Amino acid dipepetide frequency for Blastomyces silverae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.156AlaAla: 8.156 ± 0.07
0.959AlaCys: 0.959 ± 0.018
4.004AlaAsp: 4.004 ± 0.035
4.985AlaGlu: 4.985 ± 0.052
2.888AlaPhe: 2.888 ± 0.028
5.512AlaGly: 5.512 ± 0.041
1.66AlaHis: 1.66 ± 0.022
4.134AlaIle: 4.134 ± 0.036
3.996AlaLys: 3.996 ± 0.044
7.267AlaLeu: 7.267 ± 0.057
1.746AlaMet: 1.746 ± 0.023
2.929AlaAsn: 2.929 ± 0.029
4.437AlaPro: 4.437 ± 0.044
3.109AlaGln: 3.109 ± 0.033
4.797AlaArg: 4.797 ± 0.039
7.039AlaSer: 7.039 ± 0.056
4.981AlaThr: 4.981 ± 0.041
4.932AlaVal: 4.932 ± 0.039
0.977AlaTrp: 0.977 ± 0.018
1.904AlaTyr: 1.904 ± 0.024
0.0AlaXaa: 0.0 ± 0.0
Cys
0.882CysAla: 0.882 ± 0.016
0.241CysCys: 0.241 ± 0.009
0.636CysAsp: 0.636 ± 0.015
0.619CysGlu: 0.619 ± 0.014
0.517CysPhe: 0.517 ± 0.011
0.89CysGly: 0.89 ± 0.016
0.316CysHis: 0.316 ± 0.01
0.692CysIle: 0.692 ± 0.015
0.536CysLys: 0.536 ± 0.013
1.229CysLeu: 1.229 ± 0.022
0.264CysMet: 0.264 ± 0.008
0.42CysAsn: 0.42 ± 0.013
0.683CysPro: 0.683 ± 0.016
0.469CysGln: 0.469 ± 0.012
0.768CysArg: 0.768 ± 0.018
0.929CysSer: 0.929 ± 0.018
0.65CysThr: 0.65 ± 0.016
0.73CysVal: 0.73 ± 0.014
0.189CysTrp: 0.189 ± 0.007
0.348CysTyr: 0.348 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
4.257AspAla: 4.257 ± 0.037
0.608AspCys: 0.608 ± 0.013
4.537AspAsp: 4.537 ± 0.066
4.501AspGlu: 4.501 ± 0.053
2.114AspPhe: 2.114 ± 0.026
4.114AspGly: 4.114 ± 0.043
1.207AspHis: 1.207 ± 0.016
3.357AspIle: 3.357 ± 0.031
2.43AspLys: 2.43 ± 0.028
4.831AspLeu: 4.831 ± 0.041
1.27AspMet: 1.27 ± 0.02
2.048AspAsn: 2.048 ± 0.026
3.334AspPro: 3.334 ± 0.032
1.825AspGln: 1.825 ± 0.023
3.108AspArg: 3.108 ± 0.031
4.326AspSer: 4.326 ± 0.039
2.939AspThr: 2.939 ± 0.027
3.534AspVal: 3.534 ± 0.031
0.776AspTrp: 0.776 ± 0.016
1.521AspTyr: 1.521 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
5.041GluAla: 5.041 ± 0.043
0.639GluCys: 0.639 ± 0.014
4.164GluAsp: 4.164 ± 0.053
5.606GluGlu: 5.606 ± 0.085
1.993GluPhe: 1.993 ± 0.023
3.806GluGly: 3.806 ± 0.037
1.38GluHis: 1.38 ± 0.02
3.271GluIle: 3.271 ± 0.031
3.883GluLys: 3.883 ± 0.045
5.246GluLeu: 5.246 ± 0.043
1.492GluMet: 1.492 ± 0.024
2.579GluAsn: 2.579 ± 0.03
2.926GluPro: 2.926 ± 0.043
2.501GluGln: 2.501 ± 0.033
4.145GluArg: 4.145 ± 0.042
4.467GluSer: 4.467 ± 0.039
3.459GluThr: 3.459 ± 0.038
3.345GluVal: 3.345 ± 0.035
0.854GluTrp: 0.854 ± 0.018
1.709GluTyr: 1.709 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
2.813PheAla: 2.813 ± 0.03
0.546PheCys: 0.546 ± 0.013
2.193PheAsp: 2.193 ± 0.023
2.165PheGlu: 2.165 ± 0.025
1.517PhePhe: 1.517 ± 0.024
2.676PheGly: 2.676 ± 0.036
0.928PheHis: 0.928 ± 0.017
1.8PheIle: 1.8 ± 0.025
1.574PheLys: 1.574 ± 0.023
3.423PheLeu: 3.423 ± 0.035
0.759PheMet: 0.759 ± 0.016
1.424PheAsn: 1.424 ± 0.019
2.068PhePro: 2.068 ± 0.024
1.362PheGln: 1.362 ± 0.021
2.064PheArg: 2.064 ± 0.024
3.165PheSer: 3.165 ± 0.032
2.08PheThr: 2.08 ± 0.027
2.222PheVal: 2.222 ± 0.029
0.584PheTrp: 0.584 ± 0.013
1.079PheTyr: 1.079 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
4.845GlyAla: 4.845 ± 0.039
0.818GlyCys: 0.818 ± 0.017
3.781GlyAsp: 3.781 ± 0.031
3.887GlyGlu: 3.887 ± 0.038
2.562GlyPhe: 2.562 ± 0.027
5.855GlyGly: 5.855 ± 0.064
1.622GlyHis: 1.622 ± 0.025
3.511GlyIle: 3.511 ± 0.027
3.609GlyLys: 3.609 ± 0.04
5.618GlyLeu: 5.618 ± 0.046
1.608GlyMet: 1.608 ± 0.023
2.67GlyAsn: 2.67 ± 0.034
3.178GlyPro: 3.178 ± 0.033
2.436GlyGln: 2.436 ± 0.028
4.153GlyArg: 4.153 ± 0.034
5.716GlySer: 5.716 ± 0.045
3.758GlyThr: 3.758 ± 0.039
4.151GlyVal: 4.151 ± 0.037
1.074GlyTrp: 1.074 ± 0.019
1.998GlyTyr: 1.998 ± 0.028
0.0GlyXaa: 0.0 ± 0.0
His
1.807HisAla: 1.807 ± 0.024
0.331HisCys: 0.331 ± 0.009
1.312HisAsp: 1.312 ± 0.021
1.299HisGlu: 1.299 ± 0.02
0.928HisPhe: 0.928 ± 0.017
1.665HisGly: 1.665 ± 0.024
0.98HisHis: 0.98 ± 0.023
1.304HisIle: 1.304 ± 0.02
0.924HisLys: 0.924 ± 0.017
2.267HisLeu: 2.267 ± 0.026
0.484HisMet: 0.484 ± 0.012
0.912HisAsn: 0.912 ± 0.016
1.87HisPro: 1.87 ± 0.028
1.092HisGln: 1.092 ± 0.023
1.642HisArg: 1.642 ± 0.025
2.069HisSer: 2.069 ± 0.026
1.279HisThr: 1.279 ± 0.019
1.338HisVal: 1.338 ± 0.019
0.299HisTrp: 0.299 ± 0.009
0.683HisTyr: 0.683 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
3.941IleAla: 3.941 ± 0.033
0.783IleCys: 0.783 ± 0.015
2.994IleAsp: 2.994 ± 0.032
2.945IleGlu: 2.945 ± 0.03
2.116IlePhe: 2.116 ± 0.028
3.084IleGly: 3.084 ± 0.035
1.291IleHis: 1.291 ± 0.018
2.691IleIle: 2.691 ± 0.032
2.284IleLys: 2.284 ± 0.03
4.806IleLeu: 4.806 ± 0.046
1.014IleMet: 1.014 ± 0.017
1.913IleAsn: 1.913 ± 0.025
3.408IlePro: 3.408 ± 0.034
1.948IleGln: 1.948 ± 0.025
2.989IleArg: 2.989 ± 0.031
4.445IleSer: 4.445 ± 0.042
2.897IleThr: 2.897 ± 0.031
3.084IleVal: 3.084 ± 0.031
0.687IleTrp: 0.687 ± 0.015
1.498IleTyr: 1.498 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
4.048LysAla: 4.048 ± 0.041
0.552LysCys: 0.552 ± 0.013
2.731LysAsp: 2.731 ± 0.031
3.527LysGlu: 3.527 ± 0.041
1.594LysPhe: 1.594 ± 0.021
3.065LysGly: 3.065 ± 0.035
1.176LysHis: 1.176 ± 0.018
2.498LysIle: 2.498 ± 0.026
3.491LysLys: 3.491 ± 0.059
4.404LysLeu: 4.404 ± 0.039
1.033LysMet: 1.033 ± 0.017
1.902LysAsn: 1.902 ± 0.022
2.992LysPro: 2.992 ± 0.031
1.975LysGln: 1.975 ± 0.028
3.746LysArg: 3.746 ± 0.04
3.854LysSer: 3.854 ± 0.039
2.766LysThr: 2.766 ± 0.029
2.732LysVal: 2.732 ± 0.03
0.643LysTrp: 0.643 ± 0.013
1.46LysTyr: 1.46 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
7.334LeuAla: 7.334 ± 0.05
1.179LeuCys: 1.179 ± 0.021
5.046LeuAsp: 5.046 ± 0.036
5.621LeuGlu: 5.621 ± 0.049
3.312LeuPhe: 3.312 ± 0.038
5.571LeuGly: 5.571 ± 0.047
2.28LeuHis: 2.28 ± 0.025
4.062LeuIle: 4.062 ± 0.043
4.486LeuLys: 4.486 ± 0.039
8.543LeuLeu: 8.543 ± 0.079
1.734LeuMet: 1.734 ± 0.024
3.256LeuAsn: 3.256 ± 0.03
5.627LeuPro: 5.627 ± 0.04
3.831LeuGln: 3.831 ± 0.038
5.916LeuArg: 5.916 ± 0.042
7.661LeuSer: 7.661 ± 0.061
4.711LeuThr: 4.711 ± 0.042
5.068LeuVal: 5.068 ± 0.043
1.087LeuTrp: 1.087 ± 0.019
2.306LeuTyr: 2.306 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.066MetAla: 2.066 ± 0.024
0.245MetCys: 0.245 ± 0.009
1.266MetAsp: 1.266 ± 0.018
1.393MetGlu: 1.393 ± 0.019
0.733MetPhe: 0.733 ± 0.014
1.439MetGly: 1.439 ± 0.022
0.432MetHis: 0.432 ± 0.011
1.02MetIle: 1.02 ± 0.018
1.119MetLys: 1.119 ± 0.018
1.789MetLeu: 1.789 ± 0.023
0.54MetMet: 0.54 ± 0.015
0.792MetAsn: 0.792 ± 0.014
1.196MetPro: 1.196 ± 0.02
0.807MetGln: 0.807 ± 0.015
1.242MetArg: 1.242 ± 0.021
1.82MetSer: 1.82 ± 0.025
1.253MetThr: 1.253 ± 0.018
1.283MetVal: 1.283 ± 0.021
0.25MetTrp: 0.25 ± 0.008
0.471MetTyr: 0.471 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.051AsnAla: 3.051 ± 0.03
0.461AsnCys: 0.461 ± 0.012
2.168AsnAsp: 2.168 ± 0.029
2.161AsnGlu: 2.161 ± 0.026
1.374AsnPhe: 1.374 ± 0.02
3.062AsnGly: 3.062 ± 0.035
0.954AsnHis: 0.954 ± 0.017
2.319AsnIle: 2.319 ± 0.025
1.678AsnLys: 1.678 ± 0.024
3.389AsnLeu: 3.389 ± 0.037
0.86AsnMet: 0.86 ± 0.017
2.082AsnAsn: 2.082 ± 0.068
2.721AsnPro: 2.721 ± 0.031
1.44AsnGln: 1.44 ± 0.023
2.185AsnArg: 2.185 ± 0.027
3.163AsnSer: 3.163 ± 0.033
2.282AsnThr: 2.282 ± 0.029
2.266AsnVal: 2.266 ± 0.026
0.5AsnTrp: 0.5 ± 0.011
1.035AsnTyr: 1.035 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
5.105ProAla: 5.105 ± 0.052
0.538ProCys: 0.538 ± 0.013
3.246ProAsp: 3.246 ± 0.029
3.86ProGlu: 3.86 ± 0.041
2.127ProPhe: 2.127 ± 0.024
3.868ProGly: 3.868 ± 0.041
1.492ProHis: 1.492 ± 0.026
2.747ProIle: 2.747 ± 0.027
2.821ProLys: 2.821 ± 0.037
5.08ProLeu: 5.08 ± 0.039
1.052ProMet: 1.052 ± 0.018
2.45ProAsn: 2.45 ± 0.027
5.972ProPro: 5.972 ± 0.082
2.694ProGln: 2.694 ± 0.037
3.601ProArg: 3.601 ± 0.041
6.718ProSer: 6.718 ± 0.068
4.319ProThr: 4.319 ± 0.045
3.436ProVal: 3.436 ± 0.04
0.674ProTrp: 0.674 ± 0.014
1.509ProTyr: 1.509 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.153GlnAla: 3.153 ± 0.031
0.435GlnCys: 0.435 ± 0.012
1.946GlnAsp: 1.946 ± 0.023
2.393GlnGlu: 2.393 ± 0.029
1.303GlnPhe: 1.303 ± 0.021
2.293GlnGly: 2.293 ± 0.028
1.185GlnHis: 1.185 ± 0.022
1.959GlnIle: 1.959 ± 0.028
2.084GlnLys: 2.084 ± 0.026
3.504GlnLeu: 3.504 ± 0.034
0.842GlnMet: 0.842 ± 0.018
1.726GlnAsn: 1.726 ± 0.027
2.797GlnPro: 2.797 ± 0.036
2.871GlnGln: 2.871 ± 0.07
2.779GlnArg: 2.779 ± 0.031
3.252GlnSer: 3.252 ± 0.037
2.271GlnThr: 2.271 ± 0.03
2.006GlnVal: 2.006 ± 0.023
0.49GlnTrp: 0.49 ± 0.012
1.081GlnTyr: 1.081 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
4.699ArgAla: 4.699 ± 0.045
0.743ArgCys: 0.743 ± 0.015
3.431ArgAsp: 3.431 ± 0.032
4.043ArgGlu: 4.043 ± 0.043
2.173ArgPhe: 2.173 ± 0.025
3.887ArgGly: 3.887 ± 0.038
1.643ArgHis: 1.643 ± 0.024
3.081ArgIle: 3.081 ± 0.03
3.779ArgLys: 3.779 ± 0.039
5.56ArgLeu: 5.56 ± 0.041
1.364ArgMet: 1.364 ± 0.018
2.569ArgAsn: 2.569 ± 0.03
3.626ArgPro: 3.626 ± 0.042
2.719ArgGln: 2.719 ± 0.032
5.528ArgArg: 5.528 ± 0.051
5.145ArgSer: 5.145 ± 0.052
3.432ArgThr: 3.432 ± 0.036
3.367ArgVal: 3.367 ± 0.031
0.893ArgTrp: 0.893 ± 0.016
1.688ArgTyr: 1.688 ± 0.022
0.0ArgXaa: 0.0 ± 0.0
Ser
6.564SerAla: 6.564 ± 0.044
0.896SerCys: 0.896 ± 0.015
4.302SerAsp: 4.302 ± 0.037
4.271SerGlu: 4.271 ± 0.041
3.101SerPhe: 3.101 ± 0.034
5.653SerGly: 5.653 ± 0.049
2.177SerHis: 2.177 ± 0.027
4.218SerIle: 4.218 ± 0.042
4.075SerLys: 4.075 ± 0.036
7.497SerLeu: 7.497 ± 0.056
1.769SerMet: 1.769 ± 0.023
3.416SerAsn: 3.416 ± 0.034
6.367SerPro: 6.367 ± 0.078
3.514SerGln: 3.514 ± 0.043
5.571SerArg: 5.571 ± 0.057
10.043SerSer: 10.043 ± 0.104
5.973SerThr: 5.973 ± 0.058
4.464SerVal: 4.464 ± 0.04
1.073SerTrp: 1.073 ± 0.018
2.046SerTyr: 2.046 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
5.032ThrAla: 5.032 ± 0.041
0.715ThrCys: 0.715 ± 0.018
2.807ThrAsp: 2.807 ± 0.03
3.122ThrGlu: 3.122 ± 0.036
2.177ThrPhe: 2.177 ± 0.026
3.936ThrGly: 3.936 ± 0.039
1.338ThrHis: 1.338 ± 0.02
3.045ThrIle: 3.045 ± 0.031
2.686ThrLys: 2.686 ± 0.025
5.139ThrLeu: 5.139 ± 0.042
1.135ThrMet: 1.135 ± 0.016
2.198ThrAsn: 2.198 ± 0.025
4.553ThrPro: 4.553 ± 0.048
2.086ThrGln: 2.086 ± 0.025
3.228ThrArg: 3.228 ± 0.028
5.633ThrSer: 5.633 ± 0.056
4.663ThrThr: 4.663 ± 0.103
3.488ThrVal: 3.488 ± 0.033
0.728ThrTrp: 0.728 ± 0.015
1.481ThrTyr: 1.481 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
4.669ValAla: 4.669 ± 0.035
0.751ValCys: 0.751 ± 0.014
3.667ValAsp: 3.667 ± 0.032
3.818ValGlu: 3.818 ± 0.033
2.267ValPhe: 2.267 ± 0.026
3.798ValGly: 3.798 ± 0.033
1.339ValHis: 1.339 ± 0.019
2.932ValIle: 2.932 ± 0.031
2.875ValLys: 2.875 ± 0.03
5.225ValLeu: 5.225 ± 0.045
1.249ValMet: 1.249 ± 0.018
2.203ValAsn: 2.203 ± 0.024
3.413ValPro: 3.413 ± 0.033
2.124ValGln: 2.124 ± 0.026
3.37ValArg: 3.37 ± 0.03
4.525ValSer: 4.525 ± 0.039
3.23ValThr: 3.23 ± 0.03
3.947ValVal: 3.947 ± 0.044
0.772ValTrp: 0.772 ± 0.015
1.543ValTyr: 1.543 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
1.013TrpAla: 1.013 ± 0.018
0.177TrpCys: 0.177 ± 0.007
0.831TrpAsp: 0.831 ± 0.018
0.813TrpGlu: 0.813 ± 0.017
0.475TrpPhe: 0.475 ± 0.011
0.83TrpGly: 0.83 ± 0.015
0.314TrpHis: 0.314 ± 0.009
0.718TrpIle: 0.718 ± 0.015
0.781TrpLys: 0.781 ± 0.015
1.21TrpLeu: 1.21 ± 0.02
0.34TrpMet: 0.34 ± 0.009
0.585TrpAsn: 0.585 ± 0.013
0.542TrpPro: 0.542 ± 0.013
0.491TrpGln: 0.491 ± 0.012
0.939TrpArg: 0.939 ± 0.016
0.947TrpSer: 0.947 ± 0.017
0.772TrpThr: 0.772 ± 0.014
0.79TrpVal: 0.79 ± 0.016
0.248TrpTrp: 0.248 ± 0.01
0.362TrpTyr: 0.362 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.932TyrAla: 1.932 ± 0.024
0.389TyrCys: 0.389 ± 0.011
1.577TyrAsp: 1.577 ± 0.02
1.478TyrGlu: 1.478 ± 0.018
1.169TyrPhe: 1.169 ± 0.021
1.848TyrGly: 1.848 ± 0.023
0.769TyrHis: 0.769 ± 0.015
1.462TyrIle: 1.462 ± 0.02
1.077TyrLys: 1.077 ± 0.018
2.608TyrLeu: 2.608 ± 0.027
0.601TyrMet: 0.601 ± 0.014
1.078TyrAsn: 1.078 ± 0.018
1.602TyrPro: 1.602 ± 0.033
1.076TyrGln: 1.076 ± 0.016
1.599TyrArg: 1.599 ± 0.022
2.073TyrSer: 2.073 ± 0.028
1.474TyrThr: 1.474 ± 0.02
1.534TyrVal: 1.534 ± 0.021
0.379TyrTrp: 0.379 ± 0.011
0.862TyrTyr: 0.862 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8561 proteins (3669030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski