human papillomavirus 81

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 3

Average proteome isoelectric point is 6.24

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 8 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q705E7|Q705E7_9PAPI Replication protein E1 OS=human papillomavirus 81 OX=333771 GN=E1 PE=3 SV=1
MM1 pKa = 7.57HH2 pKa = 6.87GQAATIKK9 pKa = 10.58DD10 pKa = 3.73IVLDD14 pKa = 4.52EE15 pKa = 4.5YY16 pKa = 10.92PDD18 pKa = 4.24VIDD21 pKa = 4.02LHH23 pKa = 7.14CHH25 pKa = 4.69EE26 pKa = 5.02QLLDD30 pKa = 3.71SSEE33 pKa = 4.6EE34 pKa = 4.0EE35 pKa = 3.92VDD37 pKa = 3.8VDD39 pKa = 5.09DD40 pKa = 5.96RR41 pKa = 11.84DD42 pKa = 3.63SGEE45 pKa = 3.96QLVEE49 pKa = 4.04QAQQAYY55 pKa = 9.36RR56 pKa = 11.84VVTTCGICKK65 pKa = 9.95CLVRR69 pKa = 11.84LVVLSGDD76 pKa = 3.23ADD78 pKa = 3.81LRR80 pKa = 11.84LLQQLLTDD88 pKa = 4.17TLSIVCPGCAA98 pKa = 3.65

Molecular weight: 10.78 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A159E0B5|A0A159E0B5_9PAPI Major capsid protein L1 OS=human papillomavirus 81 OX=333771 GN=L1 PE=3 SV=1
MM1 pKa = 7.07NHH3 pKa = 5.59ATLYY7 pKa = 9.43LAPRR11 pKa = 11.84TPCEE15 pKa = 4.15KK16 pKa = 10.93YY17 pKa = 10.25PLLKK21 pKa = 10.77LLTDD25 pKa = 4.48CCTPPNPPPVPSTWAPPRR43 pKa = 11.84PPRR46 pKa = 11.84PQCRR50 pKa = 11.84RR51 pKa = 11.84RR52 pKa = 11.84LASDD56 pKa = 3.51SEE58 pKa = 4.73STGTEE63 pKa = 3.93CGSPTLHH70 pKa = 6.63HH71 pKa = 6.51RR72 pKa = 11.84TSGWTITNQGPTVTLTAQKK91 pKa = 9.98HH92 pKa = 4.58GTSVTVTLHH101 pKa = 5.91LL102 pKa = 4.56

Molecular weight: 11.15 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

8

0

8

2404

46

650

300.5

33.48

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

7.529 ± 0.35

2.745 ± 0.68

5.74 ± 0.482

5.366 ± 0.844

3.536 ± 0.563

6.448 ± 0.302

2.995 ± 0.423

4.243 ± 0.442

4.617 ± 0.602

8.361 ± 0.75

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.121 ± 0.418

3.037 ± 0.482

6.614 ± 1.08

4.451 ± 0.58

5.2 ± 0.228

6.947 ± 0.891

7.654 ± 0.848

6.947 ± 0.72

1.747 ± 0.369

3.702 ± 0.338
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski