Amino acid dipepetide frequency for Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847) (Methanoplanus petrolearius)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.687AlaAla: 6.687 ± 0.116
0.949AlaCys: 0.949 ± 0.039
4.223AlaAsp: 4.223 ± 0.074
5.532AlaGlu: 5.532 ± 0.089
2.951AlaPhe: 2.951 ± 0.062
7.401AlaGly: 7.401 ± 0.108
0.95AlaHis: 0.95 ± 0.037
6.056AlaIle: 6.056 ± 0.115
3.607AlaLys: 3.607 ± 0.075
6.729AlaLeu: 6.729 ± 0.106
2.109AlaMet: 2.109 ± 0.051
2.201AlaAsn: 2.201 ± 0.059
2.144AlaPro: 2.144 ± 0.054
1.312AlaGln: 1.312 ± 0.043
2.811AlaArg: 2.811 ± 0.06
4.175AlaSer: 4.175 ± 0.079
3.295AlaThr: 3.295 ± 0.08
6.448AlaVal: 6.448 ± 0.112
0.582AlaTrp: 0.582 ± 0.024
2.253AlaTyr: 2.253 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.82CysAla: 0.82 ± 0.032
0.248CysCys: 0.248 ± 0.019
0.776CysAsp: 0.776 ± 0.033
0.77CysGlu: 0.77 ± 0.032
0.466CysPhe: 0.466 ± 0.024
1.517CysGly: 1.517 ± 0.052
0.273CysHis: 0.273 ± 0.021
1.066CysIle: 1.066 ± 0.04
0.535CysLys: 0.535 ± 0.025
1.066CysLeu: 1.066 ± 0.037
0.341CysMet: 0.341 ± 0.022
0.52CysAsn: 0.52 ± 0.023
0.843CysPro: 0.843 ± 0.038
0.249CysGln: 0.249 ± 0.019
0.843CysArg: 0.843 ± 0.03
1.065CysSer: 1.065 ± 0.041
0.84CysThr: 0.84 ± 0.034
0.692CysVal: 0.692 ± 0.028
0.117CysTrp: 0.117 ± 0.01
0.445CysTyr: 0.445 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.06AspAla: 4.06 ± 0.08
0.737AspCys: 0.737 ± 0.035
3.446AspAsp: 3.446 ± 0.073
5.116AspGlu: 5.116 ± 0.091
2.565AspPhe: 2.565 ± 0.057
4.302AspGly: 4.302 ± 0.088
0.975AspHis: 0.975 ± 0.031
5.431AspIle: 5.431 ± 0.084
2.863AspLys: 2.863 ± 0.057
5.923AspLeu: 5.923 ± 0.089
1.556AspMet: 1.556 ± 0.05
2.246AspAsn: 2.246 ± 0.05
2.94AspPro: 2.94 ± 0.077
1.214AspGln: 1.214 ± 0.042
2.557AspArg: 2.557 ± 0.054
3.905AspSer: 3.905 ± 0.068
2.975AspThr: 2.975 ± 0.064
3.974AspVal: 3.974 ± 0.077
0.599AspTrp: 0.599 ± 0.028
2.453AspTyr: 2.453 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.851GluAla: 4.851 ± 0.101
0.923GluCys: 0.923 ± 0.036
4.401GluAsp: 4.401 ± 0.066
6.521GluGlu: 6.521 ± 0.113
2.822GluPhe: 2.822 ± 0.057
4.725GluGly: 4.725 ± 0.081
1.02GluHis: 1.02 ± 0.033
7.309GluIle: 7.309 ± 0.122
6.314GluLys: 6.314 ± 0.103
5.776GluLeu: 5.776 ± 0.092
2.235GluMet: 2.235 ± 0.059
3.959GluAsn: 3.959 ± 0.081
2.318GluPro: 2.318 ± 0.06
1.655GluGln: 1.655 ± 0.047
3.585GluArg: 3.585 ± 0.068
4.538GluSer: 4.538 ± 0.069
3.855GluThr: 3.855 ± 0.074
4.274GluVal: 4.274 ± 0.094
0.742GluTrp: 0.742 ± 0.03
2.931GluTyr: 2.931 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.028PheAla: 3.028 ± 0.07
0.653PheCys: 0.653 ± 0.027
2.484PheAsp: 2.484 ± 0.056
2.81PheGlu: 2.81 ± 0.061
2.127PhePhe: 2.127 ± 0.071
3.527PheGly: 3.527 ± 0.068
0.645PheHis: 0.645 ± 0.028
3.439PheIle: 3.439 ± 0.078
1.589PheLys: 1.589 ± 0.048
3.996PheLeu: 3.996 ± 0.089
1.082PheMet: 1.082 ± 0.039
1.59PheAsn: 1.59 ± 0.045
1.655PhePro: 1.655 ± 0.04
0.851PheGln: 0.851 ± 0.031
2.072PheArg: 2.072 ± 0.048
3.691PheSer: 3.691 ± 0.071
2.449PheThr: 2.449 ± 0.064
2.952PheVal: 2.952 ± 0.056
0.438PheTrp: 0.438 ± 0.025
1.5PheTyr: 1.5 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.253GlyAla: 5.253 ± 0.092
1.303GlyCys: 1.303 ± 0.042
4.931GlyAsp: 4.931 ± 0.091
5.785GlyGlu: 5.785 ± 0.091
3.541GlyPhe: 3.541 ± 0.08
5.976GlyGly: 5.976 ± 0.125
1.209GlyHis: 1.209 ± 0.042
7.253GlyIle: 7.253 ± 0.117
5.029GlyLys: 5.029 ± 0.087
6.399GlyLeu: 6.399 ± 0.094
2.41GlyMet: 2.41 ± 0.058
3.15GlyAsn: 3.15 ± 0.078
2.018GlyPro: 2.018 ± 0.051
1.598GlyGln: 1.598 ± 0.044
3.677GlyArg: 3.677 ± 0.083
5.345GlySer: 5.345 ± 0.097
4.672GlyThr: 4.672 ± 0.084
5.39GlyVal: 5.39 ± 0.112
0.837GlyTrp: 0.837 ± 0.032
3.23GlyTyr: 3.23 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.099HisAla: 1.099 ± 0.041
0.269HisCys: 0.269 ± 0.018
0.939HisAsp: 0.939 ± 0.034
1.048HisGlu: 1.048 ± 0.037
0.699HisPhe: 0.699 ± 0.03
1.183HisGly: 1.183 ± 0.037
0.361HisHis: 0.361 ± 0.023
1.215HisIle: 1.215 ± 0.039
0.701HisLys: 0.701 ± 0.03
1.358HisLeu: 1.358 ± 0.039
0.432HisMet: 0.432 ± 0.022
0.582HisAsn: 0.582 ± 0.026
0.985HisPro: 0.985 ± 0.035
0.342HisGln: 0.342 ± 0.018
0.78HisArg: 0.78 ± 0.029
0.939HisSer: 0.939 ± 0.034
0.801HisThr: 0.801 ± 0.034
0.991HisVal: 0.991 ± 0.036
0.155HisTrp: 0.155 ± 0.013
0.609HisTyr: 0.609 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.636IleAla: 6.636 ± 0.099
1.112IleCys: 1.112 ± 0.039
5.018IleAsp: 5.018 ± 0.072
5.916IleGlu: 5.916 ± 0.095
3.775IlePhe: 3.775 ± 0.077
5.78IleGly: 5.78 ± 0.095
1.243IleHis: 1.243 ± 0.039
7.206IleIle: 7.206 ± 0.126
4.117IleLys: 4.117 ± 0.082
7.706IleLeu: 7.706 ± 0.126
1.999IleMet: 1.999 ± 0.052
3.233IleAsn: 3.233 ± 0.068
4.02IlePro: 4.02 ± 0.067
1.744IleGln: 1.744 ± 0.044
4.063IleArg: 4.063 ± 0.07
6.643IleSer: 6.643 ± 0.095
4.807IleThr: 4.807 ± 0.087
5.864IleVal: 5.864 ± 0.101
0.689IleTrp: 0.689 ± 0.033
2.668IleTyr: 2.668 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
3.693LysAla: 3.693 ± 0.076
0.744LysCys: 0.744 ± 0.031
3.489LysAsp: 3.489 ± 0.069
5.004LysGlu: 5.004 ± 0.085
1.851LysPhe: 1.851 ± 0.053
4.039LysGly: 4.039 ± 0.08
0.73LysHis: 0.73 ± 0.031
5.115LysIle: 5.115 ± 0.093
5.179LysLys: 5.179 ± 0.098
3.801LysLeu: 3.801 ± 0.073
1.661LysMet: 1.661 ± 0.046
2.978LysAsn: 2.978 ± 0.064
2.056LysPro: 2.056 ± 0.055
1.231LysGln: 1.231 ± 0.04
2.73LysArg: 2.73 ± 0.063
3.579LysSer: 3.579 ± 0.067
3.388LysThr: 3.388 ± 0.067
3.276LysVal: 3.276 ± 0.057
0.561LysTrp: 0.561 ± 0.032
2.141LysTyr: 2.141 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
6.505LeuAla: 6.505 ± 0.1
1.129LeuCys: 1.129 ± 0.036
4.933LeuAsp: 4.933 ± 0.081
5.869LeuGlu: 5.869 ± 0.105
4.054LeuPhe: 4.054 ± 0.091
6.038LeuGly: 6.038 ± 0.089
1.396LeuHis: 1.396 ± 0.047
7.119LeuIle: 7.119 ± 0.142
5.599LeuLys: 5.599 ± 0.081
7.851LeuLeu: 7.851 ± 0.131
2.419LeuMet: 2.419 ± 0.056
3.664LeuAsn: 3.664 ± 0.075
3.654LeuPro: 3.654 ± 0.066
1.839LeuGln: 1.839 ± 0.048
3.85LeuArg: 3.85 ± 0.076
6.958LeuSer: 6.958 ± 0.085
4.299LeuThr: 4.299 ± 0.078
6.027LeuVal: 6.027 ± 0.1
0.754LeuTrp: 0.754 ± 0.032
2.743LeuTyr: 2.743 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.03MetAla: 2.03 ± 0.048
0.286MetCys: 0.286 ± 0.016
1.509MetAsp: 1.509 ± 0.045
1.82MetGlu: 1.82 ± 0.049
0.947MetPhe: 0.947 ± 0.031
1.873MetGly: 1.873 ± 0.048
0.474MetHis: 0.474 ± 0.025
2.272MetIle: 2.272 ± 0.05
2.228MetLys: 2.228 ± 0.05
2.263MetLeu: 2.263 ± 0.053
0.812MetMet: 0.812 ± 0.034
1.462MetAsn: 1.462 ± 0.044
1.181MetPro: 1.181 ± 0.038
0.748MetGln: 0.748 ± 0.031
1.232MetArg: 1.232 ± 0.041
1.661MetSer: 1.661 ± 0.047
1.705MetThr: 1.705 ± 0.044
1.729MetVal: 1.729 ± 0.048
0.175MetTrp: 0.175 ± 0.014
0.73MetTyr: 0.73 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.594AsnAla: 2.594 ± 0.061
0.519AsnCys: 0.519 ± 0.028
2.173AsnAsp: 2.173 ± 0.056
2.796AsnGlu: 2.796 ± 0.066
1.597AsnPhe: 1.597 ± 0.04
3.121AsnGly: 3.121 ± 0.071
0.629AsnHis: 0.629 ± 0.027
3.562AsnIle: 3.562 ± 0.075
1.905AsnLys: 1.905 ± 0.057
3.602AsnLeu: 3.602 ± 0.076
1.066AsnMet: 1.066 ± 0.037
1.848AsnAsn: 1.848 ± 0.053
2.589AsnPro: 2.589 ± 0.062
0.911AsnGln: 0.911 ± 0.035
2.02AsnArg: 2.02 ± 0.054
2.972AsnSer: 2.972 ± 0.081
2.216AsnThr: 2.216 ± 0.061
2.732AsnVal: 2.732 ± 0.067
0.425AsnTrp: 0.425 ± 0.024
1.537AsnTyr: 1.537 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.302ProAla: 3.302 ± 0.07
0.474ProCys: 0.474 ± 0.024
3.3ProAsp: 3.3 ± 0.066
4.471ProGlu: 4.471 ± 0.084
1.821ProPhe: 1.821 ± 0.044
3.946ProGly: 3.946 ± 0.078
0.62ProHis: 0.62 ± 0.028
2.0ProIle: 2.0 ± 0.058
1.75ProLys: 1.75 ± 0.056
3.301ProLeu: 3.301 ± 0.065
0.833ProMet: 0.833 ± 0.033
1.202ProAsn: 1.202 ± 0.043
1.591ProPro: 1.591 ± 0.056
0.895ProGln: 0.895 ± 0.038
1.302ProArg: 1.302 ± 0.046
2.611ProSer: 2.611 ± 0.054
1.715ProThr: 1.715 ± 0.056
4.261ProVal: 4.261 ± 0.076
0.34ProTrp: 0.34 ± 0.022
1.491ProTyr: 1.491 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
1.626GlnAla: 1.626 ± 0.045
0.263GlnCys: 0.263 ± 0.018
1.134GlnAsp: 1.134 ± 0.038
1.508GlnGlu: 1.508 ± 0.042
0.819GlnPhe: 0.819 ± 0.034
1.407GlnGly: 1.407 ± 0.047
0.31GlnHis: 0.31 ± 0.018
1.85GlnIle: 1.85 ± 0.051
1.608GlnLys: 1.608 ± 0.045
1.637GlnLeu: 1.637 ± 0.042
0.702GlnMet: 0.702 ± 0.03
1.101GlnAsn: 1.101 ± 0.041
0.789GlnPro: 0.789 ± 0.029
0.645GlnGln: 0.645 ± 0.032
1.014GlnArg: 1.014 ± 0.041
1.297GlnSer: 1.297 ± 0.049
1.171GlnThr: 1.171 ± 0.038
1.476GlnVal: 1.476 ± 0.043
0.236GlnTrp: 0.236 ± 0.019
0.889GlnTyr: 0.889 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.777ArgAla: 2.777 ± 0.069
0.649ArgCys: 0.649 ± 0.029
2.857ArgAsp: 2.857 ± 0.061
3.777ArgGlu: 3.777 ± 0.07
1.919ArgPhe: 1.919 ± 0.052
2.921ArgGly: 2.921 ± 0.063
0.837ArgHis: 0.837 ± 0.032
4.107ArgIle: 4.107 ± 0.082
3.098ArgLys: 3.098 ± 0.068
3.829ArgLeu: 3.829 ± 0.069
1.433ArgMet: 1.433 ± 0.041
2.05ArgAsn: 2.05 ± 0.063
1.563ArgPro: 1.563 ± 0.053
1.196ArgGln: 1.196 ± 0.036
2.345ArgArg: 2.345 ± 0.06
2.7ArgSer: 2.7 ± 0.066
2.144ArgThr: 2.144 ± 0.053
2.816ArgVal: 2.816 ± 0.065
0.449ArgTrp: 0.449 ± 0.023
1.776ArgTyr: 1.776 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.135SerAla: 5.135 ± 0.092
0.918SerCys: 0.918 ± 0.034
4.303SerAsp: 4.303 ± 0.083
4.984SerGlu: 4.984 ± 0.083
3.061SerPhe: 3.061 ± 0.065
7.735SerGly: 7.735 ± 0.139
1.114SerHis: 1.114 ± 0.034
4.962SerIle: 4.962 ± 0.079
3.153SerLys: 3.153 ± 0.071
6.05SerLeu: 6.05 ± 0.093
1.73SerMet: 1.73 ± 0.05
2.219SerAsn: 2.219 ± 0.064
3.082SerPro: 3.082 ± 0.067
1.503SerGln: 1.503 ± 0.047
2.951SerArg: 2.951 ± 0.06
5.019SerSer: 5.019 ± 0.129
3.345SerThr: 3.345 ± 0.085
5.056SerVal: 5.056 ± 0.082
0.733SerTrp: 0.733 ± 0.04
2.444SerTyr: 2.444 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.368ThrAla: 4.368 ± 0.082
0.666ThrCys: 0.666 ± 0.032
3.283ThrAsp: 3.283 ± 0.073
3.532ThrGlu: 3.532 ± 0.07
2.112ThrPhe: 2.112 ± 0.059
5.912ThrGly: 5.912 ± 0.08
0.797ThrHis: 0.797 ± 0.035
4.408ThrIle: 4.408 ± 0.077
2.292ThrLys: 2.292 ± 0.059
4.46ThrLeu: 4.46 ± 0.075
1.191ThrMet: 1.191 ± 0.04
1.853ThrAsn: 1.853 ± 0.059
2.634ThrPro: 2.634 ± 0.059
0.978ThrGln: 0.978 ± 0.035
1.931ThrArg: 1.931 ± 0.047
3.36ThrSer: 3.36 ± 0.084
2.894ThrThr: 2.894 ± 0.074
4.17ThrVal: 4.17 ± 0.096
0.453ThrTrp: 0.453 ± 0.022
1.884ThrTyr: 1.884 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
4.967ValAla: 4.967 ± 0.076
1.067ValCys: 1.067 ± 0.04
3.747ValAsp: 3.747 ± 0.067
4.42ValGlu: 4.42 ± 0.087
3.484ValPhe: 3.484 ± 0.073
4.264ValGly: 4.264 ± 0.092
1.078ValHis: 1.078 ± 0.039
6.102ValIle: 6.102 ± 0.09
3.64ValLys: 3.64 ± 0.07
6.704ValLeu: 6.704 ± 0.099
1.982ValMet: 1.982 ± 0.053
2.667ValAsn: 2.667 ± 0.063
3.234ValPro: 3.234 ± 0.064
1.484ValGln: 1.484 ± 0.045
3.3ValArg: 3.3 ± 0.065
5.548ValSer: 5.548 ± 0.092
4.077ValThr: 4.077 ± 0.094
5.243ValVal: 5.243 ± 0.102
0.667ValTrp: 0.667 ± 0.031
2.397ValTyr: 2.397 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.553TrpAla: 0.553 ± 0.026
0.104TrpCys: 0.104 ± 0.01
0.604TrpAsp: 0.604 ± 0.03
0.676TrpGlu: 0.676 ± 0.028
0.45TrpPhe: 0.45 ± 0.026
0.639TrpGly: 0.639 ± 0.027
0.172TrpHis: 0.172 ± 0.015
0.881TrpIle: 0.881 ± 0.035
0.595TrpLys: 0.595 ± 0.029
0.855TrpLeu: 0.855 ± 0.033
0.269TrpMet: 0.269 ± 0.02
0.552TrpAsn: 0.552 ± 0.029
0.243TrpPro: 0.243 ± 0.017
0.284TrpGln: 0.284 ± 0.021
0.445TrpArg: 0.445 ± 0.025
0.554TrpSer: 0.554 ± 0.03
0.491TrpThr: 0.491 ± 0.025
0.577TrpVal: 0.577 ± 0.025
0.167TrpTrp: 0.167 ± 0.015
0.391TrpTyr: 0.391 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.43TyrAla: 2.43 ± 0.059
0.482TyrCys: 0.482 ± 0.024
2.287TyrAsp: 2.287 ± 0.073
2.4TyrGlu: 2.4 ± 0.058
1.515TyrPhe: 1.515 ± 0.049
2.698TyrGly: 2.698 ± 0.061
0.653TyrHis: 0.653 ± 0.027
2.885TyrIle: 2.885 ± 0.059
1.445TyrLys: 1.445 ± 0.043
3.398TyrLeu: 3.398 ± 0.078
0.875TyrMet: 0.875 ± 0.035
1.739TyrAsn: 1.739 ± 0.05
1.682TyrPro: 1.682 ± 0.049
0.805TyrGln: 0.805 ± 0.031
1.732TyrArg: 1.732 ± 0.043
2.94TyrSer: 2.94 ± 0.065
2.038TyrThr: 2.038 ± 0.064
2.125TyrVal: 2.125 ± 0.046
0.385TyrTrp: 0.385 ± 0.024
1.583TyrTyr: 1.583 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2779 proteins (826422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski