Amino acid dipepetide frequency for Coccidioides immitis RMSCC 3703

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.902AlaAla: 7.902 ± 0.065	1.059AlaCys: 1.059 ± 0.018	3.844AlaAsp: 3.844 ± 0.037	4.946AlaGlu: 4.946 ± 0.045	2.965AlaPhe: 2.965 ± 0.031	5.372AlaGly: 5.372 ± 0.04	1.735AlaHis: 1.735 ± 0.022	4.112AlaIle: 4.112 ± 0.039	4.083AlaLys: 4.083 ± 0.038	7.333AlaLeu: 7.333 ± 0.054	1.806AlaMet: 1.806 ± 0.024	2.821AlaAsn: 2.821 ± 0.029	4.44AlaPro: 4.44 ± 0.046	3.144AlaGln: 3.144 ± 0.035	5.082AlaArg: 5.082 ± 0.043	7.016AlaSer: 7.016 ± 0.048	4.791AlaThr: 4.791 ± 0.036	4.936AlaVal: 4.936 ± 0.039	1.009AlaTrp: 1.009 ± 0.019	1.894AlaTyr: 1.894 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.946CysAla: 0.946 ± 0.018	0.315CysCys: 0.315 ± 0.011	0.662CysAsp: 0.662 ± 0.015	0.688CysGlu: 0.688 ± 0.013	0.591CysPhe: 0.591 ± 0.013	0.991CysGly: 0.991 ± 0.017	0.399CysHis: 0.399 ± 0.012	0.736CysIle: 0.736 ± 0.015	0.548CysLys: 0.548 ± 0.012	1.376CysLeu: 1.376 ± 0.02	0.327CysMet: 0.327 ± 0.011	0.457CysAsn: 0.457 ± 0.011	0.792CysPro: 0.792 ± 0.017	0.509CysGln: 0.509 ± 0.012	0.937CysArg: 0.937 ± 0.016	1.089CysSer: 1.089 ± 0.02	0.695CysThr: 0.695 ± 0.018	0.814CysVal: 0.814 ± 0.016	0.223CysTrp: 0.223 ± 0.009	0.377CysTyr: 0.377 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.167AspAla: 4.167 ± 0.04	0.669AspCys: 0.669 ± 0.015	4.007AspAsp: 4.007 ± 0.05	4.229AspGlu: 4.229 ± 0.045	2.101AspPhe: 2.101 ± 0.024	3.856AspGly: 3.856 ± 0.034	1.23AspHis: 1.23 ± 0.021	3.243AspIle: 3.243 ± 0.031	2.341AspLys: 2.341 ± 0.028	4.886AspLeu: 4.886 ± 0.043	1.212AspMet: 1.212 ± 0.02	1.866AspAsn: 1.866 ± 0.022	3.343AspPro: 3.343 ± 0.035	1.824AspGln: 1.824 ± 0.025	3.18AspArg: 3.18 ± 0.036	4.157AspSer: 4.157 ± 0.034	2.788AspThr: 2.788 ± 0.03	3.483AspVal: 3.483 ± 0.033	0.809AspTrp: 0.809 ± 0.015	1.467AspTyr: 1.467 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.093GluAla: 5.093 ± 0.039	0.687GluCys: 0.687 ± 0.013	4.048GluAsp: 4.048 ± 0.042	5.537GluGlu: 5.537 ± 0.062	2.04GluPhe: 2.04 ± 0.024	3.637GluGly: 3.637 ± 0.03	1.371GluHis: 1.371 ± 0.019	3.264GluIle: 3.264 ± 0.036	3.876GluLys: 3.876 ± 0.045	5.333GluLeu: 5.333 ± 0.049	1.448GluMet: 1.448 ± 0.019	2.526GluAsn: 2.526 ± 0.025	2.959GluPro: 2.959 ± 0.034	2.484GluGln: 2.484 ± 0.03	4.235GluArg: 4.235 ± 0.041	4.616GluSer: 4.616 ± 0.043	3.372GluThr: 3.372 ± 0.032	3.378GluVal: 3.378 ± 0.035	0.848GluTrp: 0.848 ± 0.015	1.675GluTyr: 1.675 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.854PheAla: 2.854 ± 0.031	0.631PheCys: 0.631 ± 0.014	2.177PheAsp: 2.177 ± 0.026	2.163PheGlu: 2.163 ± 0.024	1.568PhePhe: 1.568 ± 0.025	2.696PheGly: 2.696 ± 0.028	0.946PheHis: 0.946 ± 0.015	1.784PheIle: 1.784 ± 0.024	1.573PheLys: 1.573 ± 0.022	3.541PheLeu: 3.541 ± 0.039	0.786PheMet: 0.786 ± 0.017	1.405PheAsn: 1.405 ± 0.02	2.124PhePro: 2.124 ± 0.022	1.411PheGln: 1.411 ± 0.02	2.174PheArg: 2.174 ± 0.025	3.238PheSer: 3.238 ± 0.032	2.069PheThr: 2.069 ± 0.024	2.249PheVal: 2.249 ± 0.029	0.602PheTrp: 0.602 ± 0.013	1.063PheTyr: 1.063 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.834GlyAla: 4.834 ± 0.04	0.915GlyCys: 0.915 ± 0.017	3.535GlyAsp: 3.535 ± 0.03	3.714GlyGlu: 3.714 ± 0.037	2.642GlyPhe: 2.642 ± 0.03	5.432GlyGly: 5.432 ± 0.063	1.625GlyHis: 1.625 ± 0.027	3.563GlyIle: 3.563 ± 0.033	3.599GlyLys: 3.599 ± 0.029	5.8GlyLeu: 5.8 ± 0.041	1.573GlyMet: 1.573 ± 0.023	2.536GlyAsn: 2.536 ± 0.029	3.315GlyPro: 3.315 ± 0.036	2.477GlyGln: 2.477 ± 0.029	4.423GlyArg: 4.423 ± 0.044	5.661GlySer: 5.661 ± 0.049	3.669GlyThr: 3.669 ± 0.037	4.098GlyVal: 4.098 ± 0.034	1.121GlyTrp: 1.121 ± 0.019	2.015GlyTyr: 2.015 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.863HisAla: 1.863 ± 0.022	0.392HisCys: 0.392 ± 0.011	1.261HisAsp: 1.261 ± 0.02	1.312HisGlu: 1.312 ± 0.019	0.966HisPhe: 0.966 ± 0.017	1.75HisGly: 1.75 ± 0.026	0.85HisHis: 0.85 ± 0.02	1.344HisIle: 1.344 ± 0.02	0.966HisLys: 0.966 ± 0.018	2.291HisLeu: 2.291 ± 0.026	0.512HisMet: 0.512 ± 0.013	0.853HisAsn: 0.853 ± 0.015	1.816HisPro: 1.816 ± 0.024	1.012HisGln: 1.012 ± 0.019	1.804HisArg: 1.804 ± 0.026	2.04HisSer: 2.04 ± 0.024	1.292HisThr: 1.292 ± 0.021	1.403HisVal: 1.403 ± 0.02	0.327HisTrp: 0.327 ± 0.009	0.646HisTyr: 0.646 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.013IleAla: 4.013 ± 0.038	0.823IleCys: 0.823 ± 0.014	2.845IleAsp: 2.845 ± 0.031	2.944IleGlu: 2.944 ± 0.03	2.065IlePhe: 2.065 ± 0.028	3.069IleGly: 3.069 ± 0.031	1.311IleHis: 1.311 ± 0.021	2.581IleIle: 2.581 ± 0.033	2.294IleLys: 2.294 ± 0.027	4.831IleLeu: 4.831 ± 0.039	1.064IleMet: 1.064 ± 0.017	1.818IleAsn: 1.818 ± 0.024	3.418IlePro: 3.418 ± 0.035	1.957IleGln: 1.957 ± 0.023	3.138IleArg: 3.138 ± 0.028	4.341IleSer: 4.341 ± 0.04	2.747IleThr: 2.747 ± 0.03	3.044IleVal: 3.044 ± 0.03	0.689IleTrp: 0.689 ± 0.016	1.421IleTyr: 1.421 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.223LysAla: 4.223 ± 0.04	0.589LysCys: 0.589 ± 0.012	2.821LysAsp: 2.821 ± 0.029	3.588LysGlu: 3.588 ± 0.039	1.578LysPhe: 1.578 ± 0.024	3.086LysGly: 3.086 ± 0.035	1.204LysHis: 1.204 ± 0.022	2.455LysIle: 2.455 ± 0.028	3.549LysLys: 3.549 ± 0.055	4.334LysLeu: 4.334 ± 0.041	1.062LysMet: 1.062 ± 0.017	1.821LysAsn: 1.821 ± 0.027	2.924LysPro: 2.924 ± 0.032	2.051LysGln: 2.051 ± 0.026	3.873LysArg: 3.873 ± 0.038	3.809LysSer: 3.809 ± 0.036	2.723LysThr: 2.723 ± 0.029	2.829LysVal: 2.829 ± 0.028	0.654LysTrp: 0.654 ± 0.012	1.442LysTyr: 1.442 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.349LeuAla: 7.349 ± 0.052	1.307LeuCys: 1.307 ± 0.018	5.047LeuAsp: 5.047 ± 0.042	5.684LeuGlu: 5.684 ± 0.047	3.352LeuPhe: 3.352 ± 0.037	5.788LeuGly: 5.788 ± 0.039	2.363LeuHis: 2.363 ± 0.026	4.034LeuIle: 4.034 ± 0.041	4.464LeuLys: 4.464 ± 0.039	8.446LeuLeu: 8.446 ± 0.06	1.754LeuMet: 1.754 ± 0.022	3.283LeuAsn: 3.283 ± 0.035	5.6LeuPro: 5.6 ± 0.042	3.872LeuGln: 3.872 ± 0.033	6.242LeuArg: 6.242 ± 0.044	7.831LeuSer: 7.831 ± 0.051	4.599LeuThr: 4.599 ± 0.039	5.244LeuVal: 5.244 ± 0.04	1.167LeuTrp: 1.167 ± 0.021	2.304LeuTyr: 2.304 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.194MetAla: 2.194 ± 0.024	0.257MetCys: 0.257 ± 0.008	1.235MetAsp: 1.235 ± 0.018	1.399MetGlu: 1.399 ± 0.02	0.716MetPhe: 0.716 ± 0.016	1.479MetGly: 1.479 ± 0.023	0.489MetHis: 0.489 ± 0.012	1.029MetIle: 1.029 ± 0.016	1.134MetLys: 1.134 ± 0.017	1.837MetLeu: 1.837 ± 0.024	0.55MetMet: 0.55 ± 0.014	0.811MetAsn: 0.811 ± 0.017	1.246MetPro: 1.246 ± 0.018	0.851MetGln: 0.851 ± 0.018	1.307MetArg: 1.307 ± 0.02	1.85MetSer: 1.85 ± 0.023	1.238MetThr: 1.238 ± 0.017	1.263MetVal: 1.263 ± 0.021	0.264MetTrp: 0.264 ± 0.009	0.502MetTyr: 0.502 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.994AsnAla: 2.994 ± 0.028	0.498AsnCys: 0.498 ± 0.013	1.941AsnAsp: 1.941 ± 0.024	2.108AsnGlu: 2.108 ± 0.025	1.39AsnPhe: 1.39 ± 0.018	2.881AsnGly: 2.881 ± 0.029	0.908AsnHis: 0.908 ± 0.016	2.158AsnIle: 2.158 ± 0.027	1.632AsnLys: 1.632 ± 0.023	3.323AsnLeu: 3.323 ± 0.03	0.828AsnMet: 0.828 ± 0.015	1.483AsnAsn: 1.483 ± 0.024	2.644AsnPro: 2.644 ± 0.029	1.363AsnGln: 1.363 ± 0.019	2.228AsnArg: 2.228 ± 0.026	2.894AsnSer: 2.894 ± 0.032	2.104AsnThr: 2.104 ± 0.027	2.262AsnVal: 2.262 ± 0.028	0.531AsnTrp: 0.531 ± 0.011	0.989AsnTyr: 0.989 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.02ProAla: 5.02 ± 0.045	0.69ProCys: 0.69 ± 0.016	3.146ProAsp: 3.146 ± 0.033	3.946ProGlu: 3.946 ± 0.038	2.174ProPhe: 2.174 ± 0.025	4.016ProGly: 4.016 ± 0.039	1.479ProHis: 1.479 ± 0.02	2.685ProIle: 2.685 ± 0.029	2.88ProLys: 2.88 ± 0.035	4.953ProLeu: 4.953 ± 0.036	1.109ProMet: 1.109 ± 0.018	2.346ProAsn: 2.346 ± 0.025	5.637ProPro: 5.637 ± 0.079	2.563ProGln: 2.563 ± 0.035	3.788ProArg: 3.788 ± 0.035	6.48ProSer: 6.48 ± 0.068	3.963ProThr: 3.963 ± 0.039	3.618ProVal: 3.618 ± 0.034	0.747ProTrp: 0.747 ± 0.015	1.529ProTyr: 1.529 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.233GlnAla: 3.233 ± 0.039	0.49GlnCys: 0.49 ± 0.012	1.937GlnAsp: 1.937 ± 0.02	2.399GlnGlu: 2.399 ± 0.028	1.301GlnPhe: 1.301 ± 0.017	2.421GlnGly: 2.421 ± 0.026	1.087GlnHis: 1.087 ± 0.02	1.918GlnIle: 1.918 ± 0.022	2.138GlnLys: 2.138 ± 0.028	3.483GlnLeu: 3.483 ± 0.033	0.889GlnMet: 0.889 ± 0.016	1.653GlnAsn: 1.653 ± 0.024	2.712GlnPro: 2.712 ± 0.042	2.261GlnGln: 2.261 ± 0.041	2.886GlnArg: 2.886 ± 0.029	3.315GlnSer: 3.315 ± 0.038	2.195GlnThr: 2.195 ± 0.028	2.038GlnVal: 2.038 ± 0.022	0.498GlnTrp: 0.498 ± 0.013	1.07GlnTyr: 1.07 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.861ArgAla: 4.861 ± 0.038	0.917ArgCys: 0.917 ± 0.016	3.527ArgAsp: 3.527 ± 0.037	4.201ArgGlu: 4.201 ± 0.042	2.314ArgPhe: 2.314 ± 0.029	4.058ArgGly: 4.058 ± 0.043	1.764ArgHis: 1.764 ± 0.025	3.245ArgIle: 3.245 ± 0.031	3.874ArgLys: 3.874 ± 0.025	5.88ArgLeu: 5.88 ± 0.039	1.471ArgMet: 1.471 ± 0.017	2.555ArgAsn: 2.555 ± 0.028	3.932ArgPro: 3.932 ± 0.039	2.799ArgGln: 2.799 ± 0.03	6.004ArgArg: 6.004 ± 0.055	5.551ArgSer: 5.551 ± 0.044	3.537ArgThr: 3.537 ± 0.027	3.567ArgVal: 3.567 ± 0.033	0.971ArgTrp: 0.971 ± 0.019	1.744ArgTyr: 1.744 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.513SerAla: 6.513 ± 0.045	1.002SerCys: 1.002 ± 0.017	4.212SerAsp: 4.212 ± 0.041	4.401SerGlu: 4.401 ± 0.04	3.165SerPhe: 3.165 ± 0.032	5.615SerGly: 5.615 ± 0.047	2.201SerHis: 2.201 ± 0.029	4.187SerIle: 4.187 ± 0.037	4.141SerLys: 4.141 ± 0.038	7.727SerLeu: 7.727 ± 0.046	1.85SerMet: 1.85 ± 0.025	3.169SerAsn: 3.169 ± 0.029	6.021SerPro: 6.021 ± 0.058	3.515SerGln: 3.515 ± 0.04	5.883SerArg: 5.883 ± 0.042	9.457SerSer: 9.457 ± 0.087	5.649SerThr: 5.649 ± 0.044	4.529SerVal: 4.529 ± 0.033	1.081SerTrp: 1.081 ± 0.019	2.027SerTyr: 2.027 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	4.633ThrAla: 4.633 ± 0.041	0.764ThrCys: 0.764 ± 0.016	2.679ThrAsp: 2.679 ± 0.026	3.075ThrGlu: 3.075 ± 0.031	2.15ThrPhe: 2.15 ± 0.028	3.958ThrGly: 3.958 ± 0.036	1.306ThrHis: 1.306 ± 0.018	2.957ThrIle: 2.957 ± 0.03	2.683ThrLys: 2.683 ± 0.031	5.084ThrLeu: 5.084 ± 0.042	1.182ThrMet: 1.182 ± 0.018	1.976ThrAsn: 1.976 ± 0.023	4.182ThrPro: 4.182 ± 0.042	2.01ThrGln: 2.01 ± 0.023	3.367ThrArg: 3.367 ± 0.036	5.283ThrSer: 5.283 ± 0.038	3.782ThrThr: 3.782 ± 0.048	3.403ThrVal: 3.403 ± 0.031	0.766ThrTrp: 0.766 ± 0.013	1.454ThrTyr: 1.454 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.685ValAla: 4.685 ± 0.034	0.835ValCys: 0.835 ± 0.018	3.552ValAsp: 3.552 ± 0.028	3.814ValGlu: 3.814 ± 0.032	2.306ValPhe: 2.306 ± 0.025	3.7ValGly: 3.7 ± 0.037	1.355ValHis: 1.355 ± 0.019	2.905ValIle: 2.905 ± 0.028	2.943ValLys: 2.943 ± 0.031	5.366ValLeu: 5.366 ± 0.05	1.262ValMet: 1.262 ± 0.018	2.161ValAsn: 2.161 ± 0.025	3.545ValPro: 3.545 ± 0.034	2.241ValGln: 2.241 ± 0.024	3.517ValArg: 3.517 ± 0.034	4.673ValSer: 4.673 ± 0.034	3.236ValThr: 3.236 ± 0.033	3.932ValVal: 3.932 ± 0.038	0.798ValTrp: 0.798 ± 0.014	1.581ValTyr: 1.581 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.03TrpAla: 1.03 ± 0.018	0.204TrpCys: 0.204 ± 0.008	0.853TrpAsp: 0.853 ± 0.018	0.832TrpGlu: 0.832 ± 0.016	0.483TrpPhe: 0.483 ± 0.013	0.836TrpGly: 0.836 ± 0.016	0.341TrpHis: 0.341 ± 0.011	0.741TrpIle: 0.741 ± 0.015	0.797TrpLys: 0.797 ± 0.016	1.28TrpLeu: 1.28 ± 0.019	0.37TrpMet: 0.37 ± 0.01	0.616TrpAsn: 0.616 ± 0.012	0.613TrpPro: 0.613 ± 0.013	0.532TrpGln: 0.532 ± 0.014	1.009TrpArg: 1.009 ± 0.016	0.998TrpSer: 0.998 ± 0.018	0.802TrpThr: 0.802 ± 0.016	0.802TrpVal: 0.802 ± 0.016	0.258TrpTrp: 0.258 ± 0.008	0.363TrpTyr: 0.363 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.882TyrAla: 1.882 ± 0.021	0.425TyrCys: 0.425 ± 0.012	1.532TyrAsp: 1.532 ± 0.021	1.449TyrGlu: 1.449 ± 0.021	1.186TyrPhe: 1.186 ± 0.019	1.907TyrGly: 1.907 ± 0.027	0.736TyrHis: 0.736 ± 0.015	1.472TyrIle: 1.472 ± 0.02	1.099TyrLys: 1.099 ± 0.016	2.624TyrLeu: 2.624 ± 0.03	0.596TyrMet: 0.596 ± 0.012	1.003TyrAsn: 1.003 ± 0.018	1.507TyrPro: 1.507 ± 0.02	1.047TyrGln: 1.047 ± 0.018	1.696TyrArg: 1.696 ± 0.022	2.045TyrSer: 2.045 ± 0.026	1.442TyrThr: 1.442 ± 0.02	1.515TyrVal: 1.515 ± 0.021	0.399TyrTrp: 0.399 ± 0.01	0.853TyrTyr: 0.853 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10461 proteins (3675961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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