Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA261F19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.57AlaAla: 4.57 ± 0.206
0.83AlaCys: 0.83 ± 0.078
3.271AlaAsp: 3.271 ± 0.162
5.846AlaGlu: 5.846 ± 0.202
2.715AlaPhe: 2.715 ± 0.14
5.321AlaGly: 5.321 ± 0.222
1.068AlaHis: 1.068 ± 0.083
4.595AlaIle: 4.595 ± 0.206
5.022AlaLys: 5.022 ± 0.193
6.529AlaLeu: 6.529 ± 0.22
1.593AlaMet: 1.593 ± 0.11
1.928AlaAsn: 1.928 ± 0.121
2.361AlaPro: 2.361 ± 0.116
1.623AlaGln: 1.623 ± 0.119
4.399AlaArg: 4.399 ± 0.174
4.296AlaSer: 4.296 ± 0.189
3.008AlaThr: 3.008 ± 0.168
4.851AlaVal: 4.851 ± 0.213
0.647AlaTrp: 0.647 ± 0.071
1.623AlaTyr: 1.623 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.074
0.207CysCys: 0.207 ± 0.04
0.598CysAsp: 0.598 ± 0.06
0.805CysGlu: 0.805 ± 0.082
0.421CysPhe: 0.421 ± 0.057
1.348CysGly: 1.348 ± 0.096
0.207CysHis: 0.207 ± 0.04
0.567CysIle: 0.567 ± 0.068
0.775CysLys: 0.775 ± 0.066
0.927CysLeu: 0.927 ± 0.079
0.232CysMet: 0.232 ± 0.038
0.409CysAsn: 0.409 ± 0.052
0.824CysPro: 0.824 ± 0.072
0.226CysGln: 0.226 ± 0.035
0.714CysArg: 0.714 ± 0.08
0.751CysSer: 0.751 ± 0.071
0.433CysThr: 0.433 ± 0.058
0.616CysVal: 0.616 ± 0.063
0.128CysTrp: 0.128 ± 0.029
0.317CysTyr: 0.317 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
3.411AspAla: 3.411 ± 0.162
0.635AspCys: 0.635 ± 0.069
2.374AspAsp: 2.374 ± 0.122
4.881AspGlu: 4.881 ± 0.167
2.441AspPhe: 2.441 ± 0.102
3.747AspGly: 3.747 ± 0.174
0.879AspHis: 0.879 ± 0.083
4.241AspIle: 4.241 ± 0.167
3.387AspLys: 3.387 ± 0.137
6.48AspLeu: 6.48 ± 0.189
1.294AspMet: 1.294 ± 0.091
1.507AspAsn: 1.507 ± 0.104
2.758AspPro: 2.758 ± 0.128
1.196AspGln: 1.196 ± 0.081
3.295AspArg: 3.295 ± 0.141
2.813AspSer: 2.813 ± 0.116
2.038AspThr: 2.038 ± 0.114
4.29AspVal: 4.29 ± 0.16
0.769AspTrp: 0.769 ± 0.078
2.178AspTyr: 2.178 ± 0.123
0.0AspXaa: 0.0 ± 0.0
Glu
5.742GluAla: 5.742 ± 0.214
0.812GluCys: 0.812 ± 0.081
5.113GluAsp: 5.113 ± 0.186
10.678GluGlu: 10.678 ± 0.354
3.063GluPhe: 3.063 ± 0.134
6.23GluGly: 6.23 ± 0.189
1.239GluHis: 1.239 ± 0.082
7.572GluIle: 7.572 ± 0.239
8.732GluLys: 8.732 ± 0.303
8.848GluLeu: 8.848 ± 0.246
2.203GluMet: 2.203 ± 0.126
3.887GluAsn: 3.887 ± 0.185
2.734GluPro: 2.734 ± 0.158
1.513GluGln: 1.513 ± 0.109
6.09GluArg: 6.09 ± 0.207
4.54GluSer: 4.54 ± 0.154
3.814GluThr: 3.814 ± 0.133
6.81GluVal: 6.81 ± 0.216
0.86GluTrp: 0.86 ± 0.068
2.038GluTyr: 2.038 ± 0.123
0.0GluXaa: 0.0 ± 0.0
Phe
2.441PheAla: 2.441 ± 0.133
0.5PheCys: 0.5 ± 0.057
2.349PheAsp: 2.349 ± 0.13
3.136PheGlu: 3.136 ± 0.147
1.745PhePhe: 1.745 ± 0.125
3.124PheGly: 3.124 ± 0.143
0.726PheHis: 0.726 ± 0.063
2.184PheIle: 2.184 ± 0.116
2.471PheLys: 2.471 ± 0.121
4.119PheLeu: 4.119 ± 0.19
0.812PheMet: 0.812 ± 0.082
1.178PheAsn: 1.178 ± 0.083
1.464PhePro: 1.464 ± 0.093
0.958PheGln: 0.958 ± 0.091
2.087PheArg: 2.087 ± 0.109
2.758PheSer: 2.758 ± 0.133
1.837PheThr: 1.837 ± 0.094
2.618PheVal: 2.618 ± 0.132
0.433PheTrp: 0.433 ± 0.052
1.275PheTyr: 1.275 ± 0.098
0.0PheXaa: 0.0 ± 0.0
Gly
5.144GlyAla: 5.144 ± 0.246
0.927GlyCys: 0.927 ± 0.1
3.923GlyAsp: 3.923 ± 0.157
6.608GlyGlu: 6.608 ± 0.21
3.112GlyPhe: 3.112 ± 0.135
5.986GlyGly: 5.986 ± 0.272
1.257GlyHis: 1.257 ± 0.086
5.919GlyIle: 5.919 ± 0.207
6.254GlyLys: 6.254 ± 0.226
6.816GlyLeu: 6.816 ± 0.235
1.946GlyMet: 1.946 ± 0.108
2.355GlyAsn: 2.355 ± 0.126
2.575GlyPro: 2.575 ± 0.137
1.318GlyGln: 1.318 ± 0.088
4.906GlyArg: 4.906 ± 0.212
4.674GlySer: 4.674 ± 0.18
3.411GlyThr: 3.411 ± 0.154
5.907GlyVal: 5.907 ± 0.185
0.903GlyTrp: 0.903 ± 0.077
2.367GlyTyr: 2.367 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
0.958HisAla: 0.958 ± 0.087
0.25HisCys: 0.25 ± 0.036
0.952HisAsp: 0.952 ± 0.077
1.263HisGlu: 1.263 ± 0.09
0.622HisPhe: 0.622 ± 0.059
1.239HisGly: 1.239 ± 0.1
0.397HisHis: 0.397 ± 0.053
1.098HisIle: 1.098 ± 0.088
0.885HisLys: 0.885 ± 0.069
1.837HisLeu: 1.837 ± 0.129
0.348HisMet: 0.348 ± 0.046
0.494HisAsn: 0.494 ± 0.048
1.239HisPro: 1.239 ± 0.093
0.525HisGln: 0.525 ± 0.057
1.098HisArg: 1.098 ± 0.07
1.013HisSer: 1.013 ± 0.082
0.555HisThr: 0.555 ± 0.063
1.129HisVal: 1.129 ± 0.089
0.189HisTrp: 0.189 ± 0.033
0.409HisTyr: 0.409 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
4.918IleAla: 4.918 ± 0.185
0.842IleCys: 0.842 ± 0.075
4.357IleAsp: 4.357 ± 0.176
6.273IleGlu: 6.273 ± 0.212
2.679IlePhe: 2.679 ± 0.139
5.522IleGly: 5.522 ± 0.224
1.178IleHis: 1.178 ± 0.086
3.96IleIle: 3.96 ± 0.168
5.058IleLys: 5.058 ± 0.194
6.584IleLeu: 6.584 ± 0.236
1.342IleMet: 1.342 ± 0.086
2.514IleAsn: 2.514 ± 0.123
3.1IlePro: 3.1 ± 0.132
1.812IleGln: 1.812 ± 0.098
4.381IleArg: 4.381 ± 0.168
5.083IleSer: 5.083 ± 0.156
3.179IleThr: 3.179 ± 0.127
4.82IleVal: 4.82 ± 0.22
0.574IleTrp: 0.574 ± 0.056
1.965IleTyr: 1.965 ± 0.115
0.0IleXaa: 0.0 ± 0.0
Lys
5.333LysAla: 5.333 ± 0.22
0.683LysCys: 0.683 ± 0.062
3.948LysAsp: 3.948 ± 0.175
7.932LysGlu: 7.932 ± 0.242
2.837LysPhe: 2.837 ± 0.122
5.235LysGly: 5.235 ± 0.191
1.172LysHis: 1.172 ± 0.09
6.498LysIle: 6.498 ± 0.219
6.895LysLys: 6.895 ± 0.237
7.096LysLeu: 7.096 ± 0.243
1.867LysMet: 1.867 ± 0.121
3.008LysAsn: 3.008 ± 0.138
2.85LysPro: 2.85 ± 0.125
1.739LysGln: 1.739 ± 0.118
4.973LysArg: 4.973 ± 0.214
4.399LysSer: 4.399 ± 0.169
3.301LysThr: 3.301 ± 0.13
5.278LysVal: 5.278 ± 0.206
0.696LysTrp: 0.696 ± 0.072
2.184LysTyr: 2.184 ± 0.115
0.0LysXaa: 0.0 ± 0.0
Leu
7.072LeuAla: 7.072 ± 0.246
0.988LeuCys: 0.988 ± 0.08
5.766LeuAsp: 5.766 ± 0.213
8.658LeuGlu: 8.658 ± 0.23
3.057LeuPhe: 3.057 ± 0.161
7.652LeuGly: 7.652 ± 0.238
1.574LeuHis: 1.574 ± 0.099
6.029LeuIle: 6.029 ± 0.199
7.493LeuLys: 7.493 ± 0.257
7.92LeuLeu: 7.92 ± 0.273
2.081LeuMet: 2.081 ± 0.13
3.789LeuAsn: 3.789 ± 0.132
3.972LeuPro: 3.972 ± 0.152
2.337LeuGln: 2.337 ± 0.126
6.267LeuArg: 6.267 ± 0.201
6.352LeuSer: 6.352 ± 0.21
4.222LeuThr: 4.222 ± 0.188
6.157LeuVal: 6.157 ± 0.182
0.927LeuTrp: 0.927 ± 0.081
2.343LeuTyr: 2.343 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
1.666MetAla: 1.666 ± 0.101
0.214MetCys: 0.214 ± 0.037
1.312MetAsp: 1.312 ± 0.1
2.032MetGlu: 2.032 ± 0.117
0.58MetPhe: 0.58 ± 0.064
1.8MetGly: 1.8 ± 0.105
0.336MetHis: 0.336 ± 0.048
1.55MetIle: 1.55 ± 0.118
1.739MetLys: 1.739 ± 0.103
1.837MetLeu: 1.837 ± 0.109
0.561MetMet: 0.561 ± 0.058
0.903MetAsn: 0.903 ± 0.076
1.08MetPro: 1.08 ± 0.073
0.439MetGln: 0.439 ± 0.052
1.678MetArg: 1.678 ± 0.099
1.434MetSer: 1.434 ± 0.097
1.324MetThr: 1.324 ± 0.086
1.788MetVal: 1.788 ± 0.113
0.201MetTrp: 0.201 ± 0.035
0.336MetTyr: 0.336 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
2.069AsnAla: 2.069 ± 0.115
0.549AsnCys: 0.549 ± 0.054
1.696AsnAsp: 1.696 ± 0.112
2.746AsnGlu: 2.746 ± 0.126
1.672AsnPhe: 1.672 ± 0.117
2.148AsnGly: 2.148 ± 0.117
0.543AsnHis: 0.543 ± 0.061
2.294AsnIle: 2.294 ± 0.129
1.959AsnLys: 1.959 ± 0.099
4.259AsnLeu: 4.259 ± 0.149
0.726AsnMet: 0.726 ± 0.065
0.958AsnAsn: 0.958 ± 0.087
2.16AsnPro: 2.16 ± 0.116
1.043AsnGln: 1.043 ± 0.083
2.172AsnArg: 2.172 ± 0.107
1.94AsnSer: 1.94 ± 0.111
1.275AsnThr: 1.275 ± 0.098
2.648AsnVal: 2.648 ± 0.137
0.47AsnTrp: 0.47 ± 0.053
1.104AsnTyr: 1.104 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.245ProAla: 2.245 ± 0.127
0.47ProCys: 0.47 ± 0.059
2.575ProAsp: 2.575 ± 0.124
4.509ProGlu: 4.509 ± 0.19
1.58ProPhe: 1.58 ± 0.104
2.984ProGly: 2.984 ± 0.151
0.873ProHis: 0.873 ± 0.071
2.789ProIle: 2.789 ± 0.139
2.917ProLys: 2.917 ± 0.131
3.502ProLeu: 3.502 ± 0.143
0.805ProMet: 0.805 ± 0.076
1.471ProAsn: 1.471 ± 0.091
1.959ProPro: 1.959 ± 0.133
1.05ProGln: 1.05 ± 0.076
2.581ProArg: 2.581 ± 0.137
3.039ProSer: 3.039 ± 0.155
2.13ProThr: 2.13 ± 0.116
2.758ProVal: 2.758 ± 0.146
0.537ProTrp: 0.537 ± 0.055
1.3ProTyr: 1.3 ± 0.091
0.0ProXaa: 0.0 ± 0.0
Gln
1.538GlnAla: 1.538 ± 0.093
0.159GlnCys: 0.159 ± 0.031
1.147GlnAsp: 1.147 ± 0.083
2.056GlnGlu: 2.056 ± 0.099
0.873GlnPhe: 0.873 ± 0.08
1.507GlnGly: 1.507 ± 0.089
0.329GlnHis: 0.329 ± 0.044
1.721GlnIle: 1.721 ± 0.12
2.367GlnLys: 2.367 ± 0.15
2.117GlnLeu: 2.117 ± 0.125
0.537GlnMet: 0.537 ± 0.059
0.897GlnAsn: 0.897 ± 0.078
0.751GlnPro: 0.751 ± 0.068
0.671GlnGln: 0.671 ± 0.08
1.702GlnArg: 1.702 ± 0.12
1.135GlnSer: 1.135 ± 0.084
0.976GlnThr: 0.976 ± 0.069
1.605GlnVal: 1.605 ± 0.105
0.183GlnTrp: 0.183 ± 0.03
0.757GlnTyr: 0.757 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
4.351ArgAla: 4.351 ± 0.161
0.592ArgCys: 0.592 ± 0.058
2.965ArgAsp: 2.965 ± 0.129
6.413ArgGlu: 6.413 ± 0.236
2.239ArgPhe: 2.239 ± 0.113
4.869ArgGly: 4.869 ± 0.2
0.921ArgHis: 0.921 ± 0.086
4.692ArgIle: 4.692 ± 0.193
6.083ArgLys: 6.083 ± 0.199
5.62ArgLeu: 5.62 ± 0.193
1.593ArgMet: 1.593 ± 0.092
2.093ArgAsn: 2.093 ± 0.108
2.319ArgPro: 2.319 ± 0.129
1.22ArgGln: 1.22 ± 0.095
4.656ArgArg: 4.656 ± 0.193
3.655ArgSer: 3.655 ± 0.15
2.85ArgThr: 2.85 ± 0.151
4.448ArgVal: 4.448 ± 0.22
0.616ArgTrp: 0.616 ± 0.055
1.733ArgTyr: 1.733 ± 0.112
0.0ArgXaa: 0.0 ± 0.0
Ser
3.801SerAla: 3.801 ± 0.164
0.647SerCys: 0.647 ± 0.069
3.417SerAsp: 3.417 ± 0.155
5.894SerGlu: 5.894 ± 0.182
2.642SerPhe: 2.642 ± 0.127
4.851SerGly: 4.851 ± 0.195
0.927SerHis: 0.927 ± 0.087
4.381SerIle: 4.381 ± 0.178
4.906SerLys: 4.906 ± 0.14
5.736SerLeu: 5.736 ± 0.214
1.495SerMet: 1.495 ± 0.085
1.946SerAsn: 1.946 ± 0.1
2.666SerPro: 2.666 ± 0.124
1.715SerGln: 1.715 ± 0.127
3.801SerArg: 3.801 ± 0.137
4.296SerSer: 4.296 ± 0.17
2.776SerThr: 2.776 ± 0.115
4.009SerVal: 4.009 ± 0.175
0.671SerTrp: 0.671 ± 0.058
1.806SerTyr: 1.806 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.953ThrAla: 2.953 ± 0.148
0.482ThrCys: 0.482 ± 0.052
2.166ThrAsp: 2.166 ± 0.122
3.21ThrGlu: 3.21 ± 0.148
1.757ThrPhe: 1.757 ± 0.09
3.978ThrGly: 3.978 ± 0.158
0.775ThrHis: 0.775 ± 0.075
3.283ThrIle: 3.283 ± 0.143
2.764ThrLys: 2.764 ± 0.145
4.265ThrLeu: 4.265 ± 0.167
0.976ThrMet: 0.976 ± 0.095
1.226ThrAsn: 1.226 ± 0.085
2.416ThrPro: 2.416 ± 0.127
0.964ThrGln: 0.964 ± 0.082
2.532ThrArg: 2.532 ± 0.123
3.1ThrSer: 3.1 ± 0.143
2.172ThrThr: 2.172 ± 0.118
3.362ThrVal: 3.362 ± 0.162
0.421ThrTrp: 0.421 ± 0.048
1.226ThrTyr: 1.226 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
4.875ValAla: 4.875 ± 0.208
0.812ValCys: 0.812 ± 0.067
4.479ValAsp: 4.479 ± 0.171
6.62ValGlu: 6.62 ± 0.244
2.538ValPhe: 2.538 ± 0.128
5.486ValGly: 5.486 ± 0.19
1.355ValHis: 1.355 ± 0.091
4.357ValIle: 4.357 ± 0.166
5.406ValLys: 5.406 ± 0.188
6.328ValLeu: 6.328 ± 0.229
1.593ValMet: 1.593 ± 0.113
2.593ValAsn: 2.593 ± 0.135
2.959ValPro: 2.959 ± 0.135
1.635ValGln: 1.635 ± 0.094
4.088ValArg: 4.088 ± 0.166
4.534ValSer: 4.534 ± 0.167
3.24ValThr: 3.24 ± 0.154
5.528ValVal: 5.528 ± 0.223
0.677ValTrp: 0.677 ± 0.063
1.855ValTyr: 1.855 ± 0.107
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.063
0.146TrpCys: 0.146 ± 0.029
0.47TrpAsp: 0.47 ± 0.054
0.757TrpGlu: 0.757 ± 0.064
0.415TrpPhe: 0.415 ± 0.061
0.622TrpGly: 0.622 ± 0.054
0.195TrpHis: 0.195 ± 0.029
0.86TrpIle: 0.86 ± 0.071
1.068TrpLys: 1.068 ± 0.094
0.927TrpLeu: 0.927 ± 0.07
0.281TrpMet: 0.281 ± 0.039
0.433TrpAsn: 0.433 ± 0.047
0.354TrpPro: 0.354 ± 0.044
0.256TrpGln: 0.256 ± 0.042
0.842TrpArg: 0.842 ± 0.076
0.659TrpSer: 0.659 ± 0.066
0.397TrpThr: 0.397 ± 0.045
0.696TrpVal: 0.696 ± 0.07
0.171TrpTrp: 0.171 ± 0.032
0.207TrpTyr: 0.207 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.69TyrAla: 1.69 ± 0.101
0.409TyrCys: 0.409 ± 0.048
1.733TyrAsp: 1.733 ± 0.114
2.197TyrGlu: 2.197 ± 0.123
1.226TyrPhe: 1.226 ± 0.089
2.66TyrGly: 2.66 ± 0.14
0.549TyrHis: 0.549 ± 0.058
1.556TyrIle: 1.556 ± 0.092
1.745TyrLys: 1.745 ± 0.107
2.911TyrLeu: 2.911 ± 0.146
0.519TyrMet: 0.519 ± 0.051
0.842TyrAsn: 0.842 ± 0.069
1.532TyrPro: 1.532 ± 0.105
0.787TyrGln: 0.787 ± 0.074
1.666TyrArg: 1.666 ± 0.099
1.916TyrSer: 1.916 ± 0.105
1.092TyrThr: 1.092 ± 0.065
1.641TyrVal: 1.641 ± 0.11
0.354TyrTrp: 0.354 ± 0.042
0.781TyrTyr: 0.781 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 687 proteins (163887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski