Amino acid dipepetide frequency for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.856AlaAla: 8.856 ± 0.059
1.095AlaCys: 1.095 ± 0.016
4.276AlaAsp: 4.276 ± 0.03
5.334AlaGlu: 5.334 ± 0.048
3.12AlaPhe: 3.12 ± 0.027
5.828AlaGly: 5.828 ± 0.043
1.791AlaHis: 1.791 ± 0.018
4.344AlaIle: 4.344 ± 0.032
3.823AlaLys: 3.823 ± 0.033
7.941AlaLeu: 7.941 ± 0.046
1.917AlaMet: 1.917 ± 0.018
2.914AlaAsn: 2.914 ± 0.024
4.527AlaPro: 4.527 ± 0.042
3.386AlaGln: 3.386 ± 0.034
5.021AlaArg: 5.021 ± 0.034
7.244AlaSer: 7.244 ± 0.045
5.167AlaThr: 5.167 ± 0.035
5.509AlaVal: 5.509 ± 0.035
1.146AlaTrp: 1.146 ± 0.02
2.274AlaTyr: 2.274 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
0.964CysAla: 0.964 ± 0.013
0.252CysCys: 0.252 ± 0.008
0.683CysAsp: 0.683 ± 0.015
0.612CysGlu: 0.612 ± 0.013
0.539CysPhe: 0.539 ± 0.012
0.944CysGly: 0.944 ± 0.016
0.339CysHis: 0.339 ± 0.009
0.726CysIle: 0.726 ± 0.012
0.471CysLys: 0.471 ± 0.011
1.337CysLeu: 1.337 ± 0.017
0.28CysMet: 0.28 ± 0.007
0.421CysAsn: 0.421 ± 0.011
0.675CysPro: 0.675 ± 0.012
0.466CysGln: 0.466 ± 0.01
0.805CysArg: 0.805 ± 0.014
0.977CysSer: 0.977 ± 0.014
0.712CysThr: 0.712 ± 0.013
0.807CysVal: 0.807 ± 0.015
0.206CysTrp: 0.206 ± 0.006
0.363CysTyr: 0.363 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.569AspAla: 4.569 ± 0.033
0.622AspCys: 0.622 ± 0.012
3.857AspAsp: 3.857 ± 0.042
4.29AspGlu: 4.29 ± 0.037
2.145AspPhe: 2.145 ± 0.023
3.947AspGly: 3.947 ± 0.03
1.233AspHis: 1.233 ± 0.019
3.181AspIle: 3.181 ± 0.025
2.207AspLys: 2.207 ± 0.026
5.048AspLeu: 5.048 ± 0.036
1.179AspMet: 1.179 ± 0.015
1.883AspAsn: 1.883 ± 0.02
3.279AspPro: 3.279 ± 0.027
1.847AspGln: 1.847 ± 0.019
3.119AspArg: 3.119 ± 0.03
4.228AspSer: 4.228 ± 0.031
2.966AspThr: 2.966 ± 0.026
3.498AspVal: 3.498 ± 0.026
0.881AspTrp: 0.881 ± 0.014
1.67AspTyr: 1.67 ± 0.018
0.0AspXaa: 0.0 ± 0.0
Glu
5.287GluAla: 5.287 ± 0.047
0.636GluCys: 0.636 ± 0.012
3.976GluAsp: 3.976 ± 0.035
5.323GluGlu: 5.323 ± 0.052
1.966GluPhe: 1.966 ± 0.019
3.707GluGly: 3.707 ± 0.03
1.389GluHis: 1.389 ± 0.018
3.153GluIle: 3.153 ± 0.029
3.585GluLys: 3.585 ± 0.033
5.328GluLeu: 5.328 ± 0.041
1.377GluMet: 1.377 ± 0.017
2.406GluAsn: 2.406 ± 0.021
2.864GluPro: 2.864 ± 0.038
2.567GluGln: 2.567 ± 0.027
4.033GluArg: 4.033 ± 0.039
4.451GluSer: 4.451 ± 0.034
3.667GluThr: 3.667 ± 0.035
3.49GluVal: 3.49 ± 0.027
0.878GluTrp: 0.878 ± 0.015
1.799GluTyr: 1.799 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.074PheAla: 3.074 ± 0.025
0.57PheCys: 0.57 ± 0.011
2.211PheAsp: 2.211 ± 0.022
2.107PheGlu: 2.107 ± 0.02
1.66PhePhe: 1.66 ± 0.024
2.788PheGly: 2.788 ± 0.031
0.906PheHis: 0.906 ± 0.013
1.847PheIle: 1.847 ± 0.024
1.416PheLys: 1.416 ± 0.016
3.571PheLeu: 3.571 ± 0.035
0.767PheMet: 0.767 ± 0.012
1.414PheAsn: 1.414 ± 0.017
1.992PhePro: 1.992 ± 0.02
1.385PheGln: 1.385 ± 0.016
2.031PheArg: 2.031 ± 0.023
3.091PheSer: 3.091 ± 0.03
2.163PheThr: 2.163 ± 0.02
2.37PheVal: 2.37 ± 0.025
0.655PheTrp: 0.655 ± 0.013
1.148PheTyr: 1.148 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
5.249GlyAla: 5.249 ± 0.037
0.913GlyCys: 0.913 ± 0.016
3.548GlyAsp: 3.548 ± 0.03
3.628GlyGlu: 3.628 ± 0.031
2.819GlyPhe: 2.819 ± 0.028
5.379GlyGly: 5.379 ± 0.05
1.678GlyHis: 1.678 ± 0.021
3.632GlyIle: 3.632 ± 0.029
3.268GlyLys: 3.268 ± 0.034
6.298GlyLeu: 6.298 ± 0.043
1.493GlyMet: 1.493 ± 0.02
2.528GlyAsn: 2.528 ± 0.023
3.352GlyPro: 3.352 ± 0.032
2.538GlyGln: 2.538 ± 0.027
4.078GlyArg: 4.078 ± 0.033
5.718GlySer: 5.718 ± 0.049
3.921GlyThr: 3.921 ± 0.033
4.436GlyVal: 4.436 ± 0.036
1.17GlyTrp: 1.17 ± 0.016
2.232GlyTyr: 2.232 ± 0.028
0.0GlyXaa: 0.0 ± 0.0
His
1.803HisAla: 1.803 ± 0.022
0.33HisCys: 0.33 ± 0.009
1.269HisAsp: 1.269 ± 0.018
1.319HisGlu: 1.319 ± 0.016
0.928HisPhe: 0.928 ± 0.013
1.717HisGly: 1.717 ± 0.021
0.793HisHis: 0.793 ± 0.015
1.258HisIle: 1.258 ± 0.015
0.863HisLys: 0.863 ± 0.014
2.262HisLeu: 2.262 ± 0.022
0.463HisMet: 0.463 ± 0.01
0.826HisAsn: 0.826 ± 0.013
1.682HisPro: 1.682 ± 0.021
0.947HisGln: 0.947 ± 0.014
1.564HisArg: 1.564 ± 0.02
1.929HisSer: 1.929 ± 0.02
1.274HisThr: 1.274 ± 0.016
1.372HisVal: 1.372 ± 0.017
0.361HisTrp: 0.361 ± 0.008
0.727HisTyr: 0.727 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
4.265IleAla: 4.265 ± 0.034
0.785IleCys: 0.785 ± 0.013
2.852IleAsp: 2.852 ± 0.026
2.906IleGlu: 2.906 ± 0.026
2.011IlePhe: 2.011 ± 0.022
3.196IleGly: 3.196 ± 0.029
1.213IleHis: 1.213 ± 0.013
2.585IleIle: 2.585 ± 0.027
2.086IleLys: 2.086 ± 0.026
4.828IleLeu: 4.828 ± 0.035
0.991IleMet: 0.991 ± 0.016
1.856IleAsn: 1.856 ± 0.021
3.193IlePro: 3.193 ± 0.028
2.0IleGln: 2.0 ± 0.019
2.95IleArg: 2.95 ± 0.026
4.048IleSer: 4.048 ± 0.033
2.902IleThr: 2.902 ± 0.026
3.21IleVal: 3.21 ± 0.025
0.723IleTrp: 0.723 ± 0.013
1.523IleTyr: 1.523 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.007LysAla: 4.007 ± 0.035
0.483LysCys: 0.483 ± 0.01
2.595LysAsp: 2.595 ± 0.024
3.258LysGlu: 3.258 ± 0.035
1.323LysPhe: 1.323 ± 0.017
2.901LysGly: 2.901 ± 0.03
1.057LysHis: 1.057 ± 0.015
2.184LysIle: 2.184 ± 0.022
2.946LysLys: 2.946 ± 0.038
3.976LysLeu: 3.976 ± 0.033
0.893LysMet: 0.893 ± 0.013
1.673LysAsn: 1.673 ± 0.02
2.596LysPro: 2.596 ± 0.028
1.86LysGln: 1.86 ± 0.023
3.35LysArg: 3.35 ± 0.032
3.287LysSer: 3.287 ± 0.027
2.652LysThr: 2.652 ± 0.024
2.624LysVal: 2.624 ± 0.025
0.622LysTrp: 0.622 ± 0.012
1.371LysTyr: 1.371 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
8.025LeuAla: 8.025 ± 0.041
1.258LeuCys: 1.258 ± 0.018
5.279LeuAsp: 5.279 ± 0.032
5.678LeuGlu: 5.678 ± 0.039
3.402LeuPhe: 3.402 ± 0.028
6.084LeuGly: 6.084 ± 0.042
2.257LeuHis: 2.257 ± 0.023
4.161LeuIle: 4.161 ± 0.034
4.098LeuLys: 4.098 ± 0.036
8.681LeuLeu: 8.681 ± 0.061
1.762LeuMet: 1.762 ± 0.02
3.319LeuAsn: 3.319 ± 0.024
5.57LeuPro: 5.57 ± 0.038
3.964LeuGln: 3.964 ± 0.036
6.018LeuArg: 6.018 ± 0.043
7.702LeuSer: 7.702 ± 0.048
5.022LeuThr: 5.022 ± 0.034
5.566LeuVal: 5.566 ± 0.041
1.233LeuTrp: 1.233 ± 0.017
2.54LeuTyr: 2.54 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
2.1MetAla: 2.1 ± 0.019
0.243MetCys: 0.243 ± 0.006
1.181MetAsp: 1.181 ± 0.015
1.217MetGlu: 1.217 ± 0.016
0.682MetPhe: 0.682 ± 0.011
1.409MetGly: 1.409 ± 0.017
0.477MetHis: 0.477 ± 0.01
0.985MetIle: 0.985 ± 0.016
0.944MetLys: 0.944 ± 0.013
1.804MetLeu: 1.804 ± 0.019
0.498MetMet: 0.498 ± 0.011
0.779MetAsn: 0.779 ± 0.013
1.203MetPro: 1.203 ± 0.018
0.827MetGln: 0.827 ± 0.014
1.219MetArg: 1.219 ± 0.016
1.757MetSer: 1.757 ± 0.019
1.232MetThr: 1.232 ± 0.015
1.288MetVal: 1.288 ± 0.018
0.239MetTrp: 0.239 ± 0.007
0.531MetTyr: 0.531 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.176AsnAla: 3.176 ± 0.028
0.461AsnCys: 0.461 ± 0.011
1.907AsnAsp: 1.907 ± 0.019
2.108AsnGlu: 2.108 ± 0.022
1.283AsnPhe: 1.283 ± 0.017
2.889AsnGly: 2.889 ± 0.026
0.852AsnHis: 0.852 ± 0.012
2.085AsnIle: 2.085 ± 0.023
1.483AsnLys: 1.483 ± 0.021
3.276AsnLeu: 3.276 ± 0.023
0.807AsnMet: 0.807 ± 0.014
1.452AsnAsn: 1.452 ± 0.02
2.525AsnPro: 2.525 ± 0.023
1.396AsnGln: 1.396 ± 0.02
2.071AsnArg: 2.071 ± 0.021
2.815AsnSer: 2.815 ± 0.023
2.217AsnThr: 2.217 ± 0.021
2.296AsnVal: 2.296 ± 0.025
0.597AsnTrp: 0.597 ± 0.012
1.089AsnTyr: 1.089 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
5.19ProAla: 5.19 ± 0.045
0.575ProCys: 0.575 ± 0.012
3.241ProAsp: 3.241 ± 0.032
3.885ProGlu: 3.885 ± 0.032
2.102ProPhe: 2.102 ± 0.025
3.999ProGly: 3.999 ± 0.035
1.29ProHis: 1.29 ± 0.017
2.543ProIle: 2.543 ± 0.024
2.465ProLys: 2.465 ± 0.025
4.845ProLeu: 4.845 ± 0.035
0.998ProMet: 0.998 ± 0.013
2.178ProAsn: 2.178 ± 0.02
4.695ProPro: 4.695 ± 0.068
2.423ProGln: 2.423 ± 0.033
3.438ProArg: 3.438 ± 0.033
6.086ProSer: 6.086 ± 0.046
3.91ProThr: 3.91 ± 0.035
3.685ProVal: 3.685 ± 0.033
0.754ProTrp: 0.754 ± 0.014
1.573ProTyr: 1.573 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.433GlnAla: 3.433 ± 0.038
0.459GlnCys: 0.459 ± 0.009
2.038GlnAsp: 2.038 ± 0.02
2.431GlnGlu: 2.431 ± 0.029
1.314GlnPhe: 1.314 ± 0.017
2.412GlnGly: 2.412 ± 0.025
1.049GlnHis: 1.049 ± 0.014
1.924GlnIle: 1.924 ± 0.021
1.966GlnLys: 1.966 ± 0.025
3.606GlnLeu: 3.606 ± 0.031
0.853GlnMet: 0.853 ± 0.014
1.551GlnAsn: 1.551 ± 0.021
2.548GlnPro: 2.548 ± 0.033
2.3GlnGln: 2.3 ± 0.047
2.737GlnArg: 2.737 ± 0.026
3.24GlnSer: 3.24 ± 0.03
2.388GlnThr: 2.388 ± 0.024
2.175GlnVal: 2.175 ± 0.021
0.56GlnTrp: 0.56 ± 0.011
1.217GlnTyr: 1.217 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
4.885ArgAla: 4.885 ± 0.032
0.756ArgCys: 0.756 ± 0.014
3.354ArgAsp: 3.354 ± 0.032
3.935ArgGlu: 3.935 ± 0.039
2.267ArgPhe: 2.267 ± 0.022
3.691ArgGly: 3.691 ± 0.031
1.579ArgHis: 1.579 ± 0.02
3.028ArgIle: 3.028 ± 0.029
3.415ArgLys: 3.415 ± 0.029
5.846ArgLeu: 5.846 ± 0.04
1.313ArgMet: 1.313 ± 0.018
2.342ArgAsn: 2.342 ± 0.024
3.532ArgPro: 3.532 ± 0.032
2.634ArgGln: 2.634 ± 0.026
5.234ArgArg: 5.234 ± 0.048
4.941ArgSer: 4.941 ± 0.041
3.464ArgThr: 3.464 ± 0.028
3.546ArgVal: 3.546 ± 0.027
0.982ArgTrp: 0.982 ± 0.013
1.781ArgTyr: 1.781 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
6.811SerAla: 6.811 ± 0.043
0.935SerCys: 0.935 ± 0.017
4.304SerAsp: 4.304 ± 0.031
4.332SerGlu: 4.332 ± 0.031
3.077SerPhe: 3.077 ± 0.024
5.62SerGly: 5.62 ± 0.034
1.993SerHis: 1.993 ± 0.022
4.102SerIle: 4.102 ± 0.031
3.523SerLys: 3.523 ± 0.028
7.569SerLeu: 7.569 ± 0.048
1.651SerMet: 1.651 ± 0.018
3.037SerAsn: 3.037 ± 0.026
5.541SerPro: 5.541 ± 0.05
3.422SerGln: 3.422 ± 0.032
5.281SerArg: 5.281 ± 0.041
8.834SerSer: 8.834 ± 0.071
5.658SerThr: 5.658 ± 0.046
4.765SerVal: 4.765 ± 0.028
1.153SerTrp: 1.153 ± 0.017
2.186SerTyr: 2.186 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
5.299ThrAla: 5.299 ± 0.036
0.745ThrCys: 0.745 ± 0.013
2.904ThrAsp: 2.904 ± 0.026
3.278ThrGlu: 3.278 ± 0.032
2.228ThrPhe: 2.228 ± 0.019
4.315ThrGly: 4.315 ± 0.032
1.259ThrHis: 1.259 ± 0.015
3.054ThrIle: 3.054 ± 0.026
2.461ThrLys: 2.461 ± 0.023
5.371ThrLeu: 5.371 ± 0.034
1.136ThrMet: 1.136 ± 0.017
2.097ThrAsn: 2.097 ± 0.023
4.301ThrPro: 4.301 ± 0.038
2.11ThrGln: 2.11 ± 0.023
3.212ThrArg: 3.212 ± 0.03
5.316ThrSer: 5.316 ± 0.039
4.134ThrThr: 4.134 ± 0.046
3.885ThrVal: 3.885 ± 0.028
0.856ThrTrp: 0.856 ± 0.014
1.658ThrTyr: 1.658 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
5.112ValAla: 5.112 ± 0.035
0.835ValCys: 0.835 ± 0.014
3.637ValAsp: 3.637 ± 0.03
3.793ValGlu: 3.793 ± 0.03
2.518ValPhe: 2.518 ± 0.028
3.95ValGly: 3.95 ± 0.033
1.408ValHis: 1.408 ± 0.017
3.042ValIle: 3.042 ± 0.026
2.725ValLys: 2.725 ± 0.024
5.769ValLeu: 5.769 ± 0.039
1.243ValMet: 1.243 ± 0.015
2.29ValAsn: 2.29 ± 0.024
3.572ValPro: 3.572 ± 0.029
2.447ValGln: 2.447 ± 0.023
3.611ValArg: 3.611 ± 0.03
4.872ValSer: 4.872 ± 0.032
3.525ValThr: 3.525 ± 0.03
4.167ValVal: 4.167 ± 0.032
0.868ValTrp: 0.868 ± 0.014
1.85ValTyr: 1.85 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.136TrpAla: 1.136 ± 0.016
0.19TrpCys: 0.19 ± 0.006
0.876TrpAsp: 0.876 ± 0.015
0.855TrpGlu: 0.855 ± 0.013
0.547TrpPhe: 0.547 ± 0.01
0.928TrpGly: 0.928 ± 0.015
0.35TrpHis: 0.35 ± 0.008
0.771TrpIle: 0.771 ± 0.012
0.795TrpLys: 0.795 ± 0.014
1.418TrpLeu: 1.418 ± 0.017
0.363TrpMet: 0.363 ± 0.008
0.644TrpAsn: 0.644 ± 0.012
0.608TrpPro: 0.608 ± 0.01
0.551TrpGln: 0.551 ± 0.011
0.984TrpArg: 0.984 ± 0.014
1.08TrpSer: 1.08 ± 0.015
0.923TrpThr: 0.923 ± 0.015
0.901TrpVal: 0.901 ± 0.015
0.278TrpTrp: 0.278 ± 0.008
0.431TrpTyr: 0.431 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.272TyrAla: 2.272 ± 0.024
0.434TyrCys: 0.434 ± 0.01
1.662TyrAsp: 1.662 ± 0.018
1.594TyrGlu: 1.594 ± 0.018
1.238TyrPhe: 1.238 ± 0.019
2.174TyrGly: 2.174 ± 0.024
0.777TyrHis: 0.777 ± 0.012
1.515TyrIle: 1.515 ± 0.019
1.118TyrLys: 1.118 ± 0.016
2.845TyrLeu: 2.845 ± 0.027
0.631TyrMet: 0.631 ± 0.012
1.176TyrAsn: 1.176 ± 0.018
1.619TyrPro: 1.619 ± 0.021
1.13TyrGln: 1.13 ± 0.016
1.769TyrArg: 1.769 ± 0.016
2.177TyrSer: 2.177 ± 0.023
1.721TyrThr: 1.721 ± 0.018
1.645TyrVal: 1.645 ± 0.019
0.469TyrTrp: 0.469 ± 0.01
1.004TyrTyr: 1.004 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10559 proteins (5092340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski