Amino acid dipepetide frequency for Moelleriella libera RCEF 2490

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.673AlaAla: 11.673 ± 0.099	1.132AlaCys: 1.132 ± 0.019	4.891AlaAsp: 4.891 ± 0.042	5.389AlaGlu: 5.389 ± 0.05	3.214AlaPhe: 3.214 ± 0.034	6.42AlaGly: 6.42 ± 0.045	1.967AlaHis: 1.967 ± 0.024	4.126AlaIle: 4.126 ± 0.037	4.306AlaLys: 4.306 ± 0.035	8.072AlaLeu: 8.072 ± 0.05	2.11AlaMet: 2.11 ± 0.024	3.023AlaAsn: 3.023 ± 0.035	5.051AlaPro: 5.051 ± 0.049	3.725AlaGln: 3.725 ± 0.038	5.739AlaArg: 5.739 ± 0.037	8.184AlaSer: 8.184 ± 0.065	5.532AlaThr: 5.532 ± 0.04	5.995AlaVal: 5.995 ± 0.047	1.228AlaTrp: 1.228 ± 0.02	2.09AlaTyr: 2.09 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.015	0.242CysCys: 0.242 ± 0.008	0.698CysAsp: 0.698 ± 0.013	0.594CysGlu: 0.594 ± 0.012	0.539CysPhe: 0.539 ± 0.012	0.928CysGly: 0.928 ± 0.016	0.343CysHis: 0.343 ± 0.012	0.634CysIle: 0.634 ± 0.012	0.501CysLys: 0.501 ± 0.012	1.284CysLeu: 1.284 ± 0.023	0.262CysMet: 0.262 ± 0.008	0.402CysAsn: 0.402 ± 0.01	0.652CysPro: 0.652 ± 0.015	0.454CysGln: 0.454 ± 0.013	0.811CysArg: 0.811 ± 0.017	0.89CysSer: 0.89 ± 0.015	0.636CysThr: 0.636 ± 0.014	0.833CysVal: 0.833 ± 0.016	0.18CysTrp: 0.18 ± 0.006	0.317CysTyr: 0.317 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.529AspAla: 5.529 ± 0.045	0.683AspCys: 0.683 ± 0.015	5.105AspAsp: 5.105 ± 0.072	4.714AspGlu: 4.714 ± 0.05	2.267AspPhe: 2.267 ± 0.029	4.577AspGly: 4.577 ± 0.04	1.334AspHis: 1.334 ± 0.017	2.722AspIle: 2.722 ± 0.028	2.516AspLys: 2.516 ± 0.031	5.012AspLeu: 5.012 ± 0.038	1.374AspMet: 1.374 ± 0.02	1.838AspAsn: 1.838 ± 0.023	2.993AspPro: 2.993 ± 0.033	1.97AspGln: 1.97 ± 0.023	3.235AspArg: 3.235 ± 0.036	4.173AspSer: 4.173 ± 0.042	2.821AspThr: 2.821 ± 0.025	4.065AspVal: 4.065 ± 0.035	0.886AspTrp: 0.886 ± 0.014	1.457AspTyr: 1.457 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.753GluAla: 5.753 ± 0.041	0.603GluCys: 0.603 ± 0.013	4.0GluAsp: 4.0 ± 0.045	4.982GluGlu: 4.982 ± 0.078	1.819GluPhe: 1.819 ± 0.018	3.532GluGly: 3.532 ± 0.036	1.407GluHis: 1.407 ± 0.02	2.654GluIle: 2.654 ± 0.027	3.43GluLys: 3.43 ± 0.035	5.107GluLeu: 5.107 ± 0.051	1.43GluMet: 1.43 ± 0.019	2.048GluAsn: 2.048 ± 0.022	2.745GluPro: 2.745 ± 0.044	2.562GluGln: 2.562 ± 0.03	3.928GluArg: 3.928 ± 0.038	4.149GluSer: 4.149 ± 0.04	3.341GluThr: 3.341 ± 0.031	3.338GluVal: 3.338 ± 0.033	0.813GluTrp: 0.813 ± 0.015	1.457GluTyr: 1.457 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.228PheAla: 3.228 ± 0.032	0.533PheCys: 0.533 ± 0.013	2.285PheAsp: 2.285 ± 0.024	2.085PheGlu: 2.085 ± 0.024	1.545PhePhe: 1.545 ± 0.024	2.799PheGly: 2.799 ± 0.034	0.888PheHis: 0.888 ± 0.014	1.568PheIle: 1.568 ± 0.025	1.402PheLys: 1.402 ± 0.021	3.327PheLeu: 3.327 ± 0.033	0.786PheMet: 0.786 ± 0.014	1.312PheAsn: 1.312 ± 0.016	1.877PhePro: 1.877 ± 0.023	1.319PheGln: 1.319 ± 0.02	2.028PheArg: 2.028 ± 0.023	2.877PheSer: 2.877 ± 0.029	1.954PheThr: 1.954 ± 0.022	2.515PheVal: 2.515 ± 0.028	0.615PheTrp: 0.615 ± 0.012	1.003PheTyr: 1.003 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.823GlyAla: 5.823 ± 0.043	0.834GlyCys: 0.834 ± 0.016	3.876GlyAsp: 3.876 ± 0.033	3.569GlyGlu: 3.569 ± 0.031	2.716GlyPhe: 2.716 ± 0.032	6.591GlyGly: 6.591 ± 0.08	1.853GlyHis: 1.853 ± 0.022	3.338GlyIle: 3.338 ± 0.033	3.474GlyLys: 3.474 ± 0.034	6.163GlyLeu: 6.163 ± 0.05	1.54GlyMet: 1.54 ± 0.024	2.501GlyAsn: 2.501 ± 0.033	3.608GlyPro: 3.608 ± 0.045	2.833GlyGln: 2.833 ± 0.031	4.597GlyArg: 4.597 ± 0.041	6.148GlySer: 6.148 ± 0.063	3.982GlyThr: 3.982 ± 0.033	4.29GlyVal: 4.29 ± 0.037	1.104GlyTrp: 1.104 ± 0.018	1.857GlyTyr: 1.857 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.036HisAla: 2.036 ± 0.019	0.336HisCys: 0.336 ± 0.009	1.531HisAsp: 1.531 ± 0.022	1.372HisGlu: 1.372 ± 0.019	0.916HisPhe: 0.916 ± 0.015	1.937HisGly: 1.937 ± 0.024	1.06HisHis: 1.06 ± 0.024	1.106HisIle: 1.106 ± 0.018	0.93HisLys: 0.93 ± 0.016	2.241HisLeu: 2.241 ± 0.023	0.505HisMet: 0.505 ± 0.011	0.812HisAsn: 0.812 ± 0.015	1.548HisPro: 1.548 ± 0.021	1.126HisGln: 1.126 ± 0.023	1.649HisArg: 1.649 ± 0.024	1.796HisSer: 1.796 ± 0.025	1.141HisThr: 1.141 ± 0.017	1.628HisVal: 1.628 ± 0.024	0.341HisTrp: 0.341 ± 0.009	0.648HisTyr: 0.648 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.984IleAla: 3.984 ± 0.038	0.701IleCys: 0.701 ± 0.014	2.706IleAsp: 2.706 ± 0.027	2.596IleGlu: 2.596 ± 0.029	1.814IlePhe: 1.814 ± 0.024	2.984IleGly: 2.984 ± 0.034	1.07IleHis: 1.07 ± 0.017	2.221IleIle: 2.221 ± 0.047	2.064IleLys: 2.064 ± 0.026	4.158IleLeu: 4.158 ± 0.041	1.002IleMet: 1.002 ± 0.015	1.578IleAsn: 1.578 ± 0.02	2.619IlePro: 2.619 ± 0.027	1.679IleGln: 1.679 ± 0.021	2.801IleArg: 2.801 ± 0.028	3.462IleSer: 3.462 ± 0.031	2.503IleThr: 2.503 ± 0.028	3.063IleVal: 3.063 ± 0.027	0.666IleTrp: 0.666 ± 0.013	1.142IleTyr: 1.142 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.401LysAla: 4.401 ± 0.045	0.5LysCys: 0.5 ± 0.011	2.709LysAsp: 2.709 ± 0.034	2.99LysGlu: 2.99 ± 0.038	1.444LysPhe: 1.444 ± 0.02	2.931LysGly: 2.931 ± 0.032	1.127LysHis: 1.127 ± 0.016	2.121LysIle: 2.121 ± 0.024	3.451LysLys: 3.451 ± 0.103	4.05LysLeu: 4.05 ± 0.033	1.025LysMet: 1.025 ± 0.016	1.613LysAsn: 1.613 ± 0.021	2.645LysPro: 2.645 ± 0.031	1.906LysGln: 1.906 ± 0.026	3.394LysArg: 3.394 ± 0.036	3.404LysSer: 3.404 ± 0.031	2.87LysThr: 2.87 ± 0.026	2.69LysVal: 2.69 ± 0.033	0.615LysTrp: 0.615 ± 0.013	1.236LysTyr: 1.236 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.318LeuAla: 8.318 ± 0.056	1.215LeuCys: 1.215 ± 0.018	5.261LeuAsp: 5.261 ± 0.04	5.196LeuGlu: 5.196 ± 0.051	3.208LeuPhe: 3.208 ± 0.036	6.037LeuGly: 6.037 ± 0.046	2.191LeuHis: 2.191 ± 0.023	3.686LeuIle: 3.686 ± 0.042	3.957LeuLys: 3.957 ± 0.039	8.294LeuLeu: 8.294 ± 0.068	1.799LeuMet: 1.799 ± 0.022	2.904LeuAsn: 2.904 ± 0.026	5.357LeuPro: 5.357 ± 0.04	3.794LeuGln: 3.794 ± 0.03	6.147LeuArg: 6.147 ± 0.046	7.335LeuSer: 7.335 ± 0.05	4.653LeuThr: 4.653 ± 0.034	5.598LeuVal: 5.598 ± 0.046	1.146LeuTrp: 1.146 ± 0.017	2.13LeuTyr: 2.13 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.414MetAla: 2.414 ± 0.027	0.245MetCys: 0.245 ± 0.009	1.263MetAsp: 1.263 ± 0.019	1.197MetGlu: 1.197 ± 0.018	0.725MetPhe: 0.725 ± 0.016	1.452MetGly: 1.452 ± 0.02	0.492MetHis: 0.492 ± 0.011	0.922MetIle: 0.922 ± 0.014	0.996MetLys: 0.996 ± 0.017	1.845MetLeu: 1.845 ± 0.024	0.59MetMet: 0.59 ± 0.014	0.755MetAsn: 0.755 ± 0.014	1.328MetPro: 1.328 ± 0.021	0.873MetGln: 0.873 ± 0.015	1.383MetArg: 1.383 ± 0.019	1.914MetSer: 1.914 ± 0.024	1.374MetThr: 1.374 ± 0.017	1.274MetVal: 1.274 ± 0.018	0.262MetTrp: 0.262 ± 0.009	0.508MetTyr: 0.508 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.108AsnAla: 3.108 ± 0.028	0.415AsnCys: 0.415 ± 0.012	1.952AsnAsp: 1.952 ± 0.025	1.881AsnGlu: 1.881 ± 0.018	1.285AsnPhe: 1.285 ± 0.019	2.912AsnGly: 2.912 ± 0.037	0.827AsnHis: 0.827 ± 0.016	1.717AsnIle: 1.717 ± 0.022	1.529AsnLys: 1.529 ± 0.021	3.007AsnLeu: 3.007 ± 0.024	0.8AsnMet: 0.8 ± 0.015	1.46AsnAsn: 1.46 ± 0.053	2.153AsnPro: 2.153 ± 0.025	1.23AsnGln: 1.23 ± 0.02	1.908AsnArg: 1.908 ± 0.022	2.493AsnSer: 2.493 ± 0.031	1.945AsnThr: 1.945 ± 0.025	2.269AsnVal: 2.269 ± 0.026	0.496AsnTrp: 0.496 ± 0.012	0.899AsnTyr: 0.899 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.65ProAla: 5.65 ± 0.053	0.55ProCys: 0.55 ± 0.013	3.365ProAsp: 3.365 ± 0.034	3.479ProGlu: 3.479 ± 0.036	1.967ProPhe: 1.967 ± 0.02	4.268ProGly: 4.268 ± 0.062	1.343ProHis: 1.343 ± 0.022	2.229ProIle: 2.229 ± 0.024	2.489ProLys: 2.489 ± 0.027	4.667ProLeu: 4.667 ± 0.035	1.037ProMet: 1.037 ± 0.016	1.952ProAsn: 1.952 ± 0.026	5.437ProPro: 5.437 ± 0.086	2.436ProGln: 2.436 ± 0.031	3.701ProArg: 3.701 ± 0.036	5.98ProSer: 5.98 ± 0.052	3.471ProThr: 3.471 ± 0.04	3.579ProVal: 3.579 ± 0.037	0.727ProTrp: 0.727 ± 0.013	1.323ProTyr: 1.323 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.705GlnAla: 3.705 ± 0.037	0.453GlnCys: 0.453 ± 0.012	2.318GlnAsp: 2.318 ± 0.023	2.376GlnGlu: 2.376 ± 0.027	1.255GlnPhe: 1.255 ± 0.017	2.531GlnGly: 2.531 ± 0.026	1.23GlnHis: 1.23 ± 0.02	1.813GlnIle: 1.813 ± 0.022	1.954GlnLys: 1.954 ± 0.023	3.515GlnLeu: 3.515 ± 0.032	0.93GlnMet: 0.93 ± 0.016	1.463GlnAsn: 1.463 ± 0.021	2.597GlnPro: 2.597 ± 0.034	3.3GlnGln: 3.3 ± 0.097	2.869GlnArg: 2.869 ± 0.029	3.256GlnSer: 3.256 ± 0.036	2.303GlnThr: 2.303 ± 0.024	2.262GlnVal: 2.262 ± 0.024	0.549GlnTrp: 0.549 ± 0.011	1.038GlnTyr: 1.038 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.377ArgAla: 5.377 ± 0.044	0.766ArgCys: 0.766 ± 0.015	3.873ArgAsp: 3.873 ± 0.037	3.908ArgGlu: 3.908 ± 0.04	2.188ArgPhe: 2.188 ± 0.024	4.132ArgGly: 4.132 ± 0.031	1.831ArgHis: 1.831 ± 0.024	2.874ArgIle: 2.874 ± 0.026	3.441ArgLys: 3.441 ± 0.036	5.866ArgLeu: 5.866 ± 0.049	1.366ArgMet: 1.366 ± 0.017	2.272ArgAsn: 2.272 ± 0.024	3.897ArgPro: 3.897 ± 0.043	3.008ArgGln: 3.008 ± 0.026	5.929ArgArg: 5.929 ± 0.063	5.157ArgSer: 5.157 ± 0.043	3.347ArgThr: 3.347 ± 0.03	3.521ArgVal: 3.521 ± 0.033	0.931ArgTrp: 0.931 ± 0.014	1.596ArgTyr: 1.596 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.304SerAla: 7.304 ± 0.061	0.92SerCys: 0.92 ± 0.019	4.331SerAsp: 4.331 ± 0.039	4.003SerGlu: 4.003 ± 0.037	2.925SerPhe: 2.925 ± 0.03	5.829SerGly: 5.829 ± 0.059	2.016SerHis: 2.016 ± 0.022	3.693SerIle: 3.693 ± 0.034	3.597SerLys: 3.597 ± 0.037	7.296SerLeu: 7.296 ± 0.052	1.768SerMet: 1.768 ± 0.022	2.776SerAsn: 2.776 ± 0.029	5.601SerPro: 5.601 ± 0.065	3.432SerGln: 3.432 ± 0.037	5.618SerArg: 5.618 ± 0.05	9.554SerSer: 9.554 ± 0.1	5.188SerThr: 5.188 ± 0.047	4.644SerVal: 4.644 ± 0.034	1.125SerTrp: 1.125 ± 0.017	1.851SerTyr: 1.851 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.491ThrAla: 5.491 ± 0.042	0.707ThrCys: 0.707 ± 0.015	2.805ThrAsp: 2.805 ± 0.028	2.921ThrGlu: 2.921 ± 0.037	2.099ThrPhe: 2.099 ± 0.022	4.049ThrGly: 4.049 ± 0.037	1.191ThrHis: 1.191 ± 0.017	2.762ThrIle: 2.762 ± 0.032	2.458ThrLys: 2.458 ± 0.029	4.94ThrLeu: 4.94 ± 0.037	1.201ThrMet: 1.201 ± 0.018	1.933ThrAsn: 1.933 ± 0.029	3.922ThrPro: 3.922 ± 0.039	2.038ThrGln: 2.038 ± 0.03	3.296ThrArg: 3.296 ± 0.028	5.208ThrSer: 5.208 ± 0.046	4.228ThrThr: 4.228 ± 0.054	3.649ThrVal: 3.649 ± 0.034	0.801ThrTrp: 0.801 ± 0.014	1.426ThrTyr: 1.426 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.837ValAla: 5.837 ± 0.041	0.833ValCys: 0.833 ± 0.015	3.87ValAsp: 3.87 ± 0.034	3.685ValGlu: 3.685 ± 0.034	2.441ValPhe: 2.441 ± 0.028	4.004ValGly: 4.004 ± 0.034	1.434ValHis: 1.434 ± 0.019	2.783ValIle: 2.783 ± 0.029	2.883ValLys: 2.883 ± 0.026	5.68ValLeu: 5.68 ± 0.049	1.363ValMet: 1.363 ± 0.016	2.149ValAsn: 2.149 ± 0.023	3.718ValPro: 3.718 ± 0.036	2.453ValGln: 2.453 ± 0.026	3.718ValArg: 3.718 ± 0.029	4.727ValSer: 4.727 ± 0.038	3.571ValThr: 3.571 ± 0.041	4.455ValVal: 4.455 ± 0.04	0.826ValTrp: 0.826 ± 0.016	1.584ValTyr: 1.584 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.02	0.194TrpCys: 0.194 ± 0.007	0.895TrpAsp: 0.895 ± 0.016	0.783TrpGlu: 0.783 ± 0.014	0.5TrpPhe: 0.5 ± 0.01	0.871TrpGly: 0.871 ± 0.017	0.375TrpHis: 0.375 ± 0.01	0.699TrpIle: 0.699 ± 0.014	0.716TrpLys: 0.716 ± 0.014	1.33TrpLeu: 1.33 ± 0.02	0.35TrpMet: 0.35 ± 0.009	0.569TrpAsn: 0.569 ± 0.013	0.617TrpPro: 0.617 ± 0.012	0.597TrpGln: 0.597 ± 0.013	0.986TrpArg: 0.986 ± 0.017	1.001TrpSer: 1.001 ± 0.016	0.904TrpThr: 0.904 ± 0.015	0.787TrpVal: 0.787 ± 0.014	0.276TrpTrp: 0.276 ± 0.009	0.382TrpTyr: 0.382 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.035TyrAla: 2.035 ± 0.024	0.38TyrCys: 0.38 ± 0.009	1.536TyrAsp: 1.536 ± 0.022	1.379TyrGlu: 1.379 ± 0.02	1.078TyrPhe: 1.078 ± 0.018	1.911TyrGly: 1.911 ± 0.028	0.682TyrHis: 0.682 ± 0.013	1.141TyrIle: 1.141 ± 0.018	1.028TyrLys: 1.028 ± 0.017	2.374TyrLeu: 2.374 ± 0.027	0.576TyrMet: 0.576 ± 0.012	0.927TyrAsn: 0.927 ± 0.015	1.283TyrPro: 1.283 ± 0.018	0.981TyrGln: 0.981 ± 0.017	1.544TyrArg: 1.544 ± 0.02	1.763TyrSer: 1.763 ± 0.023	1.364TyrThr: 1.364 ± 0.019	1.561TyrVal: 1.561 ± 0.022	0.401TyrTrp: 0.401 ± 0.01	0.765TyrTyr: 0.765 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8458 proteins (4278114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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