Amino acid dipepetide frequency for Pseudoloma neurophilia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.62AlaAla: 1.62 ± 0.086	0.573AlaCys: 0.573 ± 0.026	1.799AlaAsp: 1.799 ± 0.048	2.159AlaGlu: 2.159 ± 0.059	1.84AlaPhe: 1.84 ± 0.044	1.295AlaGly: 1.295 ± 0.068	0.764AlaHis: 0.764 ± 0.035	3.174AlaIle: 3.174 ± 0.078	2.642AlaLys: 2.642 ± 0.066	3.313AlaLeu: 3.313 ± 0.069	0.833AlaMet: 0.833 ± 0.037	1.836AlaAsn: 1.836 ± 0.051	1.081AlaPro: 1.081 ± 0.046	1.473AlaGln: 1.473 ± 0.054	1.3AlaArg: 1.3 ± 0.04	2.345AlaSer: 2.345 ± 0.064	1.772AlaThr: 1.772 ± 0.048	1.996AlaVal: 1.996 ± 0.053	0.155AlaTrp: 0.155 ± 0.013	1.282AlaTyr: 1.282 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.605CysAla: 0.605 ± 0.027	0.346CysCys: 0.346 ± 0.024	1.024CysAsp: 1.024 ± 0.041	0.954CysGlu: 0.954 ± 0.035	1.141CysPhe: 1.141 ± 0.033	0.83CysGly: 0.83 ± 0.028	0.397CysHis: 0.397 ± 0.024	1.168CysIle: 1.168 ± 0.04	1.486CysLys: 1.486 ± 0.042	1.788CysLeu: 1.788 ± 0.053	0.31CysMet: 0.31 ± 0.019	0.988CysAsn: 0.988 ± 0.039	0.613CysPro: 0.613 ± 0.032	0.737CysGln: 0.737 ± 0.028	0.63CysArg: 0.63 ± 0.025	1.24CysSer: 1.24 ± 0.033	0.834CysThr: 0.834 ± 0.034	0.781CysVal: 0.781 ± 0.03	0.094CysTrp: 0.094 ± 0.012	0.706CysTyr: 0.706 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	1.778AspAla: 1.778 ± 0.056	1.068AspCys: 1.068 ± 0.035	3.681AspAsp: 3.681 ± 0.081	4.554AspGlu: 4.554 ± 0.076	3.437AspPhe: 3.437 ± 0.076	2.219AspGly: 2.219 ± 0.045	1.43AspHis: 1.43 ± 0.057	4.72AspIle: 4.72 ± 0.081	5.185AspLys: 5.185 ± 0.087	5.917AspLeu: 5.917 ± 0.095	1.191AspMet: 1.191 ± 0.037	3.424AspAsn: 3.424 ± 0.075	1.602AspPro: 1.602 ± 0.042	2.826AspGln: 2.826 ± 0.074	2.167AspArg: 2.167 ± 0.054	4.225AspSer: 4.225 ± 0.089	2.739AspThr: 2.739 ± 0.066	2.511AspVal: 2.511 ± 0.065	0.393AspTrp: 0.393 ± 0.022	1.923AspTyr: 1.923 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	2.048GluAla: 2.048 ± 0.057	1.106GluCys: 1.106 ± 0.039	3.355GluAsp: 3.355 ± 0.077	5.414GluGlu: 5.414 ± 0.103	3.074GluPhe: 3.074 ± 0.058	2.053GluGly: 2.053 ± 0.054	1.46GluHis: 1.46 ± 0.04	7.181GluIle: 7.181 ± 0.1	9.647GluLys: 9.647 ± 0.166	5.329GluLeu: 5.329 ± 0.089	2.052GluMet: 2.052 ± 0.05	6.916GluAsn: 6.916 ± 0.092	1.756GluPro: 1.756 ± 0.056	3.194GluGln: 3.194 ± 0.078	2.978GluArg: 2.978 ± 0.076	5.052GluSer: 5.052 ± 0.09	3.834GluThr: 3.834 ± 0.066	2.502GluVal: 2.502 ± 0.058	0.443GluTrp: 0.443 ± 0.023	2.498GluTyr: 2.498 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	1.746PheAla: 1.746 ± 0.041	1.235PheCys: 1.235 ± 0.033	3.603PheAsp: 3.603 ± 0.073	3.871PheGlu: 3.871 ± 0.072	4.107PhePhe: 4.107 ± 0.079	2.062PheGly: 2.062 ± 0.06	1.214PheHis: 1.214 ± 0.039	5.198PheIle: 5.198 ± 0.078	4.929PheLys: 4.929 ± 0.088	6.645PheLeu: 6.645 ± 0.102	1.084PheMet: 1.084 ± 0.033	3.469PheAsn: 3.469 ± 0.065	1.367PhePro: 1.367 ± 0.038	1.774PheGln: 1.774 ± 0.046	1.887PheArg: 1.887 ± 0.047	4.877PheSer: 4.877 ± 0.085	3.013PheThr: 3.013 ± 0.068	2.796PheVal: 2.796 ± 0.056	0.327PheTrp: 0.327 ± 0.019	2.832PheTyr: 2.832 ± 0.067	0.0PheXaa: 0.0 ± 0.0
Gly	1.371GlyAla: 1.371 ± 0.056	0.716GlyCys: 0.716 ± 0.03	1.783GlyAsp: 1.783 ± 0.056	2.003GlyGlu: 2.003 ± 0.051	1.99GlyPhe: 1.99 ± 0.051	1.899GlyGly: 1.899 ± 0.109	1.061GlyHis: 1.061 ± 0.039	3.344GlyIle: 3.344 ± 0.072	3.439GlyLys: 3.439 ± 0.067	3.423GlyLeu: 3.423 ± 0.066	0.973GlyMet: 0.973 ± 0.048	2.382GlyAsn: 2.382 ± 0.07	1.103GlyPro: 1.103 ± 0.042	1.677GlyGln: 1.677 ± 0.071	1.663GlyArg: 1.663 ± 0.052	2.764GlySer: 2.764 ± 0.069	2.184GlyThr: 2.184 ± 0.055	1.882GlyVal: 1.882 ± 0.053	0.276GlyTrp: 0.276 ± 0.018	1.438GlyTyr: 1.438 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	0.575HisAla: 0.575 ± 0.026	0.391HisCys: 0.391 ± 0.024	1.012HisAsp: 1.012 ± 0.034	1.221HisGlu: 1.221 ± 0.042	1.564HisPhe: 1.564 ± 0.042	0.896HisGly: 0.896 ± 0.033	0.511HisHis: 0.511 ± 0.025	1.683HisIle: 1.683 ± 0.044	1.811HisLys: 1.811 ± 0.054	2.277HisLeu: 2.277 ± 0.058	0.47HisMet: 0.47 ± 0.025	1.327HisAsn: 1.327 ± 0.046	0.839HisPro: 0.839 ± 0.031	0.901HisGln: 0.901 ± 0.041	0.847HisArg: 0.847 ± 0.033	1.954HisSer: 1.954 ± 0.066	1.079HisThr: 1.079 ± 0.039	0.925HisVal: 0.925 ± 0.033	0.121HisTrp: 0.121 ± 0.011	0.667HisTyr: 0.667 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	2.981IleAla: 2.981 ± 0.073	1.662IleCys: 1.662 ± 0.044	5.169IleAsp: 5.169 ± 0.076	6.581IleGlu: 6.581 ± 0.084	5.953IlePhe: 5.953 ± 0.1	3.305IleGly: 3.305 ± 0.075	1.642IleHis: 1.642 ± 0.046	7.266IleIle: 7.266 ± 0.118	8.385IleLys: 8.385 ± 0.107	9.227IleLeu: 9.227 ± 0.121	1.493IleMet: 1.493 ± 0.047	5.389IleAsn: 5.389 ± 0.09	2.676IlePro: 2.676 ± 0.062	3.194IleGln: 3.194 ± 0.06	3.549IleArg: 3.549 ± 0.065	6.818IleSer: 6.818 ± 0.095	4.76IleThr: 4.76 ± 0.082	3.996IleVal: 3.996 ± 0.07	0.522IleTrp: 0.522 ± 0.022	3.067IleTyr: 3.067 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	2.585LysAla: 2.585 ± 0.06	1.552LysCys: 1.552 ± 0.043	5.388LysAsp: 5.388 ± 0.11	7.6LysGlu: 7.6 ± 0.133	4.11LysPhe: 4.11 ± 0.07	3.103LysGly: 3.103 ± 0.059	1.79LysHis: 1.79 ± 0.045	9.601LysIle: 9.601 ± 0.111	11.686LysLys: 11.686 ± 0.178	7.492LysLeu: 7.492 ± 0.108	2.847LysMet: 2.847 ± 0.06	9.583LysAsn: 9.583 ± 0.132	2.801LysPro: 2.801 ± 0.073	3.746LysGln: 3.746 ± 0.08	4.426LysArg: 4.426 ± 0.072	7.117LysSer: 7.117 ± 0.131	5.938LysThr: 5.938 ± 0.083	3.548LysVal: 3.548 ± 0.068	0.676LysTrp: 0.676 ± 0.027	4.01LysTyr: 4.01 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	3.097LeuAla: 3.097 ± 0.065	1.436LeuCys: 1.436 ± 0.04	4.904LeuAsp: 4.904 ± 0.077	6.376LeuGlu: 6.376 ± 0.101	5.698LeuPhe: 5.698 ± 0.096	3.129LeuGly: 3.129 ± 0.068	1.78LeuHis: 1.78 ± 0.05	8.062LeuIle: 8.062 ± 0.127	10.507LeuLys: 10.507 ± 0.128	9.156LeuLeu: 9.156 ± 0.119	1.794LeuMet: 1.794 ± 0.042	6.868LeuAsn: 6.868 ± 0.109	3.026LeuPro: 3.026 ± 0.065	3.695LeuGln: 3.695 ± 0.068	4.09LeuArg: 4.09 ± 0.073	7.551LeuSer: 7.551 ± 0.09	4.828LeuThr: 4.828 ± 0.075	3.881LeuVal: 3.881 ± 0.078	0.515LeuTrp: 0.515 ± 0.022	3.194LeuTyr: 3.194 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.276MetAla: 1.276 ± 0.046	0.344MetCys: 0.344 ± 0.025	1.192MetAsp: 1.192 ± 0.033	1.237MetGlu: 1.237 ± 0.039	1.135MetPhe: 1.135 ± 0.036	0.79MetGly: 0.79 ± 0.037	0.31MetHis: 0.31 ± 0.017	2.029MetIle: 2.029 ± 0.051	2.198MetLys: 2.198 ± 0.052	1.802MetLeu: 1.802 ± 0.042	0.519MetMet: 0.519 ± 0.025	1.618MetAsn: 1.618 ± 0.047	0.791MetPro: 0.791 ± 0.028	0.56MetGln: 0.56 ± 0.028	0.926MetArg: 0.926 ± 0.031	1.794MetSer: 1.794 ± 0.054	1.477MetThr: 1.477 ± 0.037	1.315MetVal: 1.315 ± 0.037	0.079MetTrp: 0.079 ± 0.008	0.579MetTyr: 0.579 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	1.799AsnAla: 1.799 ± 0.051	1.294AsnCys: 1.294 ± 0.043	4.511AsnAsp: 4.511 ± 0.09	5.652AsnGlu: 5.652 ± 0.095	4.004AsnPhe: 4.004 ± 0.088	2.886AsnGly: 2.886 ± 0.065	1.69AsnHis: 1.69 ± 0.052	6.655AsnIle: 6.655 ± 0.086	6.295AsnLys: 6.295 ± 0.118	7.181AsnLeu: 7.181 ± 0.104	1.562AsnMet: 1.562 ± 0.045	5.359AsnAsn: 5.359 ± 0.134	2.068AsnPro: 2.068 ± 0.045	3.53AsnGln: 3.53 ± 0.085	2.694AsnArg: 2.694 ± 0.062	5.246AsnSer: 5.246 ± 0.096	4.04AsnThr: 4.04 ± 0.11	3.337AsnVal: 3.337 ± 0.065	0.451AsnTrp: 0.451 ± 0.021	2.443AsnTyr: 2.443 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.046ProAla: 1.046 ± 0.056	0.511ProCys: 0.511 ± 0.031	1.796ProAsp: 1.796 ± 0.048	2.463ProGlu: 2.463 ± 0.073	2.302ProPhe: 2.302 ± 0.054	1.205ProGly: 1.205 ± 0.039	0.579ProHis: 0.579 ± 0.022	2.617ProIle: 2.617 ± 0.056	2.403ProLys: 2.403 ± 0.061	2.778ProLeu: 2.778 ± 0.062	0.542ProMet: 0.542 ± 0.023	1.69ProAsn: 1.69 ± 0.048	1.035ProPro: 1.035 ± 0.051	1.19ProGln: 1.19 ± 0.056	1.004ProArg: 1.004 ± 0.039	2.53ProSer: 2.53 ± 0.058	1.582ProThr: 1.582 ± 0.052	1.944ProVal: 1.944 ± 0.063	0.18ProTrp: 0.18 ± 0.013	1.14ProTyr: 1.14 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.403GlnAla: 1.403 ± 0.058	0.456GlnCys: 0.456 ± 0.027	1.75GlnAsp: 1.75 ± 0.047	2.807GlnGlu: 2.807 ± 0.075	2.055GlnPhe: 2.055 ± 0.055	1.223GlnGly: 1.223 ± 0.06	0.714GlnHis: 0.714 ± 0.029	3.971GlnIle: 3.971 ± 0.066	4.857GlnLys: 4.857 ± 0.091	2.952GlnLeu: 2.952 ± 0.061	1.094GlnMet: 1.094 ± 0.042	3.945GlnAsn: 3.945 ± 0.093	1.46GlnPro: 1.46 ± 0.061	1.981GlnGln: 1.981 ± 0.086	1.484GlnArg: 1.484 ± 0.038	3.313GlnSer: 3.313 ± 0.08	2.39GlnThr: 2.39 ± 0.063	1.561GlnVal: 1.561 ± 0.047	0.243GlnTrp: 0.243 ± 0.015	1.16GlnTyr: 1.16 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.58ArgAla: 1.58 ± 0.045	0.581ArgCys: 0.581 ± 0.026	2.016ArgAsp: 2.016 ± 0.051	2.805ArgGlu: 2.805 ± 0.061	2.008ArgPhe: 2.008 ± 0.044	1.486ArgGly: 1.486 ± 0.049	0.884ArgHis: 0.884 ± 0.033	3.486ArgIle: 3.486 ± 0.062	4.158ArgLys: 4.158 ± 0.063	3.512ArgLeu: 3.512 ± 0.063	1.065ArgMet: 1.065 ± 0.035	2.957ArgAsn: 2.957 ± 0.058	1.374ArgPro: 1.374 ± 0.047	1.471ArgGln: 1.471 ± 0.038	1.948ArgArg: 1.948 ± 0.047	2.756ArgSer: 2.756 ± 0.064	2.155ArgThr: 2.155 ± 0.052	1.885ArgVal: 1.885 ± 0.047	0.33ArgTrp: 0.33 ± 0.021	1.301ArgTyr: 1.301 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	2.638SerAla: 2.638 ± 0.07	0.99SerCys: 0.99 ± 0.033	5.224SerAsp: 5.224 ± 0.097	6.065SerGlu: 6.065 ± 0.12	4.417SerPhe: 4.417 ± 0.076	3.002SerGly: 3.002 ± 0.074	1.608SerHis: 1.608 ± 0.052	5.864SerIle: 5.864 ± 0.082	7.038SerLys: 7.038 ± 0.095	7.09SerLeu: 7.09 ± 0.093	1.443SerMet: 1.443 ± 0.045	5.682SerAsn: 5.682 ± 0.1	2.137SerPro: 2.137 ± 0.065	3.217SerGln: 3.217 ± 0.077	2.812SerArg: 2.812 ± 0.058	5.862SerSer: 5.862 ± 0.144	4.097SerThr: 4.097 ± 0.083	3.824SerVal: 3.824 ± 0.074	0.364SerTrp: 0.364 ± 0.019	2.525SerTyr: 2.525 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.214ThrAla: 2.214 ± 0.053	0.775ThrCys: 0.775 ± 0.032	3.543ThrAsp: 3.543 ± 0.082	4.274ThrGlu: 4.274 ± 0.075	3.135ThrPhe: 3.135 ± 0.064	2.614ThrGly: 2.614 ± 0.068	1.11ThrHis: 1.11 ± 0.042	4.664ThrIle: 4.664 ± 0.077	4.619ThrLys: 4.619 ± 0.074	4.531ThrLeu: 4.531 ± 0.082	1.021ThrMet: 1.021 ± 0.036	3.492ThrAsn: 3.492 ± 0.068	1.932ThrPro: 1.932 ± 0.055	2.081ThrGln: 2.081 ± 0.059	1.924ThrArg: 1.924 ± 0.049	4.044ThrSer: 4.044 ± 0.083	3.313ThrThr: 3.313 ± 0.082	3.43ThrVal: 3.43 ± 0.08	0.271ThrTrp: 0.271 ± 0.017	1.582ThrTyr: 1.582 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	1.639ValAla: 1.639 ± 0.05	0.803ValCys: 0.803 ± 0.03	2.565ValAsp: 2.565 ± 0.048	3.061ValGlu: 3.061 ± 0.058	3.015ValPhe: 3.015 ± 0.062	1.673ValGly: 1.673 ± 0.048	1.031ValHis: 1.031 ± 0.034	3.915ValIle: 3.915 ± 0.071	4.44ValLys: 4.44 ± 0.076	4.772ValLeu: 4.772 ± 0.084	0.872ValMet: 0.872 ± 0.031	2.856ValAsn: 2.856 ± 0.066	1.784ValPro: 1.784 ± 0.066	1.831ValGln: 1.831 ± 0.058	1.644ValArg: 1.644 ± 0.041	3.424ValSer: 3.424 ± 0.076	2.432ValThr: 2.432 ± 0.056	2.225ValVal: 2.225 ± 0.06	0.27ValTrp: 0.27 ± 0.017	1.771ValTyr: 1.771 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.253TrpAla: 0.253 ± 0.019	0.123TrpCys: 0.123 ± 0.011	0.28TrpAsp: 0.28 ± 0.019	0.3TrpGlu: 0.3 ± 0.02	0.356TrpPhe: 0.356 ± 0.021	0.246TrpGly: 0.246 ± 0.017	0.15TrpHis: 0.15 ± 0.012	0.476TrpIle: 0.476 ± 0.019	0.535TrpLys: 0.535 ± 0.023	0.635TrpLeu: 0.635 ± 0.025	0.162TrpMet: 0.162 ± 0.013	0.368TrpAsn: 0.368 ± 0.021	0.219TrpPro: 0.219 ± 0.016	0.269TrpGln: 0.269 ± 0.018	0.253TrpArg: 0.253 ± 0.014	0.47TrpSer: 0.47 ± 0.022	0.344TrpThr: 0.344 ± 0.02	0.253TrpVal: 0.253 ± 0.016	0.045TrpTrp: 0.045 ± 0.008	0.236TrpTyr: 0.236 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	0.998TyrAla: 0.998 ± 0.034	0.712TyrCys: 0.712 ± 0.035	2.395TyrAsp: 2.395 ± 0.065	2.493TyrGlu: 2.493 ± 0.065	2.695TyrPhe: 2.695 ± 0.062	1.454TyrGly: 1.454 ± 0.045	0.943TyrHis: 0.943 ± 0.04	2.56TyrIle: 2.56 ± 0.056	3.339TyrLys: 3.339 ± 0.066	3.766TyrLeu: 3.766 ± 0.071	0.645TyrMet: 0.645 ± 0.027	2.551TyrAsn: 2.551 ± 0.064	0.873TyrPro: 0.873 ± 0.032	1.469TyrGln: 1.469 ± 0.041	1.533TyrArg: 1.533 ± 0.043	2.517TyrSer: 2.517 ± 0.062	1.758TyrThr: 1.758 ± 0.041	1.434TyrVal: 1.434 ± 0.044	0.217TyrTrp: 0.217 ± 0.015	1.306TyrTyr: 1.306 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3636 proteins (957747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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