Amino acid dipepetide frequency for Halovenus sp. WSH3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.063AlaAla: 12.063 ± 0.166	0.68AlaCys: 0.68 ± 0.029	8.501AlaAsp: 8.501 ± 0.118	9.54AlaGlu: 9.54 ± 0.135	3.367AlaPhe: 3.367 ± 0.068	9.185AlaGly: 9.185 ± 0.117	1.694AlaHis: 1.694 ± 0.046	4.476AlaIle: 4.476 ± 0.07	1.694AlaLys: 1.694 ± 0.048	9.516AlaLeu: 9.516 ± 0.112	1.895AlaMet: 1.895 ± 0.044	2.309AlaAsn: 2.309 ± 0.053	3.531AlaPro: 3.531 ± 0.064	2.355AlaGln: 2.355 ± 0.055	5.822AlaArg: 5.822 ± 0.084	5.016AlaSer: 5.016 ± 0.069	6.272AlaThr: 6.272 ± 0.106	10.408AlaVal: 10.408 ± 0.132	0.888AlaTrp: 0.888 ± 0.03	2.568AlaTyr: 2.568 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.641CysAla: 0.641 ± 0.03	0.095CysCys: 0.095 ± 0.011	0.52CysAsp: 0.52 ± 0.024	0.63CysGlu: 0.63 ± 0.026	0.213CysPhe: 0.213 ± 0.014	0.867CysGly: 0.867 ± 0.035	0.18CysHis: 0.18 ± 0.015	0.258CysIle: 0.258 ± 0.016	0.12CysLys: 0.12 ± 0.012	0.589CysLeu: 0.589 ± 0.025	0.102CysMet: 0.102 ± 0.011	0.179CysAsn: 0.179 ± 0.014	0.571CysPro: 0.571 ± 0.029	0.198CysGln: 0.198 ± 0.015	0.54CysArg: 0.54 ± 0.026	0.457CysSer: 0.457 ± 0.026	0.428CysThr: 0.428 ± 0.019	0.43CysVal: 0.43 ± 0.022	0.106CysTrp: 0.106 ± 0.011	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.052AspAla: 8.052 ± 0.094	0.727AspCys: 0.727 ± 0.031	6.941AspAsp: 6.941 ± 0.116	7.958AspGlu: 7.958 ± 0.118	1.775AspPhe: 1.775 ± 0.04	8.133AspGly: 8.133 ± 0.133	1.84AspHis: 1.84 ± 0.053	3.783AspIle: 3.783 ± 0.066	1.058AspLys: 1.058 ± 0.034	7.016AspLeu: 7.016 ± 0.098	1.168AspMet: 1.168 ± 0.036	1.485AspAsn: 1.485 ± 0.046	4.849AspPro: 4.849 ± 0.071	2.189AspGln: 2.189 ± 0.051	6.584AspArg: 6.584 ± 0.092	4.535AspSer: 4.535 ± 0.079	4.072AspThr: 4.072 ± 0.074	6.243AspVal: 6.243 ± 0.082	0.969AspTrp: 0.969 ± 0.032	1.473AspTyr: 1.473 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.678GluAla: 8.678 ± 0.122	0.587GluCys: 0.587 ± 0.028	5.917GluAsp: 5.917 ± 0.094	8.694GluGlu: 8.694 ± 0.129	3.389GluPhe: 3.389 ± 0.072	5.752GluGly: 5.752 ± 0.085	2.152GluHis: 2.152 ± 0.054	5.093GluIle: 5.093 ± 0.073	1.936GluLys: 1.936 ± 0.053	8.258GluLeu: 8.258 ± 0.116	2.19GluMet: 2.19 ± 0.049	2.533GluAsn: 2.533 ± 0.057	4.237GluPro: 4.237 ± 0.08	4.373GluGln: 4.373 ± 0.086	7.804GluArg: 7.804 ± 0.119	5.5GluSer: 5.5 ± 0.087	7.371GluThr: 7.371 ± 0.107	5.721GluVal: 5.721 ± 0.091	1.185GluTrp: 1.185 ± 0.036	3.331GluTyr: 3.331 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.376PheAla: 3.376 ± 0.065	0.309PheCys: 0.309 ± 0.015	3.031PheAsp: 3.031 ± 0.057	3.613PheGlu: 3.613 ± 0.067	0.986PhePhe: 0.986 ± 0.037	3.303PheGly: 3.303 ± 0.076	0.553PheHis: 0.553 ± 0.024	1.124PheIle: 1.124 ± 0.042	0.457PheLys: 0.457 ± 0.021	2.664PheLeu: 2.664 ± 0.064	0.473PheMet: 0.473 ± 0.024	0.706PheAsn: 0.706 ± 0.026	1.302PhePro: 1.302 ± 0.041	0.843PheGln: 0.843 ± 0.032	1.774PheArg: 1.774 ± 0.043	1.667PheSer: 1.667 ± 0.038	1.77PheThr: 1.77 ± 0.047	3.118PheVal: 3.118 ± 0.055	0.394PheTrp: 0.394 ± 0.021	0.853PheTyr: 0.853 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.797GlyAla: 7.797 ± 0.111	0.707GlyCys: 0.707 ± 0.029	6.137GlyAsp: 6.137 ± 0.082	7.88GlyGlu: 7.88 ± 0.105	3.115GlyPhe: 3.115 ± 0.062	7.324GlyGly: 7.324 ± 0.12	1.615GlyHis: 1.615 ± 0.047	4.458GlyIle: 4.458 ± 0.075	1.859GlyLys: 1.859 ± 0.042	7.518GlyLeu: 7.518 ± 0.114	1.65GlyMet: 1.65 ± 0.047	2.01GlyAsn: 2.01 ± 0.055	3.447GlyPro: 3.447 ± 0.068	2.402GlyGln: 2.402 ± 0.058	4.842GlyArg: 4.842 ± 0.079	5.108GlySer: 5.108 ± 0.088	6.048GlyThr: 6.048 ± 0.093	7.218GlyVal: 7.218 ± 0.105	1.098GlyTrp: 1.098 ± 0.032	2.686GlyTyr: 2.686 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.819HisAla: 1.819 ± 0.045	0.214HisCys: 0.214 ± 0.015	1.695HisAsp: 1.695 ± 0.049	1.74HisGlu: 1.74 ± 0.05	0.479HisPhe: 0.479 ± 0.026	1.882HisGly: 1.882 ± 0.044	0.469HisHis: 0.469 ± 0.023	0.778HisIle: 0.778 ± 0.028	0.278HisLys: 0.278 ± 0.018	1.671HisLeu: 1.671 ± 0.041	0.308HisMet: 0.308 ± 0.019	0.467HisAsn: 0.467 ± 0.024	1.212HisPro: 1.212 ± 0.031	0.481HisGln: 0.481 ± 0.024	1.199HisArg: 1.199 ± 0.04	0.948HisSer: 0.948 ± 0.032	1.105HisThr: 1.105 ± 0.032	1.562HisVal: 1.562 ± 0.039	0.233HisTrp: 0.233 ± 0.017	0.506HisTyr: 0.506 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.923IleAla: 4.923 ± 0.084	0.303IleCys: 0.303 ± 0.018	4.633IleAsp: 4.633 ± 0.078	5.324IleGlu: 5.324 ± 0.081	1.121IlePhe: 1.121 ± 0.041	3.876IleGly: 3.876 ± 0.073	0.879IleHis: 0.879 ± 0.031	1.716IleIle: 1.716 ± 0.045	0.817IleLys: 0.817 ± 0.03	3.116IleLeu: 3.116 ± 0.07	0.519IleMet: 0.519 ± 0.023	1.178IleAsn: 1.178 ± 0.037	2.074IlePro: 2.074 ± 0.048	1.346IleGln: 1.346 ± 0.036	2.844IleArg: 2.844 ± 0.058	2.479IleSer: 2.479 ± 0.052	2.909IleThr: 2.909 ± 0.06	3.79IleVal: 3.79 ± 0.069	0.374IleTrp: 0.374 ± 0.021	1.05IleTyr: 1.05 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.607LysAla: 1.607 ± 0.047	0.129LysCys: 0.129 ± 0.013	0.984LysAsp: 0.984 ± 0.031	1.385LysGlu: 1.385 ± 0.045	0.521LysPhe: 0.521 ± 0.023	1.236LysGly: 1.236 ± 0.038	0.455LysHis: 0.455 ± 0.02	0.953LysIle: 0.953 ± 0.033	0.526LysLys: 0.526 ± 0.029	1.703LysLeu: 1.703 ± 0.048	0.353LysMet: 0.353 ± 0.018	0.56LysAsn: 0.56 ± 0.026	0.899LysPro: 0.899 ± 0.035	0.893LysGln: 0.893 ± 0.038	1.594LysArg: 1.594 ± 0.045	1.11LysSer: 1.11 ± 0.038	1.244LysThr: 1.244 ± 0.043	1.097LysVal: 1.097 ± 0.035	0.229LysTrp: 0.229 ± 0.016	0.603LysTyr: 0.603 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.245LeuAla: 10.245 ± 0.117	0.628LeuCys: 0.628 ± 0.026	8.125LeuAsp: 8.125 ± 0.118	6.707LeuGlu: 6.707 ± 0.104	3.251LeuPhe: 3.251 ± 0.064	7.717LeuGly: 7.717 ± 0.112	1.36LeuHis: 1.36 ± 0.037	3.325LeuIle: 3.325 ± 0.073	1.476LeuLys: 1.476 ± 0.042	8.401LeuLeu: 8.401 ± 0.134	1.3LeuMet: 1.3 ± 0.043	1.84LeuAsn: 1.84 ± 0.049	4.098LeuPro: 4.098 ± 0.077	2.226LeuGln: 2.226 ± 0.058	5.661LeuArg: 5.661 ± 0.08	6.153LeuSer: 6.153 ± 0.093	5.557LeuThr: 5.557 ± 0.078	7.764LeuVal: 7.764 ± 0.129	0.828LeuTrp: 0.828 ± 0.036	2.259LeuTyr: 2.259 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.613MetAla: 1.613 ± 0.043	0.134MetCys: 0.134 ± 0.011	1.237MetAsp: 1.237 ± 0.039	1.295MetGlu: 1.295 ± 0.038	0.48MetPhe: 0.48 ± 0.025	1.368MetGly: 1.368 ± 0.048	0.344MetHis: 0.344 ± 0.019	0.774MetIle: 0.774 ± 0.032	0.391MetLys: 0.391 ± 0.021	1.463MetLeu: 1.463 ± 0.049	0.303MetMet: 0.303 ± 0.017	0.586MetAsn: 0.586 ± 0.023	0.807MetPro: 0.807 ± 0.029	0.511MetGln: 0.511 ± 0.024	1.126MetArg: 1.126 ± 0.033	1.553MetSer: 1.553 ± 0.038	1.498MetThr: 1.498 ± 0.037	1.202MetVal: 1.202 ± 0.033	0.158MetTrp: 0.158 ± 0.013	0.38MetTyr: 0.38 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.354AsnAla: 2.354 ± 0.049	0.233AsnCys: 0.233 ± 0.015	1.649AsnAsp: 1.649 ± 0.047	1.921AsnGlu: 1.921 ± 0.046	0.689AsnPhe: 0.689 ± 0.027	2.004AsnGly: 2.004 ± 0.059	0.463AsnHis: 0.463 ± 0.02	1.102AsnIle: 1.102 ± 0.039	0.511AsnLys: 0.511 ± 0.023	2.002AsnLeu: 2.002 ± 0.049	0.462AsnMet: 0.462 ± 0.023	0.596AsnAsn: 0.596 ± 0.026	1.528AsnPro: 1.528 ± 0.04	0.736AsnGln: 0.736 ± 0.03	1.741AsnArg: 1.741 ± 0.043	1.224AsnSer: 1.224 ± 0.041	1.371AsnThr: 1.371 ± 0.037	2.17AsnVal: 2.17 ± 0.05	0.306AsnTrp: 0.306 ± 0.017	0.636AsnTyr: 0.636 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.434ProAla: 4.434 ± 0.073	0.246ProCys: 0.246 ± 0.014	4.798ProAsp: 4.798 ± 0.081	5.426ProGlu: 5.426 ± 0.083	1.557ProPhe: 1.557 ± 0.043	3.945ProGly: 3.945 ± 0.071	0.788ProHis: 0.788 ± 0.03	1.907ProIle: 1.907 ± 0.047	0.82ProLys: 0.82 ± 0.032	3.511ProLeu: 3.511 ± 0.059	0.785ProMet: 0.785 ± 0.028	1.096ProAsn: 1.096 ± 0.033	2.226ProPro: 2.226 ± 0.054	1.189ProGln: 1.189 ± 0.038	2.194ProArg: 2.194 ± 0.048	2.541ProSer: 2.541 ± 0.061	3.135ProThr: 3.135 ± 0.056	4.134ProVal: 4.134 ± 0.065	0.442ProTrp: 0.442 ± 0.021	1.14ProTyr: 1.14 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.911GlnAla: 2.911 ± 0.06	0.207GlnCys: 0.207 ± 0.014	1.478GlnAsp: 1.478 ± 0.043	2.194GlnGlu: 2.194 ± 0.056	1.31GlnPhe: 1.31 ± 0.039	1.796GlnGly: 1.796 ± 0.045	0.623GlnHis: 0.623 ± 0.024	1.619GlnIle: 1.619 ± 0.042	0.701GlnLys: 0.701 ± 0.033	2.864GlnLeu: 2.864 ± 0.056	0.615GlnMet: 0.615 ± 0.026	0.749GlnAsn: 0.749 ± 0.032	1.398GlnPro: 1.398 ± 0.041	1.362GlnGln: 1.362 ± 0.051	2.549GlnArg: 2.549 ± 0.055	1.955GlnSer: 1.955 ± 0.047	2.202GlnThr: 2.202 ± 0.05	1.946GlnVal: 1.946 ± 0.042	0.34GlnTrp: 0.34 ± 0.02	0.948GlnTyr: 0.948 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.309ArgAla: 6.309 ± 0.091	0.433ArgCys: 0.433 ± 0.022	4.604ArgAsp: 4.604 ± 0.074	7.28ArgGlu: 7.28 ± 0.099	2.203ArgPhe: 2.203 ± 0.052	4.424ArgGly: 4.424 ± 0.066	1.153ArgHis: 1.153 ± 0.038	3.397ArgIle: 3.397 ± 0.056	1.442ArgLys: 1.442 ± 0.042	6.408ArgLeu: 6.408 ± 0.101	1.234ArgMet: 1.234 ± 0.035	1.616ArgAsn: 1.616 ± 0.044	2.712ArgPro: 2.712 ± 0.058	2.328ArgGln: 2.328 ± 0.049	4.952ArgArg: 4.952 ± 0.092	3.721ArgSer: 3.721 ± 0.069	3.898ArgThr: 3.898 ± 0.069	4.843ArgVal: 4.843 ± 0.07	0.737ArgTrp: 0.737 ± 0.031	1.918ArgTyr: 1.918 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.433SerAla: 5.433 ± 0.09	0.332SerCys: 0.332 ± 0.02	4.45SerAsp: 4.45 ± 0.078	5.362SerGlu: 5.362 ± 0.087	1.896SerPhe: 1.896 ± 0.047	5.653SerGly: 5.653 ± 0.09	1.015SerHis: 1.015 ± 0.032	2.431SerIle: 2.431 ± 0.051	1.138SerLys: 1.138 ± 0.036	4.958SerLeu: 4.958 ± 0.079	1.115SerMet: 1.115 ± 0.036	1.378SerAsn: 1.378 ± 0.044	2.6SerPro: 2.6 ± 0.055	1.619SerGln: 1.619 ± 0.043	3.301SerArg: 3.301 ± 0.06	2.952SerSer: 2.952 ± 0.069	3.544SerThr: 3.544 ± 0.083	5.214SerVal: 5.214 ± 0.081	0.578SerTrp: 0.578 ± 0.025	1.6SerTyr: 1.6 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.308ThrAla: 7.308 ± 0.121	0.364ThrCys: 0.364 ± 0.021	5.707ThrAsp: 5.707 ± 0.093	5.775ThrGlu: 5.775 ± 0.083	1.908ThrPhe: 1.908 ± 0.048	5.966ThrGly: 5.966 ± 0.09	1.184ThrHis: 1.184 ± 0.033	3.048ThrIle: 3.048 ± 0.071	0.961ThrLys: 0.961 ± 0.029	5.605ThrLeu: 5.605 ± 0.09	0.984ThrMet: 0.984 ± 0.036	1.483ThrAsn: 1.483 ± 0.044	3.168ThrPro: 3.168 ± 0.057	1.596ThrGln: 1.596 ± 0.048	3.281ThrArg: 3.281 ± 0.061	2.766ThrSer: 2.766 ± 0.055	4.196ThrThr: 4.196 ± 0.082	7.366ThrVal: 7.366 ± 0.122	0.52ThrTrp: 0.52 ± 0.024	1.628ThrTyr: 1.628 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.777ValAla: 8.777 ± 0.14	0.666ValCys: 0.666 ± 0.027	7.096ValAsp: 7.096 ± 0.096	8.238ValGlu: 8.238 ± 0.125	2.761ValPhe: 2.761 ± 0.061	7.5ValGly: 7.5 ± 0.131	1.445ValHis: 1.445 ± 0.038	3.563ValIle: 3.563 ± 0.069	1.201ValLys: 1.201 ± 0.033	7.786ValLeu: 7.786 ± 0.114	1.176ValMet: 1.176 ± 0.041	1.904ValAsn: 1.904 ± 0.044	4.033ValPro: 4.033 ± 0.078	1.915ValGln: 1.915 ± 0.044	5.105ValArg: 5.105 ± 0.076	5.115ValSer: 5.115 ± 0.079	5.935ValThr: 5.935 ± 0.093	8.083ValVal: 8.083 ± 0.116	0.735ValTrp: 0.735 ± 0.029	2.088ValTyr: 2.088 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.895TrpAla: 0.895 ± 0.033	0.089TrpCys: 0.089 ± 0.011	0.73TrpAsp: 0.73 ± 0.028	0.963TrpGlu: 0.963 ± 0.035	0.39TrpPhe: 0.39 ± 0.021	0.721TrpGly: 0.721 ± 0.034	0.207TrpHis: 0.207 ± 0.015	0.535TrpIle: 0.535 ± 0.026	0.251TrpLys: 0.251 ± 0.016	1.236TrpLeu: 1.236 ± 0.043	0.206TrpMet: 0.206 ± 0.015	0.299TrpAsn: 0.299 ± 0.017	0.389TrpPro: 0.389 ± 0.021	0.407TrpGln: 0.407 ± 0.02	0.759TrpArg: 0.759 ± 0.03	0.52TrpSer: 0.52 ± 0.022	0.704TrpThr: 0.704 ± 0.028	0.768TrpVal: 0.768 ± 0.03	0.152TrpTrp: 0.152 ± 0.013	0.376TrpTyr: 0.376 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.541TyrAla: 2.541 ± 0.055	0.255TyrCys: 0.255 ± 0.016	2.618TyrAsp: 2.618 ± 0.05	2.774TyrGlu: 2.774 ± 0.061	0.907TyrPhe: 0.907 ± 0.03	2.265TyrGly: 2.265 ± 0.051	0.627TyrHis: 0.627 ± 0.025	0.931TyrIle: 0.931 ± 0.032	0.445TyrLys: 0.445 ± 0.021	2.639TyrLeu: 2.639 ± 0.054	0.384TyrMet: 0.384 ± 0.02	0.724TyrAsn: 0.724 ± 0.025	1.233TyrPro: 1.233 ± 0.04	0.799TyrGln: 0.799 ± 0.029	1.942TyrArg: 1.942 ± 0.051	1.25TyrSer: 1.25 ± 0.037	1.553TyrThr: 1.553 ± 0.043	2.047TyrVal: 2.047 ± 0.049	0.325TyrTrp: 0.325 ± 0.016	0.808TyrTyr: 0.808 ± 0.03	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3185 proteins (956425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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