Amino acid dipepetide frequency for Natranaerobius trueperi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.575AlaAla: 3.575 ± 0.097
0.623AlaCys: 0.623 ± 0.035
2.768AlaAsp: 2.768 ± 0.07
3.598AlaGlu: 3.598 ± 0.074
2.426AlaPhe: 2.426 ± 0.065
4.265AlaGly: 4.265 ± 0.093
1.027AlaHis: 1.027 ± 0.042
5.204AlaIle: 5.204 ± 0.105
4.044AlaLys: 4.044 ± 0.078
5.96AlaLeu: 5.96 ± 0.107
1.464AlaMet: 1.464 ± 0.045
2.479AlaAsn: 2.479 ± 0.065
1.729AlaPro: 1.729 ± 0.052
1.653AlaGln: 1.653 ± 0.047
2.355AlaArg: 2.355 ± 0.064
3.678AlaSer: 3.678 ± 0.076
2.817AlaThr: 2.817 ± 0.062
4.035AlaVal: 4.035 ± 0.089
0.365AlaTrp: 0.365 ± 0.023
1.817AlaTyr: 1.817 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.027
0.123CysCys: 0.123 ± 0.015
0.553CysAsp: 0.553 ± 0.028
0.656CysGlu: 0.656 ± 0.035
0.324CysPhe: 0.324 ± 0.02
0.83CysGly: 0.83 ± 0.036
0.22CysHis: 0.22 ± 0.018
0.617CysIle: 0.617 ± 0.034
0.63CysLys: 0.63 ± 0.031
0.733CysLeu: 0.733 ± 0.033
0.201CysMet: 0.201 ± 0.017
0.501CysAsn: 0.501 ± 0.028
0.473CysPro: 0.473 ± 0.03
0.293CysGln: 0.293 ± 0.02
0.3CysArg: 0.3 ± 0.021
0.586CysSer: 0.586 ± 0.03
0.433CysThr: 0.433 ± 0.024
0.509CysVal: 0.509 ± 0.028
0.055CysTrp: 0.055 ± 0.009
0.37CysTyr: 0.37 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.624AspAla: 2.624 ± 0.072
0.488AspCys: 0.488 ± 0.027
3.384AspAsp: 3.384 ± 0.104
5.36AspGlu: 5.36 ± 0.123
2.6AspPhe: 2.6 ± 0.059
3.542AspGly: 3.542 ± 0.095
1.073AspHis: 1.073 ± 0.039
5.465AspIle: 5.465 ± 0.089
4.695AspLys: 4.695 ± 0.093
6.088AspLeu: 6.088 ± 0.1
1.357AspMet: 1.357 ± 0.05
3.171AspAsn: 3.171 ± 0.07
2.077AspPro: 2.077 ± 0.061
1.759AspGln: 1.759 ± 0.056
2.315AspArg: 2.315 ± 0.062
3.193AspSer: 3.193 ± 0.066
2.712AspThr: 2.712 ± 0.069
3.685AspVal: 3.685 ± 0.082
0.46AspTrp: 0.46 ± 0.029
2.561AspTyr: 2.561 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.403GluAla: 4.403 ± 0.087
0.48GluCys: 0.48 ± 0.03
4.889GluAsp: 4.889 ± 0.128
8.041GluGlu: 8.041 ± 0.149
2.878GluPhe: 2.878 ± 0.071
4.626GluGly: 4.626 ± 0.104
1.346GluHis: 1.346 ± 0.045
6.937GluIle: 6.937 ± 0.114
7.396GluLys: 7.396 ± 0.13
8.612GluLeu: 8.612 ± 0.117
2.0GluMet: 2.0 ± 0.055
4.737GluAsn: 4.737 ± 0.094
2.162GluPro: 2.162 ± 0.061
3.098GluGln: 3.098 ± 0.066
3.35GluArg: 3.35 ± 0.076
3.962GluSer: 3.962 ± 0.076
3.862GluThr: 3.862 ± 0.085
5.915GluVal: 5.915 ± 0.089
0.617GluTrp: 0.617 ± 0.029
2.685GluTyr: 2.685 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.214PheAla: 2.214 ± 0.068
0.372PheCys: 0.372 ± 0.024
2.563PheAsp: 2.563 ± 0.059
2.981PheGlu: 2.981 ± 0.069
2.164PhePhe: 2.164 ± 0.07
3.005PheGly: 3.005 ± 0.078
0.711PheHis: 0.711 ± 0.032
3.541PheIle: 3.541 ± 0.079
2.709PheLys: 2.709 ± 0.06
4.353PheLeu: 4.353 ± 0.107
0.979PheMet: 0.979 ± 0.037
2.227PheAsn: 2.227 ± 0.056
1.456PhePro: 1.456 ± 0.04
1.242PheGln: 1.242 ± 0.042
1.454PheArg: 1.454 ± 0.048
3.216PheSer: 3.216 ± 0.065
2.321PheThr: 2.321 ± 0.055
2.714PheVal: 2.714 ± 0.079
0.386PheTrp: 0.386 ± 0.027
1.642PheTyr: 1.642 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.444GlyAla: 4.444 ± 0.111
0.822GlyCys: 0.822 ± 0.037
3.455GlyAsp: 3.455 ± 0.077
5.151GlyGlu: 5.151 ± 0.094
3.164GlyPhe: 3.164 ± 0.078
4.848GlyGly: 4.848 ± 0.109
1.168GlyHis: 1.168 ± 0.048
6.041GlyIle: 6.041 ± 0.115
4.775GlyLys: 4.775 ± 0.071
6.574GlyLeu: 6.574 ± 0.101
1.803GlyMet: 1.803 ± 0.052
2.744GlyAsn: 2.744 ± 0.061
1.773GlyPro: 1.773 ± 0.05
1.801GlyGln: 1.801 ± 0.056
2.573GlyArg: 2.573 ± 0.074
3.772GlySer: 3.772 ± 0.089
3.76GlyThr: 3.76 ± 0.074
5.28GlyVal: 5.28 ± 0.091
0.509GlyTrp: 0.509 ± 0.027
2.963GlyTyr: 2.963 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
0.853HisAla: 0.853 ± 0.034
0.172HisCys: 0.172 ± 0.015
0.989HisAsp: 0.989 ± 0.039
1.213HisGlu: 1.213 ± 0.039
0.764HisPhe: 0.764 ± 0.035
1.244HisGly: 1.244 ± 0.045
0.449HisHis: 0.449 ± 0.027
1.36HisIle: 1.36 ± 0.046
1.116HisLys: 1.116 ± 0.031
1.812HisLeu: 1.812 ± 0.048
0.379HisMet: 0.379 ± 0.023
0.888HisAsn: 0.888 ± 0.034
0.994HisPro: 0.994 ± 0.035
0.611HisGln: 0.611 ± 0.027
0.682HisArg: 0.682 ± 0.032
1.085HisSer: 1.085 ± 0.041
0.843HisThr: 0.843 ± 0.036
0.989HisVal: 0.989 ± 0.043
0.16HisTrp: 0.16 ± 0.014
0.693HisTyr: 0.693 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.212IleAla: 5.212 ± 0.1
0.725IleCys: 0.725 ± 0.035
5.252IleAsp: 5.252 ± 0.104
6.532IleGlu: 6.532 ± 0.112
3.551IlePhe: 3.551 ± 0.092
5.658IleGly: 5.658 ± 0.11
1.258IleHis: 1.258 ± 0.04
7.024IleIle: 7.024 ± 0.129
6.068IleLys: 6.068 ± 0.1
7.648IleLeu: 7.648 ± 0.145
1.864IleMet: 1.864 ± 0.055
4.556IleAsn: 4.556 ± 0.097
3.312IlePro: 3.312 ± 0.071
2.237IleGln: 2.237 ± 0.061
3.074IleArg: 3.074 ± 0.069
6.236IleSer: 6.236 ± 0.088
5.137IleThr: 5.137 ± 0.094
5.435IleVal: 5.435 ± 0.095
0.537IleTrp: 0.537 ± 0.026
2.788IleTyr: 2.788 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.41LysAla: 4.41 ± 0.079
0.558LysCys: 0.558 ± 0.031
4.907LysAsp: 4.907 ± 0.08
8.372LysGlu: 8.372 ± 0.146
2.366LysPhe: 2.366 ± 0.064
4.471LysGly: 4.471 ± 0.071
1.282LysHis: 1.282 ± 0.044
5.914LysIle: 5.914 ± 0.106
6.777LysLys: 6.777 ± 0.129
6.999LysLeu: 6.999 ± 0.114
1.658LysMet: 1.658 ± 0.044
4.333LysAsn: 4.333 ± 0.076
2.209LysPro: 2.209 ± 0.051
2.83LysGln: 2.83 ± 0.064
3.244LysArg: 3.244 ± 0.074
4.1LysSer: 4.1 ± 0.086
4.054LysThr: 4.054 ± 0.089
5.212LysVal: 5.212 ± 0.089
0.548LysTrp: 0.548 ± 0.028
2.638LysTyr: 2.638 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
6.074LeuAla: 6.074 ± 0.11
0.711LeuCys: 0.711 ± 0.028
6.057LeuAsp: 6.057 ± 0.105
8.063LeuGlu: 8.063 ± 0.131
4.046LeuPhe: 4.046 ± 0.099
7.246LeuGly: 7.246 ± 0.115
1.493LeuHis: 1.493 ± 0.045
8.051LeuIle: 8.051 ± 0.13
7.648LeuLys: 7.648 ± 0.122
9.513LeuLeu: 9.513 ± 0.169
2.178LeuMet: 2.178 ± 0.058
5.046LeuAsn: 5.046 ± 0.101
3.72LeuPro: 3.72 ± 0.072
3.021LeuGln: 3.021 ± 0.063
3.398LeuArg: 3.398 ± 0.063
6.855LeuSer: 6.855 ± 0.104
5.65LeuThr: 5.65 ± 0.089
6.665LeuVal: 6.665 ± 0.113
0.639LeuTrp: 0.639 ± 0.034
2.984LeuTyr: 2.984 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.631MetAla: 1.631 ± 0.053
0.188MetCys: 0.188 ± 0.016
1.332MetAsp: 1.332 ± 0.042
1.583MetGlu: 1.583 ± 0.05
0.907MetPhe: 0.907 ± 0.033
1.847MetGly: 1.847 ± 0.058
0.28MetHis: 0.28 ± 0.019
1.914MetIle: 1.914 ± 0.053
1.843MetLys: 1.843 ± 0.052
2.111MetLeu: 2.111 ± 0.055
0.555MetMet: 0.555 ± 0.03
1.191MetAsn: 1.191 ± 0.038
0.724MetPro: 0.724 ± 0.034
0.634MetGln: 0.634 ± 0.031
0.89MetArg: 0.89 ± 0.035
1.642MetSer: 1.642 ± 0.043
1.488MetThr: 1.488 ± 0.058
1.723MetVal: 1.723 ± 0.05
0.143MetTrp: 0.143 ± 0.013
0.712MetTyr: 0.712 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.291AsnAla: 2.291 ± 0.058
0.529AsnCys: 0.529 ± 0.029
2.782AsnAsp: 2.782 ± 0.073
3.985AsnGlu: 3.985 ± 0.084
2.36AsnPhe: 2.36 ± 0.056
2.478AsnGly: 2.478 ± 0.062
1.062AsnHis: 1.062 ± 0.037
4.681AsnIle: 4.681 ± 0.079
4.318AsnLys: 4.318 ± 0.086
5.464AsnLeu: 5.464 ± 0.095
1.299AsnMet: 1.299 ± 0.044
3.239AsnAsn: 3.239 ± 0.088
1.989AsnPro: 1.989 ± 0.06
2.039AsnGln: 2.039 ± 0.066
2.169AsnArg: 2.169 ± 0.06
3.042AsnSer: 3.042 ± 0.073
2.642AsnThr: 2.642 ± 0.061
3.075AsnVal: 3.075 ± 0.066
0.488AsnTrp: 0.488 ± 0.029
2.24AsnTyr: 2.24 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.642ProAla: 1.642 ± 0.057
0.314ProCys: 0.314 ± 0.022
2.134ProAsp: 2.134 ± 0.063
3.028ProGlu: 3.028 ± 0.069
1.59ProPhe: 1.59 ± 0.054
2.562ProGly: 2.562 ± 0.061
0.768ProHis: 0.768 ± 0.033
2.883ProIle: 2.883 ± 0.067
2.507ProLys: 2.507 ± 0.063
3.136ProLeu: 3.136 ± 0.074
0.724ProMet: 0.724 ± 0.034
1.721ProAsn: 1.721 ± 0.048
1.122ProPro: 1.122 ± 0.049
1.105ProGln: 1.105 ± 0.042
1.132ProArg: 1.132 ± 0.038
2.077ProSer: 2.077 ± 0.056
1.822ProThr: 1.822 ± 0.05
2.67ProVal: 2.67 ± 0.061
0.257ProTrp: 0.257 ± 0.019
1.322ProTyr: 1.322 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.795GlnAla: 1.795 ± 0.058
0.217GlnCys: 0.217 ± 0.017
1.917GlnAsp: 1.917 ± 0.059
2.956GlnGlu: 2.956 ± 0.058
1.125GlnPhe: 1.125 ± 0.035
2.283GlnGly: 2.283 ± 0.07
0.45GlnHis: 0.45 ± 0.028
2.68GlnIle: 2.68 ± 0.061
2.799GlnLys: 2.799 ± 0.06
3.173GlnLeu: 3.173 ± 0.069
0.767GlnMet: 0.767 ± 0.038
1.792GlnAsn: 1.792 ± 0.051
0.811GlnPro: 0.811 ± 0.032
1.179GlnGln: 1.179 ± 0.07
1.17GlnArg: 1.17 ± 0.041
1.572GlnSer: 1.572 ± 0.049
1.516GlnThr: 1.516 ± 0.047
2.641GlnVal: 2.641 ± 0.051
0.224GlnTrp: 0.224 ± 0.02
0.956GlnTyr: 0.956 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.133ArgAla: 2.133 ± 0.053
0.344ArgCys: 0.344 ± 0.021
2.291ArgAsp: 2.291 ± 0.064
3.366ArgGlu: 3.366 ± 0.074
1.559ArgPhe: 1.559 ± 0.049
2.505ArgGly: 2.505 ± 0.06
0.656ArgHis: 0.656 ± 0.027
3.026ArgIle: 3.026 ± 0.061
3.224ArgLys: 3.224 ± 0.068
3.708ArgLeu: 3.708 ± 0.079
0.963ArgMet: 0.963 ± 0.039
1.896ArgAsn: 1.896 ± 0.057
1.311ArgPro: 1.311 ± 0.043
1.254ArgGln: 1.254 ± 0.042
1.66ArgArg: 1.66 ± 0.048
2.112ArgSer: 2.112 ± 0.055
1.847ArgThr: 1.847 ± 0.05
2.788ArgVal: 2.788 ± 0.066
0.302ArgTrp: 0.302 ± 0.023
1.46ArgTyr: 1.46 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.011SerAla: 3.011 ± 0.074
0.625SerCys: 0.625 ± 0.03
3.561SerAsp: 3.561 ± 0.08
4.74SerGlu: 4.74 ± 0.092
3.067SerPhe: 3.067 ± 0.064
4.377SerGly: 4.377 ± 0.072
1.15SerHis: 1.15 ± 0.042
5.166SerIle: 5.166 ± 0.088
4.907SerLys: 4.907 ± 0.085
6.406SerLeu: 6.406 ± 0.109
1.397SerMet: 1.397 ± 0.043
3.244SerAsn: 3.244 ± 0.078
2.242SerPro: 2.242 ± 0.061
2.157SerGln: 2.157 ± 0.048
2.394SerArg: 2.394 ± 0.059
4.096SerSer: 4.096 ± 0.088
3.074SerThr: 3.074 ± 0.068
3.847SerVal: 3.847 ± 0.081
0.515SerTrp: 0.515 ± 0.026
2.362SerTyr: 2.362 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
3.012ThrAla: 3.012 ± 0.059
0.45ThrCys: 0.45 ± 0.026
2.908ThrAsp: 2.908 ± 0.063
3.841ThrGlu: 3.841 ± 0.081
2.307ThrPhe: 2.307 ± 0.065
4.141ThrGly: 4.141 ± 0.083
0.94ThrHis: 0.94 ± 0.032
4.332ThrIle: 4.332 ± 0.08
3.772ThrLys: 3.772 ± 0.084
5.194ThrLeu: 5.194 ± 0.095
1.184ThrMet: 1.184 ± 0.042
2.664ThrAsn: 2.664 ± 0.063
2.277ThrPro: 2.277 ± 0.062
1.543ThrGln: 1.543 ± 0.041
1.935ThrArg: 1.935 ± 0.054
3.392ThrSer: 3.392 ± 0.073
3.023ThrThr: 3.023 ± 0.083
3.856ThrVal: 3.856 ± 0.077
0.411ThrTrp: 0.411 ± 0.022
1.733ThrTyr: 1.733 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.173ValAla: 4.173 ± 0.09
0.642ValCys: 0.642 ± 0.033
4.326ValAsp: 4.326 ± 0.084
5.276ValGlu: 5.276 ± 0.1
2.85ValPhe: 2.85 ± 0.055
4.723ValGly: 4.723 ± 0.101
0.966ValHis: 0.966 ± 0.033
6.057ValIle: 6.057 ± 0.101
4.685ValLys: 4.685 ± 0.09
6.699ValLeu: 6.699 ± 0.119
1.618ValMet: 1.618 ± 0.053
3.385ValAsn: 3.385 ± 0.06
2.505ValPro: 2.505 ± 0.062
1.728ValGln: 1.728 ± 0.05
2.461ValArg: 2.461 ± 0.055
5.011ValSer: 5.011 ± 0.087
3.962ValThr: 3.962 ± 0.082
5.032ValVal: 5.032 ± 0.104
0.386ValTrp: 0.386 ± 0.02
2.154ValTyr: 2.154 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.408TrpAla: 0.408 ± 0.027
0.07TrpCys: 0.07 ± 0.009
0.489TrpAsp: 0.489 ± 0.029
0.621TrpGlu: 0.621 ± 0.034
0.328TrpPhe: 0.328 ± 0.023
0.489TrpGly: 0.489 ± 0.025
0.137TrpHis: 0.137 ± 0.013
0.588TrpIle: 0.588 ± 0.028
0.538TrpLys: 0.538 ± 0.025
0.781TrpLeu: 0.781 ± 0.036
0.194TrpMet: 0.194 ± 0.017
0.369TrpAsn: 0.369 ± 0.027
0.24TrpPro: 0.24 ± 0.02
0.236TrpGln: 0.236 ± 0.018
0.303TrpArg: 0.303 ± 0.021
0.414TrpSer: 0.414 ± 0.023
0.302TrpThr: 0.302 ± 0.02
0.56TrpVal: 0.56 ± 0.036
0.084TrpTrp: 0.084 ± 0.011
0.266TrpTyr: 0.266 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.564TyrAla: 1.564 ± 0.055
0.366TyrCys: 0.366 ± 0.023
2.05TyrAsp: 2.05 ± 0.054
2.632TyrGlu: 2.632 ± 0.069
1.875TyrPhe: 1.875 ± 0.056
2.28TyrGly: 2.28 ± 0.055
0.858TyrHis: 0.858 ± 0.034
2.624TyrIle: 2.624 ± 0.07
2.429TyrLys: 2.429 ± 0.07
4.095TyrLeu: 4.095 ± 0.094
0.756TyrMet: 0.756 ± 0.03
1.989TyrAsn: 1.989 ± 0.057
1.391TyrPro: 1.391 ± 0.051
1.607TyrGln: 1.607 ± 0.047
1.545TyrArg: 1.545 ± 0.05
2.294TyrSer: 2.294 ± 0.058
1.653TyrThr: 1.653 ± 0.056
2.007TyrVal: 2.007 ± 0.052
0.332TyrTrp: 0.332 ± 0.023
1.576TyrTyr: 1.576 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2464 proteins (713096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski