Amino acid dipepetide frequency for Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.826AlaAla: 16.826 ± 0.21	1.063AlaCys: 1.063 ± 0.035	6.98AlaAsp: 6.98 ± 0.097	7.023AlaGlu: 7.023 ± 0.097	4.277AlaPhe: 4.277 ± 0.072	9.992AlaGly: 9.992 ± 0.13	2.201AlaHis: 2.201 ± 0.045	6.587AlaIle: 6.587 ± 0.09	4.159AlaLys: 4.159 ± 0.093	12.269AlaLeu: 12.269 ± 0.142	3.205AlaMet: 3.205 ± 0.065	2.972AlaAsn: 2.972 ± 0.055	5.631AlaPro: 5.631 ± 0.089	3.837AlaGln: 3.837 ± 0.065	9.689AlaArg: 9.689 ± 0.106	7.039AlaSer: 7.039 ± 0.103	6.089AlaThr: 6.089 ± 0.103	8.46AlaVal: 8.46 ± 0.104	1.353AlaTrp: 1.353 ± 0.047	2.39AlaTyr: 2.39 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.96CysAla: 0.96 ± 0.03	0.11CysCys: 0.11 ± 0.011	0.541CysAsp: 0.541 ± 0.026	0.459CysGlu: 0.459 ± 0.022	0.345CysPhe: 0.345 ± 0.02	0.887CysGly: 0.887 ± 0.035	0.221CysHis: 0.221 ± 0.016	0.419CysIle: 0.419 ± 0.02	0.249CysLys: 0.249 ± 0.016	0.72CysLeu: 0.72 ± 0.028	0.171CysMet: 0.171 ± 0.015	0.217CysAsn: 0.217 ± 0.015	0.434CysPro: 0.434 ± 0.025	0.214CysGln: 0.214 ± 0.016	0.699CysArg: 0.699 ± 0.027	0.448CysSer: 0.448 ± 0.021	0.379CysThr: 0.379 ± 0.021	0.561CysVal: 0.561 ± 0.028	0.11CysTrp: 0.11 ± 0.012	0.199CysTyr: 0.199 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.053AspAla: 7.053 ± 0.119	0.441AspCys: 0.441 ± 0.024	3.557AspAsp: 3.557 ± 0.068	3.426AspGlu: 3.426 ± 0.061	2.179AspPhe: 2.179 ± 0.057	5.004AspGly: 5.004 ± 0.08	1.456AspHis: 1.456 ± 0.046	3.337AspIle: 3.337 ± 0.063	1.876AspLys: 1.876 ± 0.047	5.842AspLeu: 5.842 ± 0.086	1.258AspMet: 1.258 ± 0.043	1.51AspAsn: 1.51 ± 0.042	3.472AspPro: 3.472 ± 0.072	1.9AspGln: 1.9 ± 0.051	4.773AspArg: 4.773 ± 0.082	2.492AspSer: 2.492 ± 0.052	2.623AspThr: 2.623 ± 0.054	4.228AspVal: 4.228 ± 0.063	0.851AspTrp: 0.851 ± 0.028	1.484AspTyr: 1.484 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.157GluAla: 7.157 ± 0.104	0.364GluCys: 0.364 ± 0.02	2.572GluAsp: 2.572 ± 0.054	2.694GluGlu: 2.694 ± 0.058	1.771GluPhe: 1.771 ± 0.04	3.887GluGly: 3.887 ± 0.072	1.133GluHis: 1.133 ± 0.041	3.393GluIle: 3.393 ± 0.065	2.407GluLys: 2.407 ± 0.054	5.015GluLeu: 5.015 ± 0.074	1.43GluMet: 1.43 ± 0.038	1.622GluAsn: 1.622 ± 0.045	2.618GluPro: 2.618 ± 0.059	2.17GluGln: 2.17 ± 0.046	5.176GluArg: 5.176 ± 0.095	2.712GluSer: 2.712 ± 0.052	3.417GluThr: 3.417 ± 0.065	3.704GluVal: 3.704 ± 0.068	0.69GluTrp: 0.69 ± 0.026	0.96GluTyr: 0.96 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.457PheAla: 4.457 ± 0.073	0.368PheCys: 0.368 ± 0.021	2.661PheAsp: 2.661 ± 0.058	2.127PheGlu: 2.127 ± 0.046	1.347PhePhe: 1.347 ± 0.039	3.4PheGly: 3.4 ± 0.076	0.761PheHis: 0.761 ± 0.026	1.771PheIle: 1.771 ± 0.047	1.127PheLys: 1.127 ± 0.035	3.144PheLeu: 3.144 ± 0.06	0.792PheMet: 0.792 ± 0.03	1.188PheAsn: 1.188 ± 0.041	1.577PhePro: 1.577 ± 0.05	1.001PheGln: 1.001 ± 0.033	2.534PheArg: 2.534 ± 0.053	2.311PheSer: 2.311 ± 0.049	1.971PheThr: 1.971 ± 0.048	2.701PheVal: 2.701 ± 0.054	0.468PheTrp: 0.468 ± 0.021	0.878PheTyr: 0.878 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.712GlyAla: 8.712 ± 0.118	0.838GlyCys: 0.838 ± 0.032	4.523GlyAsp: 4.523 ± 0.079	4.473GlyGlu: 4.473 ± 0.072	3.51GlyPhe: 3.51 ± 0.068	7.158GlyGly: 7.158 ± 0.143	1.808GlyHis: 1.808 ± 0.05	4.452GlyIle: 4.452 ± 0.074	3.355GlyLys: 3.355 ± 0.071	7.978GlyLeu: 7.978 ± 0.103	2.002GlyMet: 2.002 ± 0.05	2.18GlyAsn: 2.18 ± 0.061	3.366GlyPro: 3.366 ± 0.07	2.679GlyGln: 2.679 ± 0.049	6.446GlyArg: 6.446 ± 0.087	4.898GlySer: 4.898 ± 0.078	4.236GlyThr: 4.236 ± 0.081	5.987GlyVal: 5.987 ± 0.097	1.262GlyTrp: 1.262 ± 0.042	2.171GlyTyr: 2.171 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.355HisAla: 2.355 ± 0.055	0.245HisCys: 0.245 ± 0.017	1.313HisAsp: 1.313 ± 0.042	1.008HisGlu: 1.008 ± 0.039	0.766HisPhe: 0.766 ± 0.03	1.992HisGly: 1.992 ± 0.047	0.646HisHis: 0.646 ± 0.035	0.956HisIle: 0.956 ± 0.032	0.499HisLys: 0.499 ± 0.025	2.101HisLeu: 2.101 ± 0.05	0.418HisMet: 0.418 ± 0.021	0.488HisAsn: 0.488 ± 0.025	1.387HisPro: 1.387 ± 0.04	0.652HisGln: 0.652 ± 0.025	1.698HisArg: 1.698 ± 0.055	0.987HisSer: 0.987 ± 0.032	0.822HisThr: 0.822 ± 0.03	1.468HisVal: 1.468 ± 0.037	0.305HisTrp: 0.305 ± 0.018	0.513HisTyr: 0.513 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.219IleAla: 7.219 ± 0.094	0.515IleCys: 0.515 ± 0.023	4.046IleAsp: 4.046 ± 0.065	3.939IleGlu: 3.939 ± 0.061	1.583IlePhe: 1.583 ± 0.046	4.872IleGly: 4.872 ± 0.081	0.965IleHis: 0.965 ± 0.037	2.395IleIle: 2.395 ± 0.053	1.804IleLys: 1.804 ± 0.044	4.192IleLeu: 4.192 ± 0.08	0.959IleMet: 0.959 ± 0.034	1.571IleAsn: 1.571 ± 0.043	2.505IlePro: 2.505 ± 0.054	1.221IleGln: 1.221 ± 0.04	3.677IleArg: 3.677 ± 0.063	3.051IleSer: 3.051 ± 0.063	2.638IleThr: 2.638 ± 0.05	4.427IleVal: 4.427 ± 0.081	0.587IleTrp: 0.587 ± 0.028	1.066IleTyr: 1.066 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.375LysAla: 4.375 ± 0.084	0.178LysCys: 0.178 ± 0.013	1.875LysAsp: 1.875 ± 0.049	1.657LysGlu: 1.657 ± 0.042	1.047LysPhe: 1.047 ± 0.035	2.609LysGly: 2.609 ± 0.06	0.734LysHis: 0.734 ± 0.027	1.823LysIle: 1.823 ± 0.053	1.629LysLys: 1.629 ± 0.058	3.592LysLeu: 3.592 ± 0.07	0.76LysMet: 0.76 ± 0.03	0.977LysAsn: 0.977 ± 0.035	2.436LysPro: 2.436 ± 0.058	1.189LysGln: 1.189 ± 0.031	2.843LysArg: 2.843 ± 0.065	2.135LysSer: 2.135 ± 0.047	2.158LysThr: 2.158 ± 0.051	2.548LysVal: 2.548 ± 0.058	0.438LysTrp: 0.438 ± 0.025	0.693LysTyr: 0.693 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.466LeuAla: 12.466 ± 0.158	0.747LeuCys: 0.747 ± 0.028	5.927LeuAsp: 5.927 ± 0.101	4.754LeuGlu: 4.754 ± 0.092	3.4LeuPhe: 3.4 ± 0.066	7.324LeuGly: 7.324 ± 0.098	1.834LeuHis: 1.834 ± 0.052	4.98LeuIle: 4.98 ± 0.083	3.849LeuLys: 3.849 ± 0.077	8.557LeuLeu: 8.557 ± 0.149	2.256LeuMet: 2.256 ± 0.052	2.702LeuAsn: 2.702 ± 0.057	5.305LeuPro: 5.305 ± 0.093	2.672LeuGln: 2.672 ± 0.06	7.322LeuArg: 7.322 ± 0.104	6.228LeuSer: 6.228 ± 0.093	5.562LeuThr: 5.562 ± 0.085	6.79LeuVal: 6.79 ± 0.088	1.098LeuTrp: 1.098 ± 0.036	1.873LeuTyr: 1.873 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.818MetAla: 2.818 ± 0.057	0.157MetCys: 0.157 ± 0.012	1.014MetAsp: 1.014 ± 0.033	1.022MetGlu: 1.022 ± 0.035	0.717MetPhe: 0.717 ± 0.031	1.51MetGly: 1.51 ± 0.039	0.415MetHis: 0.415 ± 0.023	1.408MetIle: 1.408 ± 0.046	1.007MetLys: 1.007 ± 0.032	2.336MetLeu: 2.336 ± 0.055	0.673MetMet: 0.673 ± 0.027	0.761MetAsn: 0.761 ± 0.03	1.482MetPro: 1.482 ± 0.041	0.8MetGln: 0.8 ± 0.026	1.937MetArg: 1.937 ± 0.042	1.562MetSer: 1.562 ± 0.042	1.958MetThr: 1.958 ± 0.048	1.571MetVal: 1.571 ± 0.047	0.223MetTrp: 0.223 ± 0.017	0.302MetTyr: 0.302 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.418AsnAla: 3.418 ± 0.068	0.231AsnCys: 0.231 ± 0.017	1.53AsnAsp: 1.53 ± 0.043	1.424AsnGlu: 1.424 ± 0.042	1.023AsnPhe: 1.023 ± 0.031	2.567AsnGly: 2.567 ± 0.061	0.58AsnHis: 0.58 ± 0.027	1.427AsnIle: 1.427 ± 0.044	0.811AsnLys: 0.811 ± 0.03	2.59AsnLeu: 2.59 ± 0.066	0.633AsnMet: 0.633 ± 0.022	0.797AsnAsn: 0.797 ± 0.035	1.879AsnPro: 1.879 ± 0.048	0.816AsnGln: 0.816 ± 0.031	2.094AsnArg: 2.094 ± 0.047	1.333AsnSer: 1.333 ± 0.04	1.257AsnThr: 1.257 ± 0.043	2.193AsnVal: 2.193 ± 0.05	0.434AsnTrp: 0.434 ± 0.024	0.674AsnTyr: 0.674 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.401ProAla: 6.401 ± 0.099	0.345ProCys: 0.345 ± 0.019	3.926ProAsp: 3.926 ± 0.067	3.333ProGlu: 3.333 ± 0.063	1.935ProPhe: 1.935 ± 0.045	4.432ProGly: 4.432 ± 0.067	1.164ProHis: 1.164 ± 0.036	2.318ProIle: 2.318 ± 0.053	1.868ProLys: 1.868 ± 0.048	4.564ProLeu: 4.564 ± 0.084	1.184ProMet: 1.184 ± 0.034	1.405ProAsn: 1.405 ± 0.044	3.237ProPro: 3.237 ± 0.096	1.666ProGln: 1.666 ± 0.044	3.524ProArg: 3.524 ± 0.072	3.137ProSer: 3.137 ± 0.063	2.439ProThr: 2.439 ± 0.046	4.211ProVal: 4.211 ± 0.064	0.676ProTrp: 0.676 ± 0.026	1.175ProTyr: 1.175 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.881GlnAla: 3.881 ± 0.072	0.219GlnCys: 0.219 ± 0.016	1.451GlnAsp: 1.451 ± 0.04	1.38GlnGlu: 1.38 ± 0.039	1.122GlnPhe: 1.122 ± 0.035	2.344GlnGly: 2.344 ± 0.056	0.643GlnHis: 0.643 ± 0.028	1.852GlnIle: 1.852 ± 0.048	1.073GlnLys: 1.073 ± 0.036	2.749GlnLeu: 2.749 ± 0.059	0.82GlnMet: 0.82 ± 0.033	0.933GlnAsn: 0.933 ± 0.034	1.955GlnPro: 1.955 ± 0.05	1.184GlnGln: 1.184 ± 0.045	2.646GlnArg: 2.646 ± 0.06	1.839GlnSer: 1.839 ± 0.047	1.847GlnThr: 1.847 ± 0.05	2.225GlnVal: 2.225 ± 0.054	0.436GlnTrp: 0.436 ± 0.022	0.612GlnTyr: 0.612 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.728ArgAla: 8.728 ± 0.116	0.62ArgCys: 0.62 ± 0.03	4.563ArgAsp: 4.563 ± 0.071	4.526ArgGlu: 4.526 ± 0.083	3.281ArgPhe: 3.281 ± 0.063	5.45ArgGly: 5.45 ± 0.078	1.829ArgHis: 1.829 ± 0.051	4.532ArgIle: 4.532 ± 0.073	2.95ArgLys: 2.95 ± 0.056	8.29ArgLeu: 8.29 ± 0.11	1.996ArgMet: 1.996 ± 0.047	2.348ArgAsn: 2.348 ± 0.047	3.847ArgPro: 3.847 ± 0.074	2.762ArgGln: 2.762 ± 0.051	6.661ArgArg: 6.661 ± 0.092	4.425ArgSer: 4.425 ± 0.075	3.932ArgThr: 3.932 ± 0.069	5.019ArgVal: 5.019 ± 0.079	1.069ArgTrp: 1.069 ± 0.03	1.85ArgTyr: 1.85 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.098	0.481SerCys: 0.481 ± 0.021	3.337SerAsp: 3.337 ± 0.061	3.002SerGlu: 3.002 ± 0.06	2.271SerPhe: 2.271 ± 0.052	5.815SerGly: 5.815 ± 0.08	1.117SerHis: 1.117 ± 0.038	2.936SerIle: 2.936 ± 0.054	1.79SerLys: 1.79 ± 0.047	5.435SerLeu: 5.435 ± 0.083	1.351SerMet: 1.351 ± 0.042	1.573SerAsn: 1.573 ± 0.044	3.064SerPro: 3.064 ± 0.058	1.704SerGln: 1.704 ± 0.048	4.552SerArg: 4.552 ± 0.072	3.529SerSer: 3.529 ± 0.069	2.876SerThr: 2.876 ± 0.062	4.036SerVal: 4.036 ± 0.065	0.691SerTrp: 0.691 ± 0.031	1.39SerTyr: 1.39 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.233ThrAla: 6.233 ± 0.088	0.45ThrCys: 0.45 ± 0.022	2.827ThrAsp: 2.827 ± 0.051	2.691ThrGlu: 2.691 ± 0.06	2.06ThrPhe: 2.06 ± 0.042	4.98ThrGly: 4.98 ± 0.088	0.933ThrHis: 0.933 ± 0.033	2.996ThrIle: 2.996 ± 0.056	1.607ThrLys: 1.607 ± 0.044	5.636ThrLeu: 5.636 ± 0.087	1.223ThrMet: 1.223 ± 0.036	1.262ThrAsn: 1.262 ± 0.044	3.353ThrPro: 3.353 ± 0.071	1.475ThrGln: 1.475 ± 0.039	3.79ThrArg: 3.79 ± 0.071	3.093ThrSer: 3.093 ± 0.064	2.904ThrThr: 2.904 ± 0.063	4.211ThrVal: 4.211 ± 0.073	0.625ThrTrp: 0.625 ± 0.024	1.136ThrTyr: 1.136 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.863ValAla: 8.863 ± 0.105	0.582ValCys: 0.582 ± 0.024	4.081ValAsp: 4.081 ± 0.067	4.372ValGlu: 4.372 ± 0.077	2.54ValPhe: 2.54 ± 0.057	5.055ValGly: 5.055 ± 0.086	1.403ValHis: 1.403 ± 0.041	3.984ValIle: 3.984 ± 0.074	2.494ValLys: 2.494 ± 0.06	6.929ValLeu: 6.929 ± 0.101	1.81ValMet: 1.81 ± 0.042	2.092ValAsn: 2.092 ± 0.049	3.698ValPro: 3.698 ± 0.057	1.987ValGln: 1.987 ± 0.05	5.421ValArg: 5.421 ± 0.078	4.413ValSer: 4.413 ± 0.071	4.589ValThr: 4.589 ± 0.08	5.794ValVal: 5.794 ± 0.088	0.864ValTrp: 0.864 ± 0.031	1.456ValTyr: 1.456 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.026TrpAla: 1.026 ± 0.034	0.153TrpCys: 0.153 ± 0.013	0.563TrpAsp: 0.563 ± 0.024	0.49TrpGlu: 0.49 ± 0.026	0.498TrpPhe: 0.498 ± 0.023	0.803TrpGly: 0.803 ± 0.037	0.294TrpHis: 0.294 ± 0.019	0.746TrpIle: 0.746 ± 0.035	0.484TrpLys: 0.484 ± 0.025	1.52TrpLeu: 1.52 ± 0.042	0.348TrpMet: 0.348 ± 0.02	0.474TrpAsn: 0.474 ± 0.025	0.668TrpPro: 0.668 ± 0.029	0.542TrpGln: 0.542 ± 0.026	1.3TrpArg: 1.3 ± 0.039	0.861TrpSer: 0.861 ± 0.035	0.796TrpThr: 0.796 ± 0.031	0.705TrpVal: 0.705 ± 0.03	0.225TrpTrp: 0.225 ± 0.017	0.251TrpTyr: 0.251 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.43TyrAla: 2.43 ± 0.055	0.238TyrCys: 0.238 ± 0.016	1.476TyrAsp: 1.476 ± 0.045	1.088TyrGlu: 1.088 ± 0.037	0.914TyrPhe: 0.914 ± 0.033	1.953TyrGly: 1.953 ± 0.046	0.482TyrHis: 0.482 ± 0.024	0.919TyrIle: 0.919 ± 0.03	0.659TyrLys: 0.659 ± 0.03	2.189TyrLeu: 2.189 ± 0.046	0.383TyrMet: 0.383 ± 0.02	0.64TyrAsn: 0.64 ± 0.029	1.027TyrPro: 1.027 ± 0.035	0.739TyrGln: 0.739 ± 0.031	1.896TyrArg: 1.896 ± 0.055	1.118TyrSer: 1.118 ± 0.036	0.991TyrThr: 0.991 ± 0.039	1.588TyrVal: 1.588 ± 0.041	0.343TyrTrp: 0.343 ± 0.02	0.591TyrTyr: 0.591 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2980 proteins (923695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---