Amino acid dipepetide frequency for Thiopseudomonas denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.184AlaAla: 12.184 ± 0.165	1.233AlaCys: 1.233 ± 0.039	5.95AlaAsp: 5.95 ± 0.082	6.452AlaGlu: 6.452 ± 0.103	3.322AlaPhe: 3.322 ± 0.063	9.789AlaGly: 9.789 ± 0.149	1.925AlaHis: 1.925 ± 0.047	5.262AlaIle: 5.262 ± 0.081	2.983AlaLys: 2.983 ± 0.069	12.523AlaLeu: 12.523 ± 0.164	3.027AlaMet: 3.027 ± 0.063	2.839AlaAsn: 2.839 ± 0.071	3.723AlaPro: 3.723 ± 0.078	4.724AlaGln: 4.724 ± 0.079	7.044AlaArg: 7.044 ± 0.1	5.958AlaSer: 5.958 ± 0.099	4.663AlaThr: 4.663 ± 0.081	7.189AlaVal: 7.189 ± 0.103	1.419AlaTrp: 1.419 ± 0.047	2.307AlaTyr: 2.307 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.033	0.128CysCys: 0.128 ± 0.013	0.519CysAsp: 0.519 ± 0.024	0.5CysGlu: 0.5 ± 0.024	0.349CysPhe: 0.349 ± 0.02	0.864CysGly: 0.864 ± 0.035	0.335CysHis: 0.335 ± 0.022	0.544CysIle: 0.544 ± 0.028	0.3CysLys: 0.3 ± 0.018	1.079CysLeu: 1.079 ± 0.047	0.262CysMet: 0.262 ± 0.019	0.325CysAsn: 0.325 ± 0.019	0.492CysPro: 0.492 ± 0.026	0.472CysGln: 0.472 ± 0.025	0.676CysArg: 0.676 ± 0.028	0.689CysSer: 0.689 ± 0.032	0.479CysThr: 0.479 ± 0.028	0.64CysVal: 0.64 ± 0.032	0.139CysTrp: 0.139 ± 0.013	0.238CysTyr: 0.238 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.352AspAla: 5.352 ± 0.096	0.6AspCys: 0.6 ± 0.026	2.924AspAsp: 2.924 ± 0.07	3.848AspGlu: 3.848 ± 0.077	2.052AspPhe: 2.052 ± 0.058	4.291AspGly: 4.291 ± 0.082	1.063AspHis: 1.063 ± 0.041	3.143AspIle: 3.143 ± 0.07	2.118AspLys: 2.118 ± 0.061	5.55AspLeu: 5.55 ± 0.097	1.414AspMet: 1.414 ± 0.045	2.043AspAsn: 2.043 ± 0.058	2.338AspPro: 2.338 ± 0.058	1.971AspGln: 1.971 ± 0.05	2.959AspArg: 2.959 ± 0.059	3.405AspSer: 3.405 ± 0.06	2.44AspThr: 2.44 ± 0.051	3.499AspVal: 3.499 ± 0.063	1.018AspTrp: 1.018 ± 0.036	1.773AspTyr: 1.773 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.855GluAla: 5.855 ± 0.102	0.443GluCys: 0.443 ± 0.025	2.623GluAsp: 2.623 ± 0.061	3.544GluGlu: 3.544 ± 0.081	2.054GluPhe: 2.054 ± 0.053	3.594GluGly: 3.594 ± 0.079	1.793GluHis: 1.793 ± 0.049	2.9GluIle: 2.9 ± 0.066	2.292GluLys: 2.292 ± 0.072	7.791GluLeu: 7.791 ± 0.112	1.349GluMet: 1.349 ± 0.04	1.766GluAsn: 1.766 ± 0.046	2.554GluPro: 2.554 ± 0.065	5.205GluGln: 5.205 ± 0.116	4.765GluArg: 4.765 ± 0.086	2.526GluSer: 2.526 ± 0.056	2.655GluThr: 2.655 ± 0.055	4.149GluVal: 4.149 ± 0.077	0.671GluTrp: 0.671 ± 0.028	1.419GluTyr: 1.419 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.969PheAla: 3.969 ± 0.076	0.45PheCys: 0.45 ± 0.025	2.2PheAsp: 2.2 ± 0.053	1.985PheGlu: 1.985 ± 0.05	1.5PhePhe: 1.5 ± 0.056	2.882PheGly: 2.882 ± 0.073	0.7PheHis: 0.7 ± 0.028	1.875PheIle: 1.875 ± 0.054	1.127PheLys: 1.127 ± 0.038	3.406PheLeu: 3.406 ± 0.077	0.934PheMet: 0.934 ± 0.034	1.353PheAsn: 1.353 ± 0.042	1.317PhePro: 1.317 ± 0.039	1.102PheGln: 1.102 ± 0.035	1.875PheArg: 1.875 ± 0.042	2.507PheSer: 2.507 ± 0.055	2.018PheThr: 2.018 ± 0.054	2.609PheVal: 2.609 ± 0.059	0.567PheTrp: 0.567 ± 0.029	1.087PheTyr: 1.087 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.462GlyAla: 6.462 ± 0.128	0.999GlyCys: 0.999 ± 0.035	3.715GlyAsp: 3.715 ± 0.076	4.525GlyGlu: 4.525 ± 0.073	3.229GlyPhe: 3.229 ± 0.059	5.471GlyGly: 5.471 ± 0.099	1.917GlyHis: 1.917 ± 0.048	4.412GlyIle: 4.412 ± 0.077	3.439GlyLys: 3.439 ± 0.069	9.001GlyLeu: 9.001 ± 0.142	2.44GlyMet: 2.44 ± 0.06	2.445GlyAsn: 2.445 ± 0.062	2.218GlyPro: 2.218 ± 0.048	4.086GlyGln: 4.086 ± 0.082	4.979GlyArg: 4.979 ± 0.077	4.706GlySer: 4.706 ± 0.084	3.615GlyThr: 3.615 ± 0.078	5.48GlyVal: 5.48 ± 0.079	1.255GlyTrp: 1.255 ± 0.048	2.368GlyTyr: 2.368 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.357HisAla: 2.357 ± 0.056	0.344HisCys: 0.344 ± 0.024	1.419HisAsp: 1.419 ± 0.048	1.318HisGlu: 1.318 ± 0.04	0.957HisPhe: 0.957 ± 0.035	1.887HisGly: 1.887 ± 0.052	0.577HisHis: 0.577 ± 0.028	1.207HisIle: 1.207 ± 0.039	0.685HisLys: 0.685 ± 0.033	2.452HisLeu: 2.452 ± 0.06	0.588HisMet: 0.588 ± 0.029	0.843HisAsn: 0.843 ± 0.037	1.337HisPro: 1.337 ± 0.044	1.117HisGln: 1.117 ± 0.036	1.259HisArg: 1.259 ± 0.035	1.422HisSer: 1.422 ± 0.048	1.002HisThr: 1.002 ± 0.038	1.468HisVal: 1.468 ± 0.043	0.454HisTrp: 0.454 ± 0.026	0.76HisTyr: 0.76 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.532IleAla: 5.532 ± 0.085	0.463IleCys: 0.463 ± 0.022	3.182IleAsp: 3.182 ± 0.067	3.566IleGlu: 3.566 ± 0.067	1.574IlePhe: 1.574 ± 0.039	4.008IleGly: 4.008 ± 0.068	1.048IleHis: 1.048 ± 0.035	2.448IleIle: 2.448 ± 0.057	1.809IleLys: 1.809 ± 0.056	4.746IleLeu: 4.746 ± 0.079	1.06IleMet: 1.06 ± 0.044	2.094IleAsn: 2.094 ± 0.056	2.327IlePro: 2.327 ± 0.055	1.809IleGln: 1.809 ± 0.043	3.395IleArg: 3.395 ± 0.067	3.311IleSer: 3.311 ± 0.069	2.591IleThr: 2.591 ± 0.053	3.029IleVal: 3.029 ± 0.065	0.499IleTrp: 0.499 ± 0.024	1.216IleTyr: 1.216 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.471LysAla: 3.471 ± 0.081	0.175LysCys: 0.175 ± 0.012	1.827LysAsp: 1.827 ± 0.055	1.853LysGlu: 1.853 ± 0.061	0.891LysPhe: 0.891 ± 0.035	2.468LysGly: 2.468 ± 0.061	0.815LysHis: 0.815 ± 0.033	1.786LysIle: 1.786 ± 0.057	1.722LysLys: 1.722 ± 0.066	3.686LysLeu: 3.686 ± 0.071	0.761LysMet: 0.761 ± 0.034	1.342LysAsn: 1.342 ± 0.046	1.839LysPro: 1.839 ± 0.052	1.862LysGln: 1.862 ± 0.054	2.178LysArg: 2.178 ± 0.061	1.841LysSer: 1.841 ± 0.044	1.998LysThr: 1.998 ± 0.048	2.346LysVal: 2.346 ± 0.056	0.344LysTrp: 0.344 ± 0.021	0.781LysTyr: 0.781 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	13.953LeuAla: 13.953 ± 0.167	1.175LeuCys: 1.175 ± 0.039	7.039LeuAsp: 7.039 ± 0.122	7.314LeuGlu: 7.314 ± 0.106	4.155LeuPhe: 4.155 ± 0.094	8.708LeuGly: 8.708 ± 0.115	2.763LeuHis: 2.763 ± 0.062	5.202LeuIle: 5.202 ± 0.097	4.05LeuLys: 4.05 ± 0.067	14.7LeuLeu: 14.7 ± 0.244	2.709LeuMet: 2.709 ± 0.069	3.584LeuAsn: 3.584 ± 0.073	6.3LeuPro: 6.3 ± 0.106	6.839LeuGln: 6.839 ± 0.147	6.858LeuArg: 6.858 ± 0.107	6.659LeuSer: 6.659 ± 0.102	5.574LeuThr: 5.574 ± 0.094	8.031LeuVal: 8.031 ± 0.118	1.451LeuTrp: 1.451 ± 0.047	2.741LeuTyr: 2.741 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.741MetAla: 2.741 ± 0.064	0.176MetCys: 0.176 ± 0.014	1.252MetAsp: 1.252 ± 0.041	1.135MetGlu: 1.135 ± 0.038	0.667MetPhe: 0.667 ± 0.029	1.757MetGly: 1.757 ± 0.051	0.601MetHis: 0.601 ± 0.029	1.138MetIle: 1.138 ± 0.038	0.897MetLys: 0.897 ± 0.031	3.171MetLeu: 3.171 ± 0.069	0.568MetMet: 0.568 ± 0.026	0.929MetAsn: 0.929 ± 0.035	1.492MetPro: 1.492 ± 0.04	1.66MetGln: 1.66 ± 0.043	1.569MetArg: 1.569 ± 0.047	1.758MetSer: 1.758 ± 0.048	1.426MetThr: 1.426 ± 0.04	1.628MetVal: 1.628 ± 0.047	0.175MetTrp: 0.175 ± 0.014	0.413MetTyr: 0.413 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.034AsnAla: 3.034 ± 0.062	0.33AsnCys: 0.33 ± 0.021	1.583AsnAsp: 1.583 ± 0.056	1.745AsnGlu: 1.745 ± 0.043	1.111AsnPhe: 1.111 ± 0.037	2.441AsnGly: 2.441 ± 0.066	0.66AsnHis: 0.66 ± 0.03	1.748AsnIle: 1.748 ± 0.051	1.141AsnLys: 1.141 ± 0.042	3.552AsnLeu: 3.552 ± 0.074	0.769AsnMet: 0.769 ± 0.033	1.227AsnAsn: 1.227 ± 0.051	2.06AsnPro: 2.06 ± 0.049	1.429AsnGln: 1.429 ± 0.041	2.044AsnArg: 2.044 ± 0.051	1.911AsnSer: 1.911 ± 0.052	1.667AsnThr: 1.667 ± 0.061	1.893AsnVal: 1.893 ± 0.057	0.496AsnTrp: 0.496 ± 0.025	0.909AsnTyr: 0.909 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.648ProAla: 5.648 ± 0.095	0.385ProCys: 0.385 ± 0.024	3.02ProAsp: 3.02 ± 0.076	3.567ProGlu: 3.567 ± 0.069	1.62ProPhe: 1.62 ± 0.048	3.864ProGly: 3.864 ± 0.071	1.06ProHis: 1.06 ± 0.039	1.518ProIle: 1.518 ± 0.042	1.211ProLys: 1.211 ± 0.044	5.373ProLeu: 5.373 ± 0.093	1.174ProMet: 1.174 ± 0.04	1.144ProAsn: 1.144 ± 0.039	1.689ProPro: 1.689 ± 0.053	2.216ProGln: 2.216 ± 0.051	2.254ProArg: 2.254 ± 0.054	1.913ProSer: 1.913 ± 0.051	1.647ProThr: 1.647 ± 0.042	4.298ProVal: 4.298 ± 0.081	0.665ProTrp: 0.665 ± 0.032	1.086ProTyr: 1.086 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	6.224GlnAla: 6.224 ± 0.089	0.34GlnCys: 0.34 ± 0.02	2.334GlnAsp: 2.334 ± 0.055	2.769GlnGlu: 2.769 ± 0.068	1.333GlnPhe: 1.333 ± 0.039	3.594GlnGly: 3.594 ± 0.061	1.449GlnHis: 1.449 ± 0.047	2.249GlnIle: 2.249 ± 0.054	1.487GlnLys: 1.487 ± 0.049	7.263GlnLeu: 7.263 ± 0.141	1.167GlnMet: 1.167 ± 0.04	1.273GlnAsn: 1.273 ± 0.042	2.967GlnPro: 2.967 ± 0.078	4.863GlnGln: 4.863 ± 0.135	3.794GlnArg: 3.794 ± 0.08	2.332GlnSer: 2.332 ± 0.059	2.18GlnThr: 2.18 ± 0.058	3.867GlnVal: 3.867 ± 0.068	0.822GlnTrp: 0.822 ± 0.038	1.108GlnTyr: 1.108 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	5.342ArgAla: 5.342 ± 0.082	0.539ArgCys: 0.539 ± 0.025	3.4ArgAsp: 3.4 ± 0.062	4.198ArgGlu: 4.198 ± 0.086	2.613ArgPhe: 2.613 ± 0.055	3.735ArgGly: 3.735 ± 0.07	1.811ArgHis: 1.811 ± 0.054	3.758ArgIle: 3.758 ± 0.071	2.354ArgLys: 2.354 ± 0.056	8.379ArgLeu: 8.379 ± 0.111	1.772ArgMet: 1.772 ± 0.049	2.157ArgAsn: 2.157 ± 0.044	2.627ArgPro: 2.627 ± 0.056	4.065ArgGln: 4.065 ± 0.093	3.99ArgArg: 3.99 ± 0.081	3.493ArgSer: 3.493 ± 0.068	2.819ArgThr: 2.819 ± 0.065	4.129ArgVal: 4.129 ± 0.076	1.011ArgTrp: 1.011 ± 0.039	1.988ArgTyr: 1.988 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.629SerAla: 5.629 ± 0.089	0.564SerCys: 0.564 ± 0.031	2.721SerAsp: 2.721 ± 0.061	3.017SerGlu: 3.017 ± 0.072	2.342SerPhe: 2.342 ± 0.057	5.379SerGly: 5.379 ± 0.11	1.393SerHis: 1.393 ± 0.039	2.969SerIle: 2.969 ± 0.065	1.869SerLys: 1.869 ± 0.052	7.045SerLeu: 7.045 ± 0.107	1.54SerMet: 1.54 ± 0.047	1.695SerAsn: 1.695 ± 0.049	2.364SerPro: 2.364 ± 0.06	2.53SerGln: 2.53 ± 0.054	3.8SerArg: 3.8 ± 0.061	3.487SerSer: 3.487 ± 0.07	2.806SerThr: 2.806 ± 0.062	3.738SerVal: 3.738 ± 0.069	0.849SerTrp: 0.849 ± 0.03	1.444SerTyr: 1.444 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.077ThrAla: 5.077 ± 0.079	0.466ThrCys: 0.466 ± 0.026	2.567ThrAsp: 2.567 ± 0.061	2.51ThrGlu: 2.51 ± 0.052	1.483ThrPhe: 1.483 ± 0.04	4.77ThrGly: 4.77 ± 0.08	1.054ThrHis: 1.054 ± 0.04	2.12ThrIle: 2.12 ± 0.054	1.073ThrLys: 1.073 ± 0.042	6.323ThrLeu: 6.323 ± 0.106	0.901ThrMet: 0.901 ± 0.04	1.251ThrAsn: 1.251 ± 0.045	2.759ThrPro: 2.759 ± 0.062	1.694ThrGln: 1.694 ± 0.051	3.16ThrArg: 3.16 ± 0.064	2.636ThrSer: 2.636 ± 0.063	2.444ThrThr: 2.444 ± 0.06	3.277ThrVal: 3.277 ± 0.073	0.563ThrTrp: 0.563 ± 0.028	1.092ThrTyr: 1.092 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.359ValAla: 7.359 ± 0.115	0.706ValCys: 0.706 ± 0.03	3.696ValAsp: 3.696 ± 0.073	4.304ValGlu: 4.304 ± 0.08	2.631ValPhe: 2.631 ± 0.067	4.524ValGly: 4.524 ± 0.087	1.475ValHis: 1.475 ± 0.045	3.657ValIle: 3.657 ± 0.073	2.175ValLys: 2.175 ± 0.06	8.406ValLeu: 8.406 ± 0.125	1.776ValMet: 1.776 ± 0.049	2.22ValAsn: 2.22 ± 0.056	3.029ValPro: 3.029 ± 0.059	3.015ValGln: 3.015 ± 0.054	4.581ValArg: 4.581 ± 0.082	4.22ValSer: 4.22 ± 0.077	3.519ValThr: 3.519 ± 0.084	5.299ValVal: 5.299 ± 0.086	0.882ValTrp: 0.882 ± 0.032	1.571ValTyr: 1.571 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.001TrpAla: 1.001 ± 0.039	0.166TrpCys: 0.166 ± 0.014	0.552TrpAsp: 0.552 ± 0.027	0.531TrpGlu: 0.531 ± 0.025	0.551TrpPhe: 0.551 ± 0.025	0.774TrpGly: 0.774 ± 0.036	0.428TrpHis: 0.428 ± 0.024	0.628TrpIle: 0.628 ± 0.029	0.4TrpLys: 0.4 ± 0.024	2.472TrpLeu: 2.472 ± 0.07	0.374TrpMet: 0.374 ± 0.022	0.398TrpAsn: 0.398 ± 0.024	0.669TrpPro: 0.669 ± 0.031	1.297TrpGln: 1.297 ± 0.044	0.991TrpArg: 0.991 ± 0.033	0.727TrpSer: 0.727 ± 0.034	0.533TrpThr: 0.533 ± 0.023	0.849TrpVal: 0.849 ± 0.038	0.227TrpTrp: 0.227 ± 0.02	0.35TrpTyr: 0.35 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.385TyrAla: 2.385 ± 0.058	0.287TyrCys: 0.287 ± 0.019	1.279TyrAsp: 1.279 ± 0.045	1.264TyrGlu: 1.264 ± 0.042	1.027TyrPhe: 1.027 ± 0.037	1.962TyrGly: 1.962 ± 0.053	0.586TyrHis: 0.586 ± 0.026	1.144TyrIle: 1.144 ± 0.042	0.856TyrLys: 0.856 ± 0.039	2.887TyrLeu: 2.887 ± 0.061	0.568TyrMet: 0.568 ± 0.026	0.823TyrAsn: 0.823 ± 0.032	1.252TyrPro: 1.252 ± 0.033	1.459TyrGln: 1.459 ± 0.044	2.008TyrArg: 2.008 ± 0.052	1.679TyrSer: 1.679 ± 0.051	1.143TyrThr: 1.143 ± 0.04	1.629TyrVal: 1.629 ± 0.048	0.413TyrTrp: 0.413 ± 0.019	0.726TyrTyr: 0.726 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2567 proteins (833170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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