Amino acid dipepetide frequency for Ostreococcus lucimarinus (strain CCE9901)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.131AlaAla: 14.131 ± 0.161	2.257AlaCys: 2.257 ± 0.038	5.599AlaAsp: 5.599 ± 0.053	7.033AlaGlu: 7.033 ± 0.086	4.199AlaPhe: 4.199 ± 0.045	6.668AlaGly: 6.668 ± 0.067	2.38AlaHis: 2.38 ± 0.032	4.405AlaIle: 4.405 ± 0.039	6.231AlaLys: 6.231 ± 0.078	11.899AlaLeu: 11.899 ± 0.094	3.197AlaMet: 3.197 ± 0.038	3.651AlaAsn: 3.651 ± 0.036	5.256AlaPro: 5.256 ± 0.058	3.192AlaGln: 3.192 ± 0.042	10.916AlaArg: 10.916 ± 0.12	9.171AlaSer: 9.171 ± 0.08	7.334AlaThr: 7.334 ± 0.071	7.506AlaVal: 7.506 ± 0.056	1.424AlaTrp: 1.424 ± 0.026	2.6AlaTyr: 2.6 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	2.459CysAla: 2.459 ± 0.035	0.321CysCys: 0.321 ± 0.011	1.187CysAsp: 1.187 ± 0.034	1.277CysGlu: 1.277 ± 0.021	0.584CysPhe: 0.584 ± 0.014	1.497CysGly: 1.497 ± 0.029	0.291CysHis: 0.291 ± 0.013	0.545CysIle: 0.545 ± 0.018	0.625CysLys: 0.625 ± 0.018	1.212CysLeu: 1.212 ± 0.024	0.333CysMet: 0.333 ± 0.011	0.386CysAsn: 0.386 ± 0.012	0.7CysPro: 0.7 ± 0.029	0.364CysGln: 0.364 ± 0.012	0.93CysArg: 0.93 ± 0.02	0.965CysSer: 0.965 ± 0.034	0.768CysThr: 0.768 ± 0.025	1.741CysVal: 1.741 ± 0.032	0.2CysTrp: 0.2 ± 0.009	0.369CysTyr: 0.369 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	10.084AspAla: 10.084 ± 0.095	0.798AspCys: 0.798 ± 0.017	6.525AspAsp: 6.525 ± 0.095	6.056AspGlu: 6.056 ± 0.075	2.251AspPhe: 2.251 ± 0.028	5.739AspGly: 5.739 ± 0.053	0.862AspHis: 0.862 ± 0.019	2.375AspIle: 2.375 ± 0.031	2.147AspLys: 2.147 ± 0.03	4.497AspLeu: 4.497 ± 0.043	1.279AspMet: 1.279 ± 0.023	1.253AspAsn: 1.253 ± 0.021	2.333AspPro: 2.333 ± 0.032	1.059AspGln: 1.059 ± 0.02	2.991AspArg: 2.991 ± 0.032	3.183AspSer: 3.183 ± 0.044	2.285AspThr: 2.285 ± 0.035	6.002AspVal: 6.002 ± 0.06	0.772AspTrp: 0.772 ± 0.017	1.351AspTyr: 1.351 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.738GluAla: 7.738 ± 0.089	1.163GluCys: 1.163 ± 0.025	4.804GluAsp: 4.804 ± 0.058	5.618GluGlu: 5.618 ± 0.087	2.356GluPhe: 2.356 ± 0.029	4.11GluGly: 4.11 ± 0.046	1.448GluHis: 1.448 ± 0.023	3.29GluIle: 3.29 ± 0.038	3.672GluLys: 3.672 ± 0.059	6.331GluLeu: 6.331 ± 0.069	1.721GluMet: 1.721 ± 0.025	2.329GluAsn: 2.329 ± 0.03	2.184GluPro: 2.184 ± 0.031	1.943GluGln: 1.943 ± 0.034	6.44GluArg: 6.44 ± 0.082	4.332GluSer: 4.332 ± 0.05	4.231GluThr: 4.231 ± 0.046	4.19GluVal: 4.19 ± 0.041	0.816GluTrp: 0.816 ± 0.018	1.697GluTyr: 1.697 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.208PheAla: 4.208 ± 0.042	0.614PheCys: 0.614 ± 0.015	2.655PheAsp: 2.655 ± 0.032	2.543PheGlu: 2.543 ± 0.03	1.304PhePhe: 1.304 ± 0.024	2.994PheGly: 2.994 ± 0.045	0.707PheHis: 0.707 ± 0.016	1.466PheIle: 1.466 ± 0.026	1.609PheLys: 1.609 ± 0.021	2.7PheLeu: 2.7 ± 0.032	0.826PheMet: 0.826 ± 0.02	1.191PheAsn: 1.191 ± 0.032	1.357PhePro: 1.357 ± 0.023	0.936PheGln: 0.936 ± 0.023	1.854PheArg: 1.854 ± 0.024	2.223PheSer: 2.223 ± 0.032	1.978PheThr: 1.978 ± 0.035	2.952PheVal: 2.952 ± 0.039	0.469PheTrp: 0.469 ± 0.014	0.918PheTyr: 0.918 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	8.831GlyAla: 8.831 ± 0.091	1.173GlyCys: 1.173 ± 0.024	5.154GlyAsp: 5.154 ± 0.067	5.151GlyGlu: 5.151 ± 0.048	2.628GlyPhe: 2.628 ± 0.038	6.89GlyGly: 6.89 ± 0.109	1.292GlyHis: 1.292 ± 0.028	2.603GlyIle: 2.603 ± 0.04	3.617GlyLys: 3.617 ± 0.043	5.291GlyLeu: 5.291 ± 0.053	1.717GlyMet: 1.717 ± 0.028	1.955GlyAsn: 1.955 ± 0.029	2.065GlyPro: 2.065 ± 0.028	1.598GlyGln: 1.598 ± 0.026	4.711GlyArg: 4.711 ± 0.044	4.479GlySer: 4.479 ± 0.046	4.017GlyThr: 4.017 ± 0.06	5.773GlyVal: 5.773 ± 0.053	0.942GlyTrp: 0.942 ± 0.02	1.746GlyTyr: 1.746 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.485HisAla: 2.485 ± 0.039	0.344HisCys: 0.344 ± 0.014	1.109HisAsp: 1.109 ± 0.022	1.331HisGlu: 1.331 ± 0.023	0.728HisPhe: 0.728 ± 0.017	1.62HisGly: 1.62 ± 0.031	0.475HisHis: 0.475 ± 0.012	0.749HisIle: 0.749 ± 0.024	0.76HisLys: 0.76 ± 0.018	1.633HisLeu: 1.633 ± 0.029	0.417HisMet: 0.417 ± 0.013	0.503HisAsn: 0.503 ± 0.016	1.013HisPro: 1.013 ± 0.019	0.502HisGln: 0.502 ± 0.016	1.354HisArg: 1.354 ± 0.024	1.116HisSer: 1.116 ± 0.035	0.981HisThr: 0.981 ± 0.032	1.695HisVal: 1.695 ± 0.03	0.264HisTrp: 0.264 ± 0.009	0.499HisTyr: 0.499 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.643IleAla: 4.643 ± 0.042	0.602IleCys: 0.602 ± 0.02	2.965IleAsp: 2.965 ± 0.039	3.118IleGlu: 3.118 ± 0.037	1.398IlePhe: 1.398 ± 0.026	2.899IleGly: 2.899 ± 0.035	0.758IleHis: 0.758 ± 0.019	1.618IleIle: 1.618 ± 0.027	1.833IleLys: 1.833 ± 0.031	3.121IleLeu: 3.121 ± 0.052	0.848IleMet: 0.848 ± 0.017	1.132IleAsn: 1.132 ± 0.023	1.761IlePro: 1.761 ± 0.027	1.13IleGln: 1.13 ± 0.025	2.346IleArg: 2.346 ± 0.034	2.506IleSer: 2.506 ± 0.057	1.968IleThr: 1.968 ± 0.027	3.198IleVal: 3.198 ± 0.034	0.414IleTrp: 0.414 ± 0.012	0.825IleTyr: 0.825 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	5.048LysAla: 5.048 ± 0.072	0.76LysCys: 0.76 ± 0.016	2.501LysAsp: 2.501 ± 0.033	3.147LysGlu: 3.147 ± 0.048	1.728LysPhe: 1.728 ± 0.026	2.661LysGly: 2.661 ± 0.035	1.086LysHis: 1.086 ± 0.022	2.184LysIle: 2.184 ± 0.033	3.424LysLys: 3.424 ± 0.063	4.266LysLeu: 4.266 ± 0.044	1.341LysMet: 1.341 ± 0.022	1.592LysAsn: 1.592 ± 0.026	2.164LysPro: 2.164 ± 0.034	1.517LysGln: 1.517 ± 0.027	3.986LysArg: 3.986 ± 0.048	3.538LysSer: 3.538 ± 0.041	3.205LysThr: 3.205 ± 0.042	3.027LysVal: 3.027 ± 0.034	0.583LysTrp: 0.583 ± 0.014	1.386LysTyr: 1.386 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	9.444LeuAla: 9.444 ± 0.075	1.505LeuCys: 1.505 ± 0.029	5.318LeuAsp: 5.318 ± 0.044	6.23LeuGlu: 6.23 ± 0.078	2.812LeuPhe: 2.812 ± 0.034	5.931LeuGly: 5.931 ± 0.057	1.762LeuHis: 1.762 ± 0.04	3.056LeuIle: 3.056 ± 0.038	4.416LeuLys: 4.416 ± 0.045	7.052LeuLeu: 7.052 ± 0.073	1.957LeuMet: 1.957 ± 0.025	2.791LeuAsn: 2.791 ± 0.033	3.633LeuPro: 3.633 ± 0.041	2.589LeuGln: 2.589 ± 0.043	6.896LeuArg: 6.896 ± 0.052	5.703LeuSer: 5.703 ± 0.067	4.619LeuThr: 4.619 ± 0.047	5.653LeuVal: 5.653 ± 0.045	0.899LeuTrp: 0.899 ± 0.019	1.891LeuTyr: 1.891 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.279MetAla: 2.279 ± 0.03	0.442MetCys: 0.442 ± 0.013	1.401MetAsp: 1.401 ± 0.022	1.495MetGlu: 1.495 ± 0.022	0.942MetPhe: 0.942 ± 0.025	1.406MetGly: 1.406 ± 0.024	0.534MetHis: 0.534 ± 0.016	0.965MetIle: 0.965 ± 0.017	1.298MetLys: 1.298 ± 0.022	2.094MetLeu: 2.094 ± 0.03	0.72MetMet: 0.72 ± 0.018	0.848MetAsn: 0.848 ± 0.017	1.098MetPro: 1.098 ± 0.023	0.755MetGln: 0.755 ± 0.017	2.066MetArg: 2.066 ± 0.031	1.841MetSer: 1.841 ± 0.028	1.544MetThr: 1.544 ± 0.023	1.373MetVal: 1.373 ± 0.022	0.267MetTrp: 0.267 ± 0.01	0.642MetTyr: 0.642 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	4.191AsnAla: 4.191 ± 0.042	0.445AsnCys: 0.445 ± 0.012	1.949AsnAsp: 1.949 ± 0.03	2.117AsnGlu: 2.117 ± 0.03	1.151AsnPhe: 1.151 ± 0.02	2.342AsnGly: 2.342 ± 0.033	0.56AsnHis: 0.56 ± 0.016	1.28AsnIle: 1.28 ± 0.024	1.369AsnLys: 1.369 ± 0.023	2.39AsnLeu: 2.39 ± 0.035	0.701AsnMet: 0.701 ± 0.023	0.809AsnAsn: 0.809 ± 0.021	1.467AsnPro: 1.467 ± 0.02	0.751AsnGln: 0.751 ± 0.025	1.552AsnArg: 1.552 ± 0.021	1.65AsnSer: 1.65 ± 0.037	1.445AsnThr: 1.445 ± 0.03	2.675AsnVal: 2.675 ± 0.031	0.386AsnTrp: 0.386 ± 0.012	0.694AsnTyr: 0.694 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.035ProAla: 4.035 ± 0.055	0.537ProCys: 0.537 ± 0.016	2.186ProAsp: 2.186 ± 0.029	2.907ProGlu: 2.907 ± 0.044	1.478ProPhe: 1.478 ± 0.028	2.941ProGly: 2.941 ± 0.042	0.814ProHis: 0.814 ± 0.019	1.616ProIle: 1.616 ± 0.026	2.224ProLys: 2.224 ± 0.031	3.267ProLeu: 3.267 ± 0.038	0.978ProMet: 0.978 ± 0.022	1.437ProAsn: 1.437 ± 0.029	3.03ProPro: 3.03 ± 0.079	1.102ProGln: 1.102 ± 0.025	2.976ProArg: 2.976 ± 0.037	3.573ProSer: 3.573 ± 0.046	2.908ProThr: 2.908 ± 0.037	2.704ProVal: 2.704 ± 0.034	0.582ProTrp: 0.582 ± 0.016	0.976ProTyr: 0.976 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.667GlnAla: 2.667 ± 0.042	0.499GlnCys: 0.499 ± 0.032	1.205GlnAsp: 1.205 ± 0.023	1.498GlnGlu: 1.498 ± 0.026	0.915GlnPhe: 0.915 ± 0.019	1.6GlnGly: 1.6 ± 0.03	0.591GlnHis: 0.591 ± 0.018	1.306GlnIle: 1.306 ± 0.022	1.445GlnLys: 1.445 ± 0.026	2.507GlnLeu: 2.507 ± 0.041	0.763GlnMet: 0.763 ± 0.019	0.909GlnAsn: 0.909 ± 0.021	1.065GlnPro: 1.065 ± 0.025	1.047GlnGln: 1.047 ± 0.029	2.249GlnArg: 2.249 ± 0.031	1.832GlnSer: 1.832 ± 0.036	1.631GlnThr: 1.631 ± 0.027	1.731GlnVal: 1.731 ± 0.028	0.342GlnTrp: 0.342 ± 0.011	0.714GlnTyr: 0.714 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.189ArgAla: 11.189 ± 0.123	1.208ArgCys: 1.208 ± 0.027	4.993ArgAsp: 4.993 ± 0.054	6.179ArgGlu: 6.179 ± 0.084	2.268ArgPhe: 2.268 ± 0.029	5.772ArgGly: 5.772 ± 0.054	1.304ArgHis: 1.304 ± 0.03	2.42ArgIle: 2.42 ± 0.034	3.191ArgLys: 3.191 ± 0.046	5.771ArgLeu: 5.771 ± 0.053	1.628ArgMet: 1.628 ± 0.026	1.808ArgAsn: 1.808 ± 0.026	2.333ArgPro: 2.333 ± 0.035	1.901ArgGln: 1.901 ± 0.026	6.865ArgArg: 6.865 ± 0.091	4.087ArgSer: 4.087 ± 0.04	3.486ArgThr: 3.486 ± 0.037	5.725ArgVal: 5.725 ± 0.05	0.987ArgTrp: 0.987 ± 0.02	1.504ArgTyr: 1.504 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	8.033SerAla: 8.033 ± 0.066	1.017SerCys: 1.017 ± 0.034	4.004SerAsp: 4.004 ± 0.038	4.256SerGlu: 4.256 ± 0.05	2.419SerPhe: 2.419 ± 0.036	5.102SerGly: 5.102 ± 0.053	1.261SerHis: 1.261 ± 0.027	2.636SerIle: 2.636 ± 0.061	3.304SerLys: 3.304 ± 0.044	5.509SerLeu: 5.509 ± 0.065	1.649SerMet: 1.649 ± 0.03	1.937SerAsn: 1.937 ± 0.033	3.058SerPro: 3.058 ± 0.053	1.758SerGln: 1.758 ± 0.036	4.423SerArg: 4.423 ± 0.043	5.77SerSer: 5.77 ± 0.113	4.127SerThr: 4.127 ± 0.054	4.747SerVal: 4.747 ± 0.062	0.806SerTrp: 0.806 ± 0.019	1.497SerTyr: 1.497 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.804ThrAla: 5.804 ± 0.055	1.068ThrCys: 1.068 ± 0.027	2.51ThrAsp: 2.51 ± 0.032	2.807ThrGlu: 2.807 ± 0.032	2.211ThrPhe: 2.211 ± 0.029	3.625ThrGly: 3.625 ± 0.052	1.224ThrHis: 1.224 ± 0.022	2.339ThrIle: 2.339 ± 0.032	2.816ThrLys: 2.816 ± 0.031	5.451ThrLeu: 5.451 ± 0.061	1.425ThrMet: 1.425 ± 0.022	1.793ThrAsn: 1.793 ± 0.031	3.238ThrPro: 3.238 ± 0.043	1.542ThrGln: 1.542 ± 0.029	4.375ThrArg: 4.375 ± 0.044	4.365ThrSer: 4.365 ± 0.055	4.608ThrThr: 4.608 ± 0.063	3.655ThrVal: 3.655 ± 0.039	0.701ThrTrp: 0.701 ± 0.016	1.422ThrTyr: 1.422 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	7.984ValAla: 7.984 ± 0.068	1.307ValCys: 1.307 ± 0.031	5.182ValAsp: 5.182 ± 0.049	5.214ValGlu: 5.214 ± 0.049	2.68ValPhe: 2.68 ± 0.032	5.108ValGly: 5.108 ± 0.055	1.496ValHis: 1.496 ± 0.031	2.861ValIle: 2.861 ± 0.036	3.551ValLys: 3.551 ± 0.039	6.094ValLeu: 6.094 ± 0.045	1.652ValMet: 1.652 ± 0.024	2.363ValAsn: 2.363 ± 0.027	3.166ValPro: 3.166 ± 0.034	1.913ValGln: 1.913 ± 0.031	5.219ValArg: 5.219 ± 0.05	4.773ValSer: 4.773 ± 0.05	3.939ValThr: 3.939 ± 0.052	6.37ValVal: 6.37 ± 0.059	0.841ValTrp: 0.841 ± 0.018	1.758ValTyr: 1.758 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.036TrpAla: 1.036 ± 0.02	0.267TrpCys: 0.267 ± 0.009	0.799TrpAsp: 0.799 ± 0.021	0.686TrpGlu: 0.686 ± 0.016	0.486TrpPhe: 0.486 ± 0.013	0.768TrpGly: 0.768 ± 0.016	0.264TrpHis: 0.264 ± 0.011	0.534TrpIle: 0.534 ± 0.013	0.594TrpLys: 0.594 ± 0.016	1.132TrpLeu: 1.132 ± 0.022	0.332TrpMet: 0.332 ± 0.01	0.527TrpAsn: 0.527 ± 0.018	0.425TrpPro: 0.425 ± 0.013	0.343TrpGln: 0.343 ± 0.01	1.13TrpArg: 1.13 ± 0.02	0.857TrpSer: 0.857 ± 0.02	0.789TrpThr: 0.789 ± 0.017	0.695TrpVal: 0.695 ± 0.019	0.196TrpTrp: 0.196 ± 0.008	0.337TrpTyr: 0.337 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.76TyrAla: 2.76 ± 0.031	0.425TyrCys: 0.425 ± 0.014	1.797TyrAsp: 1.797 ± 0.027	1.748TyrGlu: 1.748 ± 0.026	0.967TyrPhe: 0.967 ± 0.019	1.958TyrGly: 1.958 ± 0.031	0.471TyrHis: 0.471 ± 0.013	0.837TyrIle: 0.837 ± 0.019	1.017TyrLys: 1.017 ± 0.019	1.941TyrLeu: 1.941 ± 0.03	0.529TyrMet: 0.529 ± 0.013	0.707TyrAsn: 0.707 ± 0.016	0.927TyrPro: 0.927 ± 0.024	0.576TyrGln: 0.576 ± 0.014	1.339TyrArg: 1.339 ± 0.023	1.35TyrSer: 1.35 ± 0.028	1.114TyrThr: 1.114 ± 0.02	2.055TyrVal: 2.055 ± 0.027	0.307TyrTrp: 0.307 ± 0.012	0.71TyrTyr: 0.71 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7403 proteins (2987645 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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