Human papillomavirus 178

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 24

Average proteome isoelectric point is 6.06

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|X2GCR4|X2GCR4_9PAPI Major capsid protein L1 OS=Human papillomavirus 178 OX=1478160 GN=L1 PE=3 SV=1
MM1 pKa = 7.39TSRR4 pKa = 11.84AKK6 pKa = 10.34RR7 pKa = 11.84IKK9 pKa = 10.02RR10 pKa = 11.84DD11 pKa = 3.55SVEE14 pKa = 4.15NLYY17 pKa = 10.03KK18 pKa = 10.07QCKK21 pKa = 8.31LTGQCPDD28 pKa = 3.27DD29 pKa = 4.54VINKK33 pKa = 9.39VEE35 pKa = 4.16GTTLADD41 pKa = 3.78RR42 pKa = 11.84LLKK45 pKa = 10.5IIGSVVYY52 pKa = 9.95FGGLGIGTGKK62 pKa = 10.77GSGGATGYY70 pKa = 10.55RR71 pKa = 11.84PIGATTPRR79 pKa = 11.84VTDD82 pKa = 5.33AIPVRR87 pKa = 11.84PVVPVDD93 pKa = 3.39PLVPAEE99 pKa = 5.37LIPVDD104 pKa = 4.51PGASSIIPLTEE115 pKa = 4.23AGIPDD120 pKa = 3.45ATLIEE125 pKa = 4.52SGGAVIDD132 pKa = 4.36AGSAEE137 pKa = 4.47PPVLTTIDD145 pKa = 4.64PISDD149 pKa = 3.24VTAVDD154 pKa = 3.59NQPTVITGQDD164 pKa = 3.06EE165 pKa = 4.68NIAVLDD171 pKa = 3.86IQPTPQAPKK180 pKa = 10.07RR181 pKa = 11.84VISGVRR187 pKa = 11.84SLGKK191 pKa = 10.34SPFEE195 pKa = 3.96PQILLPPPDD204 pKa = 3.82MPAIDD209 pKa = 3.36VSVFVDD215 pKa = 3.56AQLVGEE221 pKa = 4.39TVGAEE226 pKa = 4.9LIPLDD231 pKa = 5.04DD232 pKa = 4.02INLIEE237 pKa = 4.32EE238 pKa = 4.43FEE240 pKa = 4.11IQEE243 pKa = 4.21PVTRR247 pKa = 11.84TSTPEE252 pKa = 3.58QRR254 pKa = 11.84LGRR257 pKa = 11.84AFQRR261 pKa = 11.84ARR263 pKa = 11.84EE264 pKa = 4.08LYY266 pKa = 9.71NRR268 pKa = 11.84QIRR271 pKa = 11.84QIRR274 pKa = 11.84TRR276 pKa = 11.84NRR278 pKa = 11.84DD279 pKa = 3.06FLGPVSRR286 pKa = 11.84AIQFDD291 pKa = 3.81FEE293 pKa = 4.41NPAFSTDD300 pKa = 2.78VTLQFDD306 pKa = 3.51QDD308 pKa = 4.14VQNVAATPDD317 pKa = 3.75PDD319 pKa = 3.71FADD322 pKa = 4.28VITVHH327 pKa = 6.71RR328 pKa = 11.84PQYY331 pKa = 10.9SEE333 pKa = 3.9TDD335 pKa = 3.2SGRR338 pKa = 11.84VRR340 pKa = 11.84VSRR343 pKa = 11.84LARR346 pKa = 11.84RR347 pKa = 11.84GTIITRR353 pKa = 11.84SGTQIGEE360 pKa = 4.06NVHH363 pKa = 6.93FYY365 pKa = 11.19FDD367 pKa = 4.28LSTIGSDD374 pKa = 3.0AADD377 pKa = 4.61AIEE380 pKa = 5.07LGTIGQHH387 pKa = 5.6SGEE390 pKa = 4.27TAIVDD395 pKa = 3.84AVAEE399 pKa = 4.43STFVDD404 pKa = 3.58IPNSSEE410 pKa = 3.67IQFDD414 pKa = 4.83DD415 pKa = 4.3EE416 pKa = 5.59DD417 pKa = 4.64LLDD420 pKa = 3.87TQVEE424 pKa = 4.32NFEE427 pKa = 4.52GGHH430 pKa = 6.09LVLSGTGRR438 pKa = 11.84RR439 pKa = 11.84GAVYY443 pKa = 10.19SFPTLAPGVAPKK455 pKa = 10.53IFVDD459 pKa = 4.97DD460 pKa = 3.89FAKK463 pKa = 10.81NLFVSYY469 pKa = 9.8PISHH473 pKa = 6.96NKK475 pKa = 8.19TDD477 pKa = 4.07IIGPDD482 pKa = 3.34TLHH485 pKa = 6.87PLEE488 pKa = 5.09PPIILDD494 pKa = 3.99FQSSTYY500 pKa = 10.05YY501 pKa = 10.44LHH503 pKa = 6.98PSLRR507 pKa = 11.84RR508 pKa = 11.84RR509 pKa = 11.84RR510 pKa = 11.84KK511 pKa = 9.19RR512 pKa = 11.84KK513 pKa = 9.81RR514 pKa = 11.84SDD516 pKa = 2.84IYY518 pKa = 11.55DD519 pKa = 3.71FLSDD523 pKa = 3.89GSVDD527 pKa = 3.55TPEE530 pKa = 3.55WW531 pKa = 3.57

Molecular weight: 57.68 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|X2GB93|X2GB93_9PAPI Minor capsid protein L2 OS=Human papillomavirus 178 OX=1478160 GN=L2 PE=3 SV=1
MM1 pKa = 8.0DD2 pKa = 4.22WLTDD6 pKa = 3.53RR7 pKa = 11.84FNAIQDD13 pKa = 3.9NILNLIEE20 pKa = 4.79QGAEE24 pKa = 4.02DD25 pKa = 5.43LDD27 pKa = 4.07SQINYY32 pKa = 7.96WNLVRR37 pKa = 11.84QEE39 pKa = 4.11NVYY42 pKa = 10.55LYY44 pKa = 10.07YY45 pKa = 10.7GRR47 pKa = 11.84KK48 pKa = 9.39EE49 pKa = 4.09GLTHH53 pKa = 7.6FGLQPLPVAAVSEE66 pKa = 4.6YY67 pKa = 10.2KK68 pKa = 10.7AKK70 pKa = 10.48EE71 pKa = 4.24AINMVLLLQSLKK83 pKa = 10.58KK84 pKa = 9.89SAYY87 pKa = 9.85ANEE90 pKa = 3.82VWTLQDD96 pKa = 4.19ASAEE100 pKa = 4.33LINTQPKK107 pKa = 10.66DD108 pKa = 3.66CFKK111 pKa = 10.31KK112 pKa = 9.82QPYY115 pKa = 7.92TVEE118 pKa = 3.49VWFNNDD124 pKa = 2.9RR125 pKa = 11.84QNSNQYY131 pKa = 10.38INWNFIYY138 pKa = 10.69YY139 pKa = 9.94QDD141 pKa = 5.44ANDD144 pKa = 3.26VWHH147 pKa = 6.85KK148 pKa = 10.54VQGLVDD154 pKa = 4.04YY155 pKa = 11.1NGLYY159 pKa = 10.1YY160 pKa = 10.63VEE162 pKa = 4.44TGGDD166 pKa = 3.16QVYY169 pKa = 9.21FALFDD174 pKa = 4.75ADD176 pKa = 3.73DD177 pKa = 3.56QRR179 pKa = 11.84FGGTGIWSVHH189 pKa = 5.39FKK191 pKa = 11.1NKK193 pKa = 8.68TLSAPSSSASSFSPHH208 pKa = 6.37SGKK211 pKa = 10.35NYY213 pKa = 9.01ATVSSPTEE221 pKa = 3.78NTVSQSEE228 pKa = 4.65SPGRR232 pKa = 11.84LQKK235 pKa = 10.67SEE237 pKa = 4.37VGSSTSPRR245 pKa = 11.84AKK247 pKa = 8.9TSTVRR252 pKa = 11.84RR253 pKa = 11.84RR254 pKa = 11.84RR255 pKa = 11.84EE256 pKa = 3.82RR257 pKa = 11.84EE258 pKa = 3.94STPEE262 pKa = 4.03GQPSTSTKK270 pKa = 9.59RR271 pKa = 11.84RR272 pKa = 11.84RR273 pKa = 11.84GRR275 pKa = 11.84IGGGGGGGAEE285 pKa = 3.79RR286 pKa = 11.84AVPSPDD292 pKa = 3.2QVGSRR297 pKa = 11.84HH298 pKa = 5.85RR299 pKa = 11.84SVSTTHH305 pKa = 7.07LSRR308 pKa = 11.84LARR311 pKa = 11.84LQKK314 pKa = 10.09EE315 pKa = 4.0AWDD318 pKa = 4.01PPVLILTGPANVLKK332 pKa = 10.3CWRR335 pKa = 11.84YY336 pKa = 9.04RR337 pKa = 11.84KK338 pKa = 9.86KK339 pKa = 10.58NQNEE343 pKa = 3.9FSFLDD348 pKa = 3.16ISTIFTWVGSNKK360 pKa = 8.62EE361 pKa = 4.04TDD363 pKa = 3.17NKK365 pKa = 10.5GRR367 pKa = 11.84MLIAFHH373 pKa = 7.08NDD375 pKa = 2.94TEE377 pKa = 4.37RR378 pKa = 11.84EE379 pKa = 4.0QFVKK383 pKa = 10.33HH384 pKa = 4.43VHH386 pKa = 5.63FPKK389 pKa = 9.1HH390 pKa = 4.29TSYY393 pKa = 11.82AFGKK397 pKa = 10.11LDD399 pKa = 3.46KK400 pKa = 11.09LL401 pKa = 3.98

Molecular weight: 45.54 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2450

95

608

350.0

39.63

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.959 ± 0.288

2.286 ± 0.757

6.776 ± 0.548

6.0 ± 0.556

4.898 ± 0.41

5.429 ± 0.758

1.714 ± 0.187

5.429 ± 0.76

5.347 ± 0.812

8.49 ± 0.577

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.388 ± 0.294

4.571 ± 0.597

6.082 ± 0.97

5.429 ± 0.347

5.714 ± 0.709

6.816 ± 0.648

6.245 ± 0.42

6.612 ± 0.466

1.306 ± 0.33

3.51 ± 0.475
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski