Amino acid dipepetide frequency for Trichophyton interdigitale (strain MR816)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.679AlaAla: 8.679 ± 0.069	0.987AlaCys: 0.987 ± 0.017	4.03AlaAsp: 4.03 ± 0.031	5.059AlaGlu: 5.059 ± 0.042	2.856AlaPhe: 2.856 ± 0.034	5.643AlaGly: 5.643 ± 0.047	1.684AlaHis: 1.684 ± 0.022	4.23AlaIle: 4.23 ± 0.039	4.081AlaLys: 4.081 ± 0.042	7.178AlaLeu: 7.178 ± 0.047	1.847AlaMet: 1.847 ± 0.022	2.865AlaAsn: 2.865 ± 0.022	4.563AlaPro: 4.563 ± 0.048	3.226AlaGln: 3.226 ± 0.031	4.696AlaArg: 4.696 ± 0.036	7.336AlaSer: 7.336 ± 0.051	4.98AlaThr: 4.98 ± 0.039	5.062AlaVal: 5.062 ± 0.041	0.99AlaTrp: 0.99 ± 0.018	2.02AlaTyr: 2.02 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.859CysAla: 0.859 ± 0.014	0.255CysCys: 0.255 ± 0.01	0.623CysAsp: 0.623 ± 0.013	0.611CysGlu: 0.611 ± 0.014	0.526CysPhe: 0.526 ± 0.014	0.93CysGly: 0.93 ± 0.02	0.331CysHis: 0.331 ± 0.009	0.729CysIle: 0.729 ± 0.017	0.535CysLys: 0.535 ± 0.012	1.284CysLeu: 1.284 ± 0.019	0.277CysMet: 0.277 ± 0.007	0.419CysAsn: 0.419 ± 0.01	0.68CysPro: 0.68 ± 0.015	0.452CysGln: 0.452 ± 0.011	0.768CysArg: 0.768 ± 0.015	0.961CysSer: 0.961 ± 0.018	0.646CysThr: 0.646 ± 0.013	0.753CysVal: 0.753 ± 0.015	0.179CysTrp: 0.179 ± 0.006	0.363CysTyr: 0.363 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.29AspAla: 4.29 ± 0.038	0.621AspCys: 0.621 ± 0.013	4.181AspAsp: 4.181 ± 0.049	4.534AspGlu: 4.534 ± 0.044	2.049AspPhe: 2.049 ± 0.021	3.985AspGly: 3.985 ± 0.035	1.181AspHis: 1.181 ± 0.02	3.457AspIle: 3.457 ± 0.033	2.611AspLys: 2.611 ± 0.028	4.759AspLeu: 4.759 ± 0.035	1.282AspMet: 1.282 ± 0.016	2.043AspAsn: 2.043 ± 0.023	3.176AspPro: 3.176 ± 0.032	1.839AspGln: 1.839 ± 0.024	3.074AspArg: 3.074 ± 0.037	4.339AspSer: 4.339 ± 0.041	3.071AspThr: 3.071 ± 0.026	3.376AspVal: 3.376 ± 0.027	0.766AspTrp: 0.766 ± 0.013	1.522AspTyr: 1.522 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.237GluAla: 5.237 ± 0.04	0.641GluCys: 0.641 ± 0.014	4.243GluAsp: 4.243 ± 0.041	5.74GluGlu: 5.74 ± 0.06	1.996GluPhe: 1.996 ± 0.022	3.615GluGly: 3.615 ± 0.032	1.359GluHis: 1.359 ± 0.02	3.264GluIle: 3.264 ± 0.034	4.071GluLys: 4.071 ± 0.041	5.299GluLeu: 5.299 ± 0.044	1.471GluMet: 1.471 ± 0.018	2.535GluAsn: 2.535 ± 0.024	2.954GluPro: 2.954 ± 0.037	2.529GluGln: 2.529 ± 0.028	3.947GluArg: 3.947 ± 0.043	4.532GluSer: 4.532 ± 0.035	3.462GluThr: 3.462 ± 0.031	3.471GluVal: 3.471 ± 0.028	0.815GluTrp: 0.815 ± 0.015	1.766GluTyr: 1.766 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.763PheAla: 2.763 ± 0.031	0.542PheCys: 0.542 ± 0.013	2.217PheAsp: 2.217 ± 0.027	2.087PheGlu: 2.087 ± 0.022	1.508PhePhe: 1.508 ± 0.021	2.632PheGly: 2.632 ± 0.033	0.907PheHis: 0.907 ± 0.015	1.869PheIle: 1.869 ± 0.023	1.59PheLys: 1.59 ± 0.021	3.297PheLeu: 3.297 ± 0.035	0.749PheMet: 0.749 ± 0.015	1.467PheAsn: 1.467 ± 0.021	1.937PhePro: 1.937 ± 0.022	1.32PheGln: 1.32 ± 0.019	1.945PheArg: 1.945 ± 0.024	3.181PheSer: 3.181 ± 0.031	2.138PheThr: 2.138 ± 0.023	2.218PheVal: 2.218 ± 0.028	0.553PheTrp: 0.553 ± 0.011	1.08PheTyr: 1.08 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.824GlyAla: 4.824 ± 0.039	0.859GlyCys: 0.859 ± 0.017	3.571GlyAsp: 3.571 ± 0.031	3.73GlyGlu: 3.73 ± 0.035	2.576GlyPhe: 2.576 ± 0.029	5.547GlyGly: 5.547 ± 0.057	1.652GlyHis: 1.652 ± 0.026	3.562GlyIle: 3.562 ± 0.034	3.619GlyLys: 3.619 ± 0.034	5.676GlyLeu: 5.676 ± 0.048	1.568GlyMet: 1.568 ± 0.022	2.56GlyAsn: 2.56 ± 0.028	3.32GlyPro: 3.32 ± 0.039	2.569GlyGln: 2.569 ± 0.033	4.078GlyArg: 4.078 ± 0.041	5.848GlySer: 5.848 ± 0.042	3.821GlyThr: 3.821 ± 0.031	4.094GlyVal: 4.094 ± 0.036	1.037GlyTrp: 1.037 ± 0.018	2.09GlyTyr: 2.09 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.733HisAla: 1.733 ± 0.02	0.31HisCys: 0.31 ± 0.008	1.286HisAsp: 1.286 ± 0.017	1.298HisGlu: 1.298 ± 0.019	0.892HisPhe: 0.892 ± 0.015	1.731HisGly: 1.731 ± 0.025	0.989HisHis: 0.989 ± 0.027	1.326HisIle: 1.326 ± 0.018	0.942HisLys: 0.942 ± 0.017	2.201HisLeu: 2.201 ± 0.025	0.475HisMet: 0.475 ± 0.012	0.896HisAsn: 0.896 ± 0.015	1.736HisPro: 1.736 ± 0.024	1.134HisGln: 1.134 ± 0.021	1.568HisArg: 1.568 ± 0.025	2.055HisSer: 2.055 ± 0.024	1.302HisThr: 1.302 ± 0.019	1.312HisVal: 1.312 ± 0.017	0.303HisTrp: 0.303 ± 0.008	0.662HisTyr: 0.662 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.973IleAla: 3.973 ± 0.035	0.802IleCys: 0.802 ± 0.014	3.03IleAsp: 3.03 ± 0.032	3.075IleGlu: 3.075 ± 0.03	2.068IlePhe: 2.068 ± 0.028	3.122IleGly: 3.122 ± 0.034	1.28IleHis: 1.28 ± 0.02	2.722IleIle: 2.722 ± 0.034	2.456IleLys: 2.456 ± 0.029	4.764IleLeu: 4.764 ± 0.04	1.049IleMet: 1.049 ± 0.016	1.93IleAsn: 1.93 ± 0.022	3.428IlePro: 3.428 ± 0.027	2.035IleGln: 2.035 ± 0.028	3.001IleArg: 3.001 ± 0.027	4.429IleSer: 4.429 ± 0.039	2.913IleThr: 2.913 ± 0.029	3.068IleVal: 3.068 ± 0.032	0.691IleTrp: 0.691 ± 0.014	1.48IleTyr: 1.48 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.341LysAla: 4.341 ± 0.046	0.553LysCys: 0.553 ± 0.012	2.964LysAsp: 2.964 ± 0.031	3.741LysGlu: 3.741 ± 0.039	1.579LysPhe: 1.579 ± 0.023	3.161LysGly: 3.161 ± 0.032	1.161LysHis: 1.161 ± 0.018	2.489LysIle: 2.489 ± 0.026	3.691LysLys: 3.691 ± 0.063	4.408LysLeu: 4.408 ± 0.036	1.066LysMet: 1.066 ± 0.016	1.91LysAsn: 1.91 ± 0.021	3.098LysPro: 3.098 ± 0.035	2.062LysGln: 2.062 ± 0.026	3.592LysArg: 3.592 ± 0.038	3.921LysSer: 3.921 ± 0.035	2.826LysThr: 2.826 ± 0.028	2.847LysVal: 2.847 ± 0.031	0.656LysTrp: 0.656 ± 0.015	1.517LysTyr: 1.517 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	7.426LeuAla: 7.426 ± 0.048	1.173LeuCys: 1.173 ± 0.018	5.044LeuAsp: 5.044 ± 0.033	5.52LeuGlu: 5.52 ± 0.044	3.277LeuPhe: 3.277 ± 0.034	5.513LeuGly: 5.513 ± 0.045	2.156LeuHis: 2.156 ± 0.02	4.005LeuIle: 4.005 ± 0.042	4.495LeuLys: 4.495 ± 0.041	8.285LeuLeu: 8.285 ± 0.063	1.686LeuMet: 1.686 ± 0.02	3.28LeuAsn: 3.28 ± 0.03	5.521LeuPro: 5.521 ± 0.039	3.751LeuGln: 3.751 ± 0.039	5.733LeuArg: 5.733 ± 0.043	7.616LeuSer: 7.616 ± 0.052	4.703LeuThr: 4.703 ± 0.038	5.136LeuVal: 5.136 ± 0.045	1.074LeuTrp: 1.074 ± 0.016	2.337LeuTyr: 2.337 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.189MetAla: 2.189 ± 0.023	0.228MetCys: 0.228 ± 0.008	1.27MetAsp: 1.27 ± 0.02	1.369MetGlu: 1.369 ± 0.018	0.762MetPhe: 0.762 ± 0.014	1.482MetGly: 1.482 ± 0.02	0.472MetHis: 0.472 ± 0.011	1.033MetIle: 1.033 ± 0.018	1.156MetLys: 1.156 ± 0.018	1.815MetLeu: 1.815 ± 0.022	0.535MetMet: 0.535 ± 0.011	0.844MetAsn: 0.844 ± 0.015	1.178MetPro: 1.178 ± 0.017	0.837MetGln: 0.837 ± 0.015	1.164MetArg: 1.164 ± 0.018	1.774MetSer: 1.774 ± 0.023	1.216MetThr: 1.216 ± 0.018	1.314MetVal: 1.314 ± 0.021	0.224MetTrp: 0.224 ± 0.008	0.487MetTyr: 0.487 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.023AsnAla: 3.023 ± 0.027	0.457AsnCys: 0.457 ± 0.012	2.034AsnAsp: 2.034 ± 0.022	2.189AsnGlu: 2.189 ± 0.023	1.363AsnPhe: 1.363 ± 0.021	3.014AsnGly: 3.014 ± 0.032	0.896AsnHis: 0.896 ± 0.016	2.313AsnIle: 2.313 ± 0.026	1.757AsnLys: 1.757 ± 0.021	3.266AsnLeu: 3.266 ± 0.029	0.885AsnMet: 0.885 ± 0.015	1.837AsnAsn: 1.837 ± 0.032	2.59AsnPro: 2.59 ± 0.029	1.412AsnGln: 1.412 ± 0.019	2.046AsnArg: 2.046 ± 0.024	3.117AsnSer: 3.117 ± 0.03	2.362AsnThr: 2.362 ± 0.029	2.255AsnVal: 2.255 ± 0.028	0.507AsnTrp: 0.507 ± 0.011	1.04AsnTyr: 1.04 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.325ProAla: 5.325 ± 0.048	0.566ProCys: 0.566 ± 0.014	3.23ProAsp: 3.23 ± 0.029	3.96ProGlu: 3.96 ± 0.036	2.049ProPhe: 2.049 ± 0.025	4.021ProGly: 4.021 ± 0.043	1.394ProHis: 1.394 ± 0.022	2.679ProIle: 2.679 ± 0.028	2.856ProLys: 2.856 ± 0.03	4.781ProLeu: 4.781 ± 0.036	1.082ProMet: 1.082 ± 0.018	2.289ProAsn: 2.289 ± 0.027	5.555ProPro: 5.555 ± 0.083	2.654ProGln: 2.654 ± 0.036	3.43ProArg: 3.43 ± 0.029	6.457ProSer: 6.457 ± 0.056	4.097ProThr: 4.097 ± 0.043	3.617ProVal: 3.617 ± 0.036	0.661ProTrp: 0.661 ± 0.013	1.528ProTyr: 1.528 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.363GlnAla: 3.363 ± 0.036	0.429GlnCys: 0.429 ± 0.011	2.001GlnAsp: 2.001 ± 0.02	2.434GlnGlu: 2.434 ± 0.028	1.32GlnPhe: 1.32 ± 0.022	2.367GlnGly: 2.367 ± 0.031	1.233GlnHis: 1.233 ± 0.025	1.889GlnIle: 1.889 ± 0.023	2.156GlnLys: 2.156 ± 0.023	3.524GlnLeu: 3.524 ± 0.033	0.856GlnMet: 0.856 ± 0.016	1.599GlnAsn: 1.599 ± 0.022	2.883GlnPro: 2.883 ± 0.041	3.308GlnGln: 3.308 ± 0.086	2.716GlnArg: 2.716 ± 0.032	3.288GlnSer: 3.288 ± 0.033	2.237GlnThr: 2.237 ± 0.03	2.088GlnVal: 2.088 ± 0.023	0.504GlnTrp: 0.504 ± 0.011	1.16GlnTyr: 1.16 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.545ArgAla: 4.545 ± 0.035	0.745ArgCys: 0.745 ± 0.013	3.42ArgAsp: 3.42 ± 0.036	3.999ArgGlu: 3.999 ± 0.04	2.091ArgPhe: 2.091 ± 0.023	3.705ArgGly: 3.705 ± 0.04	1.591ArgHis: 1.591 ± 0.024	3.036ArgIle: 3.036 ± 0.032	3.57ArgLys: 3.57 ± 0.038	5.412ArgLeu: 5.412 ± 0.041	1.305ArgMet: 1.305 ± 0.018	2.378ArgAsn: 2.378 ± 0.026	3.545ArgPro: 3.545 ± 0.039	2.693ArgGln: 2.693 ± 0.029	5.16ArgArg: 5.16 ± 0.055	5.041ArgSer: 5.041 ± 0.047	3.202ArgThr: 3.202 ± 0.031	3.271ArgVal: 3.271 ± 0.027	0.838ArgTrp: 0.838 ± 0.014	1.708ArgTyr: 1.708 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.652SerAla: 6.652 ± 0.043	0.907SerCys: 0.907 ± 0.019	4.198SerAsp: 4.198 ± 0.042	4.326SerGlu: 4.326 ± 0.037	3.055SerPhe: 3.055 ± 0.029	5.69SerGly: 5.69 ± 0.044	2.155SerHis: 2.155 ± 0.029	4.362SerIle: 4.362 ± 0.036	4.331SerLys: 4.331 ± 0.039	7.548SerLeu: 7.548 ± 0.055	1.866SerMet: 1.866 ± 0.019	3.464SerAsn: 3.464 ± 0.032	5.959SerPro: 5.959 ± 0.055	3.585SerGln: 3.585 ± 0.037	5.513SerArg: 5.513 ± 0.052	10.101SerSer: 10.101 ± 0.088	5.965SerThr: 5.965 ± 0.049	4.59SerVal: 4.59 ± 0.034	1.045SerTrp: 1.045 ± 0.019	2.124SerTyr: 2.124 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.121ThrAla: 5.121 ± 0.038	0.721ThrCys: 0.721 ± 0.015	2.813ThrAsp: 2.813 ± 0.027	3.162ThrGlu: 3.162 ± 0.034	2.092ThrPhe: 2.092 ± 0.023	4.066ThrGly: 4.066 ± 0.037	1.292ThrHis: 1.292 ± 0.017	3.094ThrIle: 3.094 ± 0.031	2.701ThrLys: 2.701 ± 0.031	5.137ThrLeu: 5.137 ± 0.039	1.158ThrMet: 1.158 ± 0.019	2.161ThrAsn: 2.161 ± 0.021	4.535ThrPro: 4.535 ± 0.047	2.081ThrGln: 2.081 ± 0.024	3.089ThrArg: 3.089 ± 0.027	5.618ThrSer: 5.618 ± 0.048	4.258ThrThr: 4.258 ± 0.043	3.557ThrVal: 3.557 ± 0.038	0.704ThrTrp: 0.704 ± 0.013	1.517ThrTyr: 1.517 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.732ValAla: 4.732 ± 0.039	0.807ValCys: 0.807 ± 0.016	3.581ValAsp: 3.581 ± 0.032	3.797ValGlu: 3.797 ± 0.032	2.288ValPhe: 2.288 ± 0.03	3.64ValGly: 3.64 ± 0.039	1.323ValHis: 1.323 ± 0.02	3.032ValIle: 3.032 ± 0.037	3.016ValLys: 3.016 ± 0.031	5.232ValLeu: 5.232 ± 0.042	1.256ValMet: 1.256 ± 0.02	2.196ValAsn: 2.196 ± 0.025	3.454ValPro: 3.454 ± 0.037	2.24ValGln: 2.24 ± 0.024	3.264ValArg: 3.264 ± 0.028	4.69ValSer: 4.69 ± 0.037	3.338ValThr: 3.338 ± 0.033	3.926ValVal: 3.926 ± 0.039	0.736ValTrp: 0.736 ± 0.017	1.677ValTyr: 1.677 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.977TrpAla: 0.977 ± 0.017	0.167TrpCys: 0.167 ± 0.006	0.811TrpAsp: 0.811 ± 0.016	0.794TrpGlu: 0.794 ± 0.014	0.466TrpPhe: 0.466 ± 0.011	0.78TrpGly: 0.78 ± 0.016	0.313TrpHis: 0.313 ± 0.01	0.702TrpIle: 0.702 ± 0.014	0.791TrpLys: 0.791 ± 0.017	1.19TrpLeu: 1.19 ± 0.017	0.336TrpMet: 0.336 ± 0.008	0.588TrpAsn: 0.588 ± 0.012	0.535TrpPro: 0.535 ± 0.012	0.486TrpGln: 0.486 ± 0.012	0.858TrpArg: 0.858 ± 0.014	0.976TrpSer: 0.976 ± 0.016	0.778TrpThr: 0.778 ± 0.014	0.749TrpVal: 0.749 ± 0.016	0.232TrpTrp: 0.232 ± 0.008	0.37TrpTyr: 0.37 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.959TyrAla: 1.959 ± 0.024	0.412TyrCys: 0.412 ± 0.01	1.607TyrAsp: 1.607 ± 0.024	1.52TyrGlu: 1.52 ± 0.021	1.187TyrPhe: 1.187 ± 0.018	1.955TyrGly: 1.955 ± 0.027	0.783TyrHis: 0.783 ± 0.016	1.524TyrIle: 1.524 ± 0.022	1.158TyrLys: 1.158 ± 0.017	2.674TyrLeu: 2.674 ± 0.027	0.6TyrMet: 0.6 ± 0.012	1.101TyrAsn: 1.101 ± 0.016	1.585TyrPro: 1.585 ± 0.022	1.142TyrGln: 1.142 ± 0.019	1.613TyrArg: 1.613 ± 0.021	2.156TyrSer: 2.156 ± 0.023	1.562TyrThr: 1.562 ± 0.019	1.52TyrVal: 1.52 ± 0.019	0.389TyrTrp: 0.389 ± 0.01	0.893TyrTyr: 0.893 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8217 proteins (4056786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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