Amino acid dipepetide frequency for Kwoniella mangroviensis CBS 10435

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.49AlaAla: 6.49 ± 0.063	0.771AlaCys: 0.771 ± 0.017	3.219AlaAsp: 3.219 ± 0.031	4.447AlaGlu: 4.447 ± 0.045	2.548AlaPhe: 2.548 ± 0.032	5.146AlaGly: 5.146 ± 0.043	1.459AlaHis: 1.459 ± 0.02	3.96AlaIle: 3.96 ± 0.034	3.937AlaLys: 3.937 ± 0.042	6.718AlaLeu: 6.718 ± 0.048	1.624AlaMet: 1.624 ± 0.02	2.563AlaAsn: 2.563 ± 0.024	4.223AlaPro: 4.223 ± 0.049	3.054AlaGln: 3.054 ± 0.032	3.988AlaArg: 3.988 ± 0.032	6.903AlaSer: 6.903 ± 0.061	4.279AlaThr: 4.279 ± 0.038	4.152AlaVal: 4.152 ± 0.036	0.927AlaTrp: 0.927 ± 0.016	1.871AlaTyr: 1.871 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.633CysAla: 0.633 ± 0.014	0.173CysCys: 0.173 ± 0.008	0.505CysAsp: 0.505 ± 0.012	0.52CysGlu: 0.52 ± 0.012	0.411CysPhe: 0.411 ± 0.011	0.776CysGly: 0.776 ± 0.019	0.247CysHis: 0.247 ± 0.008	0.573CysIle: 0.573 ± 0.014	0.465CysLys: 0.465 ± 0.011	1.035CysLeu: 1.035 ± 0.016	0.212CysMet: 0.212 ± 0.008	0.314CysAsn: 0.314 ± 0.009	0.549CysPro: 0.549 ± 0.013	0.391CysGln: 0.391 ± 0.01	0.513CysArg: 0.513 ± 0.013	0.749CysSer: 0.749 ± 0.017	0.58CysThr: 0.58 ± 0.013	0.6CysVal: 0.6 ± 0.013	0.173CysTrp: 0.173 ± 0.007	0.304CysTyr: 0.304 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.458AspAla: 3.458 ± 0.03	0.517AspCys: 0.517 ± 0.011	4.531AspAsp: 4.531 ± 0.046	5.318AspGlu: 5.318 ± 0.051	1.815AspPhe: 1.815 ± 0.022	4.049AspGly: 4.049 ± 0.033	1.347AspHis: 1.347 ± 0.019	3.075AspIle: 3.075 ± 0.027	2.824AspLys: 2.824 ± 0.029	5.195AspLeu: 5.195 ± 0.04	1.19AspMet: 1.19 ± 0.018	2.001AspAsn: 2.001 ± 0.02	3.268AspPro: 3.268 ± 0.032	2.338AspGln: 2.338 ± 0.029	2.999AspArg: 2.999 ± 0.036	3.929AspSer: 3.929 ± 0.029	2.843AspThr: 2.843 ± 0.029	3.439AspVal: 3.439 ± 0.029	0.875AspTrp: 0.875 ± 0.017	1.48AspTyr: 1.48 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.426GluAla: 4.426 ± 0.037	0.543GluCys: 0.543 ± 0.013	4.934GluAsp: 4.934 ± 0.049	7.108GluGlu: 7.108 ± 0.085	1.697GluPhe: 1.697 ± 0.019	4.8GluGly: 4.8 ± 0.04	1.229GluHis: 1.229 ± 0.016	3.433GluIle: 3.433 ± 0.031	4.348GluLys: 4.348 ± 0.046	5.145GluLeu: 5.145 ± 0.042	1.609GluMet: 1.609 ± 0.021	2.481GluAsn: 2.481 ± 0.026	2.47GluPro: 2.47 ± 0.027	2.365GluGln: 2.365 ± 0.024	4.116GluArg: 4.116 ± 0.043	4.469GluSer: 4.469 ± 0.037	2.976GluThr: 2.976 ± 0.03	3.886GluVal: 3.886 ± 0.036	0.938GluTrp: 0.938 ± 0.016	1.67GluTyr: 1.67 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.536PheAla: 2.536 ± 0.029	0.42PheCys: 0.42 ± 0.01	2.127PheAsp: 2.127 ± 0.023	1.908PheGlu: 1.908 ± 0.025	1.354PhePhe: 1.354 ± 0.022	2.739PheGly: 2.739 ± 0.038	0.803PheHis: 0.803 ± 0.014	1.709PheIle: 1.709 ± 0.024	1.518PheLys: 1.518 ± 0.022	2.996PheLeu: 2.996 ± 0.036	0.664PheMet: 0.664 ± 0.012	1.347PheAsn: 1.347 ± 0.019	1.85PhePro: 1.85 ± 0.026	1.135PheGln: 1.135 ± 0.018	1.63PheArg: 1.63 ± 0.023	2.843PheSer: 2.843 ± 0.029	2.059PheThr: 2.059 ± 0.023	2.009PheVal: 2.009 ± 0.023	0.521PheTrp: 0.521 ± 0.012	0.936PheTyr: 0.936 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.278GlyAla: 4.278 ± 0.044	0.761GlyCys: 0.761 ± 0.015	3.615GlyAsp: 3.615 ± 0.033	4.418GlyGlu: 4.418 ± 0.037	2.48GlyPhe: 2.48 ± 0.033	6.814GlyGly: 6.814 ± 0.073	1.606GlyHis: 1.606 ± 0.024	3.664GlyIle: 3.664 ± 0.033	4.379GlyLys: 4.379 ± 0.038	6.279GlyLeu: 6.279 ± 0.045	1.825GlyMet: 1.825 ± 0.025	2.806GlyAsn: 2.806 ± 0.029	3.252GlyPro: 3.252 ± 0.034	2.816GlyGln: 2.816 ± 0.032	3.982GlyArg: 3.982 ± 0.038	6.313GlySer: 6.313 ± 0.048	3.824GlyThr: 3.824 ± 0.033	4.268GlyVal: 4.268 ± 0.036	1.333GlyTrp: 1.333 ± 0.016	2.214GlyTyr: 2.214 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.474HisAla: 1.474 ± 0.02	0.239HisCys: 0.239 ± 0.008	1.171HisAsp: 1.171 ± 0.018	1.189HisGlu: 1.189 ± 0.017	0.805HisPhe: 0.805 ± 0.015	1.499HisGly: 1.499 ± 0.021	0.969HisHis: 0.969 ± 0.024	1.18HisIle: 1.18 ± 0.016	0.902HisLys: 0.902 ± 0.013	2.388HisLeu: 2.388 ± 0.026	0.404HisMet: 0.404 ± 0.009	0.842HisAsn: 0.842 ± 0.015	1.94HisPro: 1.94 ± 0.026	1.094HisGln: 1.094 ± 0.019	1.373HisArg: 1.373 ± 0.022	2.12HisSer: 2.12 ± 0.026	1.37HisThr: 1.37 ± 0.018	1.219HisVal: 1.219 ± 0.017	0.276HisTrp: 0.276 ± 0.008	0.611HisTyr: 0.611 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.865IleAla: 3.865 ± 0.04	0.663IleCys: 0.663 ± 0.015	3.167IleAsp: 3.167 ± 0.028	3.141IleGlu: 3.141 ± 0.027	1.841IlePhe: 1.841 ± 0.024	3.492IleGly: 3.492 ± 0.036	1.288IleHis: 1.288 ± 0.021	2.811IleIle: 2.811 ± 0.03	2.702IleLys: 2.702 ± 0.027	4.683IleLeu: 4.683 ± 0.044	0.961IleMet: 0.961 ± 0.015	2.103IleAsn: 2.103 ± 0.023	3.945IlePro: 3.945 ± 0.037	1.989IleGln: 1.989 ± 0.021	2.886IleArg: 2.886 ± 0.027	4.807IleSer: 4.807 ± 0.04	3.105IleThr: 3.105 ± 0.029	3.035IleVal: 3.035 ± 0.033	0.74IleTrp: 0.74 ± 0.015	1.402IleTyr: 1.402 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.159LysAla: 4.159 ± 0.043	0.438LysCys: 0.438 ± 0.011	3.301LysAsp: 3.301 ± 0.034	4.318LysGlu: 4.318 ± 0.045	1.39LysPhe: 1.39 ± 0.021	3.957LysGly: 3.957 ± 0.035	1.081LysHis: 1.081 ± 0.014	2.707LysIle: 2.707 ± 0.026	4.268LysLys: 4.268 ± 0.055	4.22LysLeu: 4.22 ± 0.035	1.133LysMet: 1.133 ± 0.017	1.933LysAsn: 1.933 ± 0.024	2.912LysPro: 2.912 ± 0.033	1.848LysGln: 1.848 ± 0.025	3.754LysArg: 3.754 ± 0.035	4.418LysSer: 4.418 ± 0.04	2.815LysThr: 2.815 ± 0.031	3.252LysVal: 3.252 ± 0.033	0.731LysTrp: 0.731 ± 0.015	1.389LysTyr: 1.389 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.797LeuAla: 6.797 ± 0.052	0.945LeuCys: 0.945 ± 0.016	4.98LeuAsp: 4.98 ± 0.04	5.287LeuGlu: 5.287 ± 0.043	3.073LeuPhe: 3.073 ± 0.034	5.934LeuGly: 5.934 ± 0.045	2.025LeuHis: 2.025 ± 0.022	4.446LeuIle: 4.446 ± 0.04	4.596LeuLys: 4.596 ± 0.036	8.171LeuLeu: 8.171 ± 0.063	1.646LeuMet: 1.646 ± 0.019	3.508LeuAsn: 3.508 ± 0.033	6.504LeuPro: 6.504 ± 0.046	3.234LeuGln: 3.234 ± 0.032	4.942LeuArg: 4.942 ± 0.038	8.37LeuSer: 8.37 ± 0.062	5.077LeuThr: 5.077 ± 0.037	4.945LeuVal: 4.945 ± 0.044	1.017LeuTrp: 1.017 ± 0.017	2.153LeuTyr: 2.153 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.602MetAla: 1.602 ± 0.021	0.182MetCys: 0.182 ± 0.007	1.246MetAsp: 1.246 ± 0.021	1.238MetGlu: 1.238 ± 0.019	0.668MetPhe: 0.668 ± 0.013	1.566MetGly: 1.566 ± 0.023	0.315MetHis: 0.315 ± 0.01	1.174MetIle: 1.174 ± 0.019	1.1MetLys: 1.1 ± 0.015	1.591MetLeu: 1.591 ± 0.022	0.611MetMet: 0.611 ± 0.013	0.859MetAsn: 0.859 ± 0.015	1.134MetPro: 1.134 ± 0.017	0.661MetGln: 0.661 ± 0.016	1.14MetArg: 1.14 ± 0.02	2.147MetSer: 2.147 ± 0.022	1.364MetThr: 1.364 ± 0.018	1.208MetVal: 1.208 ± 0.018	0.226MetTrp: 0.226 ± 0.007	0.485MetTyr: 0.485 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.85AsnAla: 2.85 ± 0.027	0.341AsnCys: 0.341 ± 0.011	2.308AsnAsp: 2.308 ± 0.026	2.378AsnGlu: 2.378 ± 0.024	1.209AsnPhe: 1.209 ± 0.02	3.478AsnGly: 3.478 ± 0.033	0.955AsnHis: 0.955 ± 0.014	2.022AsnIle: 2.022 ± 0.021	1.904AsnLys: 1.904 ± 0.023	3.51AsnLeu: 3.51 ± 0.03	0.727AsnMet: 0.727 ± 0.014	1.828AsnAsn: 1.828 ± 0.028	2.698AsnPro: 2.698 ± 0.029	1.688AsnGln: 1.688 ± 0.022	2.008AsnArg: 2.008 ± 0.025	3.283AsnSer: 3.283 ± 0.037	2.503AsnThr: 2.503 ± 0.027	2.275AsnVal: 2.275 ± 0.028	0.52AsnTrp: 0.52 ± 0.012	0.992AsnTyr: 0.992 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.585ProAla: 4.585 ± 0.051	0.396ProCys: 0.396 ± 0.013	2.902ProAsp: 2.902 ± 0.028	3.449ProGlu: 3.449 ± 0.033	2.12ProPhe: 2.12 ± 0.021	3.532ProGly: 3.532 ± 0.036	1.506ProHis: 1.506 ± 0.022	3.517ProIle: 3.517 ± 0.036	2.97ProLys: 2.97 ± 0.03	5.379ProLeu: 5.379 ± 0.041	1.0ProMet: 1.0 ± 0.015	2.593ProAsn: 2.593 ± 0.028	6.646ProPro: 6.646 ± 0.095	2.608ProGln: 2.608 ± 0.038	3.138ProArg: 3.138 ± 0.035	8.632ProSer: 8.632 ± 0.078	5.062ProThr: 5.062 ± 0.044	3.294ProVal: 3.294 ± 0.035	0.607ProTrp: 0.607 ± 0.013	1.608ProTyr: 1.608 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.25GlnAla: 3.25 ± 0.04	0.36GlnCys: 0.36 ± 0.01	2.062GlnAsp: 2.062 ± 0.025	2.255GlnGlu: 2.255 ± 0.025	1.08GlnPhe: 1.08 ± 0.017	2.515GlnGly: 2.515 ± 0.027	1.012GlnHis: 1.012 ± 0.019	1.996GlnIle: 1.996 ± 0.023	1.819GlnLys: 1.819 ± 0.025	3.259GlnLeu: 3.259 ± 0.031	0.873GlnMet: 0.873 ± 0.016	1.699GlnAsn: 1.699 ± 0.021	2.906GlnPro: 2.906 ± 0.04	2.637GlnGln: 2.637 ± 0.08	2.312GlnArg: 2.312 ± 0.028	3.645GlnSer: 3.645 ± 0.037	2.264GlnThr: 2.264 ± 0.025	2.201GlnVal: 2.201 ± 0.022	0.497GlnTrp: 0.497 ± 0.011	1.054GlnTyr: 1.054 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	3.8ArgAla: 3.8 ± 0.036	0.536ArgCys: 0.536 ± 0.012	3.099ArgAsp: 3.099 ± 0.032	3.774ArgGlu: 3.774 ± 0.04	1.834ArgPhe: 1.834 ± 0.023	3.562ArgGly: 3.562 ± 0.035	1.294ArgHis: 1.294 ± 0.019	2.809ArgIle: 2.809 ± 0.026	3.658ArgLys: 3.658 ± 0.034	4.939ArgLeu: 4.939 ± 0.041	1.267ArgMet: 1.267 ± 0.019	2.164ArgAsn: 2.164 ± 0.025	3.514ArgPro: 3.514 ± 0.039	2.302ArgGln: 2.302 ± 0.03	4.668ArgArg: 4.668 ± 0.053	5.331ArgSer: 5.331 ± 0.054	2.967ArgThr: 2.967 ± 0.029	2.864ArgVal: 2.864 ± 0.03	0.817ArgTrp: 0.817 ± 0.014	1.624ArgTyr: 1.624 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.85SerAla: 6.85 ± 0.053	0.727SerCys: 0.727 ± 0.016	4.47SerAsp: 4.47 ± 0.035	4.55SerGlu: 4.55 ± 0.036	3.088SerPhe: 3.088 ± 0.03	6.164SerGly: 6.164 ± 0.05	2.247SerHis: 2.247 ± 0.027	4.962SerIle: 4.962 ± 0.041	4.521SerLys: 4.521 ± 0.037	8.009SerLeu: 8.009 ± 0.053	1.693SerMet: 1.693 ± 0.022	3.939SerAsn: 3.939 ± 0.035	6.977SerPro: 6.977 ± 0.075	3.653SerGln: 3.653 ± 0.04	5.225SerArg: 5.225 ± 0.048	13.675SerSer: 13.675 ± 0.14	7.837SerThr: 7.837 ± 0.074	4.444SerVal: 4.444 ± 0.031	1.027SerTrp: 1.027 ± 0.016	2.246SerTyr: 2.246 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.55ThrAla: 4.55 ± 0.037	0.611ThrCys: 0.611 ± 0.013	2.717ThrAsp: 2.717 ± 0.028	2.888ThrGlu: 2.888 ± 0.027	2.196ThrPhe: 2.196 ± 0.024	3.993ThrGly: 3.993 ± 0.036	1.39ThrHis: 1.39 ± 0.02	3.356ThrIle: 3.356 ± 0.031	2.8ThrLys: 2.8 ± 0.029	5.4ThrLeu: 5.4 ± 0.043	1.017ThrMet: 1.017 ± 0.017	2.46ThrAsn: 2.46 ± 0.027	5.275ThrPro: 5.275 ± 0.05	2.153ThrGln: 2.153 ± 0.025	2.923ThrArg: 2.923 ± 0.029	7.176ThrSer: 7.176 ± 0.067	4.582ThrThr: 4.582 ± 0.042	3.204ThrVal: 3.204 ± 0.031	0.721ThrTrp: 0.721 ± 0.015	1.622ThrTyr: 1.622 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	3.945ValAla: 3.945 ± 0.034	0.605ValCys: 0.605 ± 0.014	3.633ValAsp: 3.633 ± 0.028	4.017ValGlu: 4.017 ± 0.04	1.988ValPhe: 1.988 ± 0.023	4.004ValGly: 4.004 ± 0.039	1.255ValHis: 1.255 ± 0.019	3.134ValIle: 3.134 ± 0.03	3.248ValLys: 3.248 ± 0.034	4.985ValLeu: 4.985 ± 0.04	1.185ValMet: 1.185 ± 0.018	2.327ValAsn: 2.327 ± 0.028	3.397ValPro: 3.397 ± 0.032	2.15ValGln: 2.15 ± 0.025	2.97ValArg: 2.97 ± 0.029	4.33ValSer: 4.33 ± 0.033	3.023ValThr: 3.023 ± 0.03	3.717ValVal: 3.717 ± 0.038	0.804ValTrp: 0.804 ± 0.015	1.533ValTyr: 1.533 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.016	0.171TrpCys: 0.171 ± 0.007	0.848TrpAsp: 0.848 ± 0.015	0.907TrpGlu: 0.907 ± 0.014	0.471TrpPhe: 0.471 ± 0.01	0.908TrpGly: 0.908 ± 0.016	0.263TrpHis: 0.263 ± 0.009	0.74TrpIle: 0.74 ± 0.015	0.875TrpLys: 0.875 ± 0.014	1.199TrpLeu: 1.199 ± 0.02	0.351TrpMet: 0.351 ± 0.01	0.607TrpAsn: 0.607 ± 0.012	0.5TrpPro: 0.5 ± 0.013	0.472TrpGln: 0.472 ± 0.011	0.824TrpArg: 0.824 ± 0.014	1.093TrpSer: 1.093 ± 0.016	0.827TrpThr: 0.827 ± 0.016	0.793TrpVal: 0.793 ± 0.014	0.302TrpTrp: 0.302 ± 0.01	0.4TrpTyr: 0.4 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.844TyrAla: 1.844 ± 0.025	0.325TyrCys: 0.325 ± 0.01	1.657TyrAsp: 1.657 ± 0.022	1.537TyrGlu: 1.537 ± 0.02	1.034TyrPhe: 1.034 ± 0.018	2.0TyrGly: 2.0 ± 0.028	0.774TyrHis: 0.774 ± 0.014	1.36TyrIle: 1.36 ± 0.02	1.192TyrLys: 1.192 ± 0.018	2.548TyrLeu: 2.548 ± 0.031	0.525TyrMet: 0.525 ± 0.012	1.102TyrAsn: 1.102 ± 0.016	1.582TyrPro: 1.582 ± 0.023	1.106TyrGln: 1.106 ± 0.018	1.434TyrArg: 1.434 ± 0.02	2.07TyrSer: 2.07 ± 0.023	1.679TyrThr: 1.679 ± 0.02	1.443TyrVal: 1.443 ± 0.021	0.384TyrTrp: 0.384 ± 0.01	0.792TyrTyr: 0.792 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8428 proteins (4204977 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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