Amino acid dipepetide frequency for Plasmodium ovale curtisi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.468AlaAla: 1.468 ± 0.032	0.632AlaCys: 0.632 ± 0.012	1.717AlaAsp: 1.717 ± 0.027	2.393AlaGlu: 2.393 ± 0.037	1.322AlaPhe: 1.322 ± 0.017	1.386AlaGly: 1.386 ± 0.022	0.932AlaHis: 0.932 ± 0.014	2.09AlaIle: 2.09 ± 0.026	3.004AlaLys: 3.004 ± 0.038	2.683AlaLeu: 2.683 ± 0.033	0.626AlaMet: 0.626 ± 0.012	2.747AlaAsn: 2.747 ± 0.038	0.961AlaPro: 0.961 ± 0.016	1.145AlaGln: 1.145 ± 0.021	1.156AlaArg: 1.156 ± 0.019	2.598AlaSer: 2.598 ± 0.025	1.721AlaThr: 1.721 ± 0.026	1.53AlaVal: 1.53 ± 0.024	0.179AlaTrp: 0.179 ± 0.007	1.616AlaTyr: 1.616 ± 0.022	0.001AlaXaa: 0.001 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.013	0.433CysCys: 0.433 ± 0.01	1.289CysAsp: 1.289 ± 0.019	1.537CysGlu: 1.537 ± 0.019	0.85CysPhe: 0.85 ± 0.014	0.882CysGly: 0.882 ± 0.016	0.417CysHis: 0.417 ± 0.01	1.694CysIle: 1.694 ± 0.02	2.146CysLys: 2.146 ± 0.024	1.617CysLeu: 1.617 ± 0.02	0.404CysMet: 0.404 ± 0.009	1.853CysAsn: 1.853 ± 0.023	0.624CysPro: 0.624 ± 0.013	0.442CysGln: 0.442 ± 0.011	0.803CysArg: 0.803 ± 0.013	1.886CysSer: 1.886 ± 0.024	1.277CysThr: 1.277 ± 0.016	1.047CysVal: 1.047 ± 0.016	0.087CysTrp: 0.087 ± 0.004	0.856CysTyr: 0.856 ± 0.014	0.001CysXaa: 0.001 ± 0.0
Asp	2.15AspAla: 2.15 ± 0.029	0.911AspCys: 0.911 ± 0.014	4.396AspAsp: 4.396 ± 0.068	5.494AspGlu: 5.494 ± 0.053	2.436AspPhe: 2.436 ± 0.025	2.707AspGly: 2.707 ± 0.038	1.08AspHis: 1.08 ± 0.018	5.404AspIle: 5.404 ± 0.038	5.313AspLys: 5.313 ± 0.039	3.883AspLeu: 3.883 ± 0.029	1.452AspMet: 1.452 ± 0.022	5.122AspAsn: 5.122 ± 0.047	1.229AspPro: 1.229 ± 0.022	1.247AspGln: 1.247 ± 0.018	1.9AspArg: 1.9 ± 0.033	4.054AspSer: 4.054 ± 0.039	2.886AspThr: 2.886 ± 0.028	3.391AspVal: 3.391 ± 0.029	0.298AspTrp: 0.298 ± 0.009	2.716AspTyr: 2.716 ± 0.028	0.001AspXaa: 0.001 ± 0.001
Glu	2.47GluAla: 2.47 ± 0.039	1.365GluCys: 1.365 ± 0.018	5.046GluAsp: 5.046 ± 0.045	9.687GluGlu: 9.687 ± 0.111	2.297GluPhe: 2.297 ± 0.027	3.718GluGly: 3.718 ± 0.04	1.828GluHis: 1.828 ± 0.025	5.269GluIle: 5.269 ± 0.043	11.024GluLys: 11.024 ± 0.085	5.218GluLeu: 5.218 ± 0.045	1.731GluMet: 1.731 ± 0.021	8.296GluAsn: 8.296 ± 0.064	1.143GluPro: 1.143 ± 0.019	2.5GluGln: 2.5 ± 0.03	3.48GluArg: 3.48 ± 0.043	4.549GluSer: 4.549 ± 0.041	3.124GluThr: 3.124 ± 0.031	3.143GluVal: 3.143 ± 0.043	0.514GluTrp: 0.514 ± 0.015	3.234GluTyr: 3.234 ± 0.029	0.001GluXaa: 0.001 ± 0.0
Phe	1.268PheAla: 1.268 ± 0.017	1.131PheCys: 1.131 ± 0.015	2.493PheAsp: 2.493 ± 0.023	2.588PheGlu: 2.588 ± 0.03	3.233PhePhe: 3.233 ± 0.041	1.703PheGly: 1.703 ± 0.033	1.163PheHis: 1.163 ± 0.018	3.289PheIle: 3.289 ± 0.033	3.527PheLys: 3.527 ± 0.032	5.06PheLeu: 5.06 ± 0.049	0.846PheMet: 0.846 ± 0.012	3.54PheAsn: 3.54 ± 0.031	1.446PhePro: 1.446 ± 0.017	1.206PheGln: 1.206 ± 0.017	1.485PheArg: 1.485 ± 0.021	3.913PheSer: 3.913 ± 0.035	2.144PheThr: 2.144 ± 0.025	2.159PheVal: 2.159 ± 0.024	0.284PheTrp: 0.284 ± 0.009	2.711PheTyr: 2.711 ± 0.031	0.002PheXaa: 0.002 ± 0.001
Gly	1.627GlyAla: 1.627 ± 0.024	0.809GlyCys: 0.809 ± 0.013	3.046GlyAsp: 3.046 ± 0.038	4.569GlyGlu: 4.569 ± 0.049	1.33GlyPhe: 1.33 ± 0.021	3.549GlyGly: 3.549 ± 0.06	0.94GlyHis: 0.94 ± 0.017	3.23GlyIle: 3.23 ± 0.03	5.259GlyLys: 5.259 ± 0.052	2.275GlyLeu: 2.275 ± 0.023	0.905GlyMet: 0.905 ± 0.017	4.568GlyAsn: 4.568 ± 0.056	0.707GlyPro: 0.707 ± 0.016	1.038GlyGln: 1.038 ± 0.018	2.22GlyArg: 2.22 ± 0.035	4.117GlySer: 4.117 ± 0.055	2.301GlyThr: 2.301 ± 0.03	2.277GlyVal: 2.277 ± 0.026	0.231GlyTrp: 0.231 ± 0.007	1.815GlyTyr: 1.815 ± 0.025	0.001GlyXaa: 0.001 ± 0.001
His	0.851HisAla: 0.851 ± 0.015	0.442HisCys: 0.442 ± 0.009	1.264HisAsp: 1.264 ± 0.019	1.489HisGlu: 1.489 ± 0.02	1.473HisPhe: 1.473 ± 0.021	1.124HisGly: 1.124 ± 0.018	0.602HisHis: 0.602 ± 0.015	2.173HisIle: 2.173 ± 0.025	1.858HisLys: 1.858 ± 0.021	2.165HisLeu: 2.165 ± 0.027	0.652HisMet: 0.652 ± 0.012	2.023HisAsn: 2.023 ± 0.026	0.712HisPro: 0.712 ± 0.013	0.506HisGln: 0.506 ± 0.012	0.924HisArg: 0.924 ± 0.017	1.903HisSer: 1.903 ± 0.022	1.206HisThr: 1.206 ± 0.018	1.382HisVal: 1.382 ± 0.018	0.142HisTrp: 0.142 ± 0.006	1.051HisTyr: 1.051 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	2.157IleAla: 2.157 ± 0.022	1.888IleCys: 1.888 ± 0.02	4.135IleAsp: 4.135 ± 0.031	4.839IleGlu: 4.839 ± 0.045	4.093IlePhe: 4.093 ± 0.039	2.911IleGly: 2.911 ± 0.031	1.963IleHis: 1.963 ± 0.022	5.64IleIle: 5.64 ± 0.042	7.304IleLys: 7.304 ± 0.059	7.023IleLeu: 7.023 ± 0.054	1.329IleMet: 1.329 ± 0.016	7.095IleAsn: 7.095 ± 0.059	2.438IlePro: 2.438 ± 0.025	2.153IleGln: 2.153 ± 0.022	2.634IleArg: 2.634 ± 0.025	6.117IleSer: 6.117 ± 0.04	3.307IleThr: 3.307 ± 0.032	3.089IleVal: 3.089 ± 0.028	0.502IleTrp: 0.502 ± 0.01	4.173IleTyr: 4.173 ± 0.041	0.001IleXaa: 0.001 ± 0.0
Lys	2.513LysAla: 2.513 ± 0.039	2.322LysCys: 2.322 ± 0.025	5.341LysAsp: 5.341 ± 0.042	9.533LysGlu: 9.533 ± 0.081	3.476LysPhe: 3.476 ± 0.031	4.837LysGly: 4.837 ± 0.037	2.197LysHis: 2.197 ± 0.025	8.149LysIle: 8.149 ± 0.054	15.915LysLys: 15.915 ± 0.118	7.318LysLeu: 7.318 ± 0.044	2.472LysMet: 2.472 ± 0.025	11.128LysAsn: 11.128 ± 0.075	1.61LysPro: 1.61 ± 0.024	2.673LysGln: 2.673 ± 0.03	5.251LysArg: 5.251 ± 0.045	6.349LysSer: 6.349 ± 0.04	4.143LysThr: 4.143 ± 0.035	3.897LysVal: 3.897 ± 0.032	0.847LysTrp: 0.847 ± 0.017	5.323LysTyr: 5.323 ± 0.043	0.01LysXaa: 0.01 ± 0.002
Leu	2.106LeuAla: 2.106 ± 0.024	1.957LeuCys: 1.957 ± 0.022	3.567LeuAsp: 3.567 ± 0.031	4.776LeuGlu: 4.776 ± 0.046	4.43LeuPhe: 4.43 ± 0.043	3.049LeuGly: 3.049 ± 0.032	2.281LeuHis: 2.281 ± 0.024	5.163LeuIle: 5.163 ± 0.04	8.346LeuLys: 8.346 ± 0.053	7.727LeuLeu: 7.727 ± 0.063	1.408LeuMet: 1.408 ± 0.018	7.158LeuAsn: 7.158 ± 0.053	2.577LeuPro: 2.577 ± 0.027	2.582LeuGln: 2.582 ± 0.027	3.335LeuArg: 3.335 ± 0.034	6.377LeuSer: 6.377 ± 0.039	3.359LeuThr: 3.359 ± 0.029	2.864LeuVal: 2.864 ± 0.03	0.549LeuTrp: 0.549 ± 0.012	4.692LeuTyr: 4.692 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	0.61MetAla: 0.61 ± 0.013	0.466MetCys: 0.466 ± 0.011	1.31MetAsp: 1.31 ± 0.017	1.75MetGlu: 1.75 ± 0.02	0.835MetPhe: 0.835 ± 0.016	1.047MetGly: 1.047 ± 0.017	0.702MetHis: 0.702 ± 0.013	1.113MetIle: 1.113 ± 0.016	2.325MetLys: 2.325 ± 0.022	1.61MetLeu: 1.61 ± 0.018	0.431MetMet: 0.431 ± 0.01	2.312MetAsn: 2.312 ± 0.035	0.531MetPro: 0.531 ± 0.012	0.755MetGln: 0.755 ± 0.014	0.852MetArg: 0.852 ± 0.016	1.563MetSer: 1.563 ± 0.019	0.77MetThr: 0.77 ± 0.013	0.818MetVal: 0.818 ± 0.013	0.151MetTrp: 0.151 ± 0.006	1.162MetTyr: 1.162 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.271AsnAla: 3.271 ± 0.034	1.849AsnCys: 1.849 ± 0.023	5.909AsnAsp: 5.909 ± 0.051	7.632AsnGlu: 7.632 ± 0.055	4.593AsnPhe: 4.593 ± 0.043	4.484AsnGly: 4.484 ± 0.053	1.688AsnHis: 1.688 ± 0.022	8.682AsnIle: 8.682 ± 0.063	8.448AsnLys: 8.448 ± 0.056	6.543AsnLeu: 6.543 ± 0.043	2.486AsnMet: 2.486 ± 0.033	9.556AsnAsn: 9.556 ± 0.119	1.987AsnPro: 1.987 ± 0.024	1.862AsnGln: 1.862 ± 0.03	3.302AsnArg: 3.302 ± 0.032	7.544AsnSer: 7.544 ± 0.066	4.478AsnThr: 4.478 ± 0.034	5.494AsnVal: 5.494 ± 0.048	0.446AsnTrp: 0.446 ± 0.011	5.102AsnTyr: 5.102 ± 0.041	0.001AsnXaa: 0.001 ± 0.001
Pro	0.699ProAla: 0.699 ± 0.015	0.563ProCys: 0.563 ± 0.011	1.173ProAsp: 1.173 ± 0.022	1.42ProGlu: 1.42 ± 0.025	1.636ProPhe: 1.636 ± 0.018	0.962ProGly: 0.962 ± 0.018	0.731ProHis: 0.731 ± 0.013	1.851ProIle: 1.851 ± 0.022	1.814ProLys: 1.814 ± 0.029	2.45ProLeu: 2.45 ± 0.025	0.488ProMet: 0.488 ± 0.01	2.028ProAsn: 2.028 ± 0.027	1.162ProPro: 1.162 ± 0.028	0.844ProGln: 0.844 ± 0.017	0.867ProArg: 0.867 ± 0.015	2.399ProSer: 2.399 ± 0.025	1.255ProThr: 1.255 ± 0.02	1.265ProVal: 1.265 ± 0.023	0.195ProTrp: 0.195 ± 0.007	1.241ProTyr: 1.241 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	0.815GlnAla: 0.815 ± 0.018	0.539GlnCys: 0.539 ± 0.011	1.244GlnAsp: 1.244 ± 0.02	2.056GlnGlu: 2.056 ± 0.024	1.094GlnPhe: 1.094 ± 0.016	1.273GlnGly: 1.273 ± 0.018	0.652GlnHis: 0.652 ± 0.013	1.98GlnIle: 1.98 ± 0.026	3.081GlnLys: 3.081 ± 0.031	2.104GlnLeu: 2.104 ± 0.024	0.744GlnMet: 0.744 ± 0.023	2.987GlnAsn: 2.987 ± 0.036	0.632GlnPro: 0.632 ± 0.014	0.978GlnGln: 0.978 ± 0.019	1.251GlnArg: 1.251 ± 0.021	1.861GlnSer: 1.861 ± 0.022	1.262GlnThr: 1.262 ± 0.019	1.157GlnVal: 1.157 ± 0.018	0.23GlnTrp: 0.23 ± 0.007	1.222GlnTyr: 1.222 ± 0.019	0.001GlnXaa: 0.001 ± 0.0
Arg	1.189ArgAla: 1.189 ± 0.017	0.894ArgCys: 0.894 ± 0.014	2.409ArgAsp: 2.409 ± 0.032	3.694ArgGlu: 3.694 ± 0.041	1.206ArgPhe: 1.206 ± 0.016	2.47ArgGly: 2.47 ± 0.032	0.846ArgHis: 0.846 ± 0.015	2.617ArgIle: 2.617 ± 0.024	5.266ArgLys: 5.266 ± 0.057	2.265ArgLeu: 2.265 ± 0.026	0.825ArgMet: 0.825 ± 0.015	4.045ArgAsn: 4.045 ± 0.034	0.593ArgPro: 0.593 ± 0.013	0.964ArgGln: 0.964 ± 0.014	2.588ArgArg: 2.588 ± 0.037	3.067ArgSer: 3.067 ± 0.044	1.696ArgThr: 1.696 ± 0.021	1.601ArgVal: 1.601 ± 0.023	0.284ArgTrp: 0.284 ± 0.008	1.591ArgTyr: 1.591 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	2.785SerAla: 2.785 ± 0.027	1.524SerCys: 1.524 ± 0.021	4.624SerAsp: 4.624 ± 0.041	5.349SerGlu: 5.349 ± 0.04	3.79SerPhe: 3.79 ± 0.035	4.227SerGly: 4.227 ± 0.055	1.889SerHis: 1.889 ± 0.02	5.38SerIle: 5.38 ± 0.035	6.577SerLys: 6.577 ± 0.049	6.089SerLeu: 6.089 ± 0.04	1.48SerMet: 1.48 ± 0.021	7.056SerAsn: 7.056 ± 0.066	2.227SerPro: 2.227 ± 0.03	2.061SerGln: 2.061 ± 0.022	2.852SerArg: 2.852 ± 0.036	8.227SerSer: 8.227 ± 0.068	4.054SerThr: 4.054 ± 0.039	3.693SerVal: 3.693 ± 0.03	0.445SerTrp: 0.445 ± 0.011	3.706SerTyr: 3.706 ± 0.032	0.001SerXaa: 0.001 ± 0.0
Thr	1.633ThrAla: 1.633 ± 0.028	1.114ThrCys: 1.114 ± 0.017	2.408ThrAsp: 2.408 ± 0.026	2.99ThrGlu: 2.99 ± 0.029	2.365ThrPhe: 2.365 ± 0.024	2.041ThrGly: 2.041 ± 0.028	1.348ThrHis: 1.348 ± 0.016	3.052ThrIle: 3.052 ± 0.026	4.098ThrLys: 4.098 ± 0.037	3.756ThrLeu: 3.756 ± 0.033	0.812ThrMet: 0.812 ± 0.014	4.315ThrAsn: 4.315 ± 0.039	1.846ThrPro: 1.846 ± 0.025	1.449ThrGln: 1.449 ± 0.017	1.516ThrArg: 1.516 ± 0.024	4.092ThrSer: 4.092 ± 0.033	2.442ThrThr: 2.442 ± 0.034	2.192ThrVal: 2.192 ± 0.025	0.304ThrTrp: 0.304 ± 0.008	2.404ThrTyr: 2.404 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	1.616ValAla: 1.616 ± 0.023	1.001ValCys: 1.001 ± 0.014	2.816ValAsp: 2.816 ± 0.033	3.653ValGlu: 3.653 ± 0.042	1.81ValPhe: 1.81 ± 0.023	2.278ValGly: 2.278 ± 0.032	1.459ValHis: 1.459 ± 0.02	3.065ValIle: 3.065 ± 0.03	4.537ValLys: 4.537 ± 0.036	3.745ValLeu: 3.745 ± 0.032	0.769ValMet: 0.769 ± 0.014	4.12ValAsn: 4.12 ± 0.038	1.336ValPro: 1.336 ± 0.021	1.533ValGln: 1.533 ± 0.019	1.832ValArg: 1.832 ± 0.024	3.552ValSer: 3.552 ± 0.033	2.188ValThr: 2.188 ± 0.026	2.207ValVal: 2.207 ± 0.029	0.261ValTrp: 0.261 ± 0.007	2.146ValTyr: 2.146 ± 0.025	0.001ValXaa: 0.001 ± 0.001
Trp	0.17TrpAla: 0.17 ± 0.006	0.123TrpCys: 0.123 ± 0.005	0.373TrpAsp: 0.373 ± 0.008	0.495TrpGlu: 0.495 ± 0.01	0.274TrpPhe: 0.274 ± 0.008	0.35TrpGly: 0.35 ± 0.009	0.107TrpHis: 0.107 ± 0.005	0.603TrpIle: 0.603 ± 0.013	0.846TrpLys: 0.846 ± 0.016	0.679TrpLeu: 0.679 ± 0.014	0.161TrpMet: 0.161 ± 0.007	0.565TrpAsn: 0.565 ± 0.012	0.1TrpPro: 0.1 ± 0.006	0.131TrpGln: 0.131 ± 0.005	0.276TrpArg: 0.276 ± 0.008	0.382TrpSer: 0.382 ± 0.01	0.235TrpThr: 0.235 ± 0.008	0.334TrpVal: 0.334 ± 0.009	0.047TrpTrp: 0.047 ± 0.003	0.205TrpTyr: 0.205 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.671TyrAla: 1.671 ± 0.019	1.017TyrCys: 1.017 ± 0.016	3.508TyrAsp: 3.508 ± 0.033	3.695TyrGlu: 3.695 ± 0.033	2.647TyrPhe: 2.647 ± 0.028	1.818TyrGly: 1.818 ± 0.025	1.115TyrHis: 1.115 ± 0.018	4.344TyrIle: 4.344 ± 0.042	4.607TyrLys: 4.607 ± 0.041	4.092TyrLeu: 4.092 ± 0.037	1.091TyrMet: 1.091 ± 0.016	4.844TyrAsn: 4.844 ± 0.042	1.183TyrPro: 1.183 ± 0.018	1.095TyrGln: 1.095 ± 0.016	1.583TyrArg: 1.583 ± 0.02	3.484TyrSer: 3.484 ± 0.029	2.329TyrThr: 2.329 ± 0.023	2.385TyrVal: 2.385 ± 0.026	0.459TyrTrp: 0.459 ± 0.011	2.614TyrTyr: 2.614 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.008XaaLys: 0.008 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.071XaaXaa: 0.071 ± 0.007

Statistics based on 8608 proteins (4757509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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