Amino acid dipepetide frequency for Aspergillus candidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.105AlaAla: 9.105 ± 0.068	1.079AlaCys: 1.079 ± 0.018	4.526AlaAsp: 4.526 ± 0.037	5.037AlaGlu: 5.037 ± 0.045	3.066AlaPhe: 3.066 ± 0.031	5.974AlaGly: 5.974 ± 0.042	1.947AlaHis: 1.947 ± 0.018	3.975AlaIle: 3.975 ± 0.031	3.617AlaLys: 3.617 ± 0.036	7.855AlaLeu: 7.855 ± 0.05	1.992AlaMet: 1.992 ± 0.022	2.786AlaAsn: 2.786 ± 0.025	5.249AlaPro: 5.249 ± 0.047	3.479AlaGln: 3.479 ± 0.036	5.231AlaArg: 5.231 ± 0.038	7.211AlaSer: 7.211 ± 0.048	5.16AlaThr: 5.16 ± 0.032	5.657AlaVal: 5.657 ± 0.042	1.155AlaTrp: 1.155 ± 0.02	2.124AlaTyr: 2.124 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.016	0.258CysCys: 0.258 ± 0.008	0.693CysAsp: 0.693 ± 0.014	0.613CysGlu: 0.613 ± 0.012	0.553CysPhe: 0.553 ± 0.011	0.971CysGly: 0.971 ± 0.016	0.348CysHis: 0.348 ± 0.009	0.674CysIle: 0.674 ± 0.012	0.455CysLys: 0.455 ± 0.012	1.319CysLeu: 1.319 ± 0.022	0.286CysMet: 0.286 ± 0.008	0.417CysAsn: 0.417 ± 0.01	0.694CysPro: 0.694 ± 0.017	0.476CysGln: 0.476 ± 0.011	0.826CysArg: 0.826 ± 0.012	0.929CysSer: 0.929 ± 0.017	0.679CysThr: 0.679 ± 0.012	0.847CysVal: 0.847 ± 0.016	0.209CysTrp: 0.209 ± 0.007	0.359CysTyr: 0.359 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.937AspAla: 4.937 ± 0.034	0.639AspCys: 0.639 ± 0.012	4.456AspAsp: 4.456 ± 0.051	4.384AspGlu: 4.384 ± 0.039	2.16AspPhe: 2.16 ± 0.02	4.248AspGly: 4.248 ± 0.031	1.405AspHis: 1.405 ± 0.017	2.908AspIle: 2.908 ± 0.027	2.213AspLys: 2.213 ± 0.025	5.247AspLeu: 5.247 ± 0.04	1.255AspMet: 1.255 ± 0.017	1.825AspAsn: 1.825 ± 0.021	3.718AspPro: 3.718 ± 0.026	2.016AspGln: 2.016 ± 0.022	3.43AspArg: 3.43 ± 0.029	4.218AspSer: 4.218 ± 0.037	3.054AspThr: 3.054 ± 0.025	3.721AspVal: 3.721 ± 0.03	0.878AspTrp: 0.878 ± 0.014	1.644AspTyr: 1.644 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.005GluAla: 5.005 ± 0.049	0.618GluCys: 0.618 ± 0.012	4.099GluAsp: 4.099 ± 0.036	5.223GluGlu: 5.223 ± 0.056	1.923GluPhe: 1.923 ± 0.019	3.854GluGly: 3.854 ± 0.038	1.37GluHis: 1.37 ± 0.016	2.897GluIle: 2.897 ± 0.027	3.412GluLys: 3.412 ± 0.041	4.944GluLeu: 4.944 ± 0.041	1.481GluMet: 1.481 ± 0.019	2.152GluAsn: 2.152 ± 0.021	2.882GluPro: 2.882 ± 0.033	2.421GluGln: 2.421 ± 0.025	4.002GluArg: 4.002 ± 0.038	4.353GluSer: 4.353 ± 0.033	3.443GluThr: 3.443 ± 0.032	3.482GluVal: 3.482 ± 0.031	0.868GluTrp: 0.868 ± 0.015	1.603GluTyr: 1.603 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.034PheAla: 3.034 ± 0.029	0.587PheCys: 0.587 ± 0.012	2.278PheAsp: 2.278 ± 0.022	2.026PheGlu: 2.026 ± 0.023	1.723PhePhe: 1.723 ± 0.025	2.781PheGly: 2.781 ± 0.032	0.982PheHis: 0.982 ± 0.014	1.683PheIle: 1.683 ± 0.021	1.323PheLys: 1.323 ± 0.015	3.646PheLeu: 3.646 ± 0.032	0.776PheMet: 0.776 ± 0.012	1.344PheAsn: 1.344 ± 0.019	2.076PhePro: 2.076 ± 0.024	1.415PheGln: 1.415 ± 0.017	2.042PheArg: 2.042 ± 0.021	2.988PheSer: 2.988 ± 0.028	2.096PheThr: 2.096 ± 0.023	2.469PheVal: 2.469 ± 0.027	0.629PheTrp: 0.629 ± 0.012	1.123PheTyr: 1.123 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.547GlyAla: 5.547 ± 0.045	0.919GlyCys: 0.919 ± 0.017	3.938GlyAsp: 3.938 ± 0.033	3.817GlyGlu: 3.817 ± 0.036	2.81GlyPhe: 2.81 ± 0.028	6.087GlyGly: 6.087 ± 0.056	1.725GlyHis: 1.725 ± 0.022	3.36GlyIle: 3.36 ± 0.032	3.296GlyLys: 3.296 ± 0.029	6.244GlyLeu: 6.244 ± 0.043	1.647GlyMet: 1.647 ± 0.02	2.322GlyAsn: 2.322 ± 0.024	3.682GlyPro: 3.682 ± 0.031	2.571GlyGln: 2.571 ± 0.027	4.332GlyArg: 4.332 ± 0.033	5.809GlySer: 5.809 ± 0.045	3.813GlyThr: 3.813 ± 0.031	4.735GlyVal: 4.735 ± 0.039	1.199GlyTrp: 1.199 ± 0.018	2.108GlyTyr: 2.108 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.002HisAla: 2.002 ± 0.022	0.352HisCys: 0.352 ± 0.01	1.405HisAsp: 1.405 ± 0.019	1.314HisGlu: 1.314 ± 0.019	0.958HisPhe: 0.958 ± 0.013	1.826HisGly: 1.826 ± 0.022	1.0HisHis: 1.0 ± 0.02	1.205HisIle: 1.205 ± 0.017	0.836HisLys: 0.836 ± 0.013	2.383HisLeu: 2.383 ± 0.023	0.506HisMet: 0.506 ± 0.01	0.853HisAsn: 0.853 ± 0.017	1.951HisPro: 1.951 ± 0.022	1.044HisGln: 1.044 ± 0.015	1.734HisArg: 1.734 ± 0.021	1.916HisSer: 1.916 ± 0.024	1.338HisThr: 1.338 ± 0.018	1.494HisVal: 1.494 ± 0.018	0.364HisTrp: 0.364 ± 0.009	0.711HisTyr: 0.711 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.95IleAla: 3.95 ± 0.032	0.744IleCys: 0.744 ± 0.013	2.698IleAsp: 2.698 ± 0.024	2.525IleGlu: 2.525 ± 0.025	1.925IlePhe: 1.925 ± 0.026	3.029IleGly: 3.029 ± 0.034	1.22IleHis: 1.22 ± 0.017	2.26IleIle: 2.26 ± 0.026	1.87IleLys: 1.87 ± 0.024	4.456IleLeu: 4.456 ± 0.038	0.975IleMet: 0.975 ± 0.015	1.616IleAsn: 1.616 ± 0.021	3.099IlePro: 3.099 ± 0.029	1.82IleGln: 1.82 ± 0.022	2.767IleArg: 2.767 ± 0.027	3.518IleSer: 3.518 ± 0.03	2.629IleThr: 2.629 ± 0.025	3.05IleVal: 3.05 ± 0.032	0.649IleTrp: 0.649 ± 0.012	1.382IleTyr: 1.382 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.819LysAla: 3.819 ± 0.038	0.476LysCys: 0.476 ± 0.012	2.638LysAsp: 2.638 ± 0.027	3.013LysGlu: 3.013 ± 0.035	1.304LysPhe: 1.304 ± 0.017	2.804LysGly: 2.804 ± 0.028	1.044LysHis: 1.044 ± 0.016	1.998LysIle: 1.998 ± 0.022	2.929LysLys: 2.929 ± 0.048	3.628LysLeu: 3.628 ± 0.034	0.933LysMet: 0.933 ± 0.016	1.602LysAsn: 1.602 ± 0.021	2.632LysPro: 2.632 ± 0.034	1.725LysGln: 1.725 ± 0.02	3.213LysArg: 3.213 ± 0.034	3.223LysSer: 3.223 ± 0.033	2.6LysThr: 2.6 ± 0.025	2.576LysVal: 2.576 ± 0.028	0.597LysTrp: 0.597 ± 0.012	1.26LysTyr: 1.26 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.883LeuAla: 7.883 ± 0.056	1.273LeuCys: 1.273 ± 0.02	5.298LeuAsp: 5.298 ± 0.036	5.299LeuGlu: 5.299 ± 0.042	3.418LeuPhe: 3.418 ± 0.034	6.086LeuGly: 6.086 ± 0.043	2.37LeuHis: 2.37 ± 0.025	3.796LeuIle: 3.796 ± 0.033	3.793LeuLys: 3.793 ± 0.038	8.589LeuLeu: 8.589 ± 0.063	1.834LeuMet: 1.834 ± 0.022	3.04LeuAsn: 3.04 ± 0.028	5.658LeuPro: 5.658 ± 0.042	3.84LeuGln: 3.84 ± 0.035	6.055LeuArg: 6.055 ± 0.043	7.498LeuSer: 7.498 ± 0.046	4.876LeuThr: 4.876 ± 0.035	5.66LeuVal: 5.66 ± 0.045	1.196LeuTrp: 1.196 ± 0.017	2.385LeuTyr: 2.385 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.185MetAla: 2.185 ± 0.023	0.267MetCys: 0.267 ± 0.008	1.313MetAsp: 1.313 ± 0.018	1.312MetGlu: 1.312 ± 0.017	0.741MetPhe: 0.741 ± 0.013	1.613MetGly: 1.613 ± 0.023	0.486MetHis: 0.486 ± 0.01	0.982MetIle: 0.982 ± 0.014	0.958MetLys: 0.958 ± 0.014	1.825MetLeu: 1.825 ± 0.022	0.581MetMet: 0.581 ± 0.011	0.768MetAsn: 0.768 ± 0.015	1.245MetPro: 1.245 ± 0.018	0.838MetGln: 0.838 ± 0.015	1.315MetArg: 1.315 ± 0.019	1.885MetSer: 1.885 ± 0.019	1.328MetThr: 1.328 ± 0.016	1.417MetVal: 1.417 ± 0.019	0.249MetTrp: 0.249 ± 0.007	0.529MetTyr: 0.529 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.025	0.43AsnCys: 0.43 ± 0.01	1.87AsnAsp: 1.87 ± 0.02	1.846AsnGlu: 1.846 ± 0.022	1.249AsnPhe: 1.249 ± 0.018	2.661AsnGly: 2.661 ± 0.028	0.884AsnHis: 0.884 ± 0.017	1.813AsnIle: 1.813 ± 0.019	1.395AsnLys: 1.395 ± 0.02	3.11AsnLeu: 3.11 ± 0.031	0.795AsnMet: 0.795 ± 0.012	1.401AsnAsn: 1.401 ± 0.025	2.534AsnPro: 2.534 ± 0.026	1.293AsnGln: 1.293 ± 0.016	1.965AsnArg: 1.965 ± 0.02	2.471AsnSer: 2.471 ± 0.025	2.036AsnThr: 2.036 ± 0.021	2.204AsnVal: 2.204 ± 0.023	0.509AsnTrp: 0.509 ± 0.011	0.989AsnTyr: 0.989 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.836ProAla: 5.836 ± 0.057	0.589ProCys: 0.589 ± 0.012	3.542ProAsp: 3.542 ± 0.031	3.946ProGlu: 3.946 ± 0.038	2.153ProPhe: 2.153 ± 0.022	4.277ProGly: 4.277 ± 0.04	1.516ProHis: 1.516 ± 0.02	2.465ProIle: 2.465 ± 0.024	2.512ProLys: 2.512 ± 0.027	4.928ProLeu: 4.928 ± 0.035	1.132ProMet: 1.132 ± 0.016	2.147ProAsn: 2.147 ± 0.024	5.822ProPro: 5.822 ± 0.076	2.595ProGln: 2.595 ± 0.037	3.834ProArg: 3.834 ± 0.034	6.551ProSer: 6.551 ± 0.053	4.275ProThr: 4.275 ± 0.033	3.887ProVal: 3.887 ± 0.034	0.79ProTrp: 0.79 ± 0.013	1.546ProTyr: 1.546 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.353GlnAla: 3.353 ± 0.029	0.455GlnCys: 0.455 ± 0.011	2.077GlnAsp: 2.077 ± 0.022	2.389GlnGlu: 2.389 ± 0.027	1.298GlnPhe: 1.298 ± 0.017	2.467GlnGly: 2.467 ± 0.023	1.098GlnHis: 1.098 ± 0.018	1.835GlnIle: 1.835 ± 0.022	1.909GlnLys: 1.909 ± 0.022	3.414GlnLeu: 3.414 ± 0.031	0.91GlnMet: 0.91 ± 0.015	1.467GlnAsn: 1.467 ± 0.022	2.707GlnPro: 2.707 ± 0.035	2.412GlnGln: 2.412 ± 0.045	2.776GlnArg: 2.776 ± 0.027	3.238GlnSer: 3.238 ± 0.03	2.375GlnThr: 2.375 ± 0.025	2.207GlnVal: 2.207 ± 0.022	0.569GlnTrp: 0.569 ± 0.012	1.105GlnTyr: 1.105 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.982ArgAla: 4.982 ± 0.033	0.779ArgCys: 0.779 ± 0.014	3.6ArgAsp: 3.6 ± 0.032	4.007ArgGlu: 4.007 ± 0.04	2.288ArgPhe: 2.288 ± 0.021	4.066ArgGly: 4.066 ± 0.032	1.663ArgHis: 1.663 ± 0.024	2.853ArgIle: 2.853 ± 0.026	3.314ArgLys: 3.314 ± 0.03	5.834ArgLeu: 5.834 ± 0.042	1.382ArgMet: 1.382 ± 0.017	2.166ArgAsn: 2.166 ± 0.024	3.886ArgPro: 3.886 ± 0.038	2.689ArgGln: 2.689 ± 0.026	5.553ArgArg: 5.553 ± 0.05	5.119ArgSer: 5.119 ± 0.046	3.411ArgThr: 3.411 ± 0.032	3.727ArgVal: 3.727 ± 0.035	1.01ArgTrp: 1.01 ± 0.017	1.722ArgTyr: 1.722 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.771SerAla: 6.771 ± 0.042	0.903SerCys: 0.903 ± 0.014	4.337SerAsp: 4.337 ± 0.038	4.024SerGlu: 4.024 ± 0.034	3.075SerPhe: 3.075 ± 0.026	5.645SerGly: 5.645 ± 0.039	2.116SerHis: 2.116 ± 0.026	3.723SerIle: 3.723 ± 0.027	3.41SerLys: 3.41 ± 0.031	7.42SerLeu: 7.42 ± 0.05	1.729SerMet: 1.729 ± 0.02	2.76SerAsn: 2.76 ± 0.026	5.954SerPro: 5.954 ± 0.057	3.311SerGln: 3.311 ± 0.027	5.282SerArg: 5.282 ± 0.037	8.686SerSer: 8.686 ± 0.089	5.49SerThr: 5.49 ± 0.049	4.731SerVal: 4.731 ± 0.031	1.115SerTrp: 1.115 ± 0.017	2.018SerTyr: 2.018 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.343ThrAla: 5.343 ± 0.036	0.736ThrCys: 0.736 ± 0.013	2.999ThrAsp: 2.999 ± 0.022	3.03ThrGlu: 3.03 ± 0.026	2.113ThrPhe: 2.113 ± 0.023	4.257ThrGly: 4.257 ± 0.033	1.391ThrHis: 1.391 ± 0.015	2.827ThrIle: 2.827 ± 0.026	2.384ThrLys: 2.384 ± 0.024	5.238ThrLeu: 5.238 ± 0.037	1.226ThrMet: 1.226 ± 0.016	1.955ThrAsn: 1.955 ± 0.02	4.608ThrPro: 4.608 ± 0.041	2.067ThrGln: 2.067 ± 0.024	3.254ThrArg: 3.254 ± 0.031	4.968ThrSer: 4.968 ± 0.037	4.273ThrThr: 4.273 ± 0.042	3.851ThrVal: 3.851 ± 0.035	0.818ThrTrp: 0.818 ± 0.013	1.554ThrTyr: 1.554 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.328ValAla: 5.328 ± 0.038	0.885ValCys: 0.885 ± 0.013	4.05ValAsp: 4.05 ± 0.029	3.877ValGlu: 3.877 ± 0.031	2.574ValPhe: 2.574 ± 0.027	4.289ValGly: 4.289 ± 0.038	1.5ValHis: 1.5 ± 0.02	2.882ValIle: 2.882 ± 0.03	2.637ValLys: 2.637 ± 0.031	5.734ValLeu: 5.734 ± 0.044	1.385ValMet: 1.385 ± 0.016	2.127ValAsn: 2.127 ± 0.021	3.815ValPro: 3.815 ± 0.035	2.435ValGln: 2.435 ± 0.025	3.739ValArg: 3.739 ± 0.026	4.862ValSer: 4.862 ± 0.034	3.504ValThr: 3.504 ± 0.033	4.544ValVal: 4.544 ± 0.041	0.89ValTrp: 0.89 ± 0.014	1.784ValTyr: 1.784 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.127TrpAla: 1.127 ± 0.019	0.202TrpCys: 0.202 ± 0.006	0.912TrpAsp: 0.912 ± 0.015	0.855TrpGlu: 0.855 ± 0.012	0.525TrpPhe: 0.525 ± 0.013	0.952TrpGly: 0.952 ± 0.017	0.347TrpHis: 0.347 ± 0.009	0.725TrpIle: 0.725 ± 0.015	0.751TrpLys: 0.751 ± 0.015	1.319TrpLeu: 1.319 ± 0.018	0.388TrpMet: 0.388 ± 0.009	0.591TrpAsn: 0.591 ± 0.011	0.591TrpPro: 0.591 ± 0.012	0.526TrpGln: 0.526 ± 0.01	0.995TrpArg: 0.995 ± 0.016	1.05TrpSer: 1.05 ± 0.015	0.921TrpThr: 0.921 ± 0.013	0.92TrpVal: 0.92 ± 0.017	0.287TrpTrp: 0.287 ± 0.008	0.417TrpTyr: 0.417 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.115TyrAla: 2.115 ± 0.022	0.4TyrCys: 0.4 ± 0.009	1.624TyrAsp: 1.624 ± 0.019	1.495TyrGlu: 1.495 ± 0.02	1.165TyrPhe: 1.165 ± 0.017	2.075TyrGly: 2.075 ± 0.031	0.78TyrHis: 0.78 ± 0.012	1.323TyrIle: 1.323 ± 0.018	0.999TyrLys: 0.999 ± 0.016	2.711TyrLeu: 2.711 ± 0.028	0.624TyrMet: 0.624 ± 0.013	1.033TyrAsn: 1.033 ± 0.015	1.539TyrPro: 1.539 ± 0.022	1.088TyrGln: 1.088 ± 0.016	1.706TyrArg: 1.706 ± 0.016	2.006TyrSer: 2.006 ± 0.023	1.596TyrThr: 1.596 ± 0.02	1.665TyrVal: 1.665 ± 0.019	0.422TyrTrp: 0.422 ± 0.01	0.909TyrTyr: 0.909 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 9639 proteins (4627908 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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