Amino acid dipepetide frequency for Achlya hypogyna

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.295AlaAla: 14.295 ± 0.11	1.8AlaCys: 1.8 ± 0.017	5.413AlaAsp: 5.413 ± 0.035	5.08AlaGlu: 5.08 ± 0.041	4.193AlaPhe: 4.193 ± 0.027	5.551AlaGly: 5.551 ± 0.045	2.713AlaHis: 2.713 ± 0.022	4.713AlaIle: 4.713 ± 0.026	5.255AlaLys: 5.255 ± 0.043	11.766AlaLeu: 11.766 ± 0.056	2.899AlaMet: 2.899 ± 0.021	3.202AlaAsn: 3.202 ± 0.022	6.648AlaPro: 6.648 ± 0.053	3.951AlaGln: 3.951 ± 0.033	5.718AlaArg: 5.718 ± 0.043	7.979AlaSer: 7.979 ± 0.041	8.279AlaThr: 8.279 ± 0.054	8.135AlaVal: 8.135 ± 0.043	1.396AlaTrp: 1.396 ± 0.015	2.625AlaTyr: 2.625 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.731CysAla: 1.731 ± 0.018	0.377CysCys: 0.377 ± 0.01	0.972CysAsp: 0.972 ± 0.013	0.725CysGlu: 0.725 ± 0.01	0.755CysPhe: 0.755 ± 0.01	1.272CysGly: 1.272 ± 0.017	0.497CysHis: 0.497 ± 0.009	0.877CysIle: 0.877 ± 0.012	0.68CysLys: 0.68 ± 0.013	1.769CysLeu: 1.769 ± 0.019	0.443CysMet: 0.443 ± 0.008	0.571CysAsn: 0.571 ± 0.009	0.964CysPro: 0.964 ± 0.019	0.579CysGln: 0.579 ± 0.01	1.025CysArg: 1.025 ± 0.014	1.226CysSer: 1.226 ± 0.018	1.18CysThr: 1.18 ± 0.018	1.446CysVal: 1.446 ± 0.019	0.233CysTrp: 0.233 ± 0.007	0.494CysTyr: 0.494 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.114AspAla: 7.114 ± 0.043	0.851AspCys: 0.851 ± 0.012	4.662AspAsp: 4.662 ± 0.039	3.878AspGlu: 3.878 ± 0.032	1.947AspPhe: 1.947 ± 0.017	3.816AspGly: 3.816 ± 0.031	1.249AspHis: 1.249 ± 0.014	2.519AspIle: 2.519 ± 0.021	2.172AspLys: 2.172 ± 0.023	4.871AspLeu: 4.871 ± 0.027	1.414AspMet: 1.414 ± 0.015	1.464AspAsn: 1.464 ± 0.016	2.575AspPro: 2.575 ± 0.019	1.393AspGln: 1.393 ± 0.017	2.625AspArg: 2.625 ± 0.023	2.926AspSer: 2.926 ± 0.024	2.972AspThr: 2.972 ± 0.024	4.914AspVal: 4.914 ± 0.028	0.695AspTrp: 0.695 ± 0.011	1.326AspTyr: 1.326 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	6.514GluAla: 6.514 ± 0.052	0.845GluCys: 0.845 ± 0.014	2.993GluAsp: 2.993 ± 0.029	3.375GluGlu: 3.375 ± 0.034	1.712GluPhe: 1.712 ± 0.02	2.531GluGly: 2.531 ± 0.026	1.469GluHis: 1.469 ± 0.017	2.243GluIle: 2.243 ± 0.022	2.62GluLys: 2.62 ± 0.03	5.714GluLeu: 5.714 ± 0.038	1.4GluMet: 1.4 ± 0.017	1.488GluAsn: 1.488 ± 0.017	2.469GluPro: 2.469 ± 0.023	1.815GluGln: 1.815 ± 0.022	3.36GluArg: 3.36 ± 0.03	3.143GluSer: 3.143 ± 0.024	3.159GluThr: 3.159 ± 0.027	3.526GluVal: 3.526 ± 0.026	0.767GluTrp: 0.767 ± 0.012	1.539GluTyr: 1.539 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.869PheAla: 3.869 ± 0.028	0.767PheCys: 0.767 ± 0.013	2.283PheAsp: 2.283 ± 0.021	2.129PheGlu: 2.129 ± 0.019	1.578PhePhe: 1.578 ± 0.016	2.817PheGly: 2.817 ± 0.028	1.049PheHis: 1.049 ± 0.011	1.343PheIle: 1.343 ± 0.013	1.369PheLys: 1.369 ± 0.016	3.689PheLeu: 3.689 ± 0.027	0.821PheMet: 0.821 ± 0.012	1.278PheAsn: 1.278 ± 0.016	1.629PhePro: 1.629 ± 0.017	1.453PheGln: 1.453 ± 0.013	1.955PheArg: 1.955 ± 0.017	2.445PheSer: 2.445 ± 0.02	2.075PheThr: 2.075 ± 0.022	3.314PheVal: 3.314 ± 0.026	0.487PheTrp: 0.487 ± 0.01	1.142PheTyr: 1.142 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.935GlyAla: 5.935 ± 0.057	1.183GlyCys: 1.183 ± 0.018	3.396GlyAsp: 3.396 ± 0.028	2.389GlyGlu: 2.389 ± 0.02	2.494GlyPhe: 2.494 ± 0.025	4.311GlyGly: 4.311 ± 0.071	1.87GlyHis: 1.87 ± 0.023	2.685GlyIle: 2.685 ± 0.024	2.482GlyLys: 2.482 ± 0.027	5.739GlyLeu: 5.739 ± 0.032	1.332GlyMet: 1.332 ± 0.015	2.049GlyAsn: 2.049 ± 0.024	2.405GlyPro: 2.405 ± 0.025	1.923GlyGln: 1.923 ± 0.017	3.326GlyArg: 3.326 ± 0.026	4.248GlySer: 4.248 ± 0.045	3.547GlyThr: 3.547 ± 0.043	4.501GlyVal: 4.501 ± 0.03	0.848GlyTrp: 0.848 ± 0.014	1.915GlyTyr: 1.915 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.957HisAla: 2.957 ± 0.025	0.555HisCys: 0.555 ± 0.009	1.555HisAsp: 1.555 ± 0.016	1.575HisGlu: 1.575 ± 0.016	1.016HisPhe: 1.016 ± 0.011	1.965HisGly: 1.965 ± 0.021	0.903HisHis: 0.903 ± 0.014	1.1HisIle: 1.1 ± 0.012	1.025HisLys: 1.025 ± 0.013	2.8HisLeu: 2.8 ± 0.026	0.648HisMet: 0.648 ± 0.01	0.776HisAsn: 0.776 ± 0.011	1.447HisPro: 1.447 ± 0.015	0.922HisGln: 0.922 ± 0.01	1.852HisArg: 1.852 ± 0.018	1.539HisSer: 1.539 ± 0.014	1.459HisThr: 1.459 ± 0.018	2.441HisVal: 2.441 ± 0.018	0.401HisTrp: 0.401 ± 0.008	0.725HisTyr: 0.725 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.607IleAla: 4.607 ± 0.028	0.727IleCys: 0.727 ± 0.01	2.531IleAsp: 2.531 ± 0.019	2.413IleGlu: 2.413 ± 0.023	1.57IlePhe: 1.57 ± 0.019	2.451IleGly: 2.451 ± 0.023	0.998IleHis: 0.998 ± 0.012	1.444IleIle: 1.444 ± 0.019	1.762IleLys: 1.762 ± 0.016	3.627IleLeu: 3.627 ± 0.03	0.879IleMet: 0.879 ± 0.011	1.296IleAsn: 1.296 ± 0.015	1.942IlePro: 1.942 ± 0.019	1.572IleGln: 1.572 ± 0.018	2.005IleArg: 2.005 ± 0.019	2.459IleSer: 2.459 ± 0.022	2.209IleThr: 2.209 ± 0.023	3.585IleVal: 3.585 ± 0.029	0.456IleTrp: 0.456 ± 0.009	1.143IleTyr: 1.143 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.807LysAla: 4.807 ± 0.035	0.728LysCys: 0.728 ± 0.012	2.28LysAsp: 2.28 ± 0.022	2.6LysGlu: 2.6 ± 0.029	1.272LysPhe: 1.272 ± 0.014	2.146LysGly: 2.146 ± 0.023	1.223LysHis: 1.223 ± 0.014	1.657LysIle: 1.657 ± 0.017	3.019LysLys: 3.019 ± 0.032	4.242LysLeu: 4.242 ± 0.031	1.037LysMet: 1.037 ± 0.014	1.274LysAsn: 1.274 ± 0.017	2.292LysPro: 2.292 ± 0.025	1.756LysGln: 1.756 ± 0.02	3.074LysArg: 3.074 ± 0.027	2.76LysSer: 2.76 ± 0.023	2.694LysThr: 2.694 ± 0.025	2.771LysVal: 2.771 ± 0.022	0.569LysTrp: 0.569 ± 0.01	1.326LysTyr: 1.326 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	10.947LeuAla: 10.947 ± 0.061	1.895LeuCys: 1.895 ± 0.017	5.698LeuAsp: 5.698 ± 0.029	6.057LeuGlu: 6.057 ± 0.041	3.76LeuPhe: 3.76 ± 0.027	5.875LeuGly: 5.875 ± 0.033	3.421LeuHis: 3.421 ± 0.027	2.956LeuIle: 2.956 ± 0.027	4.149LeuLys: 4.149 ± 0.031	11.348LeuLeu: 11.348 ± 0.079	2.001LeuMet: 2.001 ± 0.019	2.879LeuAsn: 2.879 ± 0.025	5.664LeuPro: 5.664 ± 0.035	5.16LeuGln: 5.16 ± 0.034	6.886LeuArg: 6.886 ± 0.04	6.921LeuSer: 6.921 ± 0.036	5.415LeuThr: 5.415 ± 0.034	7.883LeuVal: 7.883 ± 0.039	1.334LeuTrp: 1.334 ± 0.017	2.655LeuTyr: 2.655 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.72MetAla: 2.72 ± 0.02	0.381MetCys: 0.381 ± 0.008	1.522MetAsp: 1.522 ± 0.016	1.431MetGlu: 1.431 ± 0.015	0.708MetPhe: 0.708 ± 0.011	1.378MetGly: 1.378 ± 0.015	0.715MetHis: 0.715 ± 0.01	0.789MetIle: 0.789 ± 0.012	0.968MetLys: 0.968 ± 0.012	2.435MetLeu: 2.435 ± 0.022	0.584MetMet: 0.584 ± 0.011	0.752MetAsn: 0.752 ± 0.011	1.153MetPro: 1.153 ± 0.013	1.087MetGln: 1.087 ± 0.013	1.303MetArg: 1.303 ± 0.013	1.572MetSer: 1.572 ± 0.018	1.53MetThr: 1.53 ± 0.013	1.537MetVal: 1.537 ± 0.014	0.294MetTrp: 0.294 ± 0.005	0.72MetTyr: 0.72 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.275AsnAla: 3.275 ± 0.024	0.568AsnCys: 0.568 ± 0.01	1.771AsnAsp: 1.771 ± 0.017	1.621AsnGlu: 1.621 ± 0.018	1.079AsnPhe: 1.079 ± 0.013	2.192AsnGly: 2.192 ± 0.022	0.749AsnHis: 0.749 ± 0.01	1.356AsnIle: 1.356 ± 0.017	1.233AsnLys: 1.233 ± 0.016	2.726AsnLeu: 2.726 ± 0.019	0.773AsnMet: 0.773 ± 0.011	1.032AsnAsn: 1.032 ± 0.015	1.631AsnPro: 1.631 ± 0.017	1.111AsnGln: 1.111 ± 0.013	1.46AsnArg: 1.46 ± 0.015	1.738AsnSer: 1.738 ± 0.017	1.659AsnThr: 1.659 ± 0.017	2.581AsnVal: 2.581 ± 0.024	0.426AsnTrp: 0.426 ± 0.008	0.9AsnTyr: 0.9 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.066ProAla: 6.066 ± 0.046	0.712ProCys: 0.712 ± 0.012	2.453ProAsp: 2.453 ± 0.018	2.902ProGlu: 2.902 ± 0.024	1.83ProPhe: 1.83 ± 0.018	2.644ProGly: 2.644 ± 0.023	1.295ProHis: 1.295 ± 0.014	1.916ProIle: 1.916 ± 0.016	2.396ProLys: 2.396 ± 0.025	5.181ProLeu: 5.181 ± 0.036	1.261ProMet: 1.261 ± 0.015	1.503ProAsn: 1.503 ± 0.015	4.574ProPro: 4.574 ± 0.046	1.72ProGln: 1.72 ± 0.015	3.028ProArg: 3.028 ± 0.023	4.633ProSer: 4.633 ± 0.03	4.507ProThr: 4.507 ± 0.044	4.097ProVal: 4.097 ± 0.03	0.689ProTrp: 0.689 ± 0.01	1.228ProTyr: 1.228 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	4.077GlnAla: 4.077 ± 0.034	0.729GlnCys: 0.729 ± 0.014	1.601GlnAsp: 1.601 ± 0.014	1.853GlnGlu: 1.853 ± 0.022	1.315GlnPhe: 1.315 ± 0.015	1.821GlnGly: 1.821 ± 0.017	1.174GlnHis: 1.174 ± 0.012	1.409GlnIle: 1.409 ± 0.015	1.553GlnLys: 1.553 ± 0.017	4.675GlnLeu: 4.675 ± 0.029	0.904GlnMet: 0.904 ± 0.012	0.969GlnAsn: 0.969 ± 0.012	1.874GlnPro: 1.874 ± 0.02	1.874GlnGln: 1.874 ± 0.027	2.866GlnArg: 2.866 ± 0.025	2.431GlnSer: 2.431 ± 0.02	2.119GlnThr: 2.119 ± 0.019	2.603GlnVal: 2.603 ± 0.021	0.676GlnTrp: 0.676 ± 0.011	1.159GlnTyr: 1.159 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.679ArgAla: 5.679 ± 0.04	1.081ArgCys: 1.081 ± 0.014	3.001ArgAsp: 3.001 ± 0.025	2.989ArgGlu: 2.989 ± 0.026	2.206ArgPhe: 2.206 ± 0.02	3.206ArgGly: 3.206 ± 0.025	1.868ArgHis: 1.868 ± 0.022	2.378ArgIle: 2.378 ± 0.019	2.781ArgLys: 2.781 ± 0.024	6.302ArgLeu: 6.302 ± 0.037	1.319ArgMet: 1.319 ± 0.015	1.752ArgAsn: 1.752 ± 0.016	2.898ArgPro: 2.898 ± 0.024	2.611ArgGln: 2.611 ± 0.02	4.798ArgArg: 4.798 ± 0.043	3.827ArgSer: 3.827 ± 0.026	3.013ArgThr: 3.013 ± 0.022	4.152ArgVal: 4.152 ± 0.027	0.876ArgTrp: 0.876 ± 0.014	1.541ArgTyr: 1.541 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.772SerAla: 6.772 ± 0.036	1.173SerCys: 1.173 ± 0.015	3.466SerAsp: 3.466 ± 0.028	2.859SerGlu: 2.859 ± 0.023	2.895SerPhe: 2.895 ± 0.024	4.09SerGly: 4.09 ± 0.059	1.618SerHis: 1.618 ± 0.016	3.135SerIle: 3.135 ± 0.027	2.772SerLys: 2.772 ± 0.023	6.84SerLeu: 6.84 ± 0.038	1.767SerMet: 1.767 ± 0.016	2.044SerAsn: 2.044 ± 0.018	4.154SerPro: 4.154 ± 0.036	2.093SerGln: 2.093 ± 0.02	3.458SerArg: 3.458 ± 0.025	5.942SerSer: 5.942 ± 0.049	4.695SerThr: 4.695 ± 0.034	5.13SerVal: 5.13 ± 0.032	0.969SerTrp: 0.969 ± 0.013	1.895SerTyr: 1.895 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	6.667ThrAla: 6.667 ± 0.039	1.121ThrCys: 1.121 ± 0.015	3.0ThrAsp: 3.0 ± 0.022	2.813ThrGlu: 2.813 ± 0.023	2.407ThrPhe: 2.407 ± 0.024	3.491ThrGly: 3.491 ± 0.053	1.453ThrHis: 1.453 ± 0.015	2.758ThrIle: 2.758 ± 0.025	2.889ThrLys: 2.889 ± 0.023	6.25ThrLeu: 6.25 ± 0.041	1.523ThrMet: 1.523 ± 0.014	1.943ThrAsn: 1.943 ± 0.018	4.353ThrPro: 4.353 ± 0.035	2.072ThrGln: 2.072 ± 0.018	2.95ThrArg: 2.95 ± 0.022	4.636ThrSer: 4.636 ± 0.031	5.084ThrThr: 5.084 ± 0.045	4.441ThrVal: 4.441 ± 0.038	0.855ThrTrp: 0.855 ± 0.012	1.699ThrTyr: 1.699 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	9.674ValAla: 9.674 ± 0.051	1.442ValCys: 1.442 ± 0.017	4.452ValAsp: 4.452 ± 0.027	3.965ValGlu: 3.965 ± 0.026	2.963ValPhe: 2.963 ± 0.025	4.405ValGly: 4.405 ± 0.034	2.242ValHis: 2.242 ± 0.017	2.599ValIle: 2.599 ± 0.023	2.72ValLys: 2.72 ± 0.022	8.542ValLeu: 8.542 ± 0.044	1.527ValMet: 1.527 ± 0.016	2.11ValAsn: 2.11 ± 0.018	4.213ValPro: 4.213 ± 0.028	3.086ValGln: 3.086 ± 0.023	4.155ValArg: 4.155 ± 0.025	4.638ValSer: 4.638 ± 0.033	4.208ValThr: 4.208 ± 0.039	7.159ValVal: 7.159 ± 0.038	1.027ValTrp: 1.027 ± 0.014	2.172ValTyr: 2.172 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.223TrpAla: 1.223 ± 0.015	0.271TrpCys: 0.271 ± 0.006	0.689TrpAsp: 0.689 ± 0.012	0.57TrpGlu: 0.57 ± 0.011	0.546TrpPhe: 0.546 ± 0.009	0.709TrpGly: 0.709 ± 0.011	0.408TrpHis: 0.408 ± 0.008	0.607TrpIle: 0.607 ± 0.011	0.628TrpLys: 0.628 ± 0.009	1.517TrpLeu: 1.517 ± 0.019	0.336TrpMet: 0.336 ± 0.007	0.497TrpAsn: 0.497 ± 0.01	0.567TrpPro: 0.567 ± 0.011	0.563TrpGln: 0.563 ± 0.009	0.946TrpArg: 0.946 ± 0.011	0.991TrpSer: 0.991 ± 0.012	1.0TrpThr: 1.0 ± 0.013	0.891TrpVal: 0.891 ± 0.013	0.202TrpTrp: 0.202 ± 0.005	0.423TrpTyr: 0.423 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.685TyrAla: 2.685 ± 0.02	0.612TyrCys: 0.612 ± 0.012	1.645TyrAsp: 1.645 ± 0.018	1.459TyrGlu: 1.459 ± 0.019	1.243TyrPhe: 1.243 ± 0.015	1.906TyrGly: 1.906 ± 0.017	0.747TyrHis: 0.747 ± 0.009	1.189TyrIle: 1.189 ± 0.014	1.054TyrLys: 1.054 ± 0.013	2.872TyrLeu: 2.872 ± 0.022	0.712TyrMet: 0.712 ± 0.011	1.002TyrAsn: 1.002 ± 0.014	1.182TyrPro: 1.182 ± 0.014	0.941TyrGln: 0.941 ± 0.012	1.486TyrArg: 1.486 ± 0.015	1.712TyrSer: 1.712 ± 0.017	1.601TyrThr: 1.601 ± 0.019	2.193TyrVal: 2.193 ± 0.019	0.385TyrTrp: 0.385 ± 0.007	0.939TyrTyr: 0.939 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14400 proteins (7479346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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