Amino acid dipepetide frequency for Nyssa sinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.128AlaAla: 6.128 ± 0.027
1.282AlaCys: 1.282 ± 0.012
3.068AlaAsp: 3.068 ± 0.014
4.118AlaGlu: 4.118 ± 0.02
2.719AlaPhe: 2.719 ± 0.015
4.172AlaGly: 4.172 ± 0.019
1.315AlaHis: 1.315 ± 0.012
3.901AlaIle: 3.901 ± 0.021
3.764AlaLys: 3.764 ± 0.017
6.565AlaLeu: 6.565 ± 0.024
1.856AlaMet: 1.856 ± 0.012
2.642AlaAsn: 2.642 ± 0.016
2.763AlaPro: 2.763 ± 0.017
2.132AlaGln: 2.132 ± 0.013
3.318AlaArg: 3.318 ± 0.017
5.862AlaSer: 5.862 ± 0.023
3.675AlaThr: 3.675 ± 0.019
4.788AlaVal: 4.788 ± 0.022
0.78AlaTrp: 0.78 ± 0.007
1.765AlaTyr: 1.765 ± 0.012
0.0AlaXaa: 0.0 ± 0.0
Cys
0.99CysAla: 0.99 ± 0.01
0.549CysCys: 0.549 ± 0.007
0.894CysAsp: 0.894 ± 0.008
0.9CysGlu: 0.9 ± 0.009
0.924CysPhe: 0.924 ± 0.009
1.445CysGly: 1.445 ± 0.011
0.489CysHis: 0.489 ± 0.007
0.991CysIle: 0.991 ± 0.009
1.118CysLys: 1.118 ± 0.011
1.895CysLeu: 1.895 ± 0.013
0.46CysMet: 0.46 ± 0.005
0.895CysAsn: 0.895 ± 0.009
0.973CysPro: 0.973 ± 0.01
0.649CysGln: 0.649 ± 0.007
1.102CysArg: 1.102 ± 0.01
1.845CysSer: 1.845 ± 0.012
0.892CysThr: 0.892 ± 0.007
1.029CysVal: 1.029 ± 0.008
0.279CysTrp: 0.279 ± 0.005
0.583CysTyr: 0.583 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
3.326AspAla: 3.326 ± 0.016
0.959AspCys: 0.959 ± 0.009
3.571AspAsp: 3.571 ± 0.024
3.933AspGlu: 3.933 ± 0.022
2.339AspPhe: 2.339 ± 0.013
3.98AspGly: 3.98 ± 0.02
1.241AspHis: 1.241 ± 0.008
3.026AspIle: 3.026 ± 0.015
2.597AspLys: 2.597 ± 0.013
5.107AspLeu: 5.107 ± 0.022
1.33AspMet: 1.33 ± 0.01
2.084AspAsn: 2.084 ± 0.012
2.582AspPro: 2.582 ± 0.016
1.812AspGln: 1.812 ± 0.011
2.41AspArg: 2.41 ± 0.014
4.194AspSer: 4.194 ± 0.016
2.213AspThr: 2.213 ± 0.012
3.556AspVal: 3.556 ± 0.015
0.733AspTrp: 0.733 ± 0.007
1.556AspTyr: 1.556 ± 0.01
0.0AspXaa: 0.0 ± 0.0
Glu
4.696GluAla: 4.696 ± 0.023
0.923GluCys: 0.923 ± 0.009
3.922GluAsp: 3.922 ± 0.02
6.155GluGlu: 6.155 ± 0.035
2.407GluPhe: 2.407 ± 0.014
3.87GluGly: 3.87 ± 0.018
1.247GluHis: 1.247 ± 0.01
3.801GluIle: 3.801 ± 0.019
4.664GluLys: 4.664 ± 0.024
6.07GluLeu: 6.07 ± 0.027
1.814GluMet: 1.814 ± 0.013
3.15GluAsn: 3.15 ± 0.018
2.169GluPro: 2.169 ± 0.014
2.186GluGln: 2.186 ± 0.015
3.433GluArg: 3.433 ± 0.02
4.541GluSer: 4.541 ± 0.021
3.073GluThr: 3.073 ± 0.018
4.24GluVal: 4.24 ± 0.021
0.754GluTrp: 0.754 ± 0.008
1.615GluTyr: 1.615 ± 0.012
0.0GluXaa: 0.0 ± 0.0
Phe
2.478PheAla: 2.478 ± 0.015
0.926PheCys: 0.926 ± 0.008
2.342PheAsp: 2.342 ± 0.013
2.345PheGlu: 2.345 ± 0.014
1.957PhePhe: 1.957 ± 0.016
3.112PheGly: 3.112 ± 0.019
1.117PheHis: 1.117 ± 0.009
2.102PheIle: 2.102 ± 0.013
2.061PheLys: 2.061 ± 0.013
4.221PheLeu: 4.221 ± 0.022
0.987PheMet: 0.987 ± 0.007
1.839PheAsn: 1.839 ± 0.013
2.109PhePro: 2.109 ± 0.013
1.603PheGln: 1.603 ± 0.011
2.048PheArg: 2.048 ± 0.012
4.079PheSer: 4.079 ± 0.018
2.031PheThr: 2.031 ± 0.013
2.727PheVal: 2.727 ± 0.015
0.581PheTrp: 0.581 ± 0.006
1.243PheTyr: 1.243 ± 0.009
0.0PheXaa: 0.0 ± 0.0
Gly
3.866GlyAla: 3.866 ± 0.019
1.388GlyCys: 1.388 ± 0.011
3.562GlyAsp: 3.562 ± 0.016
3.764GlyGlu: 3.764 ± 0.02
3.242GlyPhe: 3.242 ± 0.018
5.658GlyGly: 5.658 ± 0.045
1.633GlyHis: 1.633 ± 0.012
3.756GlyIle: 3.756 ± 0.019
4.051GlyLys: 4.051 ± 0.018
6.129GlyLeu: 6.129 ± 0.022
1.616GlyMet: 1.616 ± 0.012
3.277GlyAsn: 3.277 ± 0.017
2.518GlyPro: 2.518 ± 0.015
2.155GlyGln: 2.155 ± 0.013
3.828GlyArg: 3.828 ± 0.02
6.122GlySer: 6.122 ± 0.025
3.333GlyThr: 3.333 ± 0.017
4.294GlyVal: 4.294 ± 0.02
0.964GlyTrp: 0.964 ± 0.01
2.076GlyTyr: 2.076 ± 0.014
0.0GlyXaa: 0.0 ± 0.0
His
1.399HisAla: 1.399 ± 0.012
0.559HisCys: 0.559 ± 0.006
1.122HisAsp: 1.122 ± 0.01
1.303HisGlu: 1.303 ± 0.01
1.095HisPhe: 1.095 ± 0.008
1.78HisGly: 1.78 ± 0.013
0.938HisHis: 0.938 ± 0.01
1.226HisIle: 1.226 ± 0.01
1.159HisLys: 1.159 ± 0.009
2.468HisLeu: 2.468 ± 0.014
0.558HisMet: 0.558 ± 0.006
0.992HisAsn: 0.992 ± 0.009
1.411HisPro: 1.411 ± 0.011
1.036HisGln: 1.036 ± 0.009
1.374HisArg: 1.374 ± 0.01
1.979HisSer: 1.979 ± 0.013
0.979HisThr: 0.979 ± 0.009
1.514HisVal: 1.514 ± 0.011
0.324HisTrp: 0.324 ± 0.005
0.717HisTyr: 0.717 ± 0.006
0.0HisXaa: 0.0 ± 0.0
Ile
3.651IleAla: 3.651 ± 0.019
1.141IleCys: 1.141 ± 0.009
2.946IleAsp: 2.946 ± 0.013
3.352IleGlu: 3.352 ± 0.018
2.322IlePhe: 2.322 ± 0.014
3.56IleGly: 3.56 ± 0.018
1.319IleHis: 1.319 ± 0.01
2.869IleIle: 2.869 ± 0.016
2.918IleLys: 2.918 ± 0.017
5.323IleLeu: 5.323 ± 0.022
1.181IleMet: 1.181 ± 0.01
2.221IleAsn: 2.221 ± 0.013
3.014IlePro: 3.014 ± 0.023
2.063IleGln: 2.063 ± 0.013
2.664IleArg: 2.664 ± 0.015
4.957IleSer: 4.957 ± 0.016
2.65IleThr: 2.65 ± 0.016
3.532IleVal: 3.532 ± 0.017
0.759IleTrp: 0.759 ± 0.009
1.558IleTyr: 1.558 ± 0.01
0.0IleXaa: 0.0 ± 0.0
Lys
3.918LysAla: 3.918 ± 0.021
0.972LysCys: 0.972 ± 0.009
3.164LysAsp: 3.164 ± 0.016
4.54LysGlu: 4.54 ± 0.026
2.159LysPhe: 2.159 ± 0.013
3.611LysGly: 3.611 ± 0.017
1.29LysHis: 1.29 ± 0.009
3.225LysIle: 3.225 ± 0.014
4.54LysLys: 4.54 ± 0.029
5.93LysLeu: 5.93 ± 0.024
1.536LysMet: 1.536 ± 0.01
2.659LysAsn: 2.659 ± 0.015
2.653LysPro: 2.653 ± 0.015
2.24LysGln: 2.24 ± 0.014
3.448LysArg: 3.448 ± 0.018
4.444LysSer: 4.444 ± 0.023
2.79LysThr: 2.79 ± 0.016
3.693LysVal: 3.693 ± 0.017
0.785LysTrp: 0.785 ± 0.007
1.537LysTyr: 1.537 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
6.512LeuAla: 6.512 ± 0.026
1.862LeuCys: 1.862 ± 0.011
5.073LeuAsp: 5.073 ± 0.022
6.442LeuGlu: 6.442 ± 0.024
3.818LeuPhe: 3.818 ± 0.02
5.969LeuGly: 5.969 ± 0.022
2.641LeuHis: 2.641 ± 0.014
4.675LeuIle: 4.675 ± 0.023
6.083LeuLys: 6.083 ± 0.026
9.816LeuLeu: 9.816 ± 0.037
2.237LeuMet: 2.237 ± 0.012
4.053LeuAsn: 4.053 ± 0.018
5.222LeuPro: 5.222 ± 0.024
4.455LeuGln: 4.455 ± 0.022
5.393LeuArg: 5.393 ± 0.026
8.594LeuSer: 8.594 ± 0.031
4.506LeuThr: 4.506 ± 0.02
6.31LeuVal: 6.31 ± 0.026
1.209LeuTrp: 1.209 ± 0.009
2.48LeuTyr: 2.48 ± 0.014
0.0LeuXaa: 0.0 ± 0.0
Met
2.199MetAla: 2.199 ± 0.013
0.32MetCys: 0.32 ± 0.004
1.482MetAsp: 1.482 ± 0.01
2.092MetGlu: 2.092 ± 0.014
0.837MetPhe: 0.837 ± 0.007
1.764MetGly: 1.764 ± 0.011
0.529MetHis: 0.529 ± 0.006
1.232MetIle: 1.232 ± 0.01
1.67MetLys: 1.67 ± 0.01
2.206MetLeu: 2.206 ± 0.012
0.698MetMet: 0.698 ± 0.008
1.02MetAsn: 1.02 ± 0.008
1.093MetPro: 1.093 ± 0.009
0.934MetGln: 0.934 ± 0.009
1.209MetArg: 1.209 ± 0.01
1.747MetSer: 1.747 ± 0.011
1.083MetThr: 1.083 ± 0.009
1.757MetVal: 1.757 ± 0.012
0.273MetTrp: 0.273 ± 0.005
0.571MetTyr: 0.571 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
2.598AsnAla: 2.598 ± 0.016
0.929AsnCys: 0.929 ± 0.009
2.055AsnAsp: 2.055 ± 0.013
2.503AsnGlu: 2.503 ± 0.017
2.041AsnPhe: 2.041 ± 0.012
3.438AsnGly: 3.438 ± 0.015
1.136AsnHis: 1.136 ± 0.01
2.506AsnIle: 2.506 ± 0.014
2.311AsnLys: 2.311 ± 0.015
4.784AsnLeu: 4.784 ± 0.021
1.067AsnMet: 1.067 ± 0.008
2.226AsnAsn: 2.226 ± 0.018
2.428AsnPro: 2.428 ± 0.012
1.8AsnGln: 1.8 ± 0.013
2.084AsnArg: 2.084 ± 0.012
4.164AsnSer: 4.164 ± 0.015
2.02AsnThr: 2.02 ± 0.012
2.721AsnVal: 2.721 ± 0.015
0.596AsnTrp: 0.596 ± 0.006
1.367AsnTyr: 1.367 ± 0.01
0.0AsnXaa: 0.0 ± 0.0
Pro
2.995ProAla: 2.995 ± 0.018
0.789ProCys: 0.789 ± 0.008
2.421ProAsp: 2.421 ± 0.012
3.117ProGlu: 3.117 ± 0.015
2.021ProPhe: 2.021 ± 0.01
2.641ProGly: 2.641 ± 0.018
1.113ProHis: 1.113 ± 0.01
2.48ProIle: 2.48 ± 0.016
2.669ProLys: 2.669 ± 0.014
4.412ProLeu: 4.412 ± 0.022
1.01ProMet: 1.01 ± 0.008
2.425ProAsn: 2.425 ± 0.015
4.042ProPro: 4.042 ± 0.058
1.847ProGln: 1.847 ± 0.014
2.36ProArg: 2.36 ± 0.014
5.285ProSer: 5.285 ± 0.029
2.751ProThr: 2.751 ± 0.016
3.095ProVal: 3.095 ± 0.016
0.615ProTrp: 0.615 ± 0.008
1.339ProTyr: 1.339 ± 0.013
0.0ProXaa: 0.0 ± 0.0
Gln
2.41GlnAla: 2.41 ± 0.014
0.6GlnCys: 0.6 ± 0.007
1.648GlnAsp: 1.648 ± 0.011
2.399GlnGlu: 2.399 ± 0.016
1.455GlnPhe: 1.455 ± 0.01
2.152GlnGly: 2.152 ± 0.014
0.941GlnHis: 0.941 ± 0.01
2.091GlnIle: 2.091 ± 0.014
2.333GlnLys: 2.333 ± 0.015
3.771GlnLeu: 3.771 ± 0.022
1.0GlnMet: 1.0 ± 0.008
1.846GlnAsn: 1.846 ± 0.013
1.824GlnPro: 1.824 ± 0.014
2.134GlnGln: 2.134 ± 0.027
2.174GlnArg: 2.174 ± 0.014
3.025GlnSer: 3.025 ± 0.018
1.795GlnThr: 1.795 ± 0.012
2.341GlnVal: 2.341 ± 0.014
0.506GlnTrp: 0.506 ± 0.006
0.938GlnTyr: 0.938 ± 0.008
0.0GlnXaa: 0.0 ± 0.0
Arg
3.238ArgAla: 3.238 ± 0.018
0.995ArgCys: 0.995 ± 0.008
2.678ArgAsp: 2.678 ± 0.015
3.413ArgGlu: 3.413 ± 0.018
2.169ArgPhe: 2.169 ± 0.013
3.364ArgGly: 3.364 ± 0.018
1.297ArgHis: 1.297 ± 0.009
2.857ArgIle: 2.857 ± 0.015
3.647ArgLys: 3.647 ± 0.019
5.02ArgLeu: 5.02 ± 0.023
1.342ArgMet: 1.342 ± 0.01
2.443ArgAsn: 2.443 ± 0.013
2.351ArgPro: 2.351 ± 0.015
1.865ArgGln: 1.865 ± 0.011
3.914ArgArg: 3.914 ± 0.02
4.35ArgSer: 4.35 ± 0.022
2.503ArgThr: 2.503 ± 0.015
3.306ArgVal: 3.306 ± 0.015
0.777ArgTrp: 0.777 ± 0.008
1.391ArgTyr: 1.391 ± 0.01
0.0ArgXaa: 0.0 ± 0.0
Ser
5.307SerAla: 5.307 ± 0.022
1.738SerCys: 1.738 ± 0.012
4.406SerAsp: 4.406 ± 0.023
4.81SerGlu: 4.81 ± 0.022
3.932SerPhe: 3.932 ± 0.019
6.025SerGly: 6.025 ± 0.024
2.057SerHis: 2.057 ± 0.013
4.755SerIle: 4.755 ± 0.02
4.734SerLys: 4.734 ± 0.02
8.69SerLeu: 8.69 ± 0.035
2.15SerMet: 2.15 ± 0.011
4.211SerAsn: 4.211 ± 0.018
4.676SerPro: 4.676 ± 0.034
3.075SerGln: 3.075 ± 0.018
4.383SerArg: 4.383 ± 0.023
10.809SerSer: 10.809 ± 0.049
4.776SerThr: 4.776 ± 0.022
5.235SerVal: 5.235 ± 0.02
1.214SerTrp: 1.214 ± 0.009
2.267SerTyr: 2.267 ± 0.012
0.0SerXaa: 0.0 ± 0.0
Thr
3.492ThrAla: 3.492 ± 0.019
0.922ThrCys: 0.922 ± 0.009
2.312ThrAsp: 2.312 ± 0.014
2.84ThrGlu: 2.84 ± 0.017
2.018ThrPhe: 2.018 ± 0.011
3.403ThrGly: 3.403 ± 0.017
1.078ThrHis: 1.078 ± 0.009
2.869ThrIle: 2.869 ± 0.015
2.627ThrLys: 2.627 ± 0.013
4.698ThrLeu: 4.698 ± 0.021
1.205ThrMet: 1.205 ± 0.009
2.134ThrAsn: 2.134 ± 0.013
2.601ThrPro: 2.601 ± 0.016
1.609ThrGln: 1.609 ± 0.011
2.363ThrArg: 2.363 ± 0.015
4.63ThrSer: 4.63 ± 0.019
3.026ThrThr: 3.026 ± 0.018
3.431ThrVal: 3.431 ± 0.017
0.672ThrTrp: 0.672 ± 0.008
1.354ThrTyr: 1.354 ± 0.012
0.0ThrXaa: 0.0 ± 0.0
Val
4.896ValAla: 4.896 ± 0.02
1.139ValCys: 1.139 ± 0.009
3.685ValAsp: 3.685 ± 0.017
4.383ValGlu: 4.383 ± 0.019
2.633ValPhe: 2.633 ± 0.014
4.376ValGly: 4.376 ± 0.02
1.524ValHis: 1.524 ± 0.011
3.405ValIle: 3.405 ± 0.016
3.732ValLys: 3.732 ± 0.017
6.274ValLeu: 6.274 ± 0.023
1.598ValMet: 1.598 ± 0.011
2.619ValAsn: 2.619 ± 0.014
3.206ValPro: 3.206 ± 0.018
2.353ValGln: 2.353 ± 0.014
3.1ValArg: 3.1 ± 0.017
5.358ValSer: 5.358 ± 0.023
3.256ValThr: 3.256 ± 0.014
4.925ValVal: 4.925 ± 0.022
0.798ValTrp: 0.798 ± 0.008
1.844ValTyr: 1.844 ± 0.013
0.0ValXaa: 0.0 ± 0.0
Trp
0.811TrpAla: 0.811 ± 0.008
0.263TrpCys: 0.263 ± 0.004
0.716TrpAsp: 0.716 ± 0.008
0.795TrpGlu: 0.795 ± 0.009
0.551TrpPhe: 0.551 ± 0.006
0.774TrpGly: 0.774 ± 0.008
0.321TrpHis: 0.321 ± 0.006
0.736TrpIle: 0.736 ± 0.009
0.951TrpLys: 0.951 ± 0.008
1.281TrpLeu: 1.281 ± 0.01
0.351TrpMet: 0.351 ± 0.005
0.721TrpAsn: 0.721 ± 0.008
0.521TrpPro: 0.521 ± 0.006
0.461TrpGln: 0.461 ± 0.006
0.868TrpArg: 0.868 ± 0.008
0.996TrpSer: 0.996 ± 0.008
0.664TrpThr: 0.664 ± 0.007
0.901TrpVal: 0.901 ± 0.008
0.272TrpTrp: 0.272 ± 0.005
0.34TrpTyr: 0.34 ± 0.006
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.705TyrAla: 1.705 ± 0.012
0.647TyrCys: 0.647 ± 0.007
1.48TyrAsp: 1.48 ± 0.01
1.525TyrGlu: 1.525 ± 0.01
1.267TyrPhe: 1.267 ± 0.01
2.139TyrGly: 2.139 ± 0.015
0.707TyrHis: 0.707 ± 0.007
1.495TyrIle: 1.495 ± 0.012
1.505TyrLys: 1.505 ± 0.014
2.691TyrLeu: 2.691 ± 0.015
0.72TyrMet: 0.72 ± 0.008
1.32TyrAsn: 1.32 ± 0.01
1.271TyrPro: 1.271 ± 0.011
0.973TyrGln: 0.973 ± 0.007
1.448TyrArg: 1.448 ± 0.01
2.272TyrSer: 2.272 ± 0.013
1.267TyrThr: 1.267 ± 0.009
1.707TyrVal: 1.707 ± 0.013
0.404TyrTrp: 0.404 ± 0.006
0.951TyrTyr: 0.951 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36118 proteins (14223905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski