Amino acid dipepetide frequency for Monosporascus sp. 5C6A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.442AlaAla: 11.442 ± 0.071
1.084AlaCys: 1.084 ± 0.017
4.999AlaAsp: 4.999 ± 0.031
5.887AlaGlu: 5.887 ± 0.041
3.206AlaPhe: 3.206 ± 0.025
6.849AlaGly: 6.849 ± 0.047
1.933AlaHis: 1.933 ± 0.019
4.184AlaIle: 4.184 ± 0.028
4.153AlaLys: 4.153 ± 0.034
8.497AlaLeu: 8.497 ± 0.047
2.133AlaMet: 2.133 ± 0.021
3.035AlaAsn: 3.035 ± 0.024
5.203AlaPro: 5.203 ± 0.041
3.611AlaGln: 3.611 ± 0.03
6.011AlaArg: 6.011 ± 0.043
7.375AlaSer: 7.375 ± 0.04
5.62AlaThr: 5.62 ± 0.036
6.215AlaVal: 6.215 ± 0.039
1.259AlaTrp: 1.259 ± 0.015
2.298AlaTyr: 2.298 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
0.981CysAla: 0.981 ± 0.014
0.221CysCys: 0.221 ± 0.007
0.645CysAsp: 0.645 ± 0.009
0.599CysGlu: 0.599 ± 0.011
0.495CysPhe: 0.495 ± 0.01
0.962CysGly: 0.962 ± 0.015
0.314CysHis: 0.314 ± 0.007
0.622CysIle: 0.622 ± 0.011
0.455CysLys: 0.455 ± 0.01
1.122CysLeu: 1.122 ± 0.016
0.242CysMet: 0.242 ± 0.006
0.391CysAsn: 0.391 ± 0.007
0.624CysPro: 0.624 ± 0.011
0.396CysGln: 0.396 ± 0.009
0.788CysArg: 0.788 ± 0.011
0.809CysSer: 0.809 ± 0.013
0.62CysThr: 0.62 ± 0.01
0.766CysVal: 0.766 ± 0.012
0.189CysTrp: 0.189 ± 0.006
0.341CysTyr: 0.341 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.449AspAla: 5.449 ± 0.034
0.597AspCys: 0.597 ± 0.01
4.541AspAsp: 4.541 ± 0.045
4.563AspGlu: 4.563 ± 0.039
2.171AspPhe: 2.171 ± 0.021
4.676AspGly: 4.676 ± 0.03
1.232AspHis: 1.232 ± 0.016
2.911AspIle: 2.911 ± 0.026
2.308AspLys: 2.308 ± 0.022
5.071AspLeu: 5.071 ± 0.031
1.267AspMet: 1.267 ± 0.014
1.87AspAsn: 1.87 ± 0.018
3.532AspPro: 3.532 ± 0.024
1.803AspGln: 1.803 ± 0.016
3.418AspArg: 3.418 ± 0.029
3.932AspSer: 3.932 ± 0.025
2.878AspThr: 2.878 ± 0.021
3.965AspVal: 3.965 ± 0.028
0.936AspTrp: 0.936 ± 0.013
1.633AspTyr: 1.633 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
6.131GluAla: 6.131 ± 0.042
0.636GluCys: 0.636 ± 0.011
4.295GluAsp: 4.295 ± 0.035
5.325GluGlu: 5.325 ± 0.049
1.939GluPhe: 1.939 ± 0.018
4.06GluGly: 4.06 ± 0.026
1.422GluHis: 1.422 ± 0.015
2.883GluIle: 2.883 ± 0.023
3.434GluLys: 3.434 ± 0.032
5.386GluLeu: 5.386 ± 0.031
1.398GluMet: 1.398 ± 0.018
2.171GluAsn: 2.171 ± 0.019
3.025GluPro: 3.025 ± 0.032
2.471GluGln: 2.471 ± 0.028
4.314GluArg: 4.314 ± 0.031
4.062GluSer: 4.062 ± 0.035
3.442GluThr: 3.442 ± 0.029
3.708GluVal: 3.708 ± 0.026
0.889GluTrp: 0.889 ± 0.013
1.611GluTyr: 1.611 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
3.133PheAla: 3.133 ± 0.027
0.509PheCys: 0.509 ± 0.009
2.241PheAsp: 2.241 ± 0.02
2.157PheGlu: 2.157 ± 0.023
1.446PhePhe: 1.446 ± 0.019
2.877PheGly: 2.877 ± 0.027
0.832PheHis: 0.832 ± 0.014
1.549PheIle: 1.549 ± 0.018
1.408PheLys: 1.408 ± 0.017
3.186PheLeu: 3.186 ± 0.024
0.731PheMet: 0.731 ± 0.012
1.28PheAsn: 1.28 ± 0.015
1.842PhePro: 1.842 ± 0.017
1.272PheGln: 1.272 ± 0.014
2.095PheArg: 2.095 ± 0.018
2.66PheSer: 2.66 ± 0.025
1.968PheThr: 1.968 ± 0.018
2.357PheVal: 2.357 ± 0.02
0.595PheTrp: 0.595 ± 0.013
1.025PheTyr: 1.025 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
6.41GlyAla: 6.41 ± 0.038
0.889GlyCys: 0.889 ± 0.016
4.204GlyAsp: 4.204 ± 0.029
3.978GlyGlu: 3.978 ± 0.031
2.75GlyPhe: 2.75 ± 0.023
6.885GlyGly: 6.885 ± 0.058
1.864GlyHis: 1.864 ± 0.022
3.439GlyIle: 3.439 ± 0.029
3.382GlyLys: 3.382 ± 0.024
6.278GlyLeu: 6.278 ± 0.032
1.6GlyMet: 1.6 ± 0.016
2.683GlyAsn: 2.683 ± 0.026
3.705GlyPro: 3.705 ± 0.032
2.648GlyGln: 2.648 ± 0.024
4.895GlyArg: 4.895 ± 0.033
5.826GlySer: 5.826 ± 0.038
4.186GlyThr: 4.186 ± 0.031
4.734GlyVal: 4.734 ± 0.031
1.215GlyTrp: 1.215 ± 0.016
2.199GlyTyr: 2.199 ± 0.022
0.0GlyXaa: 0.0 ± 0.0
His
2.003HisAla: 2.003 ± 0.021
0.306HisCys: 0.306 ± 0.008
1.315HisAsp: 1.315 ± 0.016
1.338HisGlu: 1.338 ± 0.016
0.869HisPhe: 0.869 ± 0.012
1.842HisGly: 1.842 ± 0.021
0.864HisHis: 0.864 ± 0.018
1.113HisIle: 1.113 ± 0.016
0.839HisLys: 0.839 ± 0.012
2.12HisLeu: 2.12 ± 0.019
0.486HisMet: 0.486 ± 0.01
0.789HisAsn: 0.789 ± 0.011
1.667HisPro: 1.667 ± 0.02
0.967HisGln: 0.967 ± 0.015
1.618HisArg: 1.618 ± 0.016
1.637HisSer: 1.637 ± 0.018
1.156HisThr: 1.156 ± 0.014
1.493HisVal: 1.493 ± 0.017
0.336HisTrp: 0.336 ± 0.008
0.689HisTyr: 0.689 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
4.128IleAla: 4.128 ± 0.027
0.659IleCys: 0.659 ± 0.012
2.769IleAsp: 2.769 ± 0.023
2.752IleGlu: 2.752 ± 0.024
1.707IlePhe: 1.707 ± 0.019
3.02IleGly: 3.02 ± 0.027
1.055IleHis: 1.055 ± 0.013
2.11IleIle: 2.11 ± 0.024
1.922IleLys: 1.922 ± 0.019
4.055IleLeu: 4.055 ± 0.03
0.935IleMet: 0.935 ± 0.013
1.611IleAsn: 1.611 ± 0.015
2.767IlePro: 2.767 ± 0.025
1.685IleGln: 1.685 ± 0.018
2.86IleArg: 2.86 ± 0.023
3.275IleSer: 3.275 ± 0.025
2.575IleThr: 2.575 ± 0.021
2.995IleVal: 2.995 ± 0.025
0.681IleTrp: 0.681 ± 0.012
1.254IleTyr: 1.254 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
4.232LysAla: 4.232 ± 0.031
0.426LysCys: 0.426 ± 0.01
2.634LysAsp: 2.634 ± 0.028
3.099LysGlu: 3.099 ± 0.034
1.327LysPhe: 1.327 ± 0.015
2.964LysGly: 2.964 ± 0.027
1.007LysHis: 1.007 ± 0.014
1.957LysIle: 1.957 ± 0.021
2.959LysLys: 2.959 ± 0.034
3.927LysLeu: 3.927 ± 0.03
0.922LysMet: 0.922 ± 0.015
1.512LysAsn: 1.512 ± 0.018
2.695LysPro: 2.695 ± 0.025
1.719LysGln: 1.719 ± 0.019
3.306LysArg: 3.306 ± 0.029
3.088LysSer: 3.088 ± 0.025
2.603LysThr: 2.603 ± 0.024
2.68LysVal: 2.68 ± 0.021
0.619LysTrp: 0.619 ± 0.011
1.22LysTyr: 1.22 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
8.59LeuAla: 8.59 ± 0.044
1.144LeuCys: 1.144 ± 0.015
5.282LeuAsp: 5.282 ± 0.032
5.593LeuGlu: 5.593 ± 0.036
3.132LeuPhe: 3.132 ± 0.028
6.225LeuGly: 6.225 ± 0.04
2.1LeuHis: 2.1 ± 0.019
3.588LeuIle: 3.588 ± 0.027
3.94LeuLys: 3.94 ± 0.029
8.454LeuLeu: 8.454 ± 0.049
1.763LeuMet: 1.763 ± 0.016
2.916LeuAsn: 2.916 ± 0.022
5.434LeuPro: 5.434 ± 0.034
3.621LeuGln: 3.621 ± 0.034
6.356LeuArg: 6.356 ± 0.037
6.81LeuSer: 6.81 ± 0.043
4.632LeuThr: 4.632 ± 0.03
5.571LeuVal: 5.571 ± 0.034
1.253LeuTrp: 1.253 ± 0.017
2.231LeuTyr: 2.231 ± 0.021
0.0LeuXaa: 0.0 ± 0.0
Met
2.323MetAla: 2.323 ± 0.018
0.222MetCys: 0.222 ± 0.007
1.202MetAsp: 1.202 ± 0.014
1.244MetGlu: 1.244 ± 0.015
0.695MetPhe: 0.695 ± 0.012
1.418MetGly: 1.418 ± 0.016
0.467MetHis: 0.467 ± 0.01
0.886MetIle: 0.886 ± 0.012
0.928MetLys: 0.928 ± 0.015
1.864MetLeu: 1.864 ± 0.018
0.544MetMet: 0.544 ± 0.008
0.73MetAsn: 0.73 ± 0.011
1.303MetPro: 1.303 ± 0.017
0.838MetGln: 0.838 ± 0.012
1.392MetArg: 1.392 ± 0.015
1.706MetSer: 1.706 ± 0.017
1.287MetThr: 1.287 ± 0.014
1.315MetVal: 1.315 ± 0.015
0.267MetTrp: 0.267 ± 0.008
0.485MetTyr: 0.485 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.024
0.408AsnCys: 0.408 ± 0.01
1.841AsnAsp: 1.841 ± 0.017
1.888AsnGlu: 1.888 ± 0.019
1.238AsnPhe: 1.238 ± 0.015
3.05AsnGly: 3.05 ± 0.025
0.795AsnHis: 0.795 ± 0.013
1.771AsnIle: 1.771 ± 0.018
1.391AsnLys: 1.391 ± 0.017
3.02AsnLeu: 3.02 ± 0.026
0.758AsnMet: 0.758 ± 0.011
1.444AsnAsn: 1.444 ± 0.021
2.389AsnPro: 2.389 ± 0.021
1.197AsnGln: 1.197 ± 0.016
1.996AsnArg: 1.996 ± 0.018
2.483AsnSer: 2.483 ± 0.018
1.976AsnThr: 1.976 ± 0.02
2.17AsnVal: 2.17 ± 0.019
0.534AsnTrp: 0.534 ± 0.009
0.982AsnTyr: 0.982 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
5.792ProAla: 5.792 ± 0.047
0.5ProCys: 0.5 ± 0.01
3.476ProAsp: 3.476 ± 0.029
4.049ProGlu: 4.049 ± 0.037
1.955ProPhe: 1.955 ± 0.018
4.506ProGly: 4.506 ± 0.035
1.332ProHis: 1.332 ± 0.017
2.269ProIle: 2.269 ± 0.019
2.52ProLys: 2.52 ± 0.024
4.83ProLeu: 4.83 ± 0.032
1.079ProMet: 1.079 ± 0.014
2.107ProAsn: 2.107 ± 0.02
5.44ProPro: 5.44 ± 0.061
2.442ProGln: 2.442 ± 0.027
3.769ProArg: 3.769 ± 0.032
5.633ProSer: 5.633 ± 0.04
3.862ProThr: 3.862 ± 0.037
3.665ProVal: 3.665 ± 0.031
0.775ProTrp: 0.775 ± 0.012
1.478ProTyr: 1.478 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.643GlnAla: 3.643 ± 0.031
0.405GlnCys: 0.405 ± 0.01
1.994GlnAsp: 1.994 ± 0.02
2.338GlnGlu: 2.338 ± 0.025
1.197GlnPhe: 1.197 ± 0.015
2.479GlnGly: 2.479 ± 0.024
1.056GlnHis: 1.056 ± 0.017
1.709GlnIle: 1.709 ± 0.019
1.8GlnLys: 1.8 ± 0.019
3.379GlnLeu: 3.379 ± 0.028
0.82GlnMet: 0.82 ± 0.013
1.347GlnAsn: 1.347 ± 0.015
2.589GlnPro: 2.589 ± 0.029
2.469GlnGln: 2.469 ± 0.04
2.775GlnArg: 2.775 ± 0.025
2.79GlnSer: 2.79 ± 0.024
2.134GlnThr: 2.134 ± 0.02
2.148GlnVal: 2.148 ± 0.019
0.573GlnTrp: 0.573 ± 0.01
1.088GlnTyr: 1.088 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
5.68ArgAla: 5.68 ± 0.036
0.731ArgCys: 0.731 ± 0.013
3.953ArgAsp: 3.953 ± 0.033
4.239ArgGlu: 4.239 ± 0.037
2.255ArgPhe: 2.255 ± 0.019
4.437ArgGly: 4.437 ± 0.032
1.763ArgHis: 1.763 ± 0.019
2.957ArgIle: 2.957 ± 0.023
3.309ArgLys: 3.309 ± 0.026
6.076ArgLeu: 6.076 ± 0.037
1.415ArgMet: 1.415 ± 0.016
2.364ArgAsn: 2.364 ± 0.019
3.89ArgPro: 3.89 ± 0.03
2.787ArgGln: 2.787 ± 0.024
5.916ArgArg: 5.916 ± 0.052
4.805ArgSer: 4.805 ± 0.038
3.505ArgThr: 3.505 ± 0.023
3.801ArgVal: 3.801 ± 0.027
1.027ArgTrp: 1.027 ± 0.014
1.742ArgTyr: 1.742 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
6.802SerAla: 6.802 ± 0.046
0.774SerCys: 0.774 ± 0.011
4.025SerAsp: 4.025 ± 0.028
4.02SerGlu: 4.02 ± 0.029
2.701SerPhe: 2.701 ± 0.019
5.766SerGly: 5.766 ± 0.034
1.771SerHis: 1.771 ± 0.017
3.392SerIle: 3.392 ± 0.029
3.253SerLys: 3.253 ± 0.029
6.594SerLeu: 6.594 ± 0.041
1.608SerMet: 1.608 ± 0.02
2.648SerAsn: 2.648 ± 0.021
5.251SerPro: 5.251 ± 0.046
2.966SerGln: 2.966 ± 0.028
5.059SerArg: 5.059 ± 0.03
7.868SerSer: 7.868 ± 0.06
4.937SerThr: 4.937 ± 0.035
4.425SerVal: 4.425 ± 0.026
1.074SerTrp: 1.074 ± 0.015
1.969SerTyr: 1.969 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
5.535ThrAla: 5.535 ± 0.037
0.702ThrCys: 0.702 ± 0.011
2.785ThrAsp: 2.785 ± 0.021
3.09ThrGlu: 3.09 ± 0.028
2.052ThrPhe: 2.052 ± 0.018
4.323ThrGly: 4.323 ± 0.034
1.175ThrHis: 1.175 ± 0.013
2.702ThrIle: 2.702 ± 0.022
2.354ThrLys: 2.354 ± 0.027
5.004ThrLeu: 5.004 ± 0.034
1.162ThrMet: 1.162 ± 0.015
1.894ThrAsn: 1.894 ± 0.021
4.268ThrPro: 4.268 ± 0.036
1.946ThrGln: 1.946 ± 0.02
3.361ThrArg: 3.361 ± 0.027
4.82ThrSer: 4.82 ± 0.04
4.087ThrThr: 4.087 ± 0.043
3.786ThrVal: 3.786 ± 0.029
0.846ThrTrp: 0.846 ± 0.012
1.523ThrTyr: 1.523 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
5.973ValAla: 5.973 ± 0.037
0.784ValCys: 0.784 ± 0.012
3.909ValAsp: 3.909 ± 0.026
3.992ValGlu: 3.992 ± 0.024
2.386ValPhe: 2.386 ± 0.024
4.283ValGly: 4.283 ± 0.034
1.401ValHis: 1.401 ± 0.016
2.84ValIle: 2.84 ± 0.025
2.791ValLys: 2.791 ± 0.024
5.828ValLeu: 5.828 ± 0.04
1.314ValMet: 1.314 ± 0.017
2.171ValAsn: 2.171 ± 0.021
3.783ValPro: 3.783 ± 0.027
2.326ValGln: 2.326 ± 0.02
3.935ValArg: 3.935 ± 0.029
4.495ValSer: 4.495 ± 0.031
3.602ValThr: 3.602 ± 0.032
4.662ValVal: 4.662 ± 0.039
0.877ValTrp: 0.877 ± 0.013
1.71ValTyr: 1.71 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
1.259TrpAla: 1.259 ± 0.018
0.194TrpCys: 0.194 ± 0.006
0.948TrpAsp: 0.948 ± 0.014
0.858TrpGlu: 0.858 ± 0.011
0.537TrpPhe: 0.537 ± 0.01
0.968TrpGly: 0.968 ± 0.013
0.352TrpHis: 0.352 ± 0.008
0.729TrpIle: 0.729 ± 0.012
0.741TrpLys: 0.741 ± 0.012
1.411TrpLeu: 1.411 ± 0.018
0.356TrpMet: 0.356 ± 0.007
0.591TrpAsn: 0.591 ± 0.011
0.626TrpPro: 0.626 ± 0.01
0.562TrpGln: 0.562 ± 0.008
1.065TrpArg: 1.065 ± 0.015
0.97TrpSer: 0.97 ± 0.015
0.877TrpThr: 0.877 ± 0.013
0.923TrpVal: 0.923 ± 0.013
0.273TrpTrp: 0.273 ± 0.008
0.413TrpTyr: 0.413 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.281TyrAla: 2.281 ± 0.021
0.391TyrCys: 0.391 ± 0.009
1.695TyrAsp: 1.695 ± 0.018
1.592TyrGlu: 1.592 ± 0.018
1.105TyrPhe: 1.105 ± 0.013
2.178TyrGly: 2.178 ± 0.022
0.713TyrHis: 0.713 ± 0.011
1.206TyrIle: 1.206 ± 0.015
1.007TyrLys: 1.007 ± 0.013
2.533TyrLeu: 2.533 ± 0.02
0.584TyrMet: 0.584 ± 0.009
0.987TyrAsn: 0.987 ± 0.014
1.447TyrPro: 1.447 ± 0.018
1.005TyrGln: 1.005 ± 0.013
1.719TyrArg: 1.719 ± 0.017
1.862TyrSer: 1.862 ± 0.018
1.468TyrThr: 1.468 ± 0.018
1.685TyrVal: 1.685 ± 0.019
0.434TyrTrp: 0.434 ± 0.009
0.883TyrTyr: 0.883 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.012XaaXaa: 0.012 ± 0.005
Statistics based on 12533 proteins (6089802 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski