Amino acid dipepetide frequency for Fusarium sp. AF-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.767AlaAla: 8.767 ± 0.081
1.139AlaCys: 1.139 ± 0.015
4.191AlaAsp: 4.191 ± 0.025
5.2AlaGlu: 5.2 ± 0.057
3.193AlaPhe: 3.193 ± 0.024
5.641AlaGly: 5.641 ± 0.033
1.694AlaHis: 1.694 ± 0.016
4.456AlaIle: 4.456 ± 0.031
4.144AlaLys: 4.144 ± 0.03
7.727AlaLeu: 7.727 ± 0.04
2.025AlaMet: 2.025 ± 0.017
2.803AlaAsn: 2.803 ± 0.02
4.763AlaPro: 4.763 ± 0.045
3.255AlaGln: 3.255 ± 0.028
4.659AlaArg: 4.659 ± 0.026
6.987AlaSer: 6.987 ± 0.039
5.14AlaThr: 5.14 ± 0.027
5.36AlaVal: 5.36 ± 0.028
1.282AlaTrp: 1.282 ± 0.013
2.119AlaTyr: 2.119 ± 0.017
0.0AlaXaa: 0.0 ± 0.0
Cys
0.971CysAla: 0.971 ± 0.013
0.264CysCys: 0.264 ± 0.008
0.726CysAsp: 0.726 ± 0.012
0.661CysGlu: 0.661 ± 0.011
0.589CysPhe: 0.589 ± 0.01
0.982CysGly: 0.982 ± 0.016
0.362CysHis: 0.362 ± 0.008
0.791CysIle: 0.791 ± 0.012
0.562CysLys: 0.562 ± 0.01
1.334CysLeu: 1.334 ± 0.015
0.277CysMet: 0.277 ± 0.006
0.452CysAsn: 0.452 ± 0.009
0.705CysPro: 0.705 ± 0.013
0.5CysGln: 0.5 ± 0.009
0.8CysArg: 0.8 ± 0.011
0.953CysSer: 0.953 ± 0.013
0.746CysThr: 0.746 ± 0.013
0.852CysVal: 0.852 ± 0.013
0.244CysTrp: 0.244 ± 0.006
0.379CysTyr: 0.379 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
4.747AspAla: 4.747 ± 0.031
0.691AspCys: 0.691 ± 0.014
4.66AspAsp: 4.66 ± 0.052
4.696AspGlu: 4.696 ± 0.039
2.295AspPhe: 2.295 ± 0.018
4.252AspGly: 4.252 ± 0.029
1.26AspHis: 1.26 ± 0.014
3.094AspIle: 3.094 ± 0.023
2.654AspLys: 2.654 ± 0.025
5.196AspLeu: 5.196 ± 0.031
1.38AspMet: 1.38 ± 0.013
1.963AspAsn: 1.963 ± 0.019
3.409AspPro: 3.409 ± 0.025
1.963AspGln: 1.963 ± 0.018
3.035AspArg: 3.035 ± 0.027
4.164AspSer: 4.164 ± 0.031
3.019AspThr: 3.019 ± 0.02
3.745AspVal: 3.745 ± 0.025
0.983AspTrp: 0.983 ± 0.012
1.609AspTyr: 1.609 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
5.699GluAla: 5.699 ± 0.064
0.699GluCys: 0.699 ± 0.011
4.296GluAsp: 4.296 ± 0.035
5.565GluGlu: 5.565 ± 0.06
2.037GluPhe: 2.037 ± 0.02
3.867GluGly: 3.867 ± 0.024
1.403GluHis: 1.403 ± 0.014
3.017GluIle: 3.017 ± 0.024
3.729GluLys: 3.729 ± 0.035
5.233GluLeu: 5.233 ± 0.031
1.535GluMet: 1.535 ± 0.015
2.276GluAsn: 2.276 ± 0.017
3.146GluPro: 3.146 ± 0.052
2.374GluGln: 2.374 ± 0.02
3.795GluArg: 3.795 ± 0.034
4.3GluSer: 4.3 ± 0.031
3.776GluThr: 3.776 ± 0.031
3.685GluVal: 3.685 ± 0.026
0.96GluTrp: 0.96 ± 0.012
1.689GluTyr: 1.689 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.051PheAla: 3.051 ± 0.023
0.614PheCys: 0.614 ± 0.009
2.361PheAsp: 2.361 ± 0.019
2.21PheGlu: 2.21 ± 0.016
1.724PhePhe: 1.724 ± 0.022
2.957PheGly: 2.957 ± 0.025
0.924PheHis: 0.924 ± 0.013
1.966PheIle: 1.966 ± 0.019
1.625PheLys: 1.625 ± 0.015
3.562PheLeu: 3.562 ± 0.032
0.851PheMet: 0.851 ± 0.012
1.49PheAsn: 1.49 ± 0.015
1.975PhePro: 1.975 ± 0.023
1.448PheGln: 1.448 ± 0.013
1.973PheArg: 1.973 ± 0.017
2.982PheSer: 2.982 ± 0.023
2.18PheThr: 2.18 ± 0.017
2.451PheVal: 2.451 ± 0.02
0.725PheTrp: 0.725 ± 0.01
1.135PheTyr: 1.135 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
5.2GlyAla: 5.2 ± 0.03
0.961GlyCys: 0.961 ± 0.014
3.806GlyAsp: 3.806 ± 0.03
3.684GlyGlu: 3.684 ± 0.025
2.969GlyPhe: 2.969 ± 0.025
5.547GlyGly: 5.547 ± 0.053
1.735GlyHis: 1.735 ± 0.016
3.674GlyIle: 3.674 ± 0.028
3.421GlyLys: 3.421 ± 0.028
6.252GlyLeu: 6.252 ± 0.034
1.635GlyMet: 1.635 ± 0.016
2.569GlyAsn: 2.569 ± 0.025
3.389GlyPro: 3.389 ± 0.025
2.651GlyGln: 2.651 ± 0.025
4.078GlyArg: 4.078 ± 0.029
5.687GlySer: 5.687 ± 0.068
4.033GlyThr: 4.033 ± 0.043
4.391GlyVal: 4.391 ± 0.03
1.277GlyTrp: 1.277 ± 0.018
2.182GlyTyr: 2.182 ± 0.02
0.0GlyXaa: 0.0 ± 0.0
His
1.731HisAla: 1.731 ± 0.017
0.344HisCys: 0.344 ± 0.008
1.368HisAsp: 1.368 ± 0.016
1.356HisGlu: 1.356 ± 0.015
0.945HisPhe: 0.945 ± 0.012
1.763HisGly: 1.763 ± 0.019
0.872HisHis: 0.872 ± 0.017
1.214HisIle: 1.214 ± 0.015
0.926HisLys: 0.926 ± 0.012
2.294HisLeu: 2.294 ± 0.022
0.497HisMet: 0.497 ± 0.009
0.804HisAsn: 0.804 ± 0.012
1.564HisPro: 1.564 ± 0.018
0.993HisGln: 0.993 ± 0.012
1.505HisArg: 1.505 ± 0.017
1.681HisSer: 1.681 ± 0.019
1.192HisThr: 1.192 ± 0.016
1.473HisVal: 1.473 ± 0.016
0.379HisTrp: 0.379 ± 0.008
0.682HisTyr: 0.682 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
4.147IleAla: 4.147 ± 0.026
0.808IleCys: 0.808 ± 0.012
2.932IleAsp: 2.932 ± 0.023
2.952IleGlu: 2.952 ± 0.025
2.06IlePhe: 2.06 ± 0.02
3.31IleGly: 3.31 ± 0.029
1.199IleHis: 1.199 ± 0.014
2.684IleIle: 2.684 ± 0.027
2.268IleLys: 2.268 ± 0.019
4.655IleLeu: 4.655 ± 0.031
1.106IleMet: 1.106 ± 0.014
1.861IleAsn: 1.861 ± 0.017
3.026IlePro: 3.026 ± 0.021
1.94IleGln: 1.94 ± 0.018
2.821IleArg: 2.821 ± 0.019
3.785IleSer: 3.785 ± 0.024
2.948IleThr: 2.948 ± 0.039
3.219IleVal: 3.219 ± 0.023
0.819IleTrp: 0.819 ± 0.012
1.424IleTyr: 1.424 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
4.357LysAla: 4.357 ± 0.028
0.547LysCys: 0.547 ± 0.01
2.985LysAsp: 2.985 ± 0.026
3.422LysGlu: 3.422 ± 0.031
1.527LysPhe: 1.527 ± 0.014
3.058LysGly: 3.058 ± 0.023
1.161LysHis: 1.161 ± 0.013
2.248LysIle: 2.248 ± 0.019
3.283LysLys: 3.283 ± 0.038
4.112LysLeu: 4.112 ± 0.027
1.068LysMet: 1.068 ± 0.012
1.735LysAsn: 1.735 ± 0.016
2.864LysPro: 2.864 ± 0.029
1.75LysGln: 1.75 ± 0.019
3.201LysArg: 3.201 ± 0.026
3.367LysSer: 3.367 ± 0.027
2.991LysThr: 2.991 ± 0.023
2.907LysVal: 2.907 ± 0.023
0.727LysTrp: 0.727 ± 0.011
1.361LysTyr: 1.361 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
7.912LeuAla: 7.912 ± 0.042
1.286LeuCys: 1.286 ± 0.015
5.369LeuAsp: 5.369 ± 0.033
5.641LeuGlu: 5.641 ± 0.036
3.448LeuPhe: 3.448 ± 0.029
6.198LeuGly: 6.198 ± 0.041
2.171LeuHis: 2.171 ± 0.02
4.082LeuIle: 4.082 ± 0.028
4.182LeuLys: 4.182 ± 0.033
8.309LeuLeu: 8.309 ± 0.053
1.88LeuMet: 1.88 ± 0.019
3.12LeuAsn: 3.12 ± 0.022
5.292LeuPro: 5.292 ± 0.03
3.665LeuGln: 3.665 ± 0.029
5.541LeuArg: 5.541 ± 0.031
7.098LeuSer: 7.098 ± 0.042
4.835LeuThr: 4.835 ± 0.03
5.632LeuVal: 5.632 ± 0.038
1.312LeuTrp: 1.312 ± 0.016
2.372LeuTyr: 2.372 ± 0.02
0.0LeuXaa: 0.0 ± 0.0
Met
2.383MetAla: 2.383 ± 0.018
0.269MetCys: 0.269 ± 0.006
1.318MetAsp: 1.318 ± 0.014
1.31MetGlu: 1.31 ± 0.014
0.795MetPhe: 0.795 ± 0.011
1.549MetGly: 1.549 ± 0.017
0.477MetHis: 0.477 ± 0.009
1.059MetIle: 1.059 ± 0.013
1.023MetLys: 1.023 ± 0.011
1.882MetLeu: 1.882 ± 0.018
0.635MetMet: 0.635 ± 0.009
0.791MetAsn: 0.791 ± 0.012
1.326MetPro: 1.326 ± 0.014
0.791MetGln: 0.791 ± 0.01
1.273MetArg: 1.273 ± 0.014
1.933MetSer: 1.933 ± 0.02
1.39MetThr: 1.39 ± 0.014
1.381MetVal: 1.381 ± 0.015
0.295MetTrp: 0.295 ± 0.007
0.523MetTyr: 0.523 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.93AsnAla: 2.93 ± 0.021
0.481AsnCys: 0.481 ± 0.009
1.995AsnAsp: 1.995 ± 0.017
2.004AsnGlu: 2.004 ± 0.02
1.366AsnPhe: 1.366 ± 0.014
2.923AsnGly: 2.923 ± 0.027
0.845AsnHis: 0.845 ± 0.012
1.981AsnIle: 1.981 ± 0.019
1.634AsnLys: 1.634 ± 0.018
3.302AsnLeu: 3.302 ± 0.024
0.878AsnMet: 0.878 ± 0.012
1.471AsnAsn: 1.471 ± 0.022
2.425AsnPro: 2.425 ± 0.02
1.322AsnGln: 1.322 ± 0.016
1.861AsnArg: 1.861 ± 0.018
2.611AsnSer: 2.611 ± 0.021
2.086AsnThr: 2.086 ± 0.019
2.272AsnVal: 2.272 ± 0.02
0.597AsnTrp: 0.597 ± 0.009
1.057AsnTyr: 1.057 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
4.999ProAla: 4.999 ± 0.049
0.562ProCys: 0.562 ± 0.011
3.42ProAsp: 3.42 ± 0.025
4.189ProGlu: 4.189 ± 0.035
2.095ProPhe: 2.095 ± 0.02
4.047ProGly: 4.047 ± 0.049
1.249ProHis: 1.249 ± 0.015
2.569ProIle: 2.569 ± 0.024
2.756ProLys: 2.756 ± 0.025
4.639ProLeu: 4.639 ± 0.03
1.103ProMet: 1.103 ± 0.013
2.172ProAsn: 2.172 ± 0.018
4.765ProPro: 4.765 ± 0.053
2.444ProGln: 2.444 ± 0.027
3.392ProArg: 3.392 ± 0.03
5.655ProSer: 5.655 ± 0.039
3.894ProThr: 3.894 ± 0.037
3.587ProVal: 3.587 ± 0.031
0.836ProTrp: 0.836 ± 0.013
1.475ProTyr: 1.475 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.443GlnAla: 3.443 ± 0.027
0.442GlnCys: 0.442 ± 0.008
2.256GlnAsp: 2.256 ± 0.02
2.448GlnGlu: 2.448 ± 0.023
1.272GlnPhe: 1.272 ± 0.014
2.527GlnGly: 2.527 ± 0.023
1.041GlnHis: 1.041 ± 0.014
1.774GlnIle: 1.774 ± 0.018
1.847GlnLys: 1.847 ± 0.018
3.386GlnLeu: 3.386 ± 0.025
0.86GlnMet: 0.86 ± 0.012
1.413GlnAsn: 1.413 ± 0.015
2.557GlnPro: 2.557 ± 0.034
2.297GlnGln: 2.297 ± 0.04
2.478GlnArg: 2.478 ± 0.02
2.873GlnSer: 2.873 ± 0.027
2.266GlnThr: 2.266 ± 0.021
2.291GlnVal: 2.291 ± 0.019
0.59GlnTrp: 0.59 ± 0.01
1.091GlnTyr: 1.091 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
4.438ArgAla: 4.438 ± 0.026
0.749ArgCys: 0.749 ± 0.011
3.501ArgAsp: 3.501 ± 0.034
3.682ArgGlu: 3.682 ± 0.031
2.165ArgPhe: 2.165 ± 0.018
3.676ArgGly: 3.676 ± 0.025
1.584ArgHis: 1.584 ± 0.017
2.844ArgIle: 2.844 ± 0.024
3.206ArgLys: 3.206 ± 0.025
5.453ArgLeu: 5.453 ± 0.031
1.294ArgMet: 1.294 ± 0.015
2.169ArgAsn: 2.169 ± 0.019
3.483ArgPro: 3.483 ± 0.032
2.523ArgGln: 2.523 ± 0.023
4.982ArgArg: 4.982 ± 0.042
4.451ArgSer: 4.451 ± 0.035
3.101ArgThr: 3.101 ± 0.023
3.392ArgVal: 3.392 ± 0.024
1.009ArgTrp: 1.009 ± 0.013
1.657ArgTyr: 1.657 ± 0.016
0.0ArgXaa: 0.0 ± 0.0
Ser
6.09SerAla: 6.09 ± 0.034
0.929SerCys: 0.929 ± 0.015
4.264SerAsp: 4.264 ± 0.032
4.164SerGlu: 4.164 ± 0.033
3.058SerPhe: 3.058 ± 0.024
5.45SerGly: 5.45 ± 0.077
1.863SerHis: 1.863 ± 0.02
3.964SerIle: 3.964 ± 0.029
3.658SerLys: 3.658 ± 0.025
7.053SerLeu: 7.053 ± 0.034
1.743SerMet: 1.743 ± 0.016
2.864SerAsn: 2.864 ± 0.022
5.153SerPro: 5.153 ± 0.048
3.127SerGln: 3.127 ± 0.027
4.834SerArg: 4.834 ± 0.033
8.024SerSer: 8.024 ± 0.058
5.365SerThr: 5.365 ± 0.046
4.504SerVal: 4.504 ± 0.028
1.256SerTrp: 1.256 ± 0.016
2.039SerTyr: 2.039 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
5.043ThrAla: 5.043 ± 0.036
0.819ThrCys: 0.819 ± 0.011
2.906ThrAsp: 2.906 ± 0.025
3.363ThrGlu: 3.363 ± 0.036
2.284ThrPhe: 2.284 ± 0.021
4.182ThrGly: 4.182 ± 0.033
1.233ThrHis: 1.233 ± 0.014
3.187ThrIle: 3.187 ± 0.036
2.739ThrLys: 2.739 ± 0.022
5.262ThrLeu: 5.262 ± 0.028
1.241ThrMet: 1.241 ± 0.013
2.079ThrAsn: 2.079 ± 0.018
4.246ThrPro: 4.246 ± 0.042
2.06ThrGln: 2.06 ± 0.02
3.135ThrArg: 3.135 ± 0.02
5.108ThrSer: 5.108 ± 0.042
4.387ThrThr: 4.387 ± 0.056
3.809ThrVal: 3.809 ± 0.043
0.974ThrTrp: 0.974 ± 0.013
1.623ThrTyr: 1.623 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.289ValAla: 5.289 ± 0.031
0.873ValCys: 0.873 ± 0.013
3.818ValAsp: 3.818 ± 0.024
4.039ValGlu: 4.039 ± 0.028
2.553ValPhe: 2.553 ± 0.024
4.05ValGly: 4.05 ± 0.029
1.364ValHis: 1.364 ± 0.014
3.099ValIle: 3.099 ± 0.026
2.99ValLys: 2.99 ± 0.022
5.579ValLeu: 5.579 ± 0.037
1.357ValMet: 1.357 ± 0.016
2.238ValAsn: 2.238 ± 0.02
3.625ValPro: 3.625 ± 0.028
2.345ValGln: 2.345 ± 0.02
3.365ValArg: 3.365 ± 0.023
4.632ValSer: 4.632 ± 0.027
3.693ValThr: 3.693 ± 0.044
4.446ValVal: 4.446 ± 0.032
0.926ValTrp: 0.926 ± 0.013
1.766ValTyr: 1.766 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.261TrpAla: 1.261 ± 0.016
0.225TrpCys: 0.225 ± 0.006
0.97TrpAsp: 0.97 ± 0.012
0.933TrpGlu: 0.933 ± 0.012
0.622TrpPhe: 0.622 ± 0.01
1.058TrpGly: 1.058 ± 0.014
0.395TrpHis: 0.395 ± 0.009
0.86TrpIle: 0.86 ± 0.013
0.89TrpLys: 0.89 ± 0.012
1.476TrpLeu: 1.476 ± 0.016
0.404TrpMet: 0.404 ± 0.008
0.664TrpAsn: 0.664 ± 0.011
0.686TrpPro: 0.686 ± 0.011
0.595TrpGln: 0.595 ± 0.01
0.998TrpArg: 0.998 ± 0.012
1.135TrpSer: 1.135 ± 0.014
1.047TrpThr: 1.047 ± 0.012
0.998TrpVal: 0.998 ± 0.014
0.314TrpTrp: 0.314 ± 0.006
0.468TrpTyr: 0.468 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.087TyrAla: 2.087 ± 0.018
0.451TyrCys: 0.451 ± 0.008
1.673TyrAsp: 1.673 ± 0.018
1.563TyrGlu: 1.563 ± 0.015
1.204TyrPhe: 1.204 ± 0.012
2.106TyrGly: 2.106 ± 0.019
0.75TyrHis: 0.75 ± 0.01
1.403TyrIle: 1.403 ± 0.018
1.134TyrLys: 1.134 ± 0.015
2.638TyrLeu: 2.638 ± 0.022
0.631TyrMet: 0.631 ± 0.01
1.107TyrAsn: 1.107 ± 0.014
1.453TyrPro: 1.453 ± 0.016
1.106TyrGln: 1.106 ± 0.013
1.633TyrArg: 1.633 ± 0.018
1.978TyrSer: 1.978 ± 0.015
1.589TyrThr: 1.589 ± 0.02
1.653TyrVal: 1.653 ± 0.017
0.494TyrTrp: 0.494 ± 0.009
0.919TyrTyr: 0.919 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15273 proteins (7097187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski