Amino acid dipepetide frequency for Janthinobacterium sp. B9-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.399AlaAla: 13.399 ± 0.207	1.208AlaCys: 1.208 ± 0.024	5.53AlaAsp: 5.53 ± 0.077	6.411AlaGlu: 6.411 ± 0.089	3.804AlaPhe: 3.804 ± 0.059	8.361AlaGly: 8.361 ± 0.116	2.138AlaHis: 2.138 ± 0.048	6.321AlaIle: 6.321 ± 0.083	5.282AlaLys: 5.282 ± 0.081	12.811AlaLeu: 12.811 ± 0.191	3.021AlaMet: 3.021 ± 0.046	3.713AlaAsn: 3.713 ± 0.05	4.057AlaPro: 4.057 ± 0.082	4.873AlaGln: 4.873 ± 0.099	5.193AlaArg: 5.193 ± 0.072	6.889AlaSer: 6.889 ± 0.08	5.01AlaThr: 5.01 ± 0.1	6.895AlaVal: 6.895 ± 0.1	1.426AlaTrp: 1.426 ± 0.04	2.579AlaTyr: 2.579 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.03	0.131CysCys: 0.131 ± 0.01	0.532CysAsp: 0.532 ± 0.02	0.51CysGlu: 0.51 ± 0.023	0.39CysPhe: 0.39 ± 0.018	0.898CysGly: 0.898 ± 0.028	0.265CysHis: 0.265 ± 0.015	0.535CysIle: 0.535 ± 0.022	0.435CysLys: 0.435 ± 0.02	1.091CysLeu: 1.091 ± 0.028	0.227CysMet: 0.227 ± 0.014	0.336CysAsn: 0.336 ± 0.016	0.476CysPro: 0.476 ± 0.022	0.388CysGln: 0.388 ± 0.019	0.515CysArg: 0.515 ± 0.021	0.638CysSer: 0.638 ± 0.024	0.469CysThr: 0.469 ± 0.018	0.622CysVal: 0.622 ± 0.022	0.148CysTrp: 0.148 ± 0.01	0.287CysTyr: 0.287 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.691AspAla: 5.691 ± 0.075	0.502AspCys: 0.502 ± 0.021	2.551AspAsp: 2.551 ± 0.052	3.255AspGlu: 3.255 ± 0.059	2.436AspPhe: 2.436 ± 0.044	3.881AspGly: 3.881 ± 0.079	1.08AspHis: 1.08 ± 0.032	3.135AspIle: 3.135 ± 0.057	2.394AspLys: 2.394 ± 0.051	5.695AspLeu: 5.695 ± 0.065	1.143AspMet: 1.143 ± 0.029	1.587AspAsn: 1.587 ± 0.051	2.219AspPro: 2.219 ± 0.045	2.142AspGln: 2.142 ± 0.073	2.389AspArg: 2.389 ± 0.044	2.836AspSer: 2.836 ± 0.051	2.297AspThr: 2.297 ± 0.046	3.576AspVal: 3.576 ± 0.061	0.906AspTrp: 0.906 ± 0.027	1.688AspTyr: 1.688 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.889GluAla: 5.889 ± 0.07	0.464GluCys: 0.464 ± 0.021	2.152GluAsp: 2.152 ± 0.043	2.986GluGlu: 2.986 ± 0.05	1.983GluPhe: 1.983 ± 0.043	3.466GluGly: 3.466 ± 0.059	1.357GluHis: 1.357 ± 0.035	3.787GluIle: 3.787 ± 0.066	2.891GluLys: 2.891 ± 0.051	6.517GluLeu: 6.517 ± 0.084	1.577GluMet: 1.577 ± 0.037	2.044GluAsn: 2.044 ± 0.038	1.904GluPro: 1.904 ± 0.044	3.123GluGln: 3.123 ± 0.063	3.398GluArg: 3.398 ± 0.058	3.006GluSer: 3.006 ± 0.051	2.785GluThr: 2.785 ± 0.061	3.881GluVal: 3.881 ± 0.066	0.722GluTrp: 0.722 ± 0.022	1.418GluTyr: 1.418 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.268PheAla: 4.268 ± 0.069	0.496PheCys: 0.496 ± 0.021	2.491PheAsp: 2.491 ± 0.042	2.217PheGlu: 2.217 ± 0.042	1.728PhePhe: 1.728 ± 0.048	2.965PheGly: 2.965 ± 0.054	0.735PheHis: 0.735 ± 0.026	2.396PheIle: 2.396 ± 0.047	1.841PheLys: 1.841 ± 0.036	3.388PheLeu: 3.388 ± 0.057	0.934PheMet: 0.934 ± 0.028	1.781PheAsn: 1.781 ± 0.052	1.443PhePro: 1.443 ± 0.037	1.174PheGln: 1.174 ± 0.035	1.536PheArg: 1.536 ± 0.037	3.185PheSer: 3.185 ± 0.06	2.133PheThr: 2.133 ± 0.042	2.571PheVal: 2.571 ± 0.042	0.558PheTrp: 0.558 ± 0.023	1.17PheTyr: 1.17 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.266GlyAla: 6.266 ± 0.073	0.79GlyCys: 0.79 ± 0.027	3.629GlyAsp: 3.629 ± 0.065	4.218GlyGlu: 4.218 ± 0.072	3.304GlyPhe: 3.304 ± 0.061	5.491GlyGly: 5.491 ± 0.116	1.557GlyHis: 1.557 ± 0.036	4.478GlyIle: 4.478 ± 0.076	4.254GlyLys: 4.254 ± 0.078	7.968GlyLeu: 7.968 ± 0.09	2.197GlyMet: 2.197 ± 0.047	2.542GlyAsn: 2.542 ± 0.062	2.025GlyPro: 2.025 ± 0.044	3.186GlyGln: 3.186 ± 0.07	3.601GlyArg: 3.601 ± 0.062	4.462GlySer: 4.462 ± 0.084	3.475GlyThr: 3.475 ± 0.084	5.555GlyVal: 5.555 ± 0.099	1.1GlyTrp: 1.1 ± 0.033	2.117GlyTyr: 2.117 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.27HisAla: 2.27 ± 0.049	0.266HisCys: 0.266 ± 0.014	1.081HisAsp: 1.081 ± 0.029	1.094HisGlu: 1.094 ± 0.036	1.073HisPhe: 1.073 ± 0.033	1.629HisGly: 1.629 ± 0.038	0.622HisHis: 0.622 ± 0.024	1.325HisIle: 1.325 ± 0.029	0.797HisLys: 0.797 ± 0.025	2.345HisLeu: 2.345 ± 0.052	0.427HisMet: 0.427 ± 0.019	0.614HisAsn: 0.614 ± 0.021	1.225HisPro: 1.225 ± 0.034	0.973HisGln: 0.973 ± 0.026	1.141HisArg: 1.141 ± 0.031	1.272HisSer: 1.272 ± 0.034	1.066HisThr: 1.066 ± 0.028	1.189HisVal: 1.189 ± 0.033	0.37HisTrp: 0.37 ± 0.017	0.739HisTyr: 0.739 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.273IleAla: 7.273 ± 0.135	0.614IleCys: 0.614 ± 0.022	3.525IleAsp: 3.525 ± 0.064	3.927IleGlu: 3.927 ± 0.069	1.954IlePhe: 1.954 ± 0.041	4.519IleGly: 4.519 ± 0.068	1.188IleHis: 1.188 ± 0.031	2.833IleIle: 2.833 ± 0.051	3.054IleLys: 3.054 ± 0.056	5.17IleLeu: 5.17 ± 0.072	1.148IleMet: 1.148 ± 0.032	2.581IleAsn: 2.581 ± 0.052	2.353IlePro: 2.353 ± 0.045	2.017IleGln: 2.017 ± 0.043	2.907IleArg: 2.907 ± 0.053	4.49IleSer: 4.49 ± 0.072	3.302IleThr: 3.302 ± 0.072	3.748IleVal: 3.748 ± 0.06	0.671IleTrp: 0.671 ± 0.024	1.53IleTyr: 1.53 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.852LysAla: 4.852 ± 0.069	0.262LysCys: 0.262 ± 0.014	2.395LysAsp: 2.395 ± 0.048	2.702LysGlu: 2.702 ± 0.057	1.31LysPhe: 1.31 ± 0.038	3.0LysGly: 3.0 ± 0.052	0.966LysHis: 0.966 ± 0.027	2.986LysIle: 2.986 ± 0.062	2.643LysLys: 2.643 ± 0.063	5.375LysLeu: 5.375 ± 0.077	1.431LysMet: 1.431 ± 0.035	2.168LysAsn: 2.168 ± 0.054	2.432LysPro: 2.432 ± 0.048	2.387LysGln: 2.387 ± 0.054	2.447LysArg: 2.447 ± 0.045	2.753LysSer: 2.753 ± 0.053	2.82LysThr: 2.82 ± 0.065	3.126LysVal: 3.126 ± 0.056	0.547LysTrp: 0.547 ± 0.024	1.091LysTyr: 1.091 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.668LeuAla: 13.668 ± 0.136	1.139LeuCys: 1.139 ± 0.026	5.837LeuAsp: 5.837 ± 0.08	5.687LeuGlu: 5.687 ± 0.08	4.18LeuPhe: 4.18 ± 0.06	7.928LeuGly: 7.928 ± 0.094	2.18LeuHis: 2.18 ± 0.041	6.606LeuIle: 6.606 ± 0.078	5.35LeuLys: 5.35 ± 0.08	12.857LeuLeu: 12.857 ± 0.176	2.721LeuMet: 2.721 ± 0.056	4.357LeuAsn: 4.357 ± 0.085	5.764LeuPro: 5.764 ± 0.075	4.622LeuGln: 4.622 ± 0.076	5.66LeuArg: 5.66 ± 0.072	8.352LeuSer: 8.352 ± 0.151	5.447LeuThr: 5.447 ± 0.146	6.474LeuVal: 6.474 ± 0.088	1.248LeuTrp: 1.248 ± 0.032	2.419LeuTyr: 2.419 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.729MetAla: 2.729 ± 0.051	0.172MetCys: 0.172 ± 0.012	1.176MetAsp: 1.176 ± 0.033	1.088MetGlu: 1.088 ± 0.032	0.765MetPhe: 0.765 ± 0.03	1.851MetGly: 1.851 ± 0.043	0.542MetHis: 0.542 ± 0.017	1.36MetIle: 1.36 ± 0.035	1.253MetLys: 1.253 ± 0.033	2.929MetLeu: 2.929 ± 0.056	0.724MetMet: 0.724 ± 0.03	1.035MetAsn: 1.035 ± 0.03	1.407MetPro: 1.407 ± 0.035	1.403MetGln: 1.403 ± 0.032	1.397MetArg: 1.397 ± 0.035	1.848MetSer: 1.848 ± 0.034	1.335MetThr: 1.335 ± 0.038	1.62MetVal: 1.62 ± 0.039	0.216MetTrp: 0.216 ± 0.011	0.44MetTyr: 0.44 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.695AsnAla: 3.695 ± 0.064	0.311AsnCys: 0.311 ± 0.017	1.863AsnAsp: 1.863 ± 0.049	1.926AsnGlu: 1.926 ± 0.036	1.216AsnPhe: 1.216 ± 0.03	2.914AsnGly: 2.914 ± 0.063	0.849AsnHis: 0.849 ± 0.028	2.158AsnIle: 2.158 ± 0.044	1.832AsnLys: 1.832 ± 0.044	3.603AsnLeu: 3.603 ± 0.073	0.884AsnMet: 0.884 ± 0.023	1.524AsnAsn: 1.524 ± 0.05	2.134AsnPro: 2.134 ± 0.043	1.788AsnGln: 1.788 ± 0.055	1.789AsnArg: 1.789 ± 0.039	2.235AsnSer: 2.235 ± 0.061	2.216AsnThr: 2.216 ± 0.054	2.186AsnVal: 2.186 ± 0.064	0.575AsnTrp: 0.575 ± 0.024	1.086AsnTyr: 1.086 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.936ProAla: 4.936 ± 0.087	0.361ProCys: 0.361 ± 0.018	2.647ProAsp: 2.647 ± 0.05	3.081ProGlu: 3.081 ± 0.053	1.778ProPhe: 1.778 ± 0.038	2.517ProGly: 2.517 ± 0.05	0.945ProHis: 0.945 ± 0.029	2.322ProIle: 2.322 ± 0.041	1.939ProLys: 1.939 ± 0.043	4.89ProLeu: 4.89 ± 0.074	1.002ProMet: 1.002 ± 0.029	1.525ProAsn: 1.525 ± 0.033	1.684ProPro: 1.684 ± 0.047	1.866ProGln: 1.866 ± 0.041	1.867ProArg: 1.867 ± 0.044	2.751ProSer: 2.751 ± 0.051	1.991ProThr: 1.991 ± 0.055	3.445ProVal: 3.445 ± 0.063	0.623ProTrp: 0.623 ± 0.022	1.18ProTyr: 1.18 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.23GlnAla: 5.23 ± 0.105	0.369GlnCys: 0.369 ± 0.017	1.872GlnAsp: 1.872 ± 0.039	2.028GlnGlu: 2.028 ± 0.043	1.7GlnPhe: 1.7 ± 0.038	3.043GlnGly: 3.043 ± 0.062	1.128GlnHis: 1.128 ± 0.034	2.922GlnIle: 2.922 ± 0.088	2.006GlnLys: 2.006 ± 0.046	5.416GlnLeu: 5.416 ± 0.092	1.149GlnMet: 1.149 ± 0.033	1.582GlnAsn: 1.582 ± 0.038	1.809GlnPro: 1.809 ± 0.038	2.581GlnGln: 2.581 ± 0.077	2.588GlnArg: 2.588 ± 0.055	2.89GlnSer: 2.89 ± 0.068	2.219GlnThr: 2.219 ± 0.051	2.876GlnVal: 2.876 ± 0.115	0.622GlnTrp: 0.622 ± 0.023	1.256GlnTyr: 1.256 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.484ArgAla: 4.484 ± 0.069	0.5ArgCys: 0.5 ± 0.02	2.671ArgAsp: 2.671 ± 0.053	2.934ArgGlu: 2.934 ± 0.058	2.471ArgPhe: 2.471 ± 0.043	3.027ArgGly: 3.027 ± 0.053	1.181ArgHis: 1.181 ± 0.034	3.228ArgIle: 3.228 ± 0.053	2.193ArgLys: 2.193 ± 0.049	6.053ArgLeu: 6.053 ± 0.082	1.359ArgMet: 1.359 ± 0.033	1.759ArgAsn: 1.759 ± 0.037	2.012ArgPro: 2.012 ± 0.04	2.62ArgGln: 2.62 ± 0.053	2.744ArgArg: 2.744 ± 0.057	3.053ArgSer: 3.053 ± 0.06	2.235ArgThr: 2.235 ± 0.04	3.539ArgVal: 3.539 ± 0.044	0.769ArgTrp: 0.769 ± 0.023	1.762ArgTyr: 1.762 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.803SerAla: 6.803 ± 0.081	0.618SerCys: 0.618 ± 0.025	3.492SerAsp: 3.492 ± 0.057	3.376SerGlu: 3.376 ± 0.052	2.618SerPhe: 2.618 ± 0.046	5.286SerGly: 5.286 ± 0.081	1.477SerHis: 1.477 ± 0.034	3.571SerIle: 3.571 ± 0.056	3.073SerLys: 3.073 ± 0.054	7.169SerLeu: 7.169 ± 0.082	1.569SerMet: 1.569 ± 0.037	2.472SerAsn: 2.472 ± 0.068	2.755SerPro: 2.755 ± 0.05	2.83SerGln: 2.83 ± 0.069	3.179SerArg: 3.179 ± 0.052	4.652SerSer: 4.652 ± 0.115	3.473SerThr: 3.473 ± 0.112	4.232SerVal: 4.232 ± 0.062	0.907SerTrp: 0.907 ± 0.03	1.748SerTyr: 1.748 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.564ThrAla: 5.564 ± 0.122	0.408ThrCys: 0.408 ± 0.021	2.451ThrAsp: 2.451 ± 0.079	2.509ThrGlu: 2.509 ± 0.046	1.731ThrPhe: 1.731 ± 0.047	4.06ThrGly: 4.06 ± 0.096	1.111ThrHis: 1.111 ± 0.029	2.806ThrIle: 2.806 ± 0.054	1.753ThrLys: 1.753 ± 0.044	6.365ThrLeu: 6.365 ± 0.092	1.089ThrMet: 1.089 ± 0.031	1.442ThrAsn: 1.442 ± 0.045	3.033ThrPro: 3.033 ± 0.055	2.208ThrGln: 2.208 ± 0.055	2.468ThrArg: 2.468 ± 0.054	2.993ThrSer: 2.993 ± 0.101	2.743ThrThr: 2.743 ± 0.191	3.513ThrVal: 3.513 ± 0.091	0.614ThrTrp: 0.614 ± 0.024	1.152ThrTyr: 1.152 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	7.262ValAla: 7.262 ± 0.111	0.683ValCys: 0.683 ± 0.024	3.603ValAsp: 3.603 ± 0.051	3.723ValGlu: 3.723 ± 0.07	2.773ValPhe: 2.773 ± 0.054	4.457ValGly: 4.457 ± 0.064	1.234ValHis: 1.234 ± 0.031	4.054ValIle: 4.054 ± 0.057	3.096ValLys: 3.096 ± 0.061	7.722ValLeu: 7.722 ± 0.104	1.824ValMet: 1.824 ± 0.042	2.439ValAsn: 2.439 ± 0.049	2.712ValPro: 2.712 ± 0.061	2.553ValGln: 2.553 ± 0.049	3.172ValArg: 3.172 ± 0.058	4.549ValSer: 4.549 ± 0.064	3.163ValThr: 3.163 ± 0.098	4.954ValVal: 4.954 ± 0.08	0.83ValTrp: 0.83 ± 0.025	1.594ValTyr: 1.594 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.076TrpAla: 1.076 ± 0.031	0.156TrpCys: 0.156 ± 0.011	0.585TrpAsp: 0.585 ± 0.022	0.556TrpGlu: 0.556 ± 0.022	0.581TrpPhe: 0.581 ± 0.02	0.859TrpGly: 0.859 ± 0.025	0.392TrpHis: 0.392 ± 0.017	0.673TrpIle: 0.673 ± 0.024	0.567TrpLys: 0.567 ± 0.019	2.031TrpLeu: 2.031 ± 0.049	0.348TrpMet: 0.348 ± 0.018	0.456TrpAsn: 0.456 ± 0.022	0.623TrpPro: 0.623 ± 0.022	1.054TrpGln: 1.054 ± 0.032	0.939TrpArg: 0.939 ± 0.027	0.738TrpSer: 0.738 ± 0.028	0.49TrpThr: 0.49 ± 0.023	0.88TrpVal: 0.88 ± 0.025	0.25TrpTrp: 0.25 ± 0.017	0.277TrpTyr: 0.277 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.046	0.311TyrCys: 0.311 ± 0.016	1.321TyrAsp: 1.321 ± 0.035	1.122TyrGlu: 1.122 ± 0.029	1.215TyrPhe: 1.215 ± 0.034	2.062TyrGly: 2.062 ± 0.048	0.571TyrHis: 0.571 ± 0.02	1.313TyrIle: 1.313 ± 0.033	1.044TyrLys: 1.044 ± 0.03	3.1TyrLeu: 3.1 ± 0.059	0.514TyrMet: 0.514 ± 0.019	0.824TyrAsn: 0.824 ± 0.033	1.282TyrPro: 1.282 ± 0.032	1.496TyrGln: 1.496 ± 0.041	1.668TyrArg: 1.668 ± 0.035	1.706TyrSer: 1.706 ± 0.039	1.346TyrThr: 1.346 ± 0.034	1.516TyrVal: 1.516 ± 0.037	0.429TyrTrp: 0.429 ± 0.018	0.747TyrTyr: 0.747 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4080 proteins (1323239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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