Amino acid dipepetide frequency for Niabella soli DSM 19437

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.84AlaAla: 8.84 ± 0.102
0.741AlaCys: 0.741 ± 0.023
4.53AlaAsp: 4.53 ± 0.057
3.879AlaGlu: 3.879 ± 0.06
3.848AlaPhe: 3.848 ± 0.053
6.54AlaGly: 6.54 ± 0.073
1.418AlaHis: 1.418 ± 0.033
5.694AlaIle: 5.694 ± 0.071
4.722AlaLys: 4.722 ± 0.067
8.086AlaLeu: 8.086 ± 0.089
1.816AlaMet: 1.816 ± 0.039
3.601AlaAsn: 3.601 ± 0.061
3.235AlaPro: 3.235 ± 0.056
3.313AlaGln: 3.313 ± 0.05
3.105AlaArg: 3.105 ± 0.048
4.505AlaSer: 4.505 ± 0.053
4.931AlaThr: 4.931 ± 0.068
5.614AlaVal: 5.614 ± 0.073
0.974AlaTrp: 0.974 ± 0.028
2.981AlaTyr: 2.981 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.596CysAla: 0.596 ± 0.02
0.151CysCys: 0.151 ± 0.011
0.377CysAsp: 0.377 ± 0.02
0.361CysGlu: 0.361 ± 0.017
0.495CysPhe: 0.495 ± 0.018
0.673CysGly: 0.673 ± 0.024
0.213CysHis: 0.213 ± 0.016
0.677CysIle: 0.677 ± 0.023
0.49CysLys: 0.49 ± 0.018
0.765CysLeu: 0.765 ± 0.025
0.229CysMet: 0.229 ± 0.015
0.46CysAsn: 0.46 ± 0.018
0.36CysPro: 0.36 ± 0.019
0.236CysGln: 0.236 ± 0.014
0.361CysArg: 0.361 ± 0.016
0.593CysSer: 0.593 ± 0.02
0.489CysThr: 0.489 ± 0.02
0.468CysVal: 0.468 ± 0.021
0.111CysTrp: 0.111 ± 0.009
0.355CysTyr: 0.355 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.554AspAla: 4.554 ± 0.059
0.4AspCys: 0.4 ± 0.017
2.273AspAsp: 2.273 ± 0.041
2.918AspGlu: 2.918 ± 0.052
2.797AspPhe: 2.797 ± 0.046
3.815AspGly: 3.815 ± 0.066
1.068AspHis: 1.068 ± 0.031
3.454AspIle: 3.454 ± 0.053
3.498AspLys: 3.498 ± 0.056
4.701AspLeu: 4.701 ± 0.06
1.086AspMet: 1.086 ± 0.025
2.579AspAsn: 2.579 ± 0.052
2.469AspPro: 2.469 ± 0.048
1.805AspGln: 1.805 ± 0.034
2.25AspArg: 2.25 ± 0.047
2.955AspSer: 2.955 ± 0.062
2.618AspThr: 2.618 ± 0.046
3.148AspVal: 3.148 ± 0.045
0.864AspTrp: 0.864 ± 0.028
2.451AspTyr: 2.451 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.676GluAla: 4.676 ± 0.073
0.336GluCys: 0.336 ± 0.018
2.356GluAsp: 2.356 ± 0.049
3.222GluGlu: 3.222 ± 0.07
1.993GluPhe: 1.993 ± 0.042
3.472GluGly: 3.472 ± 0.054
1.09GluHis: 1.09 ± 0.029
3.491GluIle: 3.491 ± 0.058
4.735GluLys: 4.735 ± 0.063
5.369GluLeu: 5.369 ± 0.073
1.377GluMet: 1.377 ± 0.032
2.912GluAsn: 2.912 ± 0.048
1.639GluPro: 1.639 ± 0.032
2.546GluGln: 2.546 ± 0.041
2.483GluArg: 2.483 ± 0.049
2.401GluSer: 2.401 ± 0.043
2.904GluThr: 2.904 ± 0.047
3.4GluVal: 3.4 ± 0.06
0.772GluTrp: 0.772 ± 0.029
1.939GluTyr: 1.939 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.473PheAla: 3.473 ± 0.054
0.52PheCys: 0.52 ± 0.017
2.816PheAsp: 2.816 ± 0.045
2.596PheGlu: 2.596 ± 0.044
2.691PhePhe: 2.691 ± 0.051
3.338PheGly: 3.338 ± 0.053
0.845PheHis: 0.845 ± 0.024
3.599PheIle: 3.599 ± 0.058
3.04PheLys: 3.04 ± 0.052
4.431PheLeu: 4.431 ± 0.07
1.128PheMet: 1.128 ± 0.031
2.666PheAsn: 2.666 ± 0.045
1.832PhePro: 1.832 ± 0.035
1.352PheGln: 1.352 ± 0.029
1.979PheArg: 1.979 ± 0.038
3.448PheSer: 3.448 ± 0.054
2.95PheThr: 2.95 ± 0.044
2.864PheVal: 2.864 ± 0.05
0.641PheTrp: 0.641 ± 0.027
2.144PheTyr: 2.144 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.762GlyAla: 5.762 ± 0.071
0.682GlyCys: 0.682 ± 0.024
3.506GlyAsp: 3.506 ± 0.063
3.129GlyGlu: 3.129 ± 0.055
3.702GlyPhe: 3.702 ± 0.048
5.331GlyGly: 5.331 ± 0.079
1.333GlyHis: 1.333 ± 0.032
5.37GlyIle: 5.37 ± 0.075
5.371GlyLys: 5.371 ± 0.063
6.459GlyLeu: 6.459 ± 0.076
1.907GlyMet: 1.907 ± 0.037
3.794GlyAsn: 3.794 ± 0.06
1.814GlyPro: 1.814 ± 0.04
2.435GlyGln: 2.435 ± 0.042
3.075GlyArg: 3.075 ± 0.05
4.43GlySer: 4.43 ± 0.063
4.444GlyThr: 4.444 ± 0.063
4.791GlyVal: 4.791 ± 0.071
1.222GlyTrp: 1.222 ± 0.034
3.285GlyTyr: 3.285 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.226HisAla: 1.226 ± 0.028
0.215HisCys: 0.215 ± 0.013
0.809HisAsp: 0.809 ± 0.026
0.87HisGlu: 0.87 ± 0.024
1.231HisPhe: 1.231 ± 0.031
1.1HisGly: 1.1 ± 0.033
0.53HisHis: 0.53 ± 0.023
1.326HisIle: 1.326 ± 0.031
1.043HisLys: 1.043 ± 0.029
1.977HisLeu: 1.977 ± 0.036
0.393HisMet: 0.393 ± 0.015
0.932HisAsn: 0.932 ± 0.024
1.172HisPro: 1.172 ± 0.032
0.751HisGln: 0.751 ± 0.025
0.853HisArg: 0.853 ± 0.027
1.106HisSer: 1.106 ± 0.029
1.123HisThr: 1.123 ± 0.028
0.899HisVal: 0.899 ± 0.023
0.328HisTrp: 0.328 ± 0.014
0.965HisTyr: 0.965 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.042IleAla: 6.042 ± 0.066
0.698IleCys: 0.698 ± 0.022
3.956IleAsp: 3.956 ± 0.055
3.764IleGlu: 3.764 ± 0.056
2.827IlePhe: 2.827 ± 0.053
4.687IleGly: 4.687 ± 0.065
1.26IleHis: 1.26 ± 0.031
4.706IleIle: 4.706 ± 0.072
4.663IleLys: 4.663 ± 0.059
5.735IleLeu: 5.735 ± 0.071
1.327IleMet: 1.327 ± 0.035
3.833IleAsn: 3.833 ± 0.054
3.129IlePro: 3.129 ± 0.048
2.177IleGln: 2.177 ± 0.043
3.1IleArg: 3.1 ± 0.052
4.287IleSer: 4.287 ± 0.057
4.38IleThr: 4.38 ± 0.061
4.191IleVal: 4.191 ± 0.063
0.739IleTrp: 0.739 ± 0.024
2.409IleTyr: 2.409 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.346LysAla: 5.346 ± 0.064
0.354LysCys: 0.354 ± 0.016
4.132LysAsp: 4.132 ± 0.053
5.145LysGlu: 5.145 ± 0.063
2.224LysPhe: 2.224 ± 0.045
4.864LysGly: 4.864 ± 0.058
1.088LysHis: 1.088 ± 0.028
4.847LysIle: 4.847 ± 0.065
6.144LysLys: 6.144 ± 0.078
5.3LysLeu: 5.3 ± 0.058
2.039LysMet: 2.039 ± 0.039
4.405LysAsn: 4.405 ± 0.06
2.664LysPro: 2.664 ± 0.045
2.896LysGln: 2.896 ± 0.053
2.914LysArg: 2.914 ± 0.052
3.304LysSer: 3.304 ± 0.052
4.261LysThr: 4.261 ± 0.052
3.896LysVal: 3.896 ± 0.056
0.899LysTrp: 0.899 ± 0.024
2.624LysTyr: 2.624 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
6.909LeuAla: 6.909 ± 0.067
0.884LeuCys: 0.884 ± 0.023
4.397LeuAsp: 4.397 ± 0.057
4.668LeuGlu: 4.668 ± 0.067
5.046LeuPhe: 5.046 ± 0.071
5.825LeuGly: 5.825 ± 0.071
1.84LeuHis: 1.84 ± 0.035
5.964LeuIle: 5.964 ± 0.077
7.063LeuLys: 7.063 ± 0.081
10.224LeuLeu: 10.224 ± 0.104
2.197LeuMet: 2.197 ± 0.042
5.047LeuAsn: 5.047 ± 0.076
4.41LeuPro: 4.41 ± 0.06
4.206LeuGln: 4.206 ± 0.066
3.877LeuArg: 3.877 ± 0.062
6.425LeuSer: 6.425 ± 0.082
5.229LeuThr: 5.229 ± 0.063
5.477LeuVal: 5.477 ± 0.07
1.076LeuTrp: 1.076 ± 0.031
3.464LeuTyr: 3.464 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.981MetAla: 1.981 ± 0.037
0.14MetCys: 0.14 ± 0.011
1.246MetAsp: 1.246 ± 0.031
1.382MetGlu: 1.382 ± 0.033
0.718MetPhe: 0.718 ± 0.024
1.667MetGly: 1.667 ± 0.033
0.457MetHis: 0.457 ± 0.019
1.502MetIle: 1.502 ± 0.032
1.967MetLys: 1.967 ± 0.036
2.095MetLeu: 2.095 ± 0.037
0.559MetMet: 0.559 ± 0.022
1.364MetAsn: 1.364 ± 0.034
1.147MetPro: 1.147 ± 0.029
1.091MetGln: 1.091 ± 0.027
1.054MetArg: 1.054 ± 0.03
1.253MetSer: 1.253 ± 0.032
1.191MetThr: 1.191 ± 0.029
1.41MetVal: 1.41 ± 0.034
0.208MetTrp: 0.208 ± 0.011
0.673MetTyr: 0.673 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
4.276AsnAla: 4.276 ± 0.062
0.422AsnCys: 0.422 ± 0.02
2.778AsnAsp: 2.778 ± 0.046
2.776AsnGlu: 2.776 ± 0.044
2.433AsnPhe: 2.433 ± 0.049
4.344AsnGly: 4.344 ± 0.063
0.913AsnHis: 0.913 ± 0.029
3.765AsnIle: 3.765 ± 0.055
3.659AsnLys: 3.659 ± 0.053
4.338AsnLeu: 4.338 ± 0.066
1.104AsnMet: 1.104 ± 0.028
3.349AsnAsn: 3.349 ± 0.064
2.67AsnPro: 2.67 ± 0.047
1.735AsnGln: 1.735 ± 0.033
2.455AsnArg: 2.455 ± 0.046
2.951AsnSer: 2.951 ± 0.057
3.204AsnThr: 3.204 ± 0.061
2.955AsnVal: 2.955 ± 0.052
0.835AsnTrp: 0.835 ± 0.024
2.513AsnTyr: 2.513 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
4.062ProAla: 4.062 ± 0.061
0.239ProCys: 0.239 ± 0.014
2.824ProAsp: 2.824 ± 0.045
2.974ProGlu: 2.974 ± 0.053
2.083ProPhe: 2.083 ± 0.04
3.572ProGly: 3.572 ± 0.058
0.771ProHis: 0.771 ± 0.026
2.052ProIle: 2.052 ± 0.043
2.088ProLys: 2.088 ± 0.042
3.652ProLeu: 3.652 ± 0.053
0.808ProMet: 0.808 ± 0.025
1.824ProAsn: 1.824 ± 0.04
1.361ProPro: 1.361 ± 0.033
1.67ProGln: 1.67 ± 0.036
1.435ProArg: 1.435 ± 0.034
2.289ProSer: 2.289 ± 0.041
1.835ProThr: 1.835 ± 0.04
3.895ProVal: 3.895 ± 0.061
0.548ProTrp: 0.548 ± 0.02
1.658ProTyr: 1.658 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
2.701GlnAla: 2.701 ± 0.052
0.244GlnCys: 0.244 ± 0.014
1.472GlnAsp: 1.472 ± 0.035
2.077GlnGlu: 2.077 ± 0.038
1.777GlnPhe: 1.777 ± 0.04
2.137GlnGly: 2.137 ± 0.041
0.887GlnHis: 0.887 ± 0.027
2.108GlnIle: 2.108 ± 0.043
2.827GlnLys: 2.827 ± 0.049
4.513GlnLeu: 4.513 ± 0.065
0.949GlnMet: 0.949 ± 0.033
1.87GlnAsn: 1.87 ± 0.043
1.798GlnPro: 1.798 ± 0.039
2.63GlnGln: 2.63 ± 0.053
1.746GlnArg: 1.746 ± 0.04
2.143GlnSer: 2.143 ± 0.047
2.238GlnThr: 2.238 ± 0.039
2.28GlnVal: 2.28 ± 0.033
0.65GlnTrp: 0.65 ± 0.021
1.711GlnTyr: 1.711 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.756ArgAla: 2.756 ± 0.044
0.294ArgCys: 0.294 ± 0.016
1.969ArgAsp: 1.969 ± 0.038
2.313ArgGlu: 2.313 ± 0.05
2.456ArgPhe: 2.456 ± 0.041
2.39ArgGly: 2.39 ± 0.04
0.792ArgHis: 0.792 ± 0.022
3.159ArgIle: 3.159 ± 0.047
3.079ArgLys: 3.079 ± 0.045
4.186ArgLeu: 4.186 ± 0.057
1.157ArgMet: 1.157 ± 0.029
2.472ArgAsn: 2.472 ± 0.04
1.7ArgPro: 1.7 ± 0.033
1.761ArgGln: 1.761 ± 0.042
1.908ArgArg: 1.908 ± 0.044
2.557ArgSer: 2.557 ± 0.041
2.229ArgThr: 2.229 ± 0.038
2.561ArgVal: 2.561 ± 0.044
0.64ArgTrp: 0.64 ± 0.021
2.039ArgTyr: 2.039 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.556SerAla: 4.556 ± 0.059
0.62SerCys: 0.62 ± 0.023
2.924SerAsp: 2.924 ± 0.047
2.574SerGlu: 2.574 ± 0.046
3.56SerPhe: 3.56 ± 0.049
5.148SerGly: 5.148 ± 0.07
0.941SerHis: 0.941 ± 0.03
4.089SerIle: 4.089 ± 0.054
3.668SerLys: 3.668 ± 0.053
5.731SerLeu: 5.731 ± 0.062
1.315SerMet: 1.315 ± 0.031
2.907SerAsn: 2.907 ± 0.051
2.21SerPro: 2.21 ± 0.037
1.679SerGln: 1.679 ± 0.04
2.561SerArg: 2.561 ± 0.042
3.599SerSer: 3.599 ± 0.066
3.114SerThr: 3.114 ± 0.051
4.079SerVal: 4.079 ± 0.063
0.874SerTrp: 0.874 ± 0.025
2.526SerTyr: 2.526 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.41ThrAla: 5.41 ± 0.066
0.37ThrCys: 0.37 ± 0.016
3.365ThrAsp: 3.365 ± 0.051
2.756ThrGlu: 2.756 ± 0.054
2.384ThrPhe: 2.384 ± 0.044
5.233ThrGly: 5.233 ± 0.062
1.059ThrHis: 1.059 ± 0.027
4.443ThrIle: 4.443 ± 0.062
3.214ThrLys: 3.214 ± 0.048
5.172ThrLeu: 5.172 ± 0.061
1.05ThrMet: 1.05 ± 0.027
2.856ThrAsn: 2.856 ± 0.051
2.886ThrPro: 2.886 ± 0.047
1.883ThrGln: 1.883 ± 0.038
2.175ThrArg: 2.175 ± 0.038
3.119ThrSer: 3.119 ± 0.055
3.661ThrThr: 3.661 ± 0.067
4.171ThrVal: 4.171 ± 0.054
0.716ThrTrp: 0.716 ± 0.024
2.072ThrTyr: 2.072 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
5.332ValAla: 5.332 ± 0.063
0.632ValCys: 0.632 ± 0.022
3.062ValAsp: 3.062 ± 0.048
3.005ValGlu: 3.005 ± 0.053
3.226ValPhe: 3.226 ± 0.051
3.744ValGly: 3.744 ± 0.057
1.208ValHis: 1.208 ± 0.029
4.39ValIle: 4.39 ± 0.06
4.281ValLys: 4.281 ± 0.058
6.451ValLeu: 6.451 ± 0.068
1.428ValMet: 1.428 ± 0.033
3.36ValAsn: 3.36 ± 0.045
2.83ValPro: 2.83 ± 0.048
2.334ValGln: 2.334 ± 0.041
2.485ValArg: 2.485 ± 0.039
3.944ValSer: 3.944 ± 0.055
3.958ValThr: 3.958 ± 0.051
4.27ValVal: 4.27 ± 0.066
0.756ValTrp: 0.756 ± 0.025
2.499ValTyr: 2.499 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.915TrpAla: 0.915 ± 0.027
0.149TrpCys: 0.149 ± 0.01
0.709TrpAsp: 0.709 ± 0.021
0.761TrpGlu: 0.761 ± 0.025
0.625TrpPhe: 0.625 ± 0.023
1.02TrpGly: 1.02 ± 0.028
0.313TrpHis: 0.313 ± 0.015
0.801TrpIle: 0.801 ± 0.021
0.982TrpLys: 0.982 ± 0.033
1.347TrpLeu: 1.347 ± 0.03
0.414TrpMet: 0.414 ± 0.017
0.842TrpAsn: 0.842 ± 0.025
0.474TrpPro: 0.474 ± 0.02
0.629TrpGln: 0.629 ± 0.023
0.604TrpArg: 0.604 ± 0.019
0.787TrpSer: 0.787 ± 0.027
0.686TrpThr: 0.686 ± 0.023
0.835TrpVal: 0.835 ± 0.024
0.257TrpTrp: 0.257 ± 0.014
0.555TrpTyr: 0.555 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.961TyrAla: 2.961 ± 0.042
0.37TyrCys: 0.37 ± 0.017
2.201TyrAsp: 2.201 ± 0.04
1.945TyrGlu: 1.945 ± 0.033
2.237TyrPhe: 2.237 ± 0.043
2.944TyrGly: 2.944 ± 0.052
0.823TyrHis: 0.823 ± 0.025
2.473TyrIle: 2.473 ± 0.044
2.811TyrLys: 2.811 ± 0.047
3.699TyrLeu: 3.699 ± 0.054
0.822TyrMet: 0.822 ± 0.026
2.403TyrAsn: 2.403 ± 0.049
1.841TyrPro: 1.841 ± 0.035
1.629TyrGln: 1.629 ± 0.03
1.994TyrArg: 1.994 ± 0.037
2.58TyrSer: 2.58 ± 0.05
2.548TyrThr: 2.548 ± 0.048
1.988TyrVal: 1.988 ± 0.035
0.596TyrTrp: 0.596 ± 0.021
1.994TyrTyr: 1.994 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4110 proteins (1373064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski