.862
0.0SerCys: 0.0 ± 0.0
2.259SerAsp: 2.259 ± 1.389
3.765SerGlu: 3.765 ± 1.449
3.012SerPhe: 3.012 ± 1.053
1.506SerGly: 1.506 ± 0.926
0.753SerHis: 0.753 ± 0.763
3.012SerIle: 3.012 ± 1.3
3.012SerLys: 3.012 ± 1.234
2.259SerLeu: 2.259 ± 0.871
2.259SerMet: 2.259 ± 0.57
3.012SerAsn: 3.012 ± 1.3
1.506SerPro: 1.506 ± 0.574
3.765SerGln: 3.765 ± 2.414
3.765SerArg: 3.765 ± 1.449
9.036SerSer: 9.036 ± 4.229
6.777SerThr: 6.777 ± 1.244
4.518SerVal: 4.518 ± 2.974
1.506SerTrp: 1.506 ± 0.926
0.753SerTyr: 0.753 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
3.765ThrAla: 3.765 ± 1.648
0.753ThrCys: 0.753 ± 0.763
5.271ThrAsp: 5.271 ± 0.619
3.012ThrGlu: 3.012 ± 1.055
0.753ThrPhe: 0.753 ± 0.463
5.271ThrGly: 5.271 ± 0.619
6.024ThrHis: 6.024 ± 1.406
6.024ThrIle: 6.024 ± 0.546
4.518ThrLys: 4.518 ± 1.113
4.518ThrLeu: 4.518 ± 1.743
0.753ThrMet: 0.753 ± 0.463
3.012ThrAsn: 3.012 ± 1.053
3.765ThrPro: 3.765 ± 1.206
2.259ThrGln: 2.259 ± 1.268
2.259ThrArg: 2.259 ± 0.587
6.024ThrSer: 6.024 ± 2.214
6.024ThrThr: 6.024 ± 2.36
3.012ThrVal: 3.012 ± 1.053
2.259ThrTrp: 2.259 ± 1.389
3.765ThrTyr: 3.765 ± 0.716
0.0ThrXaa: 0.0 ± 0.0
Val
1.506ValAla: 1.506 ± 0.574
0.0ValCys: 0.0 ± 0.0
1.506ValAsp: 1.506 ± 0.926
2.259ValGlu: 2.259 ± 1.487
0.753ValPhe: 0.753 ± 0.463
0.753ValGly: 0.753 ± 0.463
0.0ValHis: 0.0 ± 0.0
0.753ValIle: 0.753 ± 0.463
2.259ValLys: 2.259 ± 0.711
0.0ValLeu: 0.0 ± 0.0
3.765ValMet: 3.765 ± 0.664
0.0ValAsn: 0.0 ± 0.0
7.53ValPro: 7.53 ± 3.742
0.753ValGln: 0.753 ± 0.463
1.506ValArg: 1.506 ± 0.926
2.259ValSer: 2.259 ± 1.268
0.753ValThr: 0.753 ± 0.463
3.012ValVal: 3.012 ± 1.055
0.0ValTrp: 0.0 ± 0.0
0.753ValTyr: 0.753 ± 0.463
0.0ValXaa: 0.0 ± 0.0
Trp
0.753TrpAla: 0.753 ± 0.463
2.259TrpCys: 2.259 ± 1.487
0.753TrpAsp: 0.753 ± 0.463
0.753TrpGlu: 0.753 ± 0.463
4.518TrpPhe: 4.518 ± 1.135
5.271TrpGly: 5.271 ± 0.761
0.0TrpHis: 0.0 ± 0.0
2.259TrpIle: 2.259 ± 1.487
1.506TrpLys: 1.506 ± 0.926
2.259TrpLeu: 2.259 ± 0.711
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
2.259TrpPro: 2.259 ± 1.487
1.506TrpGln: 1.506 ± 0.926
1.506TrpArg: 1.506 ± 0.926
0.753TrpSer: 0.753 ± 0.463
1.506TrpThr: 1.506 ± 0.926
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.753TyrAla: 0.753 ± 0.463
0.0TyrCys: 0.0 ± 0.0
1.506TyrAsp: 1.506 ± 0.574
0.753TyrGlu: 0.753 ± 0.463
0.753TyrPhe: 0.753 ± 0.463
0.753TyrGly: 0.753 ± 0.463
0.0TyrHis: 0.0 ± 0.0
3.765TyrIle: 3.765 ± 2.314
6.024TyrLys: 6.024 ± 1.406
0.753TyrLeu: 0.753 ± 0.463
0.753TyrMet: 0.753 ± 0.463
1.506TyrAsn: 1.506 ± 0.926
6.024TyrPro: 6.024 ± 1.896
0.753TyrGln: 0.753 ± 0.463
3.012TyrArg: 3.012 ± 1.851
2.259TyrSer: 2.259 ± 0.871
2.259TyrThr: 2.259 ± 0.711
0.753TyrVal: 0.753 ± 0.463
2.259TyrTrp: 2.259 ± 1.389
1.506TyrTyr: 1.506 ± 0.926
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski