Amino acid dipepetide frequency for Thermanaerothrix daxensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.485AlaAla: 10.485 ± 0.139	0.982AlaCys: 0.982 ± 0.037	4.073AlaAsp: 4.073 ± 0.08	6.704AlaGlu: 6.704 ± 0.114	4.016AlaPhe: 4.016 ± 0.084	7.279AlaGly: 7.279 ± 0.09	2.218AlaHis: 2.218 ± 0.057	5.602AlaIle: 5.602 ± 0.082	2.217AlaLys: 2.217 ± 0.072	14.451AlaLeu: 14.451 ± 0.189	2.367AlaMet: 2.367 ± 0.055	2.372AlaAsn: 2.372 ± 0.06	4.418AlaPro: 4.418 ± 0.098	4.668AlaGln: 4.668 ± 0.09	7.352AlaArg: 7.352 ± 0.107	4.499AlaSer: 4.499 ± 0.081	4.853AlaThr: 4.853 ± 0.084	7.126AlaVal: 7.126 ± 0.105	1.983AlaTrp: 1.983 ± 0.062	3.053AlaTyr: 3.053 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.754CysAla: 0.754 ± 0.033	0.064CysCys: 0.064 ± 0.009	0.413CysAsp: 0.413 ± 0.025	0.425CysGlu: 0.425 ± 0.023	0.254CysPhe: 0.254 ± 0.019	0.794CysGly: 0.794 ± 0.043	0.242CysHis: 0.242 ± 0.023	0.338CysIle: 0.338 ± 0.025	0.204CysLys: 0.204 ± 0.018	0.856CysLeu: 0.856 ± 0.033	0.127CysMet: 0.127 ± 0.012	0.234CysAsn: 0.234 ± 0.017	0.576CysPro: 0.576 ± 0.031	0.364CysGln: 0.364 ± 0.025	0.562CysArg: 0.562 ± 0.027	0.366CysSer: 0.366 ± 0.022	0.426CysThr: 0.426 ± 0.026	0.53CysVal: 0.53 ± 0.022	0.118CysTrp: 0.118 ± 0.013	0.233CysTyr: 0.233 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.849AspAla: 3.849 ± 0.069	0.337AspCys: 0.337 ± 0.023	1.699AspAsp: 1.699 ± 0.052	3.129AspGlu: 3.129 ± 0.066	1.847AspPhe: 1.847 ± 0.051	3.188AspGly: 3.188 ± 0.064	0.887AspHis: 0.887 ± 0.036	2.29AspIle: 2.29 ± 0.056	1.035AspLys: 1.035 ± 0.038	6.211AspLeu: 6.211 ± 0.105	0.871AspMet: 0.871 ± 0.035	0.934AspAsn: 0.934 ± 0.038	3.204AspPro: 3.204 ± 0.062	1.528AspGln: 1.528 ± 0.047	2.665AspArg: 2.665 ± 0.063	1.581AspSer: 1.581 ± 0.046	1.902AspThr: 1.902 ± 0.048	3.241AspVal: 3.241 ± 0.071	0.884AspTrp: 0.884 ± 0.037	1.674AspTyr: 1.674 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.03GluAla: 8.03 ± 0.121	0.351GluCys: 0.351 ± 0.025	2.832GluAsp: 2.832 ± 0.068	4.77GluGlu: 4.77 ± 0.108	1.855GluPhe: 1.855 ± 0.053	4.745GluGly: 4.745 ± 0.077	1.462GluHis: 1.462 ± 0.042	4.151GluIle: 4.151 ± 0.085	2.372GluLys: 2.372 ± 0.064	4.979GluLeu: 4.979 ± 0.099	1.661GluMet: 1.661 ± 0.053	1.926GluAsn: 1.926 ± 0.05	2.778GluPro: 2.778 ± 0.076	2.804GluGln: 2.804 ± 0.061	5.638GluArg: 5.638 ± 0.106	2.741GluSer: 2.741 ± 0.067	3.576GluThr: 3.576 ± 0.071	5.718GluVal: 5.718 ± 0.102	0.996GluTrp: 0.996 ± 0.041	1.491GluTyr: 1.491 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.358PheAla: 3.358 ± 0.074	0.385PheCys: 0.385 ± 0.02	1.797PheAsp: 1.797 ± 0.047	2.202PheGlu: 2.202 ± 0.056	1.601PhePhe: 1.601 ± 0.056	2.922PheGly: 2.922 ± 0.063	0.735PheHis: 0.735 ± 0.029	2.029PheIle: 2.029 ± 0.048	0.944PheLys: 0.944 ± 0.032	4.57PheLeu: 4.57 ± 0.088	0.716PheMet: 0.716 ± 0.033	1.16PheAsn: 1.16 ± 0.034	1.979PhePro: 1.979 ± 0.057	1.247PheGln: 1.247 ± 0.039	2.236PheArg: 2.236 ± 0.057	2.271PheSer: 2.271 ± 0.062	2.123PheThr: 2.123 ± 0.049	2.59PheVal: 2.59 ± 0.058	0.767PheTrp: 0.767 ± 0.037	1.269PheTyr: 1.269 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.532GlyAla: 6.532 ± 0.118	0.729GlyCys: 0.729 ± 0.034	3.205GlyAsp: 3.205 ± 0.058	4.907GlyGlu: 4.907 ± 0.083	3.142GlyPhe: 3.142 ± 0.074	6.004GlyGly: 6.004 ± 0.093	1.615GlyHis: 1.615 ± 0.049	4.793GlyIle: 4.793 ± 0.093	2.797GlyLys: 2.797 ± 0.067	9.872GlyLeu: 9.872 ± 0.126	2.188GlyMet: 2.188 ± 0.055	2.084GlyAsn: 2.084 ± 0.057	2.782GlyPro: 2.782 ± 0.069	3.185GlyGln: 3.185 ± 0.073	4.943GlyArg: 4.943 ± 0.089	3.694GlySer: 3.694 ± 0.069	3.68GlyThr: 3.68 ± 0.078	6.726GlyVal: 6.726 ± 0.096	1.76GlyTrp: 1.76 ± 0.053	2.73GlyTyr: 2.73 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.927HisAla: 1.927 ± 0.052	0.216HisCys: 0.216 ± 0.017	0.73HisAsp: 0.73 ± 0.028	1.121HisGlu: 1.121 ± 0.041	0.822HisPhe: 0.822 ± 0.031	1.572HisGly: 1.572 ± 0.054	0.647HisHis: 0.647 ± 0.031	1.124HisIle: 1.124 ± 0.04	0.449HisLys: 0.449 ± 0.025	3.164HisLeu: 3.164 ± 0.064	0.396HisMet: 0.396 ± 0.023	0.569HisAsn: 0.569 ± 0.026	1.928HisPro: 1.928 ± 0.048	0.88HisGln: 0.88 ± 0.035	1.43HisArg: 1.43 ± 0.045	0.937HisSer: 0.937 ± 0.037	1.131HisThr: 1.131 ± 0.038	1.304HisVal: 1.304 ± 0.038	0.394HisTrp: 0.394 ± 0.023	0.748HisTyr: 0.748 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.636IleAla: 5.636 ± 0.087	0.492IleCys: 0.492 ± 0.025	2.223IleAsp: 2.223 ± 0.058	3.693IleGlu: 3.693 ± 0.073	2.142IlePhe: 2.142 ± 0.062	4.595IleGly: 4.595 ± 0.075	1.226IleHis: 1.226 ± 0.037	2.879IleIle: 2.879 ± 0.074	1.43IleLys: 1.43 ± 0.05	6.903IleLeu: 6.903 ± 0.115	0.87IleMet: 0.87 ± 0.033	1.729IleAsn: 1.729 ± 0.044	3.465IlePro: 3.465 ± 0.065	2.185IleGln: 2.185 ± 0.053	3.77IleArg: 3.77 ± 0.068	2.968IleSer: 2.968 ± 0.06	3.343IleThr: 3.343 ± 0.068	3.882IleVal: 3.882 ± 0.068	0.757IleTrp: 0.757 ± 0.034	1.674IleTyr: 1.674 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	3.088LysAla: 3.088 ± 0.077	0.178LysCys: 0.178 ± 0.015	1.285LysAsp: 1.285 ± 0.041	1.822LysGlu: 1.822 ± 0.058	0.725LysPhe: 0.725 ± 0.036	2.208LysGly: 2.208 ± 0.062	0.533LysHis: 0.533 ± 0.023	1.73LysIle: 1.73 ± 0.048	0.892LysLys: 0.892 ± 0.04	2.123LysLeu: 2.123 ± 0.062	0.668LysMet: 0.668 ± 0.029	0.781LysAsn: 0.781 ± 0.032	1.712LysPro: 1.712 ± 0.048	0.979LysGln: 0.979 ± 0.039	2.02LysArg: 2.02 ± 0.056	1.244LysSer: 1.244 ± 0.044	1.61LysThr: 1.61 ± 0.05	2.408LysVal: 2.408 ± 0.06	0.397LysTrp: 0.397 ± 0.023	0.728LysTyr: 0.728 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	13.078LeuAla: 13.078 ± 0.147	0.848LeuCys: 0.848 ± 0.037	5.51LeuAsp: 5.51 ± 0.09	7.94LeuGlu: 7.94 ± 0.116	4.194LeuPhe: 4.194 ± 0.085	10.161LeuGly: 10.161 ± 0.167	2.355LeuHis: 2.355 ± 0.058	6.982LeuIle: 6.982 ± 0.106	3.592LeuLys: 3.592 ± 0.08	13.354LeuLeu: 13.354 ± 0.182	2.555LeuMet: 2.555 ± 0.062	3.532LeuAsn: 3.532 ± 0.061	7.557LeuPro: 7.557 ± 0.111	4.563LeuGln: 4.563 ± 0.088	8.701LeuArg: 8.701 ± 0.136	6.815LeuSer: 6.815 ± 0.11	6.477LeuThr: 6.477 ± 0.097	8.699LeuVal: 8.699 ± 0.102	1.88LeuTrp: 1.88 ± 0.064	3.008LeuTyr: 3.008 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.52MetAla: 2.52 ± 0.052	0.113MetCys: 0.113 ± 0.012	1.006MetAsp: 1.006 ± 0.039	1.306MetGlu: 1.306 ± 0.042	0.602MetPhe: 0.602 ± 0.029	1.855MetGly: 1.855 ± 0.051	0.399MetHis: 0.399 ± 0.025	1.299MetIle: 1.299 ± 0.045	0.731MetLys: 0.731 ± 0.032	2.3MetLeu: 2.3 ± 0.063	0.544MetMet: 0.544 ± 0.029	0.691MetAsn: 0.691 ± 0.03	1.197MetPro: 1.197 ± 0.041	0.74MetGln: 0.74 ± 0.033	1.717MetArg: 1.717 ± 0.057	1.192MetSer: 1.192 ± 0.039	1.266MetThr: 1.266 ± 0.04	1.739MetVal: 1.739 ± 0.053	0.212MetTrp: 0.212 ± 0.018	0.368MetTyr: 0.368 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.742AsnAla: 2.742 ± 0.061	0.212AsnCys: 0.212 ± 0.017	1.128AsnAsp: 1.128 ± 0.038	1.414AsnGlu: 1.414 ± 0.052	0.987AsnPhe: 0.987 ± 0.033	2.062AsnGly: 2.062 ± 0.054	0.586AsnHis: 0.586 ± 0.029	1.395AsnIle: 1.395 ± 0.051	0.561AsnLys: 0.561 ± 0.026	3.946AsnLeu: 3.946 ± 0.076	0.463AsnMet: 0.463 ± 0.026	0.721AsnAsn: 0.721 ± 0.036	2.403AsnPro: 2.403 ± 0.061	1.065AsnGln: 1.065 ± 0.04	1.907AsnArg: 1.907 ± 0.05	1.0AsnSer: 1.0 ± 0.041	1.373AsnThr: 1.373 ± 0.045	1.916AsnVal: 1.916 ± 0.046	0.466AsnTrp: 0.466 ± 0.029	0.896AsnTyr: 0.896 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.479ProAla: 5.479 ± 0.103	0.343ProCys: 0.343 ± 0.021	3.069ProAsp: 3.069 ± 0.069	4.9ProGlu: 4.9 ± 0.095	2.164ProPhe: 2.164 ± 0.058	4.411ProGly: 4.411 ± 0.084	1.273ProHis: 1.273 ± 0.045	2.889ProIle: 2.889 ± 0.063	1.37ProLys: 1.37 ± 0.044	6.762ProLeu: 6.762 ± 0.109	1.163ProMet: 1.163 ± 0.038	1.622ProAsn: 1.622 ± 0.05	3.765ProPro: 3.765 ± 0.097	2.39ProGln: 2.39 ± 0.053	3.39ProArg: 3.39 ± 0.072	2.917ProSer: 2.917 ± 0.067	3.842ProThr: 3.842 ± 0.111	4.101ProVal: 4.101 ± 0.082	1.049ProTrp: 1.049 ± 0.041	1.776ProTyr: 1.776 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	5.336GlnAla: 5.336 ± 0.111	0.257GlnCys: 0.257 ± 0.019	1.567GlnAsp: 1.567 ± 0.038	2.402GlnGlu: 2.402 ± 0.051	1.146GlnPhe: 1.146 ± 0.035	3.174GlnGly: 3.174 ± 0.069	0.82GlnHis: 0.82 ± 0.03	2.531GlnIle: 2.531 ± 0.061	1.353GlnLys: 1.353 ± 0.05	3.106GlnLeu: 3.106 ± 0.071	1.019GlnMet: 1.019 ± 0.038	1.187GlnAsn: 1.187 ± 0.043	2.688GlnPro: 2.688 ± 0.063	1.778GlnGln: 1.778 ± 0.058	3.773GlnArg: 3.773 ± 0.086	1.917GlnSer: 1.917 ± 0.053	2.175GlnThr: 2.175 ± 0.058	3.569GlnVal: 3.569 ± 0.074	0.612GlnTrp: 0.612 ± 0.026	0.885GlnTyr: 0.885 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.795ArgAla: 6.795 ± 0.109	0.514ArgCys: 0.514 ± 0.026	2.762ArgAsp: 2.762 ± 0.064	4.952ArgGlu: 4.952 ± 0.097	2.899ArgPhe: 2.899 ± 0.069	4.609ArgGly: 4.609 ± 0.083	1.557ArgHis: 1.557 ± 0.04	3.775ArgIle: 3.775 ± 0.074	1.961ArgLys: 1.961 ± 0.052	9.517ArgLeu: 9.517 ± 0.117	1.576ArgMet: 1.576 ± 0.044	1.736ArgAsn: 1.736 ± 0.048	3.669ArgPro: 3.669 ± 0.079	3.68ArgGln: 3.68 ± 0.069	5.762ArgArg: 5.762 ± 0.112	3.055ArgSer: 3.055 ± 0.069	3.157ArgThr: 3.157 ± 0.07	5.512ArgVal: 5.512 ± 0.093	1.376ArgTrp: 1.376 ± 0.044	2.402ArgTyr: 2.402 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	4.516SerAla: 4.516 ± 0.084	0.314SerCys: 0.314 ± 0.023	2.035SerAsp: 2.035 ± 0.051	2.943SerGlu: 2.943 ± 0.064	1.716SerPhe: 1.716 ± 0.053	4.47SerGly: 4.47 ± 0.08	1.084SerHis: 1.084 ± 0.035	2.377SerIle: 2.377 ± 0.055	1.151SerLys: 1.151 ± 0.041	6.232SerLeu: 6.232 ± 0.095	1.037SerMet: 1.037 ± 0.035	1.231SerAsn: 1.231 ± 0.046	3.507SerPro: 3.507 ± 0.061	2.081SerGln: 2.081 ± 0.053	3.109SerArg: 3.109 ± 0.071	2.404SerSer: 2.404 ± 0.063	2.624SerThr: 2.624 ± 0.059	3.249SerVal: 3.249 ± 0.059	0.603SerTrp: 0.603 ± 0.027	1.11SerTyr: 1.11 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.907ThrAla: 4.907 ± 0.085	0.448ThrCys: 0.448 ± 0.027	1.95ThrAsp: 1.95 ± 0.055	2.475ThrGlu: 2.475 ± 0.054	2.159ThrPhe: 2.159 ± 0.056	3.833ThrGly: 3.833 ± 0.077	1.224ThrHis: 1.224 ± 0.039	2.659ThrIle: 2.659 ± 0.064	0.954ThrLys: 0.954 ± 0.041	7.68ThrLeu: 7.68 ± 0.108	0.96ThrMet: 0.96 ± 0.036	1.257ThrAsn: 1.257 ± 0.04	4.685ThrPro: 4.685 ± 0.11	2.09ThrGln: 2.09 ± 0.052	3.404ThrArg: 3.404 ± 0.061	2.629ThrSer: 2.629 ± 0.061	2.819ThrThr: 2.819 ± 0.072	3.539ThrVal: 3.539 ± 0.076	1.048ThrTrp: 1.048 ± 0.039	1.72ThrTyr: 1.72 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.374ValAla: 7.374 ± 0.099	0.653ValCys: 0.653 ± 0.03	3.647ValAsp: 3.647 ± 0.072	5.037ValGlu: 5.037 ± 0.092	2.823ValPhe: 2.823 ± 0.053	5.82ValGly: 5.82 ± 0.096	1.481ValHis: 1.481 ± 0.046	4.793ValIle: 4.793 ± 0.088	2.009ValLys: 2.009 ± 0.063	9.251ValLeu: 9.251 ± 0.133	1.691ValMet: 1.691 ± 0.054	2.119ValAsn: 2.119 ± 0.049	3.826ValPro: 3.826 ± 0.069	2.709ValGln: 2.709 ± 0.055	5.203ValArg: 5.203 ± 0.072	3.717ValSer: 3.717 ± 0.075	3.943ValThr: 3.943 ± 0.076	6.663ValVal: 6.663 ± 0.096	1.166ValTrp: 1.166 ± 0.038	2.044ValTyr: 2.044 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	1.453TrpAla: 1.453 ± 0.049	0.126TrpCys: 0.126 ± 0.011	0.665TrpAsp: 0.665 ± 0.028	1.07TrpGlu: 1.07 ± 0.037	0.599TrpPhe: 0.599 ± 0.032	1.341TrpGly: 1.341 ± 0.046	0.35TrpHis: 0.35 ± 0.022	0.888TrpIle: 0.888 ± 0.038	0.502TrpLys: 0.502 ± 0.025	2.622TrpLeu: 2.622 ± 0.064	0.482TrpMet: 0.482 ± 0.025	0.518TrpAsn: 0.518 ± 0.027	0.787TrpPro: 0.787 ± 0.037	1.038TrpGln: 1.038 ± 0.036	1.311TrpArg: 1.311 ± 0.049	0.664TrpSer: 0.664 ± 0.031	0.585TrpThr: 0.585 ± 0.03	1.565TrpVal: 1.565 ± 0.05	0.314TrpTrp: 0.314 ± 0.023	0.432TrpTyr: 0.432 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.858TyrAla: 2.858 ± 0.06	0.318TyrCys: 0.318 ± 0.021	1.357TyrAsp: 1.357 ± 0.045	1.661TyrGlu: 1.661 ± 0.049	1.211TyrPhe: 1.211 ± 0.049	2.33TyrGly: 2.33 ± 0.058	0.795TyrHis: 0.795 ± 0.03	1.338TyrIle: 1.338 ± 0.041	0.605TyrLys: 0.605 ± 0.029	3.903TyrLeu: 3.903 ± 0.071	0.441TyrMet: 0.441 ± 0.023	0.841TyrAsn: 0.841 ± 0.031	1.748TyrPro: 1.748 ± 0.049	1.322TyrGln: 1.322 ± 0.041	2.374TyrArg: 2.374 ± 0.063	1.182TyrSer: 1.182 ± 0.041	1.535TyrThr: 1.535 ± 0.045	1.893TyrVal: 1.893 ± 0.043	0.528TyrTrp: 0.528 ± 0.025	0.983TyrTyr: 0.983 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2394 proteins (786151 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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