Amino acid dipepetide frequency for Novosphingobium barchaimii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.855AlaAla: 17.855 ± 0.206	1.059AlaCys: 1.059 ± 0.04	7.433AlaAsp: 7.433 ± 0.088	7.205AlaGlu: 7.205 ± 0.116	4.414AlaPhe: 4.414 ± 0.061	11.076AlaGly: 11.076 ± 0.142	2.274AlaHis: 2.274 ± 0.05	6.966AlaIle: 6.966 ± 0.1	4.186AlaLys: 4.186 ± 0.075	13.599AlaLeu: 13.599 ± 0.153	4.025AlaMet: 4.025 ± 0.08	3.194AlaAsn: 3.194 ± 0.067	6.095AlaPro: 6.095 ± 0.091	4.993AlaGln: 4.993 ± 0.077	9.375AlaArg: 9.375 ± 0.123	6.863AlaSer: 6.863 ± 0.101	6.454AlaThr: 6.454 ± 0.09	8.622AlaVal: 8.622 ± 0.098	1.656AlaTrp: 1.656 ± 0.049	2.483AlaTyr: 2.483 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.035	0.081CysCys: 0.081 ± 0.009	0.545CysAsp: 0.545 ± 0.023	0.452CysGlu: 0.452 ± 0.024	0.267CysPhe: 0.267 ± 0.017	0.871CysGly: 0.871 ± 0.032	0.218CysHis: 0.218 ± 0.016	0.404CysIle: 0.404 ± 0.024	0.184CysLys: 0.184 ± 0.014	0.708CysLeu: 0.708 ± 0.023	0.154CysMet: 0.154 ± 0.013	0.215CysAsn: 0.215 ± 0.016	0.441CysPro: 0.441 ± 0.021	0.214CysGln: 0.214 ± 0.015	0.538CysArg: 0.538 ± 0.026	0.434CysSer: 0.434 ± 0.023	0.393CysThr: 0.393 ± 0.022	0.57CysVal: 0.57 ± 0.023	0.1CysTrp: 0.1 ± 0.01	0.158CysTyr: 0.158 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.457AspAla: 7.457 ± 0.096	0.453AspCys: 0.453 ± 0.025	3.237AspAsp: 3.237 ± 0.062	3.339AspGlu: 3.339 ± 0.067	2.094AspPhe: 2.094 ± 0.044	5.433AspGly: 5.433 ± 0.079	1.342AspHis: 1.342 ± 0.042	2.876AspIle: 2.876 ± 0.055	1.89AspLys: 1.89 ± 0.048	5.768AspLeu: 5.768 ± 0.08	1.347AspMet: 1.347 ± 0.036	1.348AspAsn: 1.348 ± 0.036	3.661AspPro: 3.661 ± 0.056	1.812AspGln: 1.812 ± 0.044	4.636AspArg: 4.636 ± 0.075	2.135AspSer: 2.135 ± 0.048	2.783AspThr: 2.783 ± 0.052	4.155AspVal: 4.155 ± 0.061	1.087AspTrp: 1.087 ± 0.036	1.576AspTyr: 1.576 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.684GluAla: 7.684 ± 0.123	0.334GluCys: 0.334 ± 0.017	2.81GluAsp: 2.81 ± 0.053	2.997GluGlu: 2.997 ± 0.073	1.554GluPhe: 1.554 ± 0.043	4.429GluGly: 4.429 ± 0.074	1.142GluHis: 1.142 ± 0.037	2.781GluIle: 2.781 ± 0.06	1.972GluLys: 1.972 ± 0.048	4.984GluLeu: 4.984 ± 0.08	1.478GluMet: 1.478 ± 0.042	1.362GluAsn: 1.362 ± 0.033	2.558GluPro: 2.558 ± 0.049	2.085GluGln: 2.085 ± 0.057	4.723GluArg: 4.723 ± 0.082	2.188GluSer: 2.188 ± 0.051	2.966GluThr: 2.966 ± 0.053	3.549GluVal: 3.549 ± 0.064	0.835GluTrp: 0.835 ± 0.028	0.982GluTyr: 0.982 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.831PheAla: 4.831 ± 0.078	0.354PheCys: 0.354 ± 0.018	2.53PheAsp: 2.53 ± 0.047	1.883PheGlu: 1.883 ± 0.044	1.288PhePhe: 1.288 ± 0.045	3.667PheGly: 3.667 ± 0.065	0.715PheHis: 0.715 ± 0.024	1.462PheIle: 1.462 ± 0.041	0.846PheLys: 0.846 ± 0.03	3.111PheLeu: 3.111 ± 0.054	0.755PheMet: 0.755 ± 0.025	1.07PheAsn: 1.07 ± 0.039	1.442PhePro: 1.442 ± 0.041	0.97PheGln: 0.97 ± 0.036	2.103PheArg: 2.103 ± 0.047	2.061PheSer: 2.061 ± 0.047	2.045PheThr: 2.045 ± 0.047	2.656PheVal: 2.656 ± 0.05	0.518PheTrp: 0.518 ± 0.024	0.917PheTyr: 0.917 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.735GlyAla: 9.735 ± 0.111	0.834GlyCys: 0.834 ± 0.033	4.714GlyAsp: 4.714 ± 0.068	4.802GlyGlu: 4.802 ± 0.07	3.494GlyPhe: 3.494 ± 0.065	8.025GlyGly: 8.025 ± 0.15	1.821GlyHis: 1.821 ± 0.046	4.414GlyIle: 4.414 ± 0.065	3.501GlyLys: 3.501 ± 0.07	8.885GlyLeu: 8.885 ± 0.123	2.387GlyMet: 2.387 ± 0.054	2.338GlyAsn: 2.338 ± 0.061	3.712GlyPro: 3.712 ± 0.067	3.309GlyGln: 3.309 ± 0.054	6.34GlyArg: 6.34 ± 0.081	5.02GlySer: 5.02 ± 0.086	5.044GlyThr: 5.044 ± 0.099	6.351GlyVal: 6.351 ± 0.103	1.578GlyTrp: 1.578 ± 0.048	2.385GlyTyr: 2.385 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.42HisAla: 2.42 ± 0.052	0.218HisCys: 0.218 ± 0.014	1.243HisAsp: 1.243 ± 0.033	1.039HisGlu: 1.039 ± 0.033	0.819HisPhe: 0.819 ± 0.028	1.993HisGly: 1.993 ± 0.049	0.55HisHis: 0.55 ± 0.028	0.897HisIle: 0.897 ± 0.031	0.488HisLys: 0.488 ± 0.023	1.999HisLeu: 1.999 ± 0.045	0.426HisMet: 0.426 ± 0.021	0.479HisAsn: 0.479 ± 0.022	1.292HisPro: 1.292 ± 0.035	0.6HisGln: 0.6 ± 0.024	1.493HisArg: 1.493 ± 0.046	0.951HisSer: 0.951 ± 0.038	0.778HisThr: 0.778 ± 0.028	1.45HisVal: 1.45 ± 0.041	0.339HisTrp: 0.339 ± 0.019	0.505HisTyr: 0.505 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.824IleAla: 7.824 ± 0.082	0.445IleCys: 0.445 ± 0.023	3.809IleAsp: 3.809 ± 0.063	3.362IleGlu: 3.362 ± 0.069	1.468IlePhe: 1.468 ± 0.043	5.05IleGly: 5.05 ± 0.074	0.874IleHis: 0.874 ± 0.033	2.037IleIle: 2.037 ± 0.048	1.295IleLys: 1.295 ± 0.036	3.973IleLeu: 3.973 ± 0.074	0.898IleMet: 0.898 ± 0.031	1.371IleAsn: 1.371 ± 0.033	2.3IlePro: 2.3 ± 0.047	1.173IleGln: 1.173 ± 0.032	3.132IleArg: 3.132 ± 0.064	2.7IleSer: 2.7 ± 0.053	2.75IleThr: 2.75 ± 0.057	4.347IleVal: 4.347 ± 0.073	0.575IleTrp: 0.575 ± 0.026	1.056IleTyr: 1.056 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.054LysAla: 4.054 ± 0.073	0.14LysCys: 0.14 ± 0.012	1.568LysAsp: 1.568 ± 0.04	1.334LysGlu: 1.334 ± 0.039	0.881LysPhe: 0.881 ± 0.03	2.74LysGly: 2.74 ± 0.061	0.53LysHis: 0.53 ± 0.026	1.426LysIle: 1.426 ± 0.039	1.042LysLys: 1.042 ± 0.049	3.383LysLeu: 3.383 ± 0.071	0.764LysMet: 0.764 ± 0.03	0.733LysAsn: 0.733 ± 0.028	2.024LysPro: 2.024 ± 0.054	1.037LysGln: 1.037 ± 0.037	2.241LysArg: 2.241 ± 0.057	1.657LysSer: 1.657 ± 0.045	1.672LysThr: 1.672 ± 0.045	2.404LysVal: 2.404 ± 0.057	0.381LysTrp: 0.381 ± 0.019	0.585LysTyr: 0.585 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.217LeuAla: 14.217 ± 0.163	0.801LeuCys: 0.801 ± 0.034	5.952LeuAsp: 5.952 ± 0.085	4.862LeuGlu: 4.862 ± 0.078	3.483LeuPhe: 3.483 ± 0.066	8.599LeuGly: 8.599 ± 0.099	1.84LeuHis: 1.84 ± 0.046	4.89LeuIle: 4.89 ± 0.07	2.946LeuLys: 2.946 ± 0.055	9.621LeuLeu: 9.621 ± 0.131	2.166LeuMet: 2.166 ± 0.054	2.442LeuAsn: 2.442 ± 0.058	5.675LeuPro: 5.675 ± 0.087	2.798LeuGln: 2.798 ± 0.06	7.065LeuArg: 7.065 ± 0.095	6.182LeuSer: 6.182 ± 0.077	5.784LeuThr: 5.784 ± 0.09	7.292LeuVal: 7.292 ± 0.104	1.184LeuTrp: 1.184 ± 0.031	1.923LeuTyr: 1.923 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.342MetAla: 3.342 ± 0.068	0.148MetCys: 0.148 ± 0.013	1.107MetAsp: 1.107 ± 0.033	1.063MetGlu: 1.063 ± 0.039	0.642MetPhe: 0.642 ± 0.029	1.886MetGly: 1.886 ± 0.053	0.459MetHis: 0.459 ± 0.022	1.358MetIle: 1.358 ± 0.039	0.896MetLys: 0.896 ± 0.031	2.645MetLeu: 2.645 ± 0.056	0.635MetMet: 0.635 ± 0.029	0.667MetAsn: 0.667 ± 0.026	1.48MetPro: 1.48 ± 0.043	0.808MetGln: 0.808 ± 0.029	1.831MetArg: 1.831 ± 0.047	1.471MetSer: 1.471 ± 0.043	1.797MetThr: 1.797 ± 0.049	1.677MetVal: 1.677 ± 0.036	0.23MetTrp: 0.23 ± 0.014	0.283MetTyr: 0.283 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.365AsnAla: 3.365 ± 0.063	0.256AsnCys: 0.256 ± 0.018	1.376AsnAsp: 1.376 ± 0.036	1.059AsnGlu: 1.059 ± 0.039	0.949AsnPhe: 0.949 ± 0.036	2.446AsnGly: 2.446 ± 0.057	0.485AsnHis: 0.485 ± 0.021	1.259AsnIle: 1.259 ± 0.036	0.683AsnLys: 0.683 ± 0.027	2.669AsnLeu: 2.669 ± 0.052	0.531AsnMet: 0.531 ± 0.022	0.654AsnAsn: 0.654 ± 0.031	1.833AsnPro: 1.833 ± 0.042	0.804AsnGln: 0.804 ± 0.027	1.848AsnArg: 1.848 ± 0.043	1.308AsnSer: 1.308 ± 0.041	1.265AsnThr: 1.265 ± 0.043	2.017AsnVal: 2.017 ± 0.046	0.428AsnTrp: 0.428 ± 0.026	0.706AsnTyr: 0.706 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.68ProAla: 6.68 ± 0.102	0.33ProCys: 0.33 ± 0.019	3.671ProAsp: 3.671 ± 0.062	3.523ProGlu: 3.523 ± 0.068	1.908ProPhe: 1.908 ± 0.039	4.81ProGly: 4.81 ± 0.072	1.112ProHis: 1.112 ± 0.039	2.56ProIle: 2.56 ± 0.047	1.526ProLys: 1.526 ± 0.045	5.025ProLeu: 5.025 ± 0.072	1.15ProMet: 1.15 ± 0.031	1.272ProAsn: 1.272 ± 0.04	2.622ProPro: 2.622 ± 0.071	1.918ProGln: 1.918 ± 0.047	3.126ProArg: 3.126 ± 0.06	2.948ProSer: 2.948 ± 0.063	2.597ProThr: 2.597 ± 0.052	4.272ProVal: 4.272 ± 0.066	0.728ProTrp: 0.728 ± 0.03	1.04ProTyr: 1.04 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.607GlnAla: 4.607 ± 0.083	0.216GlnCys: 0.216 ± 0.015	1.716GlnAsp: 1.716 ± 0.043	1.49GlnGlu: 1.49 ± 0.039	1.191GlnPhe: 1.191 ± 0.039	2.765GlnGly: 2.765 ± 0.049	0.652GlnHis: 0.652 ± 0.028	1.786GlnIle: 1.786 ± 0.043	0.953GlnLys: 0.953 ± 0.032	3.259GlnLeu: 3.259 ± 0.06	0.871GlnMet: 0.871 ± 0.032	0.834GlnAsn: 0.834 ± 0.031	1.919GlnPro: 1.919 ± 0.049	1.321GlnGln: 1.321 ± 0.039	2.608GlnArg: 2.608 ± 0.061	1.803GlnSer: 1.803 ± 0.041	1.786GlnThr: 1.786 ± 0.049	2.629GlnVal: 2.629 ± 0.055	0.488GlnTrp: 0.488 ± 0.021	0.699GlnTyr: 0.699 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.165ArgAla: 8.165 ± 0.097	0.517ArgCys: 0.517 ± 0.023	4.275ArgAsp: 4.275 ± 0.07	4.1ArgGlu: 4.1 ± 0.067	3.086ArgPhe: 3.086 ± 0.058	5.082ArgGly: 5.082 ± 0.089	1.769ArgHis: 1.769 ± 0.043	4.125ArgIle: 4.125 ± 0.064	2.227ArgLys: 2.227 ± 0.044	7.949ArgLeu: 7.949 ± 0.113	1.939ArgMet: 1.939 ± 0.043	1.959ArgAsn: 1.959 ± 0.042	3.624ArgPro: 3.624 ± 0.068	2.704ArgGln: 2.704 ± 0.053	5.687ArgArg: 5.687 ± 0.097	3.764ArgSer: 3.764 ± 0.061	3.495ArgThr: 3.495 ± 0.07	4.877ArgVal: 4.877 ± 0.079	1.202ArgTrp: 1.202 ± 0.038	1.872ArgTyr: 1.872 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.687SerAla: 6.687 ± 0.088	0.409SerCys: 0.409 ± 0.025	3.108SerAsp: 3.108 ± 0.057	2.628SerGlu: 2.628 ± 0.05	2.189SerPhe: 2.189 ± 0.051	5.781SerGly: 5.781 ± 0.107	1.059SerHis: 1.059 ± 0.031	2.617SerIle: 2.617 ± 0.057	1.457SerLys: 1.457 ± 0.042	5.346SerLeu: 5.346 ± 0.08	1.22SerMet: 1.22 ± 0.036	1.414SerAsn: 1.414 ± 0.039	2.892SerPro: 2.892 ± 0.053	1.761SerGln: 1.761 ± 0.041	3.736SerArg: 3.736 ± 0.07	2.983SerSer: 2.983 ± 0.062	2.73SerThr: 2.73 ± 0.063	3.749SerVal: 3.749 ± 0.057	0.763SerTrp: 0.763 ± 0.029	1.411SerTyr: 1.411 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.627ThrAla: 6.627 ± 0.091	0.419ThrCys: 0.419 ± 0.02	2.809ThrAsp: 2.809 ± 0.058	2.283ThrGlu: 2.283 ± 0.048	1.808ThrPhe: 1.808 ± 0.038	5.414ThrGly: 5.414 ± 0.086	0.929ThrHis: 0.929 ± 0.032	3.09ThrIle: 3.09 ± 0.063	1.363ThrLys: 1.363 ± 0.038	5.803ThrLeu: 5.803 ± 0.09	1.244ThrMet: 1.244 ± 0.031	1.39ThrAsn: 1.39 ± 0.047	3.43ThrPro: 3.43 ± 0.062	1.712ThrGln: 1.712 ± 0.039	3.552ThrArg: 3.552 ± 0.065	2.918ThrSer: 2.918 ± 0.062	2.804ThrThr: 2.804 ± 0.069	4.163ThrVal: 4.163 ± 0.075	0.696ThrTrp: 0.696 ± 0.026	1.18ThrTyr: 1.18 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.267ValAla: 9.267 ± 0.104	0.554ValCys: 0.554 ± 0.025	4.3ValAsp: 4.3 ± 0.059	4.292ValGlu: 4.292 ± 0.062	2.314ValPhe: 2.314 ± 0.054	5.57ValGly: 5.57 ± 0.086	1.332ValHis: 1.332 ± 0.038	3.938ValIle: 3.938 ± 0.068	2.041ValLys: 2.041 ± 0.057	7.121ValLeu: 7.121 ± 0.097	1.711ValMet: 1.711 ± 0.041	2.06ValAsn: 2.06 ± 0.051	4.05ValPro: 4.05 ± 0.062	2.182ValGln: 2.182 ± 0.054	5.208ValArg: 5.208 ± 0.076	4.397ValSer: 4.397 ± 0.073	4.587ValThr: 4.587 ± 0.081	5.543ValVal: 5.543 ± 0.09	0.895ValTrp: 0.895 ± 0.03	1.312ValTyr: 1.312 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.307TrpAla: 1.307 ± 0.037	0.146TrpCys: 0.146 ± 0.013	0.727TrpAsp: 0.727 ± 0.026	0.573TrpGlu: 0.573 ± 0.027	0.562TrpPhe: 0.562 ± 0.026	0.924TrpGly: 0.924 ± 0.03	0.379TrpHis: 0.379 ± 0.02	0.714TrpIle: 0.714 ± 0.032	0.475TrpLys: 0.475 ± 0.024	1.787TrpLeu: 1.787 ± 0.05	0.354TrpMet: 0.354 ± 0.019	0.471TrpAsn: 0.471 ± 0.024	0.724TrpPro: 0.724 ± 0.03	0.67TrpGln: 0.67 ± 0.024	1.314TrpArg: 1.314 ± 0.038	0.916TrpSer: 0.916 ± 0.036	0.828TrpThr: 0.828 ± 0.034	0.847TrpVal: 0.847 ± 0.034	0.268TrpTrp: 0.268 ± 0.018	0.306TrpTyr: 0.306 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.702TyrAla: 2.702 ± 0.051	0.238TyrCys: 0.238 ± 0.014	1.5TyrAsp: 1.5 ± 0.044	1.129TyrGlu: 1.129 ± 0.035	0.812TyrPhe: 0.812 ± 0.031	2.128TyrGly: 2.128 ± 0.055	0.497TyrHis: 0.497 ± 0.022	0.837TyrIle: 0.837 ± 0.029	0.624TyrLys: 0.624 ± 0.024	2.088TyrLeu: 2.088 ± 0.051	0.366TyrMet: 0.366 ± 0.02	0.667TyrAsn: 0.667 ± 0.03	1.045TyrPro: 1.045 ± 0.034	0.724TyrGln: 0.724 ± 0.025	1.864TyrArg: 1.864 ± 0.048	1.242TyrSer: 1.242 ± 0.038	1.076TyrThr: 1.076 ± 0.035	1.504TyrVal: 1.504 ± 0.039	0.338TyrTrp: 0.338 ± 0.019	0.622TyrTyr: 0.622 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3126 proteins (995628 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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