human papillomavirus 166

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 19

Average proteome isoelectric point is 5.77

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MND3|K4MND3_9PAPI Protein E7 OS=human papillomavirus 166 OX=1315259 GN=E7 PE=3 SV=1
MM1 pKa = 6.92YY2 pKa = 10.03RR3 pKa = 11.84AGRR6 pKa = 11.84NKK8 pKa = 9.79RR9 pKa = 11.84ASAEE13 pKa = 3.94EE14 pKa = 4.76LYY16 pKa = 10.31KK17 pKa = 10.67QCATGDD23 pKa = 3.84CPPDD27 pKa = 3.37VKK29 pKa = 11.18NKK31 pKa = 10.16IEE33 pKa = 4.24GDD35 pKa = 3.2TWADD39 pKa = 3.91RR40 pKa = 11.84LLKK43 pKa = 10.08WFGSVVYY50 pKa = 9.95FGGLGIGTGRR60 pKa = 11.84GSGGSTGYY68 pKa = 10.41RR69 pKa = 11.84PLGAGTSRR77 pKa = 11.84PIGEE81 pKa = 5.01SIPIRR86 pKa = 11.84PAVPLDD92 pKa = 4.17PIGPAEE98 pKa = 4.55ILPIDD103 pKa = 3.95TANPAGPAIVQLTDD117 pKa = 2.99VTLPDD122 pKa = 4.18PSIIDD127 pKa = 3.17ISNPTTEE134 pKa = 4.67LGAGEE139 pKa = 4.3IDD141 pKa = 3.22IVSAIDD147 pKa = 3.57PLTDD151 pKa = 2.9IGGVGGNPTIISSTDD166 pKa = 2.81EE167 pKa = 4.14SAVLDD172 pKa = 4.12VQPIPPPKK180 pKa = 10.1RR181 pKa = 11.84FALDD185 pKa = 3.24VGNKK189 pKa = 9.62PSGTHH194 pKa = 4.57LTVYY198 pKa = 10.5SATTHH203 pKa = 7.24PDD205 pKa = 2.88PDD207 pKa = 3.35INIFVTSGFEE217 pKa = 4.02GEE219 pKa = 4.14IVGDD223 pKa = 3.7VEE225 pKa = 4.82EE226 pKa = 5.13IPLEE230 pKa = 4.28TFNTMQEE237 pKa = 4.31FEE239 pKa = 4.43LQEE242 pKa = 4.18PAQKK246 pKa = 9.78TSTPSDD252 pKa = 3.35VLTRR256 pKa = 11.84FVGRR260 pKa = 11.84ARR262 pKa = 11.84NLYY265 pKa = 10.31NRR267 pKa = 11.84FTEE270 pKa = 4.34QVPTQNPYY278 pKa = 10.88FLGQASRR285 pKa = 11.84AVQFEE290 pKa = 4.18FEE292 pKa = 4.33NPAFEE297 pKa = 5.8DD298 pKa = 3.76DD299 pKa = 3.66VSFTFEE305 pKa = 3.92RR306 pKa = 11.84DD307 pKa = 2.96IAEE310 pKa = 4.06IQAAPDD316 pKa = 3.24ADD318 pKa = 3.55FRR320 pKa = 11.84DD321 pKa = 3.3IRR323 pKa = 11.84VLHH326 pKa = 6.32RR327 pKa = 11.84PSYY330 pKa = 8.81FTTDD334 pKa = 2.62TGLIRR339 pKa = 11.84VSRR342 pKa = 11.84LGEE345 pKa = 3.71RR346 pKa = 11.84ATITTRR352 pKa = 11.84SGLEE356 pKa = 3.66LGRR359 pKa = 11.84PVHH362 pKa = 6.95FYY364 pKa = 11.16QDD366 pKa = 2.68ISTIEE371 pKa = 3.84PADD374 pKa = 3.95IIEE377 pKa = 4.42LQPVNDD383 pKa = 4.02TSHH386 pKa = 7.12ISTTVNTMLDD396 pKa = 3.38NTIINPAFDD405 pKa = 3.51SDD407 pKa = 4.69LYY409 pKa = 11.58NEE411 pKa = 5.12DD412 pKa = 3.97VLLDD416 pKa = 4.31DD417 pKa = 4.14YY418 pKa = 12.1SEE420 pKa = 4.73GFEE423 pKa = 4.15NTHH426 pKa = 6.71LLVTTTDD433 pKa = 3.37ADD435 pKa = 4.0NEE437 pKa = 4.4VLTVPTLPPGPSVRR451 pKa = 11.84VFIDD455 pKa = 3.73DD456 pKa = 3.82YY457 pKa = 11.72GSGLVVFNPIITTKK471 pKa = 9.54QQTIIPSQTEE481 pKa = 3.39PHH483 pKa = 6.87LIIDD487 pKa = 4.55LFSDD491 pKa = 4.67DD492 pKa = 5.3FYY494 pKa = 11.76LHH496 pKa = 6.88PGYY499 pKa = 10.72LKK501 pKa = 10.59RR502 pKa = 11.84KK503 pKa = 8.83RR504 pKa = 11.84KK505 pKa = 9.95RR506 pKa = 11.84SDD508 pKa = 2.6IFF510 pKa = 3.93

Molecular weight: 55.78 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MKR5|K4MKR5_9PAPI Major capsid protein L1 OS=human papillomavirus 166 OX=1315259 GN=L1 PE=3 SV=1
MM1 pKa = 7.89AEE3 pKa = 4.02VCPVRR8 pKa = 11.84LDD10 pKa = 3.97DD11 pKa = 3.81FCNYY15 pKa = 10.18YY16 pKa = 10.44CVSLFDD22 pKa = 5.34LSLPCIFCKK31 pKa = 10.31FICDD35 pKa = 3.97LQDD38 pKa = 3.38LASFHH43 pKa = 6.82LKK45 pKa = 10.05RR46 pKa = 11.84LSIVWRR52 pKa = 11.84SGNPFICCRR61 pKa = 11.84KK62 pKa = 9.25CVRR65 pKa = 11.84LSALYY70 pKa = 9.78EE71 pKa = 4.01AEE73 pKa = 4.22NYY75 pKa = 8.32CVCVVKK81 pKa = 10.74ASALEE86 pKa = 4.05GLLHH90 pKa = 7.25KK91 pKa = 10.19SLQSITIRR99 pKa = 11.84CLCCYY104 pKa = 10.08QLLDD108 pKa = 3.77LCEE111 pKa = 5.17KK112 pKa = 10.55LDD114 pKa = 3.78CCVRR118 pKa = 11.84DD119 pKa = 3.61EE120 pKa = 4.32NFSLVRR126 pKa = 11.84GTWRR130 pKa = 11.84GPCRR134 pKa = 11.84TCISKK139 pKa = 10.73

Molecular weight: 15.95 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2252

101

607

375.3

42.46

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.083 ± 0.554

2.709 ± 1.411

6.572 ± 0.644

6.661 ± 0.543

5.018 ± 0.376

5.551 ± 0.715

1.51 ± 0.315

4.973 ± 0.957

5.151 ± 0.944

8.659 ± 1.139

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.732 ± 0.446

4.796 ± 0.381

5.595 ± 0.931

4.218 ± 0.538

5.506 ± 0.586

7.194 ± 0.74

6.572 ± 1.032

6.35 ± 0.224

1.51 ± 0.349

3.641 ± 0.409
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski