Amino acid dipepetide frequency for Tomato leaf curl Oman virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.625AlaAla: 4.625 ± 2.011
1.85AlaCys: 1.85 ± 0.765
0.0AlaAsp: 0.0 ± 0.0
2.775AlaGlu: 2.775 ± 1.601
0.0AlaPhe: 0.0 ± 0.0
0.0AlaGly: 0.0 ± 0.0
1.85AlaHis: 1.85 ± 1.461
1.85AlaIle: 1.85 ± 1.316
3.7AlaLys: 3.7 ± 1.199
5.55AlaLeu: 5.55 ± 2.599
0.0AlaMet: 0.0 ± 0.0
1.85AlaAsn: 1.85 ± 1.419
1.85AlaPro: 1.85 ± 1.021
2.775AlaGln: 2.775 ± 1.372
4.625AlaArg: 4.625 ± 2.707
2.775AlaSer: 2.775 ± 1.344
4.625AlaThr: 4.625 ± 1.938
3.7AlaVal: 3.7 ± 1.485
0.925AlaTrp: 0.925 ± 0.71
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.85CysCys: 1.85 ± 2.141
0.0CysAsp: 0.0 ± 0.0
0.925CysGlu: 0.925 ± 0.698
0.925CysPhe: 0.925 ± 0.996
1.85CysGly: 1.85 ± 1.047
0.0CysHis: 0.0 ± 0.0
1.85CysIle: 1.85 ± 1.82
0.925CysLys: 0.925 ± 0.698
0.0CysLeu: 0.0 ± 0.0
0.925CysMet: 0.925 ± 1.07
1.85CysAsn: 1.85 ± 1.419
3.7CysPro: 3.7 ± 2.325
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
3.7CysSer: 3.7 ± 3.157
0.925CysThr: 0.925 ± 0.698
2.775CysVal: 2.775 ± 1.281
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.85AspAla: 1.85 ± 1.419
0.925AspCys: 0.925 ± 1.132
2.775AspAsp: 2.775 ± 1.01
2.775AspGlu: 2.775 ± 0.928
1.85AspPhe: 1.85 ± 0.765
1.85AspGly: 1.85 ± 1.419
1.85AspHis: 1.85 ± 1.392
3.7AspIle: 3.7 ± 2.268
1.85AspLys: 1.85 ± 1.047
6.475AspLeu: 6.475 ± 2.547
0.925AspMet: 0.925 ± 0.669
0.925AspAsn: 0.925 ± 0.698
1.85AspPro: 1.85 ± 1.163
0.0AspGln: 0.0 ± 0.0
3.7AspArg: 3.7 ± 1.386
5.55AspSer: 5.55 ± 1.81
0.0AspThr: 0.0 ± 0.0
7.401AspVal: 7.401 ± 1.896
2.775AspTrp: 2.775 ± 1.385
1.85AspTyr: 1.85 ± 1.163
0.0AspXaa: 0.0 ± 0.0
Glu
4.625GluAla: 4.625 ± 1.018
0.0GluCys: 0.0 ± 0.0
1.85GluAsp: 1.85 ± 1.021
3.7GluGlu: 3.7 ± 1.895
1.85GluPhe: 1.85 ± 1.163
3.7GluGly: 3.7 ± 0.958
0.0GluHis: 0.0 ± 0.0
1.85GluIle: 1.85 ± 1.018
3.7GluLys: 3.7 ± 2.839
2.775GluLeu: 2.775 ± 1.372
0.0GluMet: 0.0 ± 0.0
5.55GluAsn: 5.55 ± 2.277
4.625GluPro: 4.625 ± 1.018
4.625GluGln: 4.625 ± 1.408
0.925GluArg: 0.925 ± 0.996
1.85GluSer: 1.85 ± 1.461
0.925GluThr: 0.925 ± 1.132
1.85GluVal: 1.85 ± 1.021
0.925GluTrp: 0.925 ± 1.132
0.925GluTyr: 0.925 ± 0.71
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.85PheCys: 1.85 ± 0.765
2.775PheAsp: 2.775 ± 1.281
0.0PheGlu: 0.0 ± 0.0
1.85PhePhe: 1.85 ± 1.397
0.925PheGly: 0.925 ± 0.698
3.7PheHis: 3.7 ± 0.958
2.775PheIle: 2.775 ± 1.446
2.775PheLys: 2.775 ± 1.446
8.326PheLeu: 8.326 ± 2.282
0.925PheMet: 0.925 ± 0.71
2.775PheAsn: 2.775 ± 0.928
0.925PhePro: 0.925 ± 1.07
5.55PheGln: 5.55 ± 2.3
5.55PheArg: 5.55 ± 2.042
1.85PheSer: 1.85 ± 1.047
0.925PheThr: 0.925 ± 1.132
0.925PheVal: 0.925 ± 0.71
0.0PheTrp: 0.0 ± 0.0
2.775PheTyr: 2.775 ± 1.419
0.0PheXaa: 0.0 ± 0.0
Gly
1.85GlyAla: 1.85 ± 1.419
1.85GlyCys: 1.85 ± 1.27
4.625GlyAsp: 4.625 ± 1.935
0.925GlyGlu: 0.925 ± 0.996
1.85GlyPhe: 1.85 ± 1.316
2.775GlyGly: 2.775 ± 1.3
1.85GlyHis: 1.85 ± 1.163
3.7GlyIle: 3.7 ± 1.289
4.625GlyLys: 4.625 ± 2.011
0.925GlyLeu: 0.925 ± 1.132
0.925GlyMet: 0.925 ± 0.698
0.0GlyAsn: 0.0 ± 0.0
3.7GlyPro: 3.7 ± 1.529
2.775GlyGln: 2.775 ± 1.3
1.85GlyArg: 1.85 ± 1.018
3.7GlySer: 3.7 ± 1.406
2.775GlyThr: 2.775 ± 2.302
2.775GlyVal: 2.775 ± 2.331
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
3.7HisAla: 3.7 ± 1.406
2.775HisCys: 2.775 ± 2.208
3.7HisAsp: 3.7 ± 3.172
0.0HisGlu: 0.0 ± 0.0
3.7HisPhe: 3.7 ± 1.332
1.85HisGly: 1.85 ± 1.316
1.85HisHis: 1.85 ± 2.263
1.85HisIle: 1.85 ± 1.047
1.85HisLys: 1.85 ± 1.461
0.925HisLeu: 0.925 ± 0.71
0.0HisMet: 0.0 ± 0.0
2.775HisAsn: 2.775 ± 1.446
1.85HisPro: 1.85 ± 1.419
3.7HisGln: 3.7 ± 0.982
2.775HisArg: 2.775 ± 2.302
1.85HisSer: 1.85 ± 1.047
2.775HisThr: 2.775 ± 2.095
2.775HisVal: 2.775 ± 1.453
0.0HisTrp: 0.0 ± 0.0
0.925HisTyr: 0.925 ± 0.71
0.0HisXaa: 0.0 ± 0.0
Ile
0.925IleAla: 0.925 ± 1.132
0.0IleCys: 0.0 ± 0.0
3.7IleAsp: 3.7 ± 1.936
2.775IleGlu: 2.775 ± 1.446
3.7IlePhe: 3.7 ± 2.839
0.925IleGly: 0.925 ± 0.698
1.85IleHis: 1.85 ± 1.018
5.55IleIle: 5.55 ± 1.774
4.625IleLys: 4.625 ± 0.927
0.925IleLeu: 0.925 ± 0.71
0.925IleMet: 0.925 ± 0.967
6.475IleAsn: 6.475 ± 2.008
1.85IlePro: 1.85 ± 1.419
6.475IleGln: 6.475 ± 2.097
7.401IleArg: 7.401 ± 3.156
9.251IleSer: 9.251 ± 2.163
4.625IleThr: 4.625 ± 2.985
1.85IleVal: 1.85 ± 1.397
1.85IleTrp: 1.85 ± 1.991
2.775IleTyr: 2.775 ± 2.095
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 1.922
2.775LysCys: 2.775 ± 1.446
0.925LysAsp: 0.925 ± 0.71
3.7LysGlu: 3.7 ± 1.949
2.775LysPhe: 2.775 ± 0.928
1.85LysGly: 1.85 ± 1.419
2.775LysHis: 2.775 ± 1.3
3.7LysIle: 3.7 ± 2.316
0.925LysLys: 0.925 ± 0.698
1.85LysLeu: 1.85 ± 1.419
0.0LysMet: 0.0 ± 0.0
5.55LysAsn: 5.55 ± 3.324
3.7LysPro: 3.7 ± 1.204
1.85LysGln: 1.85 ± 1.174
4.625LysArg: 4.625 ± 2.909
4.625LysSer: 4.625 ± 1.935
1.85LysThr: 1.85 ± 1.047
5.55LysVal: 5.55 ± 1.809
0.0LysTrp: 0.0 ± 0.0
4.625LysTyr: 4.625 ± 1.926
0.0LysXaa: 0.0 ± 0.0
Leu
0.925LeuAla: 0.925 ± 1.07
2.775LeuCys: 2.775 ± 1.346
5.55LeuAsp: 5.55 ± 2.116
4.625LeuGlu: 4.625 ± 1.59
1.85LeuPhe: 1.85 ± 1.419
4.625LeuGly: 4.625 ± 1.926
1.85LeuHis: 1.85 ± 1.047
4.625LeuIle: 4.625 ± 2.378
5.55LeuLys: 5.55 ± 2.327
3.7LeuLeu: 3.7 ± 1.826
1.85LeuMet: 1.85 ± 1.538
3.7LeuAsn: 3.7 ± 1.205
1.85LeuPro: 1.85 ± 1.047
1.85LeuGln: 1.85 ± 1.163
3.7LeuArg: 3.7 ± 2.197
2.775LeuSer: 2.775 ± 2.129
2.775LeuThr: 2.775 ± 1.545
1.85LeuVal: 1.85 ± 1.397
0.0LeuTrp: 0.0 ± 0.0
3.7LeuTyr: 3.7 ± 1.767
0.0LeuXaa: 0.0 ± 0.0
Met
0.925MetAla: 0.925 ± 0.698
0.0MetCys: 0.0 ± 0.0
3.7MetAsp: 3.7 ± 1.75
0.925MetGlu: 0.925 ± 1.132
2.775MetPhe: 2.775 ± 1.709
2.775MetGly: 2.775 ± 1.545
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.85MetLys: 1.85 ± 1.397
1.85MetLeu: 1.85 ± 1.163
0.925MetMet: 0.925 ± 1.132
0.0MetAsn: 0.0 ± 0.0
0.925MetPro: 0.925 ± 0.71
1.85MetGln: 1.85 ± 1.82
0.925MetArg: 0.925 ± 0.698
4.625MetSer: 4.625 ± 2.039
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.85MetTrp: 1.85 ± 1.163
1.85MetTyr: 1.85 ± 1.397
0.0MetXaa: 0.0 ± 0.0
Asn
2.775AsnAla: 2.775 ± 1.3
1.85AsnCys: 1.85 ± 1.047
1.85AsnAsp: 1.85 ± 0.765
2.775AsnGlu: 2.775 ± 1.344
2.775AsnPhe: 2.775 ± 0.928
1.85AsnGly: 1.85 ± 1.018
6.475AsnHis: 6.475 ± 2.577
4.625AsnIle: 4.625 ± 1.342
0.925AsnLys: 0.925 ± 0.698
2.775AsnLeu: 2.775 ± 1.385
1.85AsnMet: 1.85 ± 1.267
1.85AsnAsn: 1.85 ± 1.018
4.625AsnPro: 4.625 ± 1.778
2.775AsnGln: 2.775 ± 1.3
0.925AsnArg: 0.925 ± 1.132
4.625AsnSer: 4.625 ± 1.609
3.7AsnThr: 3.7 ± 1.624
4.625AsnVal: 4.625 ± 2.167
0.925AsnTrp: 0.925 ± 0.71
0.925AsnTyr: 0.925 ± 0.71
0.0AsnXaa: 0.0 ± 0.0
Pro
1.85ProAla: 1.85 ± 1.021
1.85ProCys: 1.85 ± 1.174
1.85ProAsp: 1.85 ± 1.226
2.775ProGlu: 2.775 ± 1.117
1.85ProPhe: 1.85 ± 1.018
1.85ProGly: 1.85 ± 0.765
3.7ProHis: 3.7 ± 2.187
4.625ProIle: 4.625 ± 1.018
5.55ProLys: 5.55 ± 3.203
2.775ProLeu: 2.775 ± 1.372
3.7ProMet: 3.7 ± 2.596
5.55ProAsn: 5.55 ± 1.764
1.85ProPro: 1.85 ± 1.021
0.925ProGln: 0.925 ± 0.996
6.475ProArg: 6.475 ± 1.652
6.475ProSer: 6.475 ± 3.216
3.7ProThr: 3.7 ± 1.895
2.775ProVal: 2.775 ± 1.709
0.925ProTrp: 0.925 ± 0.71
2.775ProTyr: 2.775 ± 1.281
0.0ProXaa: 0.0 ± 0.0
Gln
4.625GlnAla: 4.625 ± 3.281
0.0GlnCys: 0.0 ± 0.0
1.85GlnAsp: 1.85 ± 1.047
2.775GlnGlu: 2.775 ± 1.01
2.775GlnPhe: 2.775 ± 2.129
1.85GlnGly: 1.85 ± 0.765
0.925GlnHis: 0.925 ± 1.132
2.775GlnIle: 2.775 ± 1.446
0.0GlnLys: 0.0 ± 0.0
1.85GlnLeu: 1.85 ± 1.82
1.85GlnMet: 1.85 ± 1.047
4.625GlnAsn: 4.625 ± 2.082
3.7GlnPro: 3.7 ± 2.631
3.7GlnGln: 3.7 ± 2.234
2.775GlnArg: 2.775 ± 0.926
4.625GlnSer: 4.625 ± 1.311
3.7GlnThr: 3.7 ± 1.586
5.55GlnVal: 5.55 ± 1.797
0.0GlnTrp: 0.0 ± 0.0
1.85GlnTyr: 1.85 ± 1.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.775ArgAla: 2.775 ± 1.453
1.85ArgCys: 1.85 ± 1.174
5.55ArgAsp: 5.55 ± 2.475
3.7ArgGlu: 3.7 ± 1.571
5.55ArgPhe: 5.55 ± 2.639
3.7ArgGly: 3.7 ± 1.386
2.775ArgHis: 2.775 ± 1.117
7.401ArgIle: 7.401 ± 2.009
4.625ArgLys: 4.625 ± 2.502
1.85ArgLeu: 1.85 ± 1.174
0.925ArgMet: 0.925 ± 0.698
0.925ArgAsn: 0.925 ± 0.71
7.401ArgPro: 7.401 ± 1.936
1.85ArgGln: 1.85 ± 1.558
7.401ArgArg: 7.401 ± 3.483
4.625ArgSer: 4.625 ± 1.266
2.775ArgThr: 2.775 ± 1.293
2.775ArgVal: 2.775 ± 0.928
0.0ArgTrp: 0.0 ± 0.0
1.85ArgTyr: 1.85 ± 1.461
0.0ArgXaa: 0.0 ± 0.0
Ser
3.7SerAla: 3.7 ± 2.839
0.0SerCys: 0.0 ± 0.0
4.625SerAsp: 4.625 ± 1.935
2.775SerGlu: 2.775 ± 1.346
3.7SerPhe: 3.7 ± 1.571
1.85SerGly: 1.85 ± 1.397
3.7SerHis: 3.7 ± 2.097
7.401SerIle: 7.401 ± 1.572
3.7SerLys: 3.7 ± 1.826
4.625SerLeu: 4.625 ± 1.817
1.85SerMet: 1.85 ± 2.264
3.7SerAsn: 3.7 ± 1.386
10.176SerPro: 10.176 ± 3.566
4.625SerGln: 4.625 ± 4.271
6.475SerArg: 6.475 ± 1.901
16.651SerSer: 16.651 ± 5.719
6.475SerThr: 6.475 ± 3.447
1.85SerVal: 1.85 ± 2.141
0.925SerTrp: 0.925 ± 0.698
3.7SerTyr: 3.7 ± 1.199
0.0SerXaa: 0.0 ± 0.0
Thr
3.7ThrAla: 3.7 ± 0.982
0.0ThrCys: 0.0 ± 0.0
0.925ThrAsp: 0.925 ± 0.71
1.85ThrGlu: 1.85 ± 1.106
0.925ThrPhe: 0.925 ± 0.71
5.55ThrGly: 5.55 ± 2.026
4.625ThrHis: 4.625 ± 2.182
1.85ThrIle: 1.85 ± 1.018
2.775ThrLys: 2.775 ± 1.385
3.7ThrLeu: 3.7 ± 1.586
1.85ThrMet: 1.85 ± 0.765
2.775ThrAsn: 2.775 ± 1.559
4.625ThrPro: 4.625 ± 3.015
0.925ThrGln: 0.925 ± 1.132
0.925ThrArg: 0.925 ± 0.698
4.625ThrSer: 4.625 ± 3.557
0.925ThrThr: 0.925 ± 0.996
3.7ThrVal: 3.7 ± 1.826
0.0ThrTrp: 0.0 ± 0.0
3.7ThrTyr: 3.7 ± 1.406
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
1.85ValAsp: 1.85 ± 1.018
1.85ValGlu: 1.85 ± 2.141
3.7ValPhe: 3.7 ± 2.097
0.925ValGly: 0.925 ± 0.698
0.925ValHis: 0.925 ± 1.07
5.55ValIle: 5.55 ± 2.042
5.55ValLys: 5.55 ± 2.481
3.7ValLeu: 3.7 ± 3.983
3.7ValMet: 3.7 ± 1.406
1.85ValAsn: 1.85 ± 1.021
4.625ValPro: 4.625 ± 1.25
2.775ValGln: 2.775 ± 1.608
3.7ValArg: 3.7 ± 2.281
5.55ValSer: 5.55 ± 1.281
4.625ValThr: 4.625 ± 1.379
0.0ValVal: 0.0 ± 0.0
1.85ValTrp: 1.85 ± 0.765
1.85ValTyr: 1.85 ± 0.765
0.0ValXaa: 0.0 ± 0.0
Trp
1.85TrpAla: 1.85 ± 1.419
0.0TrpCys: 0.0 ± 0.0
0.925TrpAsp: 0.925 ± 1.07
0.925TrpGlu: 0.925 ± 0.996
0.0TrpPhe: 0.0 ± 0.0
0.925TrpGly: 0.925 ± 0.71
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.925TrpMet: 0.925 ± 0.698
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.925TrpGln: 0.925 ± 0.71
1.85TrpArg: 1.85 ± 1.047
0.925TrpSer: 0.925 ± 1.132
1.85TrpThr: 1.85 ± 1.106
0.925TrpVal: 0.925 ± 0.71
0.0TrpTrp: 0.0 ± 0.0
0.925TrpTyr: 0.925 ± 0.71
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.925TyrAla: 0.925 ± 0.698
0.0TyrCys: 0.0 ± 0.0
1.85TyrAsp: 1.85 ± 1.106
3.7TyrGlu: 3.7 ± 1.406
2.775TyrPhe: 2.775 ± 1.559
1.85TyrGly: 1.85 ± 0.765
0.925TyrHis: 0.925 ± 0.71
2.775TyrIle: 2.775 ± 2.129
1.85TyrLys: 1.85 ± 1.018
5.55TyrLeu: 5.55 ± 1.608
2.775TyrMet: 2.775 ± 1.437
2.775TyrAsn: 2.775 ± 1.085
0.925TyrPro: 0.925 ± 0.71
1.85TyrGln: 1.85 ± 1.392
3.7TyrArg: 3.7 ± 2.794
1.85TyrSer: 1.85 ± 0.765
0.0TyrThr: 0.0 ± 0.0
0.925TyrVal: 0.925 ± 1.07
0.0TyrTrp: 0.0 ± 0.0
0.925TyrTyr: 0.925 ± 1.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski