Amino acid dipepetide frequency for Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.364AlaAla: 6.364 ± 0.039	1.285AlaCys: 1.285 ± 0.014	3.256AlaAsp: 3.256 ± 0.016	4.715AlaGlu: 4.715 ± 0.029	2.26AlaPhe: 2.26 ± 0.014	4.368AlaGly: 4.368 ± 0.028	1.555AlaHis: 1.555 ± 0.012	2.59AlaIle: 2.59 ± 0.017	3.372AlaLys: 3.372 ± 0.024	6.414AlaLeu: 6.414 ± 0.032	1.597AlaMet: 1.597 ± 0.011	2.153AlaAsn: 2.153 ± 0.017	3.578AlaPro: 3.578 ± 0.025	2.97AlaGln: 2.97 ± 0.02	3.198AlaArg: 3.198 ± 0.021	5.516AlaSer: 5.516 ± 0.031	3.663AlaThr: 3.663 ± 0.023	4.939AlaVal: 4.939 ± 0.026	0.662AlaTrp: 0.662 ± 0.008	1.488AlaTyr: 1.488 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.158CysAla: 1.158 ± 0.011	0.641CysCys: 0.641 ± 0.011	1.127CysAsp: 1.127 ± 0.015	1.215CysGlu: 1.215 ± 0.015	0.831CysPhe: 0.831 ± 0.011	1.528CysGly: 1.528 ± 0.02	0.653CysHis: 0.653 ± 0.011	0.914CysIle: 0.914 ± 0.01	1.103CysLys: 1.103 ± 0.011	2.096CysLeu: 2.096 ± 0.016	0.482CysMet: 0.482 ± 0.006	0.826CysAsn: 0.826 ± 0.013	1.366CysPro: 1.366 ± 0.021	1.039CysGln: 1.039 ± 0.013	1.298CysArg: 1.298 ± 0.012	2.116CysSer: 2.116 ± 0.018	1.214CysThr: 1.214 ± 0.019	1.457CysVal: 1.457 ± 0.014	0.304CysTrp: 0.304 ± 0.005	0.607CysTyr: 0.607 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	2.979AspAla: 2.979 ± 0.018	1.179AspCys: 1.179 ± 0.019	3.156AspAsp: 3.156 ± 0.024	3.811AspGlu: 3.811 ± 0.024	2.02AspPhe: 2.02 ± 0.014	3.658AspGly: 3.658 ± 0.027	1.277AspHis: 1.277 ± 0.014	2.67AspIle: 2.67 ± 0.027	2.737AspLys: 2.737 ± 0.022	4.903AspLeu: 4.903 ± 0.028	1.34AspMet: 1.34 ± 0.011	2.003AspAsn: 2.003 ± 0.016	2.87AspPro: 2.87 ± 0.021	2.043AspGln: 2.043 ± 0.021	2.843AspArg: 2.843 ± 0.022	4.614AspSer: 4.614 ± 0.032	2.783AspThr: 2.783 ± 0.02	3.361AspVal: 3.361 ± 0.03	0.666AspTrp: 0.666 ± 0.008	1.524AspTyr: 1.524 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.847GluAla: 4.847 ± 0.032	1.188GluCys: 1.188 ± 0.014	4.503GluAsp: 4.503 ± 0.032	8.26GluGlu: 8.26 ± 0.066	1.861GluPhe: 1.861 ± 0.014	4.185GluGly: 4.185 ± 0.03	1.491GluHis: 1.491 ± 0.012	2.776GluIle: 2.776 ± 0.019	4.624GluLys: 4.624 ± 0.038	6.081GluLeu: 6.081 ± 0.039	1.766GluMet: 1.766 ± 0.015	2.646GluAsn: 2.646 ± 0.019	2.949GluPro: 2.949 ± 0.023	3.219GluGln: 3.219 ± 0.029	4.396GluArg: 4.396 ± 0.034	4.372GluSer: 4.372 ± 0.024	3.586GluThr: 3.586 ± 0.027	4.376GluVal: 4.376 ± 0.027	0.677GluTrp: 0.677 ± 0.008	1.522GluTyr: 1.522 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	1.832PheAla: 1.832 ± 0.014	0.861PheCys: 0.861 ± 0.009	1.67PheAsp: 1.67 ± 0.013	1.747PheGlu: 1.747 ± 0.013	1.459PhePhe: 1.459 ± 0.015	2.084PheGly: 2.084 ± 0.017	0.992PheHis: 0.992 ± 0.012	1.779PheIle: 1.779 ± 0.016	1.726PheLys: 1.726 ± 0.017	3.542PheLeu: 3.542 ± 0.021	0.814PheMet: 0.814 ± 0.012	1.415PheAsn: 1.415 ± 0.012	1.765PhePro: 1.765 ± 0.015	1.534PheGln: 1.534 ± 0.011	1.816PheArg: 1.816 ± 0.02	3.251PheSer: 3.251 ± 0.02	2.265PheThr: 2.265 ± 0.033	2.108PheVal: 2.108 ± 0.027	0.452PheTrp: 0.452 ± 0.007	1.137PheTyr: 1.137 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.076GlyAla: 4.076 ± 0.029	1.268GlyCys: 1.268 ± 0.012	3.307GlyAsp: 3.307 ± 0.027	4.074GlyGlu: 4.074 ± 0.03	2.324GlyPhe: 2.324 ± 0.018	5.678GlyGly: 5.678 ± 0.048	1.694GlyHis: 1.694 ± 0.015	2.503GlyIle: 2.503 ± 0.015	3.489GlyLys: 3.489 ± 0.029	5.474GlyLeu: 5.474 ± 0.029	1.459GlyMet: 1.459 ± 0.012	2.405GlyAsn: 2.405 ± 0.016	3.397GlyPro: 3.397 ± 0.051	2.814GlyGln: 2.814 ± 0.022	3.724GlyArg: 3.724 ± 0.028	5.661GlySer: 5.661 ± 0.033	3.392GlyThr: 3.392 ± 0.022	3.977GlyVal: 3.977 ± 0.021	0.774GlyTrp: 0.774 ± 0.009	1.776GlyTyr: 1.776 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.393HisAla: 1.393 ± 0.013	0.757HisCys: 0.757 ± 0.012	1.042HisAsp: 1.042 ± 0.018	1.219HisGlu: 1.219 ± 0.015	1.029HisPhe: 1.029 ± 0.011	1.629HisGly: 1.629 ± 0.013	1.248HisHis: 1.248 ± 0.023	1.302HisIle: 1.302 ± 0.013	1.295HisLys: 1.295 ± 0.012	2.749HisLeu: 2.749 ± 0.024	0.677HisMet: 0.677 ± 0.01	1.096HisAsn: 1.096 ± 0.017	1.694HisPro: 1.694 ± 0.018	1.384HisGln: 1.384 ± 0.019	1.805HisArg: 1.805 ± 0.021	2.485HisSer: 2.485 ± 0.02	1.679HisThr: 1.679 ± 0.016	1.485HisVal: 1.485 ± 0.012	0.348HisTrp: 0.348 ± 0.005	0.855HisTyr: 0.855 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.417IleAla: 2.417 ± 0.016	1.014IleCys: 1.014 ± 0.013	2.054IleAsp: 2.054 ± 0.016	2.337IleGlu: 2.337 ± 0.02	1.638IlePhe: 1.638 ± 0.015	2.188IleGly: 2.188 ± 0.018	1.241IleHis: 1.241 ± 0.014	2.27IleIle: 2.27 ± 0.019	2.464IleLys: 2.464 ± 0.02	4.072IleLeu: 4.072 ± 0.026	1.038IleMet: 1.038 ± 0.01	1.907IleAsn: 1.907 ± 0.02	2.41IlePro: 2.41 ± 0.015	2.179IleGln: 2.179 ± 0.018	2.375IleArg: 2.375 ± 0.016	3.705IleSer: 3.705 ± 0.023	2.751IleThr: 2.751 ± 0.018	2.44IleVal: 2.44 ± 0.017	0.458IleTrp: 0.458 ± 0.007	1.326IleTyr: 1.326 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.713LysAla: 3.713 ± 0.025	0.985LysCys: 0.985 ± 0.012	3.22LysAsp: 3.22 ± 0.02	4.764LysGlu: 4.764 ± 0.045	1.482LysPhe: 1.482 ± 0.014	3.214LysGly: 3.214 ± 0.036	1.417LysHis: 1.417 ± 0.013	2.348LysIle: 2.348 ± 0.017	4.377LysLys: 4.377 ± 0.035	4.815LysLeu: 4.815 ± 0.026	1.511LysMet: 1.511 ± 0.022	2.212LysAsn: 2.212 ± 0.023	2.945LysPro: 2.945 ± 0.023	2.573LysGln: 2.573 ± 0.022	3.466LysArg: 3.466 ± 0.021	3.711LysSer: 3.711 ± 0.022	3.263LysThr: 3.263 ± 0.026	3.482LysVal: 3.482 ± 0.023	0.562LysTrp: 0.562 ± 0.007	1.407LysTyr: 1.407 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	5.923LeuAla: 5.923 ± 0.029	2.165LeuCys: 2.165 ± 0.016	4.802LeuAsp: 4.802 ± 0.023	6.256LeuGlu: 6.256 ± 0.042	3.16LeuPhe: 3.16 ± 0.023	5.025LeuGly: 5.025 ± 0.024	2.835LeuHis: 2.835 ± 0.025	3.662LeuIle: 3.662 ± 0.023	5.463LeuLys: 5.463 ± 0.027	9.803LeuLeu: 9.803 ± 0.054	2.128LeuMet: 2.128 ± 0.016	3.576LeuAsn: 3.576 ± 0.023	5.406LeuPro: 5.406 ± 0.029	5.526LeuGln: 5.526 ± 0.04	5.634LeuArg: 5.634 ± 0.027	8.204LeuSer: 8.204 ± 0.04	5.279LeuThr: 5.279 ± 0.03	5.363LeuVal: 5.363 ± 0.028	1.077LeuTrp: 1.077 ± 0.01	2.515LeuTyr: 2.515 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.918MetAla: 1.918 ± 0.012	0.471MetCys: 0.471 ± 0.008	1.494MetAsp: 1.494 ± 0.012	2.04MetGlu: 2.04 ± 0.017	0.877MetPhe: 0.877 ± 0.039	1.446MetGly: 1.446 ± 0.014	0.485MetHis: 0.485 ± 0.007	0.891MetIle: 0.891 ± 0.01	1.553MetLys: 1.553 ± 0.02	2.089MetLeu: 2.089 ± 0.017	0.74MetMet: 0.74 ± 0.01	0.935MetAsn: 0.935 ± 0.014	1.127MetPro: 1.127 ± 0.018	0.975MetGln: 0.975 ± 0.01	1.231MetArg: 1.231 ± 0.014	1.943MetSer: 1.943 ± 0.015	1.366MetThr: 1.366 ± 0.014	1.568MetVal: 1.568 ± 0.013	0.276MetTrp: 0.276 ± 0.006	0.619MetTyr: 0.619 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.118AsnAla: 2.118 ± 0.017	0.853AsnCys: 0.853 ± 0.012	1.642AsnAsp: 1.642 ± 0.017	2.047AsnGlu: 2.047 ± 0.017	1.337AsnPhe: 1.337 ± 0.012	2.624AsnGly: 2.624 ± 0.022	1.091AsnHis: 1.091 ± 0.018	2.122AsnIle: 2.122 ± 0.022	2.209AsnLys: 2.209 ± 0.016	3.53AsnLeu: 3.53 ± 0.027	1.156AsnMet: 1.156 ± 0.023	1.933AsnAsn: 1.933 ± 0.031	2.206AsnPro: 2.206 ± 0.019	1.784AsnGln: 1.784 ± 0.015	2.038AsnArg: 2.038 ± 0.016	3.205AsnSer: 3.205 ± 0.019	2.38AsnThr: 2.38 ± 0.023	2.295AsnVal: 2.295 ± 0.024	0.439AsnTrp: 0.439 ± 0.006	1.147AsnTyr: 1.147 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	4.364ProAla: 4.364 ± 0.028	1.117ProCys: 1.117 ± 0.014	2.98ProAsp: 2.98 ± 0.024	3.878ProGlu: 3.878 ± 0.024	1.697ProPhe: 1.697 ± 0.015	4.139ProGly: 4.139 ± 0.058	1.591ProHis: 1.591 ± 0.018	1.855ProIle: 1.855 ± 0.015	2.588ProLys: 2.588 ± 0.028	4.901ProLeu: 4.901 ± 0.027	1.068ProMet: 1.068 ± 0.011	1.929ProAsn: 1.929 ± 0.017	5.748ProPro: 5.748 ± 0.048	2.792ProGln: 2.792 ± 0.029	2.911ProArg: 2.911 ± 0.018	5.745ProSer: 5.745 ± 0.034	3.35ProThr: 3.35 ± 0.029	3.855ProVal: 3.855 ± 0.021	0.566ProTrp: 0.566 ± 0.009	1.401ProTyr: 1.401 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.222GlnAla: 3.222 ± 0.025	0.971GlnCys: 0.971 ± 0.013	2.391GlnAsp: 2.391 ± 0.016	3.653GlnGlu: 3.653 ± 0.03	1.271GlnPhe: 1.271 ± 0.011	2.766GlnGly: 2.766 ± 0.024	1.492GlnHis: 1.492 ± 0.022	1.844GlnIle: 1.844 ± 0.015	2.552GlnLys: 2.552 ± 0.019	4.502GlnLeu: 4.502 ± 0.027	1.143GlnMet: 1.143 ± 0.012	1.746GlnAsn: 1.746 ± 0.016	2.764GlnPro: 2.764 ± 0.026	3.61GlnGln: 3.61 ± 0.055	3.341GlnArg: 3.341 ± 0.027	3.628GlnSer: 3.628 ± 0.026	2.769GlnThr: 2.769 ± 0.022	2.813GlnVal: 2.813 ± 0.021	0.558GlnTrp: 0.558 ± 0.007	1.195GlnTyr: 1.195 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	3.564ArgAla: 3.564 ± 0.023	1.286ArgCys: 1.286 ± 0.015	3.069ArgAsp: 3.069 ± 0.029	3.993ArgGlu: 3.993 ± 0.029	1.897ArgPhe: 1.897 ± 0.014	3.718ArgGly: 3.718 ± 0.031	1.638ArgHis: 1.638 ± 0.019	2.302ArgIle: 2.302 ± 0.019	3.54ArgLys: 3.54 ± 0.024	5.372ArgLeu: 5.372 ± 0.03	1.319ArgMet: 1.319 ± 0.012	2.128ArgAsn: 2.128 ± 0.018	3.161ArgPro: 3.161 ± 0.025	2.81ArgGln: 2.81 ± 0.024	4.77ArgArg: 4.77 ± 0.041	4.665ArgSer: 4.665 ± 0.03	3.081ArgThr: 3.081 ± 0.02	3.367ArgVal: 3.367 ± 0.02	0.732ArgTrp: 0.732 ± 0.009	1.54ArgTyr: 1.54 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	5.644SerAla: 5.644 ± 0.03	1.966SerCys: 1.966 ± 0.017	4.414SerAsp: 4.414 ± 0.025	4.946SerGlu: 4.946 ± 0.029	2.992SerPhe: 2.992 ± 0.022	5.55SerGly: 5.55 ± 0.029	2.288SerHis: 2.288 ± 0.017	3.253SerIle: 3.253 ± 0.018	3.924SerLys: 3.924 ± 0.022	8.214SerLeu: 8.214 ± 0.04	1.837SerMet: 1.837 ± 0.013	3.019SerAsn: 3.019 ± 0.019	6.136SerPro: 6.136 ± 0.041	3.969SerGln: 3.969 ± 0.023	4.623SerArg: 4.623 ± 0.025	10.652SerSer: 10.652 ± 0.068	5.181SerThr: 5.181 ± 0.032	5.484SerVal: 5.484 ± 0.028	1.011SerTrp: 1.011 ± 0.012	2.138SerTyr: 2.138 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	4.233ThrAla: 4.233 ± 0.026	1.363ThrCys: 1.363 ± 0.02	3.071ThrAsp: 3.071 ± 0.023	3.968ThrGlu: 3.968 ± 0.023	2.027ThrPhe: 2.027 ± 0.016	3.786ThrGly: 3.786 ± 0.026	1.481ThrHis: 1.481 ± 0.016	2.383ThrIle: 2.383 ± 0.017	2.737ThrLys: 2.737 ± 0.018	5.402ThrLeu: 5.402 ± 0.03	1.324ThrMet: 1.324 ± 0.028	2.06ThrAsn: 2.06 ± 0.022	3.841ThrPro: 3.841 ± 0.029	2.454ThrGln: 2.454 ± 0.018	2.696ThrArg: 2.696 ± 0.021	5.225ThrSer: 5.225 ± 0.029	3.95ThrThr: 3.95 ± 0.048	4.285ThrVal: 4.285 ± 0.026	0.683ThrTrp: 0.683 ± 0.01	1.432ThrTyr: 1.432 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	4.124ValAla: 4.124 ± 0.021	1.675ValCys: 1.675 ± 0.019	3.263ValAsp: 3.263 ± 0.032	4.153ValGlu: 4.153 ± 0.029	2.543ValPhe: 2.543 ± 0.026	3.42ValGly: 3.42 ± 0.019	1.593ValHis: 1.593 ± 0.013	2.892ValIle: 2.892 ± 0.019	3.586ValLys: 3.586 ± 0.025	6.179ValLeu: 6.179 ± 0.03	1.61ValMet: 1.61 ± 0.018	2.445ValAsn: 2.445 ± 0.021	3.345ValPro: 3.345 ± 0.02	2.837ValGln: 2.837 ± 0.022	3.313ValArg: 3.313 ± 0.023	5.292ValSer: 5.292 ± 0.026	4.061ValThr: 4.061 ± 0.025	4.446ValVal: 4.446 ± 0.034	0.769ValTrp: 0.769 ± 0.008	1.769ValTyr: 1.769 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.669TrpAla: 0.669 ± 0.008	0.251TrpCys: 0.251 ± 0.005	0.631TrpAsp: 0.631 ± 0.008	0.733TrpGlu: 0.733 ± 0.008	0.445TrpPhe: 0.445 ± 0.006	0.642TrpGly: 0.642 ± 0.008	0.276TrpHis: 0.276 ± 0.005	0.556TrpIle: 0.556 ± 0.008	0.724TrpLys: 0.724 ± 0.009	1.144TrpLeu: 1.144 ± 0.011	0.351TrpMet: 0.351 ± 0.005	0.484TrpAsn: 0.484 ± 0.007	0.452TrpPro: 0.452 ± 0.006	0.492TrpGln: 0.492 ± 0.006	0.809TrpArg: 0.809 ± 0.009	0.962TrpSer: 0.962 ± 0.013	0.755TrpThr: 0.755 ± 0.011	0.678TrpVal: 0.678 ± 0.009	0.199TrpTrp: 0.199 ± 0.005	0.327TrpTyr: 0.327 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.386TyrAla: 1.386 ± 0.012	0.678TyrCys: 0.678 ± 0.009	1.346TyrAsp: 1.346 ± 0.013	1.518TyrGlu: 1.518 ± 0.016	1.101TyrPhe: 1.101 ± 0.014	1.616TyrGly: 1.616 ± 0.014	0.834TyrHis: 0.834 ± 0.013	1.371TyrIle: 1.371 ± 0.016	1.406TyrLys: 1.406 ± 0.015	2.522TyrLeu: 2.522 ± 0.016	0.683TyrMet: 0.683 ± 0.012	1.239TyrAsn: 1.239 ± 0.019	1.314TyrPro: 1.314 ± 0.013	1.226TyrGln: 1.226 ± 0.01	1.663TyrArg: 1.663 ± 0.015	2.289TyrSer: 2.289 ± 0.017	1.634TyrThr: 1.634 ± 0.017	1.535TyrVal: 1.535 ± 0.014	0.367TyrTrp: 0.367 ± 0.008	0.953TyrTyr: 0.953 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 23960 proteins (13034180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---