Amino acid dipepetide frequency for Tabrizicola sp. TH137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.069AlaAla: 21.069 ± 0.229
1.113AlaCys: 1.113 ± 0.033
7.115AlaAsp: 7.115 ± 0.073
9.459AlaGlu: 9.459 ± 0.107
4.64AlaPhe: 4.64 ± 0.07
12.176AlaGly: 12.176 ± 0.119
2.424AlaHis: 2.424 ± 0.051
5.9AlaIle: 5.9 ± 0.073
3.581AlaLys: 3.581 ± 0.066
15.812AlaLeu: 15.812 ± 0.144
4.086AlaMet: 4.086 ± 0.059
2.532AlaAsn: 2.532 ± 0.042
6.472AlaPro: 6.472 ± 0.099
4.443AlaGln: 4.443 ± 0.07
10.763AlaArg: 10.763 ± 0.123
5.281AlaSer: 5.281 ± 0.064
6.675AlaThr: 6.675 ± 0.074
9.469AlaVal: 9.469 ± 0.111
1.539AlaTrp: 1.539 ± 0.036
2.444AlaTyr: 2.444 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.058CysAla: 1.058 ± 0.029
0.099CysCys: 0.099 ± 0.01
0.581CysAsp: 0.581 ± 0.021
0.389CysGlu: 0.389 ± 0.017
0.348CysPhe: 0.348 ± 0.015
0.902CysGly: 0.902 ± 0.025
0.25CysHis: 0.25 ± 0.015
0.387CysIle: 0.387 ± 0.017
0.16CysLys: 0.16 ± 0.01
0.915CysLeu: 0.915 ± 0.028
0.151CysMet: 0.151 ± 0.009
0.186CysAsn: 0.186 ± 0.012
0.499CysPro: 0.499 ± 0.019
0.199CysGln: 0.199 ± 0.011
0.596CysArg: 0.596 ± 0.02
0.386CysSer: 0.386 ± 0.014
0.466CysThr: 0.466 ± 0.019
0.561CysVal: 0.561 ± 0.021
0.125CysTrp: 0.125 ± 0.01
0.173CysTyr: 0.173 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.875AspAla: 6.875 ± 0.079
0.502AspCys: 0.502 ± 0.018
2.928AspAsp: 2.928 ± 0.07
2.924AspGlu: 2.924 ± 0.051
2.154AspPhe: 2.154 ± 0.043
5.581AspGly: 5.581 ± 0.101
1.341AspHis: 1.341 ± 0.031
2.762AspIle: 2.762 ± 0.05
1.156AspLys: 1.156 ± 0.03
6.834AspLeu: 6.834 ± 0.093
1.404AspMet: 1.404 ± 0.029
0.929AspAsn: 0.929 ± 0.028
3.996AspPro: 3.996 ± 0.057
1.7AspGln: 1.7 ± 0.033
4.817AspArg: 4.817 ± 0.059
2.011AspSer: 2.011 ± 0.061
2.485AspThr: 2.485 ± 0.068
3.668AspVal: 3.668 ± 0.054
1.348AspTrp: 1.348 ± 0.033
1.347AspTyr: 1.347 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
9.162GluAla: 9.162 ± 0.121
0.332GluCys: 0.332 ± 0.014
2.95GluAsp: 2.95 ± 0.05
3.504GluGlu: 3.504 ± 0.066
1.664GluPhe: 1.664 ± 0.035
5.541GluGly: 5.541 ± 0.075
0.902GluHis: 0.902 ± 0.025
3.102GluIle: 3.102 ± 0.047
1.813GluLys: 1.813 ± 0.039
4.584GluLeu: 4.584 ± 0.061
1.745GluMet: 1.745 ± 0.035
1.366GluAsn: 1.366 ± 0.036
2.512GluPro: 2.512 ± 0.042
1.574GluGln: 1.574 ± 0.036
4.237GluArg: 4.237 ± 0.064
1.999GluSer: 1.999 ± 0.039
3.604GluThr: 3.604 ± 0.052
4.696GluVal: 4.696 ± 0.067
0.726GluTrp: 0.726 ± 0.022
0.911GluTyr: 0.911 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.737PheAla: 4.737 ± 0.072
0.392PheCys: 0.392 ± 0.018
2.698PheAsp: 2.698 ± 0.044
1.828PheGlu: 1.828 ± 0.033
1.336PhePhe: 1.336 ± 0.039
3.658PheGly: 3.658 ± 0.056
0.727PheHis: 0.727 ± 0.024
1.465PheIle: 1.465 ± 0.035
0.737PheLys: 0.737 ± 0.026
3.683PheLeu: 3.683 ± 0.06
0.718PheMet: 0.718 ± 0.025
0.917PheAsn: 0.917 ± 0.027
1.664PhePro: 1.664 ± 0.037
0.917PheGln: 0.917 ± 0.024
2.505PheArg: 2.505 ± 0.045
1.823PheSer: 1.823 ± 0.037
2.179PheThr: 2.179 ± 0.042
2.418PheVal: 2.418 ± 0.039
0.555PheTrp: 0.555 ± 0.023
0.805PheTyr: 0.805 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.885GlyAla: 10.885 ± 0.11
0.846GlyCys: 0.846 ± 0.025
4.638GlyAsp: 4.638 ± 0.092
4.915GlyGlu: 4.915 ± 0.07
3.688GlyPhe: 3.688 ± 0.056
8.071GlyGly: 8.071 ± 0.149
2.026GlyHis: 2.026 ± 0.047
4.476GlyIle: 4.476 ± 0.063
2.864GlyLys: 2.864 ± 0.06
9.93GlyLeu: 9.93 ± 0.102
2.82GlyMet: 2.82 ± 0.048
2.214GlyAsn: 2.214 ± 0.077
4.255GlyPro: 4.255 ± 0.062
3.196GlyGln: 3.196 ± 0.052
6.647GlyArg: 6.647 ± 0.078
4.212GlySer: 4.212 ± 0.073
4.815GlyThr: 4.815 ± 0.073
6.444GlyVal: 6.444 ± 0.08
1.681GlyTrp: 1.681 ± 0.036
2.092GlyTyr: 2.092 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.462HisAla: 2.462 ± 0.058
0.231HisCys: 0.231 ± 0.012
1.21HisAsp: 1.21 ± 0.031
0.954HisGlu: 0.954 ± 0.026
0.794HisPhe: 0.794 ± 0.027
2.005HisGly: 2.005 ± 0.04
0.61HisHis: 0.61 ± 0.023
0.846HisIle: 0.846 ± 0.023
0.399HisLys: 0.399 ± 0.016
2.349HisLeu: 2.349 ± 0.05
0.471HisMet: 0.471 ± 0.019
0.396HisAsn: 0.396 ± 0.017
1.545HisPro: 1.545 ± 0.035
0.522HisGln: 0.522 ± 0.02
1.588HisArg: 1.588 ± 0.039
0.81HisSer: 0.81 ± 0.024
0.666HisThr: 0.666 ± 0.022
1.576HisVal: 1.576 ± 0.036
0.376HisTrp: 0.376 ± 0.016
0.498HisTyr: 0.498 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.106IleAla: 7.106 ± 0.079
0.55IleCys: 0.55 ± 0.02
3.265IleAsp: 3.265 ± 0.047
2.987IleGlu: 2.987 ± 0.056
1.641IlePhe: 1.641 ± 0.032
4.707IleGly: 4.707 ± 0.067
0.955IleHis: 0.955 ± 0.024
1.92IleIle: 1.92 ± 0.045
1.04IleLys: 1.04 ± 0.031
4.969IleLeu: 4.969 ± 0.065
0.832IleMet: 0.832 ± 0.025
1.123IleAsn: 1.123 ± 0.026
2.464IlePro: 2.464 ± 0.045
0.984IleGln: 0.984 ± 0.025
3.542IleArg: 3.542 ± 0.051
2.479IleSer: 2.479 ± 0.044
2.824IleThr: 2.824 ± 0.041
3.443IleVal: 3.443 ± 0.045
0.661IleTrp: 0.661 ± 0.024
0.969IleTyr: 0.969 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.81LysAla: 3.81 ± 0.067
0.149LysCys: 0.149 ± 0.01
1.4LysAsp: 1.4 ± 0.035
1.294LysGlu: 1.294 ± 0.038
0.702LysPhe: 0.702 ± 0.021
2.7LysGly: 2.7 ± 0.054
0.478LysHis: 0.478 ± 0.019
1.256LysIle: 1.256 ± 0.031
0.955LysLys: 0.955 ± 0.037
2.46LysLeu: 2.46 ± 0.045
0.752LysMet: 0.752 ± 0.025
0.627LysAsn: 0.627 ± 0.022
1.627LysPro: 1.627 ± 0.036
0.71LysGln: 0.71 ± 0.026
1.844LysArg: 1.844 ± 0.041
1.407LysSer: 1.407 ± 0.035
1.516LysThr: 1.516 ± 0.033
2.122LysVal: 2.122 ± 0.049
0.327LysTrp: 0.327 ± 0.016
0.46LysTyr: 0.46 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.556LeuAla: 15.556 ± 0.143
1.012LeuCys: 1.012 ± 0.03
5.882LeuAsp: 5.882 ± 0.079
5.03LeuGlu: 5.03 ± 0.063
3.43LeuPhe: 3.43 ± 0.054
8.779LeuGly: 8.779 ± 0.096
2.046LeuHis: 2.046 ± 0.048
5.27LeuIle: 5.27 ± 0.067
2.865LeuLys: 2.865 ± 0.049
9.654LeuLeu: 9.654 ± 0.125
2.7LeuMet: 2.7 ± 0.045
2.39LeuAsn: 2.39 ± 0.052
6.565LeuPro: 6.565 ± 0.085
2.625LeuGln: 2.625 ± 0.044
8.242LeuArg: 8.242 ± 0.089
6.409LeuSer: 6.409 ± 0.067
6.322LeuThr: 6.322 ± 0.067
6.956LeuVal: 6.956 ± 0.089
1.556LeuTrp: 1.556 ± 0.045
1.878LeuTyr: 1.878 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.889MetAla: 3.889 ± 0.053
0.144MetCys: 0.144 ± 0.01
1.356MetAsp: 1.356 ± 0.034
1.419MetGlu: 1.419 ± 0.031
0.681MetPhe: 0.681 ± 0.023
2.326MetGly: 2.326 ± 0.04
0.423MetHis: 0.423 ± 0.018
1.395MetIle: 1.395 ± 0.037
0.942MetLys: 0.942 ± 0.026
2.476MetLeu: 2.476 ± 0.05
0.749MetMet: 0.749 ± 0.025
0.707MetAsn: 0.707 ± 0.024
1.567MetPro: 1.567 ± 0.029
0.981MetGln: 0.981 ± 0.024
1.861MetArg: 1.861 ± 0.037
1.351MetSer: 1.351 ± 0.03
2.067MetThr: 2.067 ± 0.041
1.951MetVal: 1.951 ± 0.04
0.23MetTrp: 0.23 ± 0.013
0.295MetTyr: 0.295 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.825AsnAla: 2.825 ± 0.05
0.208AsnCys: 0.208 ± 0.012
1.371AsnAsp: 1.371 ± 0.081
0.99AsnGlu: 0.99 ± 0.029
0.836AsnPhe: 0.836 ± 0.026
2.161AsnGly: 2.161 ± 0.047
0.453AsnHis: 0.453 ± 0.018
1.125AsnIle: 1.125 ± 0.031
0.492AsnLys: 0.492 ± 0.021
2.358AsnLeu: 2.358 ± 0.042
0.561AsnMet: 0.561 ± 0.02
0.534AsnAsn: 0.534 ± 0.028
1.774AsnPro: 1.774 ± 0.035
0.543AsnGln: 0.543 ± 0.019
1.658AsnArg: 1.658 ± 0.036
1.002AsnSer: 1.002 ± 0.03
1.038AsnThr: 1.038 ± 0.031
1.546AsnVal: 1.546 ± 0.037
0.396AsnTrp: 0.396 ± 0.016
0.515AsnTyr: 0.515 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.15ProAla: 7.15 ± 0.092
0.407ProCys: 0.407 ± 0.017
4.06ProAsp: 4.06 ± 0.064
4.309ProGlu: 4.309 ± 0.066
2.116ProPhe: 2.116 ± 0.039
5.2ProGly: 5.2 ± 0.069
1.135ProHis: 1.135 ± 0.029
2.131ProIle: 2.131 ± 0.035
1.501ProLys: 1.501 ± 0.035
5.171ProLeu: 5.171 ± 0.069
1.379ProMet: 1.379 ± 0.035
1.153ProAsn: 1.153 ± 0.03
2.824ProPro: 2.824 ± 0.055
1.656ProGln: 1.656 ± 0.039
3.253ProArg: 3.253 ± 0.059
2.449ProSer: 2.449 ± 0.044
2.493ProThr: 2.493 ± 0.046
4.671ProVal: 4.671 ± 0.065
0.755ProTrp: 0.755 ± 0.026
1.082ProTyr: 1.082 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.151GlnAla: 4.151 ± 0.057
0.168GlnCys: 0.168 ± 0.011
1.496GlnAsp: 1.496 ± 0.034
1.386GlnGlu: 1.386 ± 0.028
0.913GlnPhe: 0.913 ± 0.03
2.881GlnGly: 2.881 ± 0.039
0.555GlnHis: 0.555 ± 0.023
1.729GlnIle: 1.729 ± 0.036
0.865GlnLys: 0.865 ± 0.03
2.352GlnLeu: 2.352 ± 0.04
0.974GlnMet: 0.974 ± 0.025
0.733GlnAsn: 0.733 ± 0.023
1.678GlnPro: 1.678 ± 0.038
0.881GlnGln: 0.881 ± 0.026
2.094GlnArg: 2.094 ± 0.045
1.561GlnSer: 1.561 ± 0.029
1.654GlnThr: 1.654 ± 0.038
2.354GlnVal: 2.354 ± 0.042
0.363GlnTrp: 0.363 ± 0.017
0.488GlnTyr: 0.488 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
9.78ArgAla: 9.78 ± 0.102
0.494ArgCys: 0.494 ± 0.022
4.277ArgAsp: 4.277 ± 0.06
3.789ArgGlu: 3.789 ± 0.061
2.885ArgPhe: 2.885 ± 0.051
5.244ArgGly: 5.244 ± 0.061
1.803ArgHis: 1.803 ± 0.042
4.22ArgIle: 4.22 ± 0.059
2.01ArgLys: 2.01 ± 0.04
8.913ArgLeu: 8.913 ± 0.107
2.163ArgMet: 2.163 ± 0.04
1.679ArgAsn: 1.679 ± 0.038
3.916ArgPro: 3.916 ± 0.056
2.282ArgGln: 2.282 ± 0.044
5.799ArgArg: 5.799 ± 0.073
3.337ArgSer: 3.337 ± 0.053
2.939ArgThr: 2.939 ± 0.044
5.128ArgVal: 5.128 ± 0.063
1.094ArgTrp: 1.094 ± 0.028
1.459ArgTyr: 1.459 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.617SerAla: 5.617 ± 0.068
0.384SerCys: 0.384 ± 0.017
2.761SerAsp: 2.761 ± 0.048
2.359SerGlu: 2.359 ± 0.044
2.026SerPhe: 2.026 ± 0.04
4.989SerGly: 4.989 ± 0.083
0.964SerHis: 0.964 ± 0.028
2.198SerIle: 2.198 ± 0.041
1.046SerLys: 1.046 ± 0.028
5.03SerLeu: 5.03 ± 0.058
1.092SerMet: 1.092 ± 0.028
1.085SerAsn: 1.085 ± 0.028
2.585SerPro: 2.585 ± 0.039
1.369SerGln: 1.369 ± 0.026
3.175SerArg: 3.175 ± 0.054
2.223SerSer: 2.223 ± 0.048
2.327SerThr: 2.327 ± 0.05
3.501SerVal: 3.501 ± 0.05
0.652SerTrp: 0.652 ± 0.025
1.043SerTyr: 1.043 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.89ThrAla: 6.89 ± 0.075
0.46ThrCys: 0.46 ± 0.019
3.014ThrAsp: 3.014 ± 0.043
2.999ThrGlu: 2.999 ± 0.05
1.892ThrPhe: 1.892 ± 0.036
5.556ThrGly: 5.556 ± 0.08
1.129ThrHis: 1.129 ± 0.033
2.57ThrIle: 2.57 ± 0.046
1.167ThrLys: 1.167 ± 0.03
6.165ThrLeu: 6.165 ± 0.093
1.189ThrMet: 1.189 ± 0.03
1.087ThrAsn: 1.087 ± 0.03
3.394ThrPro: 3.394 ± 0.047
1.342ThrGln: 1.342 ± 0.034
3.593ThrArg: 3.593 ± 0.051
2.366ThrSer: 2.366 ± 0.045
2.815ThrThr: 2.815 ± 0.058
4.284ThrVal: 4.284 ± 0.064
0.725ThrTrp: 0.725 ± 0.024
1.102ThrTyr: 1.102 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.964ValAla: 9.964 ± 0.11
0.575ValCys: 0.575 ± 0.02
3.686ValAsp: 3.686 ± 0.056
4.614ValGlu: 4.614 ± 0.068
2.66ValPhe: 2.66 ± 0.049
5.203ValGly: 5.203 ± 0.062
1.235ValHis: 1.235 ± 0.028
4.21ValIle: 4.21 ± 0.055
2.105ValLys: 2.105 ± 0.046
7.709ValLeu: 7.709 ± 0.088
2.198ValMet: 2.198 ± 0.043
1.825ValAsn: 1.825 ± 0.04
3.76ValPro: 3.76 ± 0.052
2.134ValGln: 2.134 ± 0.041
4.232ValArg: 4.232 ± 0.061
3.54ValSer: 3.54 ± 0.047
5.101ValThr: 5.101 ± 0.066
5.677ValVal: 5.677 ± 0.08
1.087ValTrp: 1.087 ± 0.026
1.293ValTyr: 1.293 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.564TrpAla: 1.564 ± 0.034
0.151TrpCys: 0.151 ± 0.011
0.735TrpAsp: 0.735 ± 0.022
0.732TrpGlu: 0.732 ± 0.023
0.602TrpPhe: 0.602 ± 0.022
1.123TrpGly: 1.123 ± 0.033
0.374TrpHis: 0.374 ± 0.017
0.679TrpIle: 0.679 ± 0.022
0.458TrpLys: 0.458 ± 0.017
1.764TrpLeu: 1.764 ± 0.04
0.402TrpMet: 0.402 ± 0.02
0.422TrpAsn: 0.422 ± 0.018
0.781TrpPro: 0.781 ± 0.028
0.65TrpGln: 0.65 ± 0.023
1.219TrpArg: 1.219 ± 0.032
0.807TrpSer: 0.807 ± 0.025
0.811TrpThr: 0.811 ± 0.025
0.981TrpVal: 0.981 ± 0.024
0.252TrpTrp: 0.252 ± 0.016
0.26TrpTyr: 0.26 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.443TyrAla: 2.443 ± 0.045
0.218TyrCys: 0.218 ± 0.012
1.336TyrAsp: 1.336 ± 0.033
1.047TyrGlu: 1.047 ± 0.031
0.749TyrPhe: 0.749 ± 0.021
1.912TyrGly: 1.912 ± 0.036
0.476TyrHis: 0.476 ± 0.021
0.821TyrIle: 0.821 ± 0.026
0.44TyrLys: 0.44 ± 0.021
2.04TyrLeu: 2.04 ± 0.035
0.422TyrMet: 0.422 ± 0.016
0.481TyrAsn: 0.481 ± 0.02
1.017TyrPro: 1.017 ± 0.029
0.565TyrGln: 0.565 ± 0.022
1.544TyrArg: 1.544 ± 0.037
0.974TyrSer: 0.974 ± 0.026
0.943TyrThr: 0.943 ± 0.029
1.366TyrVal: 1.366 ± 0.033
0.319TyrTrp: 0.319 ± 0.018
0.442TyrTyr: 0.442 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4404 proteins (1389744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski