Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA382A03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.692AlaAla: 3.692 ± 0.239
0.572AlaCys: 0.572 ± 0.077
3.459AlaAsp: 3.459 ± 0.194
5.601AlaGlu: 5.601 ± 0.248
2.364AlaPhe: 2.364 ± 0.142
4.147AlaGly: 4.147 ± 0.217
0.969AlaHis: 0.969 ± 0.1
4.535AlaIle: 4.535 ± 0.25
4.971AlaLys: 4.971 ± 0.211
5.775AlaLeu: 5.775 ± 0.21
1.444AlaMet: 1.444 ± 0.126
1.899AlaAsn: 1.899 ± 0.141
1.919AlaPro: 1.919 ± 0.147
1.376AlaGln: 1.376 ± 0.125
2.849AlaArg: 2.849 ± 0.188
3.314AlaSer: 3.314 ± 0.185
2.558AlaThr: 2.558 ± 0.154
4.215AlaVal: 4.215 ± 0.238
0.533AlaTrp: 0.533 ± 0.067
1.783AlaTyr: 1.783 ± 0.139
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.067
0.242CysCys: 0.242 ± 0.057
0.64CysAsp: 0.64 ± 0.077
0.833CysGlu: 0.833 ± 0.105
0.388CysPhe: 0.388 ± 0.054
0.998CysGly: 0.998 ± 0.125
0.252CysHis: 0.252 ± 0.05
0.64CysIle: 0.64 ± 0.077
0.659CysLys: 0.659 ± 0.08
0.649CysLeu: 0.649 ± 0.084
0.136CysMet: 0.136 ± 0.037
0.223CysAsn: 0.223 ± 0.043
0.766CysPro: 0.766 ± 0.079
0.262CysGln: 0.262 ± 0.058
0.446CysArg: 0.446 ± 0.063
0.649CysSer: 0.649 ± 0.072
0.455CysThr: 0.455 ± 0.065
0.465CysVal: 0.465 ± 0.075
0.087CysTrp: 0.087 ± 0.027
0.31CysTyr: 0.31 ± 0.058
0.0CysXaa: 0.0 ± 0.0
Asp
2.907AspAla: 2.907 ± 0.175
0.533AspCys: 0.533 ± 0.068
3.023AspAsp: 3.023 ± 0.165
5.717AspGlu: 5.717 ± 0.206
3.12AspPhe: 3.12 ± 0.171
3.362AspGly: 3.362 ± 0.231
0.988AspHis: 0.988 ± 0.1
4.709AspIle: 4.709 ± 0.207
4.448AspLys: 4.448 ± 0.226
6.386AspLeu: 6.386 ± 0.242
1.298AspMet: 1.298 ± 0.118
1.938AspAsn: 1.938 ± 0.142
2.529AspPro: 2.529 ± 0.163
1.57AspGln: 1.57 ± 0.119
3.207AspArg: 3.207 ± 0.174
3.517AspSer: 3.517 ± 0.202
2.539AspThr: 2.539 ± 0.144
4.05AspVal: 4.05 ± 0.213
0.833AspTrp: 0.833 ± 0.109
2.413AspTyr: 2.413 ± 0.138
0.0AspXaa: 0.0 ± 0.0
Glu
5.649GluAla: 5.649 ± 0.24
0.717GluCys: 0.717 ± 0.083
5.882GluAsp: 5.882 ± 0.286
12.083GluGlu: 12.083 ± 0.474
3.324GluPhe: 3.324 ± 0.183
5.775GluGly: 5.775 ± 0.265
1.395GluHis: 1.395 ± 0.123
8.556GluIle: 8.556 ± 0.364
12.723GluLys: 12.723 ± 0.424
8.682GluLeu: 8.682 ± 0.301
2.616GluMet: 2.616 ± 0.151
5.601GluAsn: 5.601 ± 0.226
2.955GluPro: 2.955 ± 0.186
1.812GluGln: 1.812 ± 0.136
5.407GluArg: 5.407 ± 0.281
5.116GluSer: 5.116 ± 0.22
5.165GluThr: 5.165 ± 0.225
5.368GluVal: 5.368 ± 0.213
0.95GluTrp: 0.95 ± 0.108
2.82GluTyr: 2.82 ± 0.163
0.0GluXaa: 0.0 ± 0.0
Phe
2.112PheAla: 2.112 ± 0.168
0.407PheCys: 0.407 ± 0.071
2.907PheAsp: 2.907 ± 0.183
3.847PheGlu: 3.847 ± 0.22
1.86PhePhe: 1.86 ± 0.194
2.704PheGly: 2.704 ± 0.2
0.698PheHis: 0.698 ± 0.082
2.345PheIle: 2.345 ± 0.16
2.539PheLys: 2.539 ± 0.159
3.944PheLeu: 3.944 ± 0.204
0.872PheMet: 0.872 ± 0.108
1.308PheAsn: 1.308 ± 0.119
1.667PhePro: 1.667 ± 0.143
1.143PheGln: 1.143 ± 0.101
1.541PheArg: 1.541 ± 0.128
3.382PheSer: 3.382 ± 0.171
1.696PheThr: 1.696 ± 0.134
2.461PheVal: 2.461 ± 0.146
0.465PheTrp: 0.465 ± 0.074
1.434PheTyr: 1.434 ± 0.109
0.0PheXaa: 0.0 ± 0.0
Gly
3.886GlyAla: 3.886 ± 0.204
0.62GlyCys: 0.62 ± 0.087
3.421GlyAsp: 3.421 ± 0.201
6.473GlyGlu: 6.473 ± 0.265
2.771GlyPhe: 2.771 ± 0.199
5.116GlyGly: 5.116 ± 0.283
0.998GlyHis: 0.998 ± 0.112
5.417GlyIle: 5.417 ± 0.262
6.231GlyLys: 6.231 ± 0.259
5.766GlyLeu: 5.766 ± 0.265
1.928GlyMet: 1.928 ± 0.145
2.626GlyAsn: 2.626 ± 0.183
2.374GlyPro: 2.374 ± 0.183
1.415GlyGln: 1.415 ± 0.093
3.595GlyArg: 3.595 ± 0.192
3.711GlySer: 3.711 ± 0.212
3.43GlyThr: 3.43 ± 0.198
4.68GlyVal: 4.68 ± 0.217
0.64GlyTrp: 0.64 ± 0.088
2.287GlyTyr: 2.287 ± 0.134
0.0GlyXaa: 0.0 ± 0.0
His
1.037HisAla: 1.037 ± 0.104
0.174HisCys: 0.174 ± 0.047
0.988HisAsp: 0.988 ± 0.098
1.376HisGlu: 1.376 ± 0.096
0.795HisPhe: 0.795 ± 0.099
1.347HisGly: 1.347 ± 0.124
0.291HisHis: 0.291 ± 0.062
1.095HisIle: 1.095 ± 0.106
0.988HisLys: 0.988 ± 0.121
1.609HisLeu: 1.609 ± 0.123
0.242HisMet: 0.242 ± 0.045
0.64HisAsn: 0.64 ± 0.085
0.959HisPro: 0.959 ± 0.113
0.494HisGln: 0.494 ± 0.07
0.891HisArg: 0.891 ± 0.089
0.979HisSer: 0.979 ± 0.09
0.795HisThr: 0.795 ± 0.091
1.037HisVal: 1.037 ± 0.096
0.203HisTrp: 0.203 ± 0.052
0.736HisTyr: 0.736 ± 0.079
0.0HisXaa: 0.0 ± 0.0
Ile
5.068IleAla: 5.068 ± 0.245
0.824IleCys: 0.824 ± 0.094
4.545IleAsp: 4.545 ± 0.21
7.781IleGlu: 7.781 ± 0.297
2.868IlePhe: 2.868 ± 0.169
5.126IleGly: 5.126 ± 0.277
1.279IleHis: 1.279 ± 0.104
5.591IleIle: 5.591 ± 0.289
5.436IleLys: 5.436 ± 0.266
6.919IleLeu: 6.919 ± 0.278
1.57IleMet: 1.57 ± 0.113
2.955IleAsn: 2.955 ± 0.17
3.498IlePro: 3.498 ± 0.183
2.025IleGln: 2.025 ± 0.154
3.663IleArg: 3.663 ± 0.19
5.281IleSer: 5.281 ± 0.234
3.798IleThr: 3.798 ± 0.195
4.632IleVal: 4.632 ± 0.223
0.64IleTrp: 0.64 ± 0.08
1.986IleTyr: 1.986 ± 0.137
0.0IleXaa: 0.0 ± 0.0
Lys
5.204LysAla: 5.204 ± 0.218
0.882LysCys: 0.882 ± 0.103
4.797LysAsp: 4.797 ± 0.264
9.661LysGlu: 9.661 ± 0.386
2.723LysPhe: 2.723 ± 0.161
5.126LysGly: 5.126 ± 0.232
1.395LysHis: 1.395 ± 0.122
8.343LysIle: 8.343 ± 0.38
9.961LysLys: 9.961 ± 0.428
6.957LysLeu: 6.957 ± 0.297
1.628LysMet: 1.628 ± 0.135
5.058LysAsn: 5.058 ± 0.271
2.674LysPro: 2.674 ± 0.152
2.112LysGln: 2.112 ± 0.139
4.642LysArg: 4.642 ± 0.204
4.806LysSer: 4.806 ± 0.244
4.709LysThr: 4.709 ± 0.205
4.787LysVal: 4.787 ± 0.197
0.833LysTrp: 0.833 ± 0.093
2.442LysTyr: 2.442 ± 0.185
0.0LysXaa: 0.0 ± 0.0
Leu
5.581LeuAla: 5.581 ± 0.226
0.717LeuCys: 0.717 ± 0.075
6.163LeuAsp: 6.163 ± 0.257
9.835LeuGlu: 9.835 ± 0.348
3.295LeuPhe: 3.295 ± 0.212
5.785LeuGly: 5.785 ± 0.226
1.415LeuHis: 1.415 ± 0.126
5.921LeuIle: 5.921 ± 0.301
7.8LeuLys: 7.8 ± 0.308
7.035LeuLeu: 7.035 ± 0.329
1.812LeuMet: 1.812 ± 0.125
4.05LeuAsn: 4.05 ± 0.196
3.333LeuPro: 3.333 ± 0.192
2.413LeuGln: 2.413 ± 0.147
4.341LeuArg: 4.341 ± 0.203
6.55LeuSer: 6.55 ± 0.254
3.992LeuThr: 3.992 ± 0.202
5.087LeuVal: 5.087 ± 0.257
0.853LeuTrp: 0.853 ± 0.09
2.219LeuTyr: 2.219 ± 0.148
0.0LeuXaa: 0.0 ± 0.0
Met
1.25MetAla: 1.25 ± 0.119
0.194MetCys: 0.194 ± 0.042
1.376MetAsp: 1.376 ± 0.112
1.822MetGlu: 1.822 ± 0.14
0.824MetPhe: 0.824 ± 0.089
1.492MetGly: 1.492 ± 0.146
0.223MetHis: 0.223 ± 0.045
1.463MetIle: 1.463 ± 0.118
2.413MetLys: 2.413 ± 0.15
1.579MetLeu: 1.579 ± 0.109
0.572MetMet: 0.572 ± 0.077
1.047MetAsn: 1.047 ± 0.097
0.891MetPro: 0.891 ± 0.112
0.572MetGln: 0.572 ± 0.068
1.172MetArg: 1.172 ± 0.096
1.512MetSer: 1.512 ± 0.104
1.366MetThr: 1.366 ± 0.11
1.56MetVal: 1.56 ± 0.126
0.136MetTrp: 0.136 ± 0.031
0.514MetTyr: 0.514 ± 0.069
0.0MetXaa: 0.0 ± 0.0
Asn
2.306AsnAla: 2.306 ± 0.14
0.591AsnCys: 0.591 ± 0.093
1.686AsnAsp: 1.686 ± 0.132
3.362AsnGlu: 3.362 ± 0.149
2.016AsnPhe: 2.016 ± 0.14
2.345AsnGly: 2.345 ± 0.178
0.843AsnHis: 0.843 ± 0.082
3.866AsnIle: 3.866 ± 0.19
3.227AsnLys: 3.227 ± 0.195
4.564AsnLeu: 4.564 ± 0.218
0.824AsnMet: 0.824 ± 0.091
1.735AsnAsn: 1.735 ± 0.152
2.81AsnPro: 2.81 ± 0.171
1.182AsnGln: 1.182 ± 0.112
2.267AsnArg: 2.267 ± 0.136
2.936AsnSer: 2.936 ± 0.178
1.986AsnThr: 1.986 ± 0.155
2.752AsnVal: 2.752 ± 0.133
0.601AsnTrp: 0.601 ± 0.077
1.521AsnTyr: 1.521 ± 0.114
0.0AsnXaa: 0.0 ± 0.0
Pro
2.248ProAla: 2.248 ± 0.14
0.242ProCys: 0.242 ± 0.045
2.655ProAsp: 2.655 ± 0.175
4.767ProGlu: 4.767 ± 0.248
1.686ProPhe: 1.686 ± 0.132
2.742ProGly: 2.742 ± 0.176
0.833ProHis: 0.833 ± 0.074
2.704ProIle: 2.704 ± 0.175
2.626ProLys: 2.626 ± 0.166
3.295ProLeu: 3.295 ± 0.18
0.736ProMet: 0.736 ± 0.089
1.696ProAsn: 1.696 ± 0.122
1.667ProPro: 1.667 ± 0.122
1.017ProGln: 1.017 ± 0.092
1.705ProArg: 1.705 ± 0.13
2.519ProSer: 2.519 ± 0.17
1.725ProThr: 1.725 ± 0.133
2.704ProVal: 2.704 ± 0.183
0.368ProTrp: 0.368 ± 0.074
1.502ProTyr: 1.502 ± 0.113
0.0ProXaa: 0.0 ± 0.0
Gln
1.638GlnAla: 1.638 ± 0.124
0.136GlnCys: 0.136 ± 0.041
1.347GlnAsp: 1.347 ± 0.116
2.771GlnGlu: 2.771 ± 0.177
0.911GlnPhe: 0.911 ± 0.101
1.638GlnGly: 1.638 ± 0.135
0.407GlnHis: 0.407 ± 0.063
1.754GlnIle: 1.754 ± 0.117
2.568GlnLys: 2.568 ± 0.173
2.025GlnLeu: 2.025 ± 0.148
0.63GlnMet: 0.63 ± 0.074
1.308GlnAsn: 1.308 ± 0.097
0.756GlnPro: 0.756 ± 0.089
0.485GlnGln: 0.485 ± 0.065
1.269GlnArg: 1.269 ± 0.125
1.337GlnSer: 1.337 ± 0.104
1.202GlnThr: 1.202 ± 0.116
1.657GlnVal: 1.657 ± 0.129
0.3GlnTrp: 0.3 ± 0.056
0.785GlnTyr: 0.785 ± 0.084
0.0GlnXaa: 0.0 ± 0.0
Arg
2.888ArgAla: 2.888 ± 0.159
0.378ArgCys: 0.378 ± 0.061
2.897ArgAsp: 2.897 ± 0.174
5.824ArgGlu: 5.824 ± 0.264
1.802ArgPhe: 1.802 ± 0.143
3.663ArgGly: 3.663 ± 0.216
0.649ArgHis: 0.649 ± 0.081
4.138ArgIle: 4.138 ± 0.2
5.698ArgLys: 5.698 ± 0.29
3.789ArgLeu: 3.789 ± 0.2
1.221ArgMet: 1.221 ± 0.097
2.364ArgAsn: 2.364 ± 0.108
1.599ArgPro: 1.599 ± 0.116
1.056ArgGln: 1.056 ± 0.102
2.985ArgArg: 2.985 ± 0.203
2.558ArgSer: 2.558 ± 0.172
2.316ArgThr: 2.316 ± 0.16
2.752ArgVal: 2.752 ± 0.174
0.63ArgTrp: 0.63 ± 0.091
1.531ArgTyr: 1.531 ± 0.123
0.0ArgXaa: 0.0 ± 0.0
Ser
3.062SerAla: 3.062 ± 0.172
0.591SerCys: 0.591 ± 0.09
3.963SerAsp: 3.963 ± 0.191
6.657SerGlu: 6.657 ± 0.264
2.752SerPhe: 2.752 ± 0.188
4.806SerGly: 4.806 ± 0.232
1.124SerHis: 1.124 ± 0.097
4.477SerIle: 4.477 ± 0.21
5.233SerLys: 5.233 ± 0.236
5.62SerLeu: 5.62 ± 0.272
1.395SerMet: 1.395 ± 0.126
2.684SerAsn: 2.684 ± 0.173
2.306SerPro: 2.306 ± 0.169
1.735SerGln: 1.735 ± 0.126
3.13SerArg: 3.13 ± 0.162
4.225SerSer: 4.225 ± 0.249
2.8SerThr: 2.8 ± 0.17
3.837SerVal: 3.837 ± 0.21
0.707SerTrp: 0.707 ± 0.084
1.725SerTyr: 1.725 ± 0.119
0.0SerXaa: 0.0 ± 0.0
Thr
2.868ThrAla: 2.868 ± 0.176
0.581ThrCys: 0.581 ± 0.089
2.752ThrAsp: 2.752 ± 0.181
4.293ThrGlu: 4.293 ± 0.198
1.87ThrPhe: 1.87 ± 0.132
3.76ThrGly: 3.76 ± 0.19
0.911ThrHis: 0.911 ± 0.105
3.847ThrIle: 3.847 ± 0.196
3.207ThrLys: 3.207 ± 0.181
4.341ThrLeu: 4.341 ± 0.225
0.901ThrMet: 0.901 ± 0.097
1.841ThrAsn: 1.841 ± 0.137
2.345ThrPro: 2.345 ± 0.162
1.386ThrGln: 1.386 ± 0.128
2.006ThrArg: 2.006 ± 0.134
3.081ThrSer: 3.081 ± 0.165
2.568ThrThr: 2.568 ± 0.164
3.517ThrVal: 3.517 ± 0.186
0.552ThrTrp: 0.552 ± 0.07
1.647ThrTyr: 1.647 ± 0.111
0.0ThrXaa: 0.0 ± 0.0
Val
3.915ValAla: 3.915 ± 0.223
0.601ValCys: 0.601 ± 0.077
3.963ValAsp: 3.963 ± 0.192
6.299ValGlu: 6.299 ± 0.223
2.432ValPhe: 2.432 ± 0.146
4.322ValGly: 4.322 ± 0.26
1.008ValHis: 1.008 ± 0.09
3.915ValIle: 3.915 ± 0.192
5.068ValLys: 5.068 ± 0.218
5.349ValLeu: 5.349 ± 0.278
1.231ValMet: 1.231 ± 0.117
2.694ValAsn: 2.694 ± 0.154
2.587ValPro: 2.587 ± 0.172
1.434ValGln: 1.434 ± 0.11
3.304ValArg: 3.304 ± 0.209
4.322ValSer: 4.322 ± 0.2
3.236ValThr: 3.236 ± 0.179
4.05ValVal: 4.05 ± 0.213
0.669ValTrp: 0.669 ± 0.09
1.647ValTyr: 1.647 ± 0.135
0.0ValXaa: 0.0 ± 0.0
Trp
0.581TrpAla: 0.581 ± 0.09
0.107TrpCys: 0.107 ± 0.031
0.669TrpAsp: 0.669 ± 0.084
0.814TrpGlu: 0.814 ± 0.091
0.3TrpPhe: 0.3 ± 0.055
0.717TrpGly: 0.717 ± 0.076
0.174TrpHis: 0.174 ± 0.042
0.64TrpIle: 0.64 ± 0.09
1.037TrpLys: 1.037 ± 0.104
1.008TrpLeu: 1.008 ± 0.094
0.291TrpMet: 0.291 ± 0.054
0.601TrpAsn: 0.601 ± 0.072
0.291TrpPro: 0.291 ± 0.057
0.3TrpGln: 0.3 ± 0.068
0.61TrpArg: 0.61 ± 0.075
0.804TrpSer: 0.804 ± 0.091
0.494TrpThr: 0.494 ± 0.064
0.649TrpVal: 0.649 ± 0.082
0.165TrpTrp: 0.165 ± 0.041
0.271TrpTyr: 0.271 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.657TyrAla: 1.657 ± 0.14
0.417TyrCys: 0.417 ± 0.064
1.957TyrAsp: 1.957 ± 0.136
2.791TyrGlu: 2.791 ± 0.148
1.231TyrPhe: 1.231 ± 0.117
2.413TyrGly: 2.413 ± 0.167
0.824TyrHis: 0.824 ± 0.08
1.531TyrIle: 1.531 ± 0.118
1.909TyrLys: 1.909 ± 0.143
2.907TyrLeu: 2.907 ± 0.174
0.62TyrMet: 0.62 ± 0.074
1.153TyrAsn: 1.153 ± 0.09
1.512TyrPro: 1.512 ± 0.122
1.134TyrGln: 1.134 ± 0.107
1.705TyrArg: 1.705 ± 0.147
2.229TyrSer: 2.229 ± 0.154
1.444TyrThr: 1.444 ± 0.13
1.783TyrVal: 1.783 ± 0.129
0.359TyrTrp: 0.359 ± 0.057
1.25TyrTyr: 1.25 ± 0.126
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 427 proteins (103200 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski