Amino acid dipepetide frequency for Thalassobius gelatinovorus (Ruegeria gelatinovora)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.95AlaAla: 14.95 ± 0.168	0.967AlaCys: 0.967 ± 0.028	7.068AlaAsp: 7.068 ± 0.082	7.512AlaGlu: 7.512 ± 0.091	3.927AlaPhe: 3.927 ± 0.071	9.681AlaGly: 9.681 ± 0.096	2.095AlaHis: 2.095 ± 0.045	5.805AlaIle: 5.805 ± 0.069	4.156AlaLys: 4.156 ± 0.073	12.785AlaLeu: 12.785 ± 0.122	3.738AlaMet: 3.738 ± 0.064	2.874AlaAsn: 2.874 ± 0.059	5.118AlaPro: 5.118 ± 0.072	4.49AlaGln: 4.49 ± 0.063	7.518AlaArg: 7.518 ± 0.102	5.35AlaSer: 5.35 ± 0.07	5.645AlaThr: 5.645 ± 0.074	8.069AlaVal: 8.069 ± 0.094	1.232AlaTrp: 1.232 ± 0.033	2.441AlaTyr: 2.441 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.985CysAla: 0.985 ± 0.032	0.115CysCys: 0.115 ± 0.011	0.699CysAsp: 0.699 ± 0.026	0.437CysGlu: 0.437 ± 0.02	0.345CysPhe: 0.345 ± 0.017	0.944CysGly: 0.944 ± 0.032	0.27CysHis: 0.27 ± 0.019	0.418CysIle: 0.418 ± 0.02	0.256CysLys: 0.256 ± 0.015	0.831CysLeu: 0.831 ± 0.027	0.175CysMet: 0.175 ± 0.012	0.265CysAsn: 0.265 ± 0.016	0.509CysPro: 0.509 ± 0.023	0.255CysGln: 0.255 ± 0.015	0.55CysArg: 0.55 ± 0.023	0.511CysSer: 0.511 ± 0.02	0.458CysThr: 0.458 ± 0.02	0.568CysVal: 0.568 ± 0.021	0.108CysTrp: 0.108 ± 0.01	0.212CysTyr: 0.212 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.048AspAla: 7.048 ± 0.086	0.593AspCys: 0.593 ± 0.025	3.79AspAsp: 3.79 ± 0.084	3.501AspGlu: 3.501 ± 0.06	2.516AspPhe: 2.516 ± 0.045	5.727AspGly: 5.727 ± 0.091	1.589AspHis: 1.589 ± 0.04	3.516AspIle: 3.516 ± 0.05	2.01AspLys: 2.01 ± 0.045	7.025AspLeu: 7.025 ± 0.089	1.944AspMet: 1.944 ± 0.044	1.404AspAsn: 1.404 ± 0.033	3.763AspPro: 3.763 ± 0.061	2.291AspGln: 2.291 ± 0.045	4.441AspArg: 4.441 ± 0.058	2.478AspSer: 2.478 ± 0.046	3.207AspThr: 3.207 ± 0.063	4.323AspVal: 4.323 ± 0.062	1.237AspTrp: 1.237 ± 0.035	1.696AspTyr: 1.696 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.992GluAla: 6.992 ± 0.086	0.356GluCys: 0.356 ± 0.017	3.682GluAsp: 3.682 ± 0.061	3.16GluGlu: 3.16 ± 0.071	1.876GluPhe: 1.876 ± 0.044	4.311GluGly: 4.311 ± 0.066	1.092GluHis: 1.092 ± 0.033	3.78GluIle: 3.78 ± 0.061	2.506GluLys: 2.506 ± 0.052	5.076GluLeu: 5.076 ± 0.075	1.845GluMet: 1.845 ± 0.04	2.034GluAsn: 2.034 ± 0.045	2.309GluPro: 2.309 ± 0.048	2.034GluGln: 2.034 ± 0.042	3.615GluArg: 3.615 ± 0.059	2.23GluSer: 2.23 ± 0.043	4.101GluThr: 4.101 ± 0.063	3.954GluVal: 3.954 ± 0.065	0.665GluTrp: 0.665 ± 0.021	1.141GluTyr: 1.141 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.23PheAla: 4.23 ± 0.07	0.436PheCys: 0.436 ± 0.018	3.03PheAsp: 3.03 ± 0.055	2.236PheGlu: 2.236 ± 0.045	1.456PhePhe: 1.456 ± 0.042	3.725PheGly: 3.725 ± 0.061	0.772PheHis: 0.772 ± 0.025	1.718PheIle: 1.718 ± 0.042	1.095PheLys: 1.095 ± 0.035	3.456PheLeu: 3.456 ± 0.059	0.902PheMet: 0.902 ± 0.03	1.143PheAsn: 1.143 ± 0.03	1.563PhePro: 1.563 ± 0.039	1.1PheGln: 1.1 ± 0.033	2.109PheArg: 2.109 ± 0.044	2.251PheSer: 2.251 ± 0.039	2.114PheThr: 2.114 ± 0.043	2.709PheVal: 2.709 ± 0.051	0.556PheTrp: 0.556 ± 0.027	0.939PheTyr: 0.939 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.063GlyAla: 9.063 ± 0.117	0.866GlyCys: 0.866 ± 0.027	4.991GlyAsp: 4.991 ± 0.085	4.466GlyGlu: 4.466 ± 0.063	3.801GlyPhe: 3.801 ± 0.066	7.158GlyGly: 7.158 ± 0.108	1.92GlyHis: 1.92 ± 0.046	4.65GlyIle: 4.65 ± 0.076	3.464GlyLys: 3.464 ± 0.068	8.977GlyLeu: 8.977 ± 0.105	2.662GlyMet: 2.662 ± 0.051	2.35GlyAsn: 2.35 ± 0.057	3.475GlyPro: 3.475 ± 0.06	3.301GlyGln: 3.301 ± 0.059	5.213GlyArg: 5.213 ± 0.076	4.392GlySer: 4.392 ± 0.07	4.494GlyThr: 4.494 ± 0.075	6.355GlyVal: 6.355 ± 0.072	1.467GlyTrp: 1.467 ± 0.041	2.423GlyTyr: 2.423 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.155HisAla: 2.155 ± 0.044	0.223HisCys: 0.223 ± 0.014	1.378HisAsp: 1.378 ± 0.036	1.02HisGlu: 1.02 ± 0.032	0.837HisPhe: 0.837 ± 0.025	1.873HisGly: 1.873 ± 0.048	0.573HisHis: 0.573 ± 0.025	1.076HisIle: 1.076 ± 0.033	0.607HisLys: 0.607 ± 0.023	2.129HisLeu: 2.129 ± 0.051	0.581HisMet: 0.581 ± 0.02	0.507HisAsn: 0.507 ± 0.023	1.422HisPro: 1.422 ± 0.041	0.616HisGln: 0.616 ± 0.021	1.335HisArg: 1.335 ± 0.034	1.03HisSer: 1.03 ± 0.032	0.837HisThr: 0.837 ± 0.027	1.451HisVal: 1.451 ± 0.038	0.356HisTrp: 0.356 ± 0.02	0.559HisTyr: 0.559 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.971IleAla: 6.971 ± 0.075	0.671IleCys: 0.671 ± 0.025	3.828IleAsp: 3.828 ± 0.062	3.839IleGlu: 3.839 ± 0.06	1.825IlePhe: 1.825 ± 0.051	5.165IleGly: 5.165 ± 0.075	0.982IleHis: 0.982 ± 0.032	2.367IleIle: 2.367 ± 0.05	1.715IleLys: 1.715 ± 0.038	5.092IleLeu: 5.092 ± 0.074	1.171IleMet: 1.171 ± 0.035	1.514IleAsn: 1.514 ± 0.035	2.442IlePro: 2.442 ± 0.043	1.338IleGln: 1.338 ± 0.032	3.327IleArg: 3.327 ± 0.054	3.218IleSer: 3.218 ± 0.049	3.01IleThr: 3.01 ± 0.05	3.939IleVal: 3.939 ± 0.064	0.756IleTrp: 0.756 ± 0.027	1.278IleTyr: 1.278 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.162LysAla: 4.162 ± 0.073	0.215LysCys: 0.215 ± 0.014	2.078LysAsp: 2.078 ± 0.051	1.68LysGlu: 1.68 ± 0.046	1.085LysPhe: 1.085 ± 0.031	2.978LysGly: 2.978 ± 0.054	0.668LysHis: 0.668 ± 0.025	2.013LysIle: 2.013 ± 0.041	1.457LysLys: 1.457 ± 0.043	3.473LysLeu: 3.473 ± 0.061	1.058LysMet: 1.058 ± 0.032	1.0LysAsn: 1.0 ± 0.029	2.022LysPro: 2.022 ± 0.048	1.159LysGln: 1.159 ± 0.031	2.418LysArg: 2.418 ± 0.054	2.099LysSer: 2.099 ± 0.046	2.326LysThr: 2.326 ± 0.045	2.567LysVal: 2.567 ± 0.055	0.453LysTrp: 0.453 ± 0.021	0.762LysTyr: 0.762 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.833LeuAla: 11.833 ± 0.132	0.923LeuCys: 0.923 ± 0.029	6.111LeuAsp: 6.111 ± 0.074	5.025LeuGlu: 5.025 ± 0.068	3.616LeuPhe: 3.616 ± 0.067	8.273LeuGly: 8.273 ± 0.098	2.046LeuHis: 2.046 ± 0.045	5.769LeuIle: 5.769 ± 0.084	3.608LeuLys: 3.608 ± 0.049	9.046LeuLeu: 9.046 ± 0.119	2.751LeuMet: 2.751 ± 0.05	3.188LeuAsn: 3.188 ± 0.053	5.402LeuPro: 5.402 ± 0.073	3.194LeuGln: 3.194 ± 0.054	6.76LeuArg: 6.76 ± 0.078	7.026LeuSer: 7.026 ± 0.094	6.254LeuThr: 6.254 ± 0.085	6.545LeuVal: 6.545 ± 0.09	1.168LeuTrp: 1.168 ± 0.037	1.97LeuTyr: 1.97 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	3.428MetAla: 3.428 ± 0.053	0.204MetCys: 0.204 ± 0.013	1.499MetAsp: 1.499 ± 0.039	1.382MetGlu: 1.382 ± 0.038	0.872MetPhe: 0.872 ± 0.028	2.332MetGly: 2.332 ± 0.045	0.498MetHis: 0.498 ± 0.021	1.746MetIle: 1.746 ± 0.037	1.256MetLys: 1.256 ± 0.038	2.744MetLeu: 2.744 ± 0.053	0.841MetMet: 0.841 ± 0.028	0.958MetAsn: 0.958 ± 0.03	1.523MetPro: 1.523 ± 0.033	1.127MetGln: 1.127 ± 0.031	1.843MetArg: 1.843 ± 0.041	1.833MetSer: 1.833 ± 0.043	2.228MetThr: 2.228 ± 0.041	2.054MetVal: 2.054 ± 0.048	0.277MetTrp: 0.277 ± 0.016	0.356MetTyr: 0.356 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.325AsnAla: 3.325 ± 0.061	0.285AsnCys: 0.285 ± 0.018	1.791AsnAsp: 1.791 ± 0.051	1.338AsnGlu: 1.338 ± 0.038	1.031AsnPhe: 1.031 ± 0.028	2.721AsnGly: 2.721 ± 0.061	0.544AsnHis: 0.544 ± 0.02	1.527AsnIle: 1.527 ± 0.032	0.841AsnLys: 0.841 ± 0.027	2.789AsnLeu: 2.789 ± 0.044	0.83AsnMet: 0.83 ± 0.029	0.749AsnAsn: 0.749 ± 0.025	1.906AsnPro: 1.906 ± 0.044	0.845AsnGln: 0.845 ± 0.032	1.848AsnArg: 1.848 ± 0.042	1.369AsnSer: 1.369 ± 0.037	1.502AsnThr: 1.502 ± 0.041	1.991AsnVal: 1.991 ± 0.045	0.484AsnTrp: 0.484 ± 0.022	0.709AsnTyr: 0.709 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.055ProAla: 5.055 ± 0.068	0.35ProCys: 0.35 ± 0.017	4.05ProAsp: 4.05 ± 0.064	3.845ProGlu: 3.845 ± 0.072	1.912ProPhe: 1.912 ± 0.04	4.198ProGly: 4.198 ± 0.06	1.026ProHis: 1.026 ± 0.031	2.345ProIle: 2.345 ± 0.041	1.864ProLys: 1.864 ± 0.048	4.39ProLeu: 4.39 ± 0.061	1.329ProMet: 1.329 ± 0.036	1.38ProAsn: 1.38 ± 0.033	1.984ProPro: 1.984 ± 0.044	1.822ProGln: 1.822 ± 0.037	2.468ProArg: 2.468 ± 0.05	2.423ProSer: 2.423 ± 0.052	2.357ProThr: 2.357 ± 0.047	4.414ProVal: 4.414 ± 0.066	0.606ProTrp: 0.606 ± 0.024	1.165ProTyr: 1.165 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.31GlnAla: 4.31 ± 0.056	0.224GlnCys: 0.224 ± 0.016	2.02GlnAsp: 2.02 ± 0.042	1.523GlnGlu: 1.523 ± 0.04	1.166GlnPhe: 1.166 ± 0.036	2.734GlnGly: 2.734 ± 0.05	0.646GlnHis: 0.646 ± 0.025	2.274GlnIle: 2.274 ± 0.045	1.28GlnLys: 1.28 ± 0.038	3.134GlnLeu: 3.134 ± 0.055	1.183GlnMet: 1.183 ± 0.035	1.067GlnAsn: 1.067 ± 0.027	1.708GlnPro: 1.708 ± 0.035	1.379GlnGln: 1.379 ± 0.038	2.213GlnArg: 2.213 ± 0.045	2.031GlnSer: 2.031 ± 0.047	2.009GlnThr: 2.009 ± 0.05	2.565GlnVal: 2.565 ± 0.047	0.426GlnTrp: 0.426 ± 0.018	0.618GlnTyr: 0.618 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.896ArgAla: 6.896 ± 0.088	0.494ArgCys: 0.494 ± 0.021	4.324ArgAsp: 4.324 ± 0.067	3.361ArgGlu: 3.361 ± 0.062	2.665ArgPhe: 2.665 ± 0.047	4.247ArgGly: 4.247 ± 0.059	1.462ArgHis: 1.462 ± 0.037	3.873ArgIle: 3.873 ± 0.07	2.475ArgLys: 2.475 ± 0.053	6.865ArgLeu: 6.865 ± 0.098	2.005ArgMet: 2.005 ± 0.041	1.924ArgAsn: 1.924 ± 0.043	2.958ArgPro: 2.958 ± 0.05	2.388ArgGln: 2.388 ± 0.045	4.389ArgArg: 4.389 ± 0.079	3.256ArgSer: 3.256 ± 0.05	2.7ArgThr: 2.7 ± 0.055	4.342ArgVal: 4.342 ± 0.063	0.852ArgTrp: 0.852 ± 0.026	1.492ArgTyr: 1.492 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.676SerAla: 5.676 ± 0.08	0.476SerCys: 0.476 ± 0.022	3.686SerAsp: 3.686 ± 0.056	3.043SerGlu: 3.043 ± 0.057	2.332SerPhe: 2.332 ± 0.045	5.548SerGly: 5.548 ± 0.078	1.129SerHis: 1.129 ± 0.03	2.632SerIle: 2.632 ± 0.054	1.786SerLys: 1.786 ± 0.044	5.045SerLeu: 5.045 ± 0.075	1.495SerMet: 1.495 ± 0.033	1.612SerAsn: 1.612 ± 0.038	2.455SerPro: 2.455 ± 0.041	1.778SerGln: 1.778 ± 0.039	3.152SerArg: 3.152 ± 0.049	2.842SerSer: 2.842 ± 0.061	2.631SerThr: 2.631 ± 0.06	3.986SerVal: 3.986 ± 0.061	0.678SerTrp: 0.678 ± 0.023	1.377SerTyr: 1.377 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.168ThrAla: 6.168 ± 0.085	0.474ThrCys: 0.474 ± 0.021	3.38ThrAsp: 3.38 ± 0.055	3.167ThrGlu: 3.167 ± 0.058	1.92ThrPhe: 1.92 ± 0.049	5.54ThrGly: 5.54 ± 0.077	1.117ThrHis: 1.117 ± 0.033	2.854ThrIle: 2.854 ± 0.047	1.72ThrLys: 1.72 ± 0.04	6.106ThrLeu: 6.106 ± 0.084	1.378ThrMet: 1.378 ± 0.034	1.337ThrAsn: 1.337 ± 0.034	3.163ThrPro: 3.163 ± 0.047	1.68ThrGln: 1.68 ± 0.04	3.377ThrArg: 3.377 ± 0.066	2.714ThrSer: 2.714 ± 0.048	2.878ThrThr: 2.878 ± 0.058	4.274ThrVal: 4.274 ± 0.072	0.632ThrTrp: 0.632 ± 0.028	1.23ThrTyr: 1.23 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.411ValAla: 8.411 ± 0.106	0.636ValCys: 0.636 ± 0.024	4.206ValAsp: 4.206 ± 0.069	4.412ValGlu: 4.412 ± 0.073	2.875ValPhe: 2.875 ± 0.055	5.207ValGly: 5.207 ± 0.069	1.26ValHis: 1.26 ± 0.036	4.36ValIle: 4.36 ± 0.062	2.441ValLys: 2.441 ± 0.055	7.687ValLeu: 7.687 ± 0.092	2.162ValMet: 2.162 ± 0.039	2.056ValAsn: 2.056 ± 0.042	3.491ValPro: 3.491 ± 0.051	2.319ValGln: 2.319 ± 0.042	3.926ValArg: 3.926 ± 0.06	4.3ValSer: 4.3 ± 0.07	4.49ValThr: 4.49 ± 0.075	5.583ValVal: 5.583 ± 0.082	0.902ValTrp: 0.902 ± 0.032	1.407ValTyr: 1.407 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.366TrpAla: 1.366 ± 0.036	0.136TrpCys: 0.136 ± 0.011	0.79TrpAsp: 0.79 ± 0.03	0.562TrpGlu: 0.562 ± 0.024	0.559TrpPhe: 0.559 ± 0.019	0.964TrpGly: 0.964 ± 0.033	0.315TrpHis: 0.315 ± 0.014	0.74TrpIle: 0.74 ± 0.026	0.502TrpLys: 0.502 ± 0.02	1.535TrpLeu: 1.535 ± 0.044	0.441TrpMet: 0.441 ± 0.021	0.427TrpAsn: 0.427 ± 0.018	0.684TrpPro: 0.684 ± 0.02	0.606TrpGln: 0.606 ± 0.024	0.981TrpArg: 0.981 ± 0.029	0.714TrpSer: 0.714 ± 0.022	0.745TrpThr: 0.745 ± 0.026	0.905TrpVal: 0.905 ± 0.03	0.196TrpTrp: 0.196 ± 0.013	0.269TrpTyr: 0.269 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.398TyrAla: 2.398 ± 0.045	0.266TyrCys: 0.266 ± 0.014	1.701TyrAsp: 1.701 ± 0.042	1.249TyrGlu: 1.249 ± 0.034	0.924TyrPhe: 0.924 ± 0.029	2.163TyrGly: 2.163 ± 0.044	0.559TyrHis: 0.559 ± 0.024	0.984TyrIle: 0.984 ± 0.03	0.632TyrLys: 0.632 ± 0.024	2.326TyrLeu: 2.326 ± 0.047	0.508TyrMet: 0.508 ± 0.02	0.638TyrAsn: 0.638 ± 0.021	1.087TyrPro: 1.087 ± 0.031	0.788TyrGln: 0.788 ± 0.026	1.483TyrArg: 1.483 ± 0.035	1.294TyrSer: 1.294 ± 0.035	1.119TyrThr: 1.119 ± 0.03	1.537TyrVal: 1.537 ± 0.035	0.387TyrTrp: 0.387 ± 0.019	0.611TyrTyr: 0.611 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3764 proteins (1164479 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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