Human papillomavirus 98

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 1

Average proteome isoelectric point is 5.86

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|C4PUC2|C4PUC2_9PAPI Replication protein E1 OS=Human papillomavirus 98 OX=587347 GN=E1 PE=3 SV=1
MM1 pKa = 7.37IGKK4 pKa = 8.93EE5 pKa = 3.9VTLQDD10 pKa = 3.06IVLEE14 pKa = 4.16LTEE17 pKa = 4.31PQPVDD22 pKa = 3.09LHH24 pKa = 8.1CEE26 pKa = 4.07EE27 pKa = 5.16EE28 pKa = 4.64LPEE31 pKa = 4.02QDD33 pKa = 3.61TEE35 pKa = 4.41VEE37 pKa = 4.27PEE39 pKa = 3.79RR40 pKa = 11.84TSYY43 pKa = 10.93KK44 pKa = 10.27IILRR48 pKa = 11.84CGGGCGTRR56 pKa = 11.84LRR58 pKa = 11.84IFVAATHH65 pKa = 5.86SGIRR69 pKa = 11.84SLQEE73 pKa = 3.54LLLEE77 pKa = 4.36EE78 pKa = 4.72VVLLCPDD85 pKa = 3.77CRR87 pKa = 11.84NSDD90 pKa = 3.36QHH92 pKa = 7.4GGQQ95 pKa = 3.3

Molecular weight: 10.6 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|C4PUC4|C4PUC4_9PAPI E4 protein OS=Human papillomavirus 98 OX=587347 GN=E4 PE=4 SV=1
MM1 pKa = 7.06EE2 pKa = 4.8TLTKK6 pKa = 10.53RR7 pKa = 11.84FDD9 pKa = 3.62ALQDD13 pKa = 3.78LLMTIYY19 pKa = 10.29EE20 pKa = 4.24QGSDD24 pKa = 3.46TIEE27 pKa = 3.84AQIEE31 pKa = 3.89HH32 pKa = 5.96WQALRR37 pKa = 11.84RR38 pKa = 11.84EE39 pKa = 4.31AVLLYY44 pKa = 9.22YY45 pKa = 10.62ARR47 pKa = 11.84QNGVLRR53 pKa = 11.84LGYY56 pKa = 10.31QPVPPLATSEE66 pKa = 4.35AKK68 pKa = 10.45AKK70 pKa = 9.88EE71 pKa = 4.4AIRR74 pKa = 11.84MVLQLQSLQQSVYY87 pKa = 10.75GKK89 pKa = 9.91EE90 pKa = 3.37KK91 pKa = 8.17WTLVDD96 pKa = 3.94TSIEE100 pKa = 4.37TYY102 pKa = 10.79KK103 pKa = 10.73NAPEE107 pKa = 3.83NHH109 pKa = 6.12FKK111 pKa = 10.75KK112 pKa = 10.75GPVNVEE118 pKa = 3.83VIYY121 pKa = 11.2DD122 pKa = 4.14GDD124 pKa = 4.07PDD126 pKa = 3.81NANLYY131 pKa = 8.07TMWKK135 pKa = 7.96YY136 pKa = 11.01VYY138 pKa = 11.27YY139 pKa = 10.14MDD141 pKa = 6.82DD142 pKa = 3.64DD143 pKa = 4.38EE144 pKa = 4.51QWQKK148 pKa = 11.71AEE150 pKa = 4.14SGANHH155 pKa = 6.56TGLYY159 pKa = 7.9YY160 pKa = 10.54TIGDD164 pKa = 4.04FKK166 pKa = 10.94HH167 pKa = 6.46YY168 pKa = 10.4YY169 pKa = 9.88VVFADD174 pKa = 3.65DD175 pKa = 3.46ASRR178 pKa = 11.84YY179 pKa = 8.91SKK181 pKa = 10.51SGQWEE186 pKa = 3.75VRR188 pKa = 11.84INKK191 pKa = 9.24EE192 pKa = 3.66IVFAPVTSSTPPEE205 pKa = 4.23SPGGSRR211 pKa = 11.84QEE213 pKa = 4.26PEE215 pKa = 3.92STATTTTDD223 pKa = 2.9SKK225 pKa = 9.98TSRR228 pKa = 11.84SAQRR232 pKa = 11.84SQQAPCDD239 pKa = 3.23KK240 pKa = 8.77TTRR243 pKa = 11.84QRR245 pKa = 11.84RR246 pKa = 11.84YY247 pKa = 9.16GRR249 pKa = 11.84RR250 pKa = 11.84SSSPTGSRR258 pKa = 11.84RR259 pKa = 11.84RR260 pKa = 11.84RR261 pKa = 11.84RR262 pKa = 11.84SASRR266 pKa = 11.84QTKK269 pKa = 8.1QGRR272 pKa = 11.84RR273 pKa = 11.84SQTRR277 pKa = 11.84SRR279 pKa = 11.84SRR281 pKa = 11.84SPVSIQTRR289 pKa = 11.84SRR291 pKa = 11.84SRR293 pKa = 11.84STSRR297 pKa = 11.84RR298 pKa = 11.84SRR300 pKa = 11.84STSRR304 pKa = 11.84GRR306 pKa = 11.84RR307 pKa = 11.84RR308 pKa = 11.84SGEE311 pKa = 3.6RR312 pKa = 11.84TPRR315 pKa = 11.84GRR317 pKa = 11.84RR318 pKa = 11.84RR319 pKa = 11.84VSATSRR325 pKa = 11.84GRR327 pKa = 11.84GGAGRR332 pKa = 11.84RR333 pKa = 11.84ASSSSSPSPRR343 pKa = 11.84TKK345 pKa = 9.85TSQRR349 pKa = 11.84GSDD352 pKa = 3.25TRR354 pKa = 11.84SVRR357 pKa = 11.84DD358 pKa = 3.66GGVSPGDD365 pKa = 3.29VGRR368 pKa = 11.84NLQTVSGRR376 pKa = 11.84HH377 pKa = 4.35TGRR380 pKa = 11.84LGRR383 pKa = 11.84LLEE386 pKa = 4.17EE387 pKa = 4.57ARR389 pKa = 11.84DD390 pKa = 3.73PPVILIRR397 pKa = 11.84GDD399 pKa = 3.55ANTVRR404 pKa = 11.84CFRR407 pKa = 11.84NRR409 pKa = 11.84AKK411 pKa = 10.3RR412 pKa = 11.84RR413 pKa = 11.84YY414 pKa = 8.39KK415 pKa = 10.27GQYY418 pKa = 8.98KK419 pKa = 10.38AFSTSFSWVAADD431 pKa = 3.35GTEE434 pKa = 3.74RR435 pKa = 11.84LGRR438 pKa = 11.84SRR440 pKa = 11.84LLVSFTSHH448 pKa = 5.9KK449 pKa = 9.98QRR451 pKa = 11.84SGFLAVVRR459 pKa = 11.84FPKK462 pKa = 10.62GVDD465 pKa = 2.85WSLGSFDD472 pKa = 4.85KK473 pKa = 11.38LL474 pKa = 3.56

Molecular weight: 53.65 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2638

95

610

376.9

42.33

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.572 ± 0.562

1.895 ± 0.692

6.141 ± 0.291

6.293 ± 0.735

3.715 ± 0.653

6.785 ± 0.972

1.933 ± 0.234

4.663 ± 0.535

4.511 ± 0.667

8.491 ± 0.883

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.554 ± 0.375

3.904 ± 0.74

6.52 ± 1.552

5.231 ± 0.329

7.127 ± 1.354

8.529 ± 1.072

6.141 ± 0.71

6.293 ± 0.71

1.289 ± 0.299

3.412 ± 0.508
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski