Amino acid dipepetide frequency for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.919AlaAla: 6.919 ± 0.053	1.438AlaCys: 1.438 ± 0.014	2.855AlaAsp: 2.855 ± 0.018	4.748AlaGlu: 4.748 ± 0.025	2.768AlaPhe: 2.768 ± 0.019	4.821AlaGly: 4.821 ± 0.03	1.593AlaHis: 1.593 ± 0.014	2.769AlaIle: 2.769 ± 0.022	3.388AlaLys: 3.388 ± 0.022	7.195AlaLeu: 7.195 ± 0.04	1.488AlaMet: 1.488 ± 0.012	1.969AlaAsn: 1.969 ± 0.014	4.247AlaPro: 4.247 ± 0.037	3.234AlaGln: 3.234 ± 0.025	3.707AlaArg: 3.707 ± 0.021	5.705AlaSer: 5.705 ± 0.027	3.595AlaThr: 3.595 ± 0.025	4.73AlaVal: 4.73 ± 0.026	0.841AlaTrp: 0.841 ± 0.01	1.536AlaTyr: 1.536 ± 0.012	0.004AlaXaa: 0.004 ± 0.001
Cys	1.275CysAla: 1.275 ± 0.013	0.71CysCys: 0.71 ± 0.016	1.018CysAsp: 1.018 ± 0.014	1.324CysGlu: 1.324 ± 0.018	0.866CysPhe: 0.866 ± 0.009	1.94CysGly: 1.94 ± 0.025	0.693CysHis: 0.693 ± 0.01	0.958CysIle: 0.958 ± 0.011	1.211CysLys: 1.211 ± 0.015	2.247CysLeu: 2.247 ± 0.019	0.436CysMet: 0.436 ± 0.006	0.853CysAsn: 0.853 ± 0.013	1.432CysPro: 1.432 ± 0.019	1.105CysGln: 1.105 ± 0.014	1.332CysArg: 1.332 ± 0.016	2.042CysSer: 2.042 ± 0.019	1.119CysThr: 1.119 ± 0.014	1.332CysVal: 1.332 ± 0.016	0.307CysTrp: 0.307 ± 0.006	0.596CysTyr: 0.596 ± 0.009	0.001CysXaa: 0.001 ± 0.0
Asp	2.831AspAla: 2.831 ± 0.017	1.072AspCys: 1.072 ± 0.014	2.572AspAsp: 2.572 ± 0.025	3.38AspGlu: 3.38 ± 0.022	2.125AspPhe: 2.125 ± 0.017	3.251AspGly: 3.251 ± 0.031	1.129AspHis: 1.129 ± 0.01	2.556AspIle: 2.556 ± 0.019	2.483AspLys: 2.483 ± 0.017	4.915AspLeu: 4.915 ± 0.023	1.108AspMet: 1.108 ± 0.011	1.639AspAsn: 1.639 ± 0.016	2.877AspPro: 2.877 ± 0.017	1.786AspGln: 1.786 ± 0.013	2.369AspArg: 2.369 ± 0.018	4.101AspSer: 4.101 ± 0.026	2.416AspThr: 2.416 ± 0.016	3.024AspVal: 3.024 ± 0.02	0.62AspTrp: 0.62 ± 0.008	1.443AspTyr: 1.443 ± 0.012	0.001AspXaa: 0.001 ± 0.0
Glu	5.242GluAla: 5.242 ± 0.031	1.572GluCys: 1.572 ± 0.027	4.414GluAsp: 4.414 ± 0.026	7.938GluGlu: 7.938 ± 0.061	2.038GluPhe: 2.038 ± 0.015	4.136GluGly: 4.136 ± 0.023	1.509GluHis: 1.509 ± 0.013	3.101GluIle: 3.101 ± 0.022	5.498GluLys: 5.498 ± 0.039	6.394GluLeu: 6.394 ± 0.036	1.661GluMet: 1.661 ± 0.015	3.121GluAsn: 3.121 ± 0.025	3.238GluPro: 3.238 ± 0.028	3.099GluGln: 3.099 ± 0.024	3.959GluArg: 3.959 ± 0.03	4.325GluSer: 4.325 ± 0.027	3.359GluThr: 3.359 ± 0.022	4.151GluVal: 4.151 ± 0.024	0.718GluTrp: 0.718 ± 0.007	1.557GluTyr: 1.557 ± 0.016	0.002GluXaa: 0.002 ± 0.0
Phe	1.991PheAla: 1.991 ± 0.014	0.976PheCys: 0.976 ± 0.011	1.658PheAsp: 1.658 ± 0.012	1.998PheGlu: 1.998 ± 0.015	1.656PhePhe: 1.656 ± 0.016	2.238PheGly: 2.238 ± 0.018	1.079PheHis: 1.079 ± 0.011	1.842PheIle: 1.842 ± 0.015	1.805PheLys: 1.805 ± 0.016	4.168PheLeu: 4.168 ± 0.026	0.78PheMet: 0.78 ± 0.009	1.347PheAsn: 1.347 ± 0.012	2.05PhePro: 2.05 ± 0.014	1.83PheGln: 1.83 ± 0.015	2.004PheArg: 2.004 ± 0.019	3.514PheSer: 3.514 ± 0.022	2.06PheThr: 2.06 ± 0.014	2.131PheVal: 2.131 ± 0.016	0.505PheTrp: 0.505 ± 0.008	1.209PheTyr: 1.209 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	4.593GlyAla: 4.593 ± 0.033	1.347GlyCys: 1.347 ± 0.014	3.116GlyAsp: 3.116 ± 0.025	4.252GlyGlu: 4.252 ± 0.034	2.456GlyPhe: 2.456 ± 0.019	5.136GlyGly: 5.136 ± 0.047	1.726GlyHis: 1.726 ± 0.015	2.788GlyIle: 2.788 ± 0.02	3.944GlyLys: 3.944 ± 0.026	6.015GlyLeu: 6.015 ± 0.036	1.313GlyMet: 1.313 ± 0.013	2.338GlyAsn: 2.338 ± 0.017	4.331GlyPro: 4.331 ± 0.064	2.819GlyGln: 2.819 ± 0.026	3.795GlyArg: 3.795 ± 0.024	5.804GlySer: 5.804 ± 0.041	3.555GlyThr: 3.555 ± 0.022	3.557GlyVal: 3.557 ± 0.022	0.811GlyTrp: 0.811 ± 0.01	1.733GlyTyr: 1.733 ± 0.019	0.004GlyXaa: 0.004 ± 0.001
His	1.337HisAla: 1.337 ± 0.013	0.759HisCys: 0.759 ± 0.01	0.878HisAsp: 0.878 ± 0.008	1.33HisGlu: 1.33 ± 0.013	1.101HisPhe: 1.101 ± 0.009	1.581HisGly: 1.581 ± 0.02	0.925HisHis: 0.925 ± 0.012	1.24HisIle: 1.24 ± 0.01	1.31HisLys: 1.31 ± 0.013	2.99HisLeu: 2.99 ± 0.017	0.606HisMet: 0.606 ± 0.007	0.87HisAsn: 0.87 ± 0.009	1.695HisPro: 1.695 ± 0.015	1.426HisGln: 1.426 ± 0.022	1.628HisArg: 1.628 ± 0.015	2.33HisSer: 2.33 ± 0.018	1.715HisThr: 1.715 ± 0.024	1.484HisVal: 1.484 ± 0.011	0.36HisTrp: 0.36 ± 0.006	0.812HisTyr: 0.812 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	2.54IleAla: 2.54 ± 0.015	1.112IleCys: 1.112 ± 0.012	1.97IleAsp: 1.97 ± 0.016	2.518IleGlu: 2.518 ± 0.021	1.919IlePhe: 1.919 ± 0.016	2.207IleGly: 2.207 ± 0.018	1.489IleHis: 1.489 ± 0.017	2.378IleIle: 2.378 ± 0.02	2.582IleLys: 2.582 ± 0.024	4.602IleLeu: 4.602 ± 0.026	0.998IleMet: 0.998 ± 0.01	1.805IleAsn: 1.805 ± 0.015	2.618IlePro: 2.618 ± 0.021	2.265IleGln: 2.265 ± 0.015	2.374IleArg: 2.374 ± 0.015	3.683IleSer: 3.683 ± 0.02	2.529IleThr: 2.529 ± 0.022	2.475IleVal: 2.475 ± 0.018	0.518IleTrp: 0.518 ± 0.008	1.402IleTyr: 1.402 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	4.065LysAla: 4.065 ± 0.024	1.232LysCys: 1.232 ± 0.014	3.088LysAsp: 3.088 ± 0.024	5.112LysGlu: 5.112 ± 0.038	1.731LysPhe: 1.731 ± 0.015	3.225LysGly: 3.225 ± 0.032	1.425LysHis: 1.425 ± 0.013	2.799LysIle: 2.799 ± 0.023	4.731LysLys: 4.731 ± 0.038	5.112LysLeu: 5.112 ± 0.027	1.477LysMet: 1.477 ± 0.013	2.396LysAsn: 2.396 ± 0.018	3.222LysPro: 3.222 ± 0.027	2.587LysGln: 2.587 ± 0.021	3.29LysArg: 3.29 ± 0.02	3.879LysSer: 3.879 ± 0.025	3.095LysThr: 3.095 ± 0.02	3.437LysVal: 3.437 ± 0.025	0.603LysTrp: 0.603 ± 0.01	1.571LysTyr: 1.571 ± 0.015	0.002LysXaa: 0.002 ± 0.0
Leu	6.917LeuAla: 6.917 ± 0.033	2.256LeuCys: 2.256 ± 0.019	4.635LeuAsp: 4.635 ± 0.023	7.134LeuGlu: 7.134 ± 0.043	3.413LeuPhe: 3.413 ± 0.02	6.004LeuGly: 6.004 ± 0.034	2.758LeuHis: 2.758 ± 0.02	3.911LeuIle: 3.911 ± 0.024	5.728LeuLys: 5.728 ± 0.03	10.961LeuLeu: 10.961 ± 0.066	2.019LeuMet: 2.019 ± 0.016	3.488LeuAsn: 3.488 ± 0.021	6.084LeuPro: 6.084 ± 0.038	5.753LeuGln: 5.753 ± 0.038	5.951LeuArg: 5.951 ± 0.031	7.978LeuSer: 7.978 ± 0.041	5.094LeuThr: 5.094 ± 0.025	5.558LeuVal: 5.558 ± 0.028	1.186LeuTrp: 1.186 ± 0.014	2.567LeuTyr: 2.567 ± 0.016	0.004LeuXaa: 0.004 ± 0.001
Met	1.962MetAla: 1.962 ± 0.013	0.408MetCys: 0.408 ± 0.007	1.233MetAsp: 1.233 ± 0.011	1.855MetGlu: 1.855 ± 0.013	0.723MetPhe: 0.723 ± 0.008	1.31MetGly: 1.31 ± 0.012	0.474MetHis: 0.474 ± 0.007	0.841MetIle: 0.841 ± 0.009	1.449MetLys: 1.449 ± 0.012	1.986MetLeu: 1.986 ± 0.016	0.56MetMet: 0.56 ± 0.008	0.898MetAsn: 0.898 ± 0.01	1.099MetPro: 1.099 ± 0.013	0.907MetGln: 0.907 ± 0.009	1.056MetArg: 1.056 ± 0.01	1.561MetSer: 1.561 ± 0.014	1.117MetThr: 1.117 ± 0.011	1.367MetVal: 1.367 ± 0.012	0.25MetTrp: 0.25 ± 0.005	0.572MetTyr: 0.572 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	2.009AsnAla: 2.009 ± 0.014	0.845AsnCys: 0.845 ± 0.011	1.488AsnAsp: 1.488 ± 0.015	2.224AsnGlu: 2.224 ± 0.019	1.482AsnPhe: 1.482 ± 0.012	2.402AsnGly: 2.402 ± 0.022	0.954AsnHis: 0.954 ± 0.01	2.101AsnIle: 2.101 ± 0.015	2.189AsnLys: 2.189 ± 0.017	3.727AsnLeu: 3.727 ± 0.022	0.906AsnMet: 0.906 ± 0.009	1.522AsnAsn: 1.522 ± 0.014	2.166AsnPro: 2.166 ± 0.015	1.634AsnGln: 1.634 ± 0.014	1.82AsnArg: 1.82 ± 0.014	3.068AsnSer: 3.068 ± 0.02	1.92AsnThr: 1.92 ± 0.017	2.161AsnVal: 2.161 ± 0.015	0.452AsnTrp: 0.452 ± 0.006	1.122AsnTyr: 1.122 ± 0.011	0.001AsnXaa: 0.001 ± 0.0
Pro	4.908ProAla: 4.908 ± 0.039	1.182ProCys: 1.182 ± 0.016	2.759ProAsp: 2.759 ± 0.018	4.462ProGlu: 4.462 ± 0.029	1.958ProPhe: 1.958 ± 0.015	5.419ProGly: 5.419 ± 0.089	1.467ProHis: 1.467 ± 0.014	1.904ProIle: 1.904 ± 0.016	2.789ProLys: 2.789 ± 0.026	5.275ProLeu: 5.275 ± 0.031	1.045ProMet: 1.045 ± 0.011	1.793ProAsn: 1.793 ± 0.014	5.995ProPro: 5.995 ± 0.073	2.838ProGln: 2.838 ± 0.026	3.442ProArg: 3.442 ± 0.025	5.604ProSer: 5.604 ± 0.037	3.077ProThr: 3.077 ± 0.027	3.783ProVal: 3.783 ± 0.025	0.728ProTrp: 0.728 ± 0.009	1.628ProTyr: 1.628 ± 0.02	0.004ProXaa: 0.004 ± 0.001
Gln	3.504GlnAla: 3.504 ± 0.028	0.98GlnCys: 0.98 ± 0.014	2.311GlnAsp: 2.311 ± 0.014	3.92GlnGlu: 3.92 ± 0.029	1.365GlnPhe: 1.365 ± 0.012	2.874GlnGly: 2.874 ± 0.025	1.319GlnHis: 1.319 ± 0.016	1.974GlnIle: 1.974 ± 0.016	2.978GlnLys: 2.978 ± 0.02	4.733GlnLeu: 4.733 ± 0.028	1.111GlnMet: 1.111 ± 0.01	1.832GlnAsn: 1.832 ± 0.014	2.828GlnPro: 2.828 ± 0.028	3.011GlnGln: 3.011 ± 0.041	3.022GlnArg: 3.022 ± 0.022	3.067GlnSer: 3.067 ± 0.021	2.286GlnThr: 2.286 ± 0.015	2.802GlnVal: 2.802 ± 0.019	0.546GlnTrp: 0.546 ± 0.007	1.127GlnTyr: 1.127 ± 0.012	0.001GlnXaa: 0.001 ± 0.0
Arg	3.915ArgAla: 3.915 ± 0.025	1.242ArgCys: 1.242 ± 0.017	2.723ArgAsp: 2.723 ± 0.02	3.939ArgGlu: 3.939 ± 0.027	1.89ArgPhe: 1.89 ± 0.013	3.717ArgGly: 3.717 ± 0.029	1.599ArgHis: 1.599 ± 0.013	2.459ArgIle: 2.459 ± 0.017	3.685ArgLys: 3.685 ± 0.023	5.45ArgLeu: 5.45 ± 0.032	1.178ArgMet: 1.178 ± 0.012	2.118ArgAsn: 2.118 ± 0.016	3.287ArgPro: 3.287 ± 0.027	2.595ArgGln: 2.595 ± 0.019	4.394ArgArg: 4.394 ± 0.034	4.226ArgSer: 4.226 ± 0.035	2.804ArgThr: 2.804 ± 0.018	3.164ArgVal: 3.164 ± 0.021	0.71ArgTrp: 0.71 ± 0.009	1.441ArgTyr: 1.441 ± 0.012	0.003ArgXaa: 0.003 ± 0.0
Ser	5.277SerAla: 5.277 ± 0.027	1.919SerCys: 1.919 ± 0.02	3.757SerAsp: 3.757 ± 0.025	5.082SerGlu: 5.082 ± 0.03	3.089SerPhe: 3.089 ± 0.019	5.663SerGly: 5.663 ± 0.04	2.173SerHis: 2.173 ± 0.019	3.183SerIle: 3.183 ± 0.019	4.018SerLys: 4.018 ± 0.024	8.193SerLeu: 8.193 ± 0.036	1.599SerMet: 1.599 ± 0.013	2.655SerAsn: 2.655 ± 0.019	5.88SerPro: 5.88 ± 0.044	3.884SerGln: 3.884 ± 0.024	4.584SerArg: 4.584 ± 0.031	9.302SerSer: 9.302 ± 0.071	4.376SerThr: 4.376 ± 0.033	4.789SerVal: 4.789 ± 0.025	1.122SerTrp: 1.122 ± 0.012	2.094SerTyr: 2.094 ± 0.016	0.003SerXaa: 0.003 ± 0.001
Thr	3.753ThrAla: 3.753 ± 0.025	1.32ThrCys: 1.32 ± 0.019	2.392ThrAsp: 2.392 ± 0.014	3.458ThrGlu: 3.458 ± 0.021	2.129ThrPhe: 2.129 ± 0.014	3.663ThrGly: 3.663 ± 0.025	1.413ThrHis: 1.413 ± 0.017	2.355ThrIle: 2.355 ± 0.018	2.611ThrLys: 2.611 ± 0.022	5.288ThrLeu: 5.288 ± 0.025	1.102ThrMet: 1.102 ± 0.009	1.713ThrAsn: 1.713 ± 0.014	3.527ThrPro: 3.527 ± 0.03	2.304ThrGln: 2.304 ± 0.016	2.463ThrArg: 2.463 ± 0.016	4.559ThrSer: 4.559 ± 0.037	2.963ThrThr: 2.963 ± 0.034	3.785ThrVal: 3.785 ± 0.027	0.702ThrTrp: 0.702 ± 0.009	1.409ThrTyr: 1.409 ± 0.013	0.002ThrXaa: 0.002 ± 0.0
Val	4.3ValAla: 4.3 ± 0.026	1.487ValCys: 1.487 ± 0.015	2.89ValAsp: 2.89 ± 0.019	3.804ValGlu: 3.804 ± 0.024	2.439ValPhe: 2.439 ± 0.018	3.415ValGly: 3.415 ± 0.022	1.598ValHis: 1.598 ± 0.014	2.892ValIle: 2.892 ± 0.019	3.324ValLys: 3.324 ± 0.025	6.213ValLeu: 6.213 ± 0.029	1.316ValMet: 1.316 ± 0.011	2.202ValAsn: 2.202 ± 0.018	3.625ValPro: 3.625 ± 0.024	2.712ValGln: 2.712 ± 0.018	2.984ValArg: 2.984 ± 0.018	4.804ValSer: 4.804 ± 0.023	3.706ValThr: 3.706 ± 0.033	3.95ValVal: 3.95 ± 0.024	0.715ValTrp: 0.715 ± 0.01	1.62ValTyr: 1.62 ± 0.012	0.003ValXaa: 0.003 ± 0.0
Trp	0.821TrpAla: 0.821 ± 0.009	0.252TrpCys: 0.252 ± 0.005	0.67TrpAsp: 0.67 ± 0.009	0.828TrpGlu: 0.828 ± 0.009	0.45TrpPhe: 0.45 ± 0.007	0.759TrpGly: 0.759 ± 0.01	0.306TrpHis: 0.306 ± 0.006	0.558TrpIle: 0.558 ± 0.01	0.82TrpLys: 0.82 ± 0.009	1.239TrpLeu: 1.239 ± 0.014	0.313TrpMet: 0.313 ± 0.005	0.54TrpAsn: 0.54 ± 0.008	0.551TrpPro: 0.551 ± 0.009	0.542TrpGln: 0.542 ± 0.006	0.768TrpArg: 0.768 ± 0.009	0.906TrpSer: 0.906 ± 0.01	0.672TrpThr: 0.672 ± 0.01	0.719TrpVal: 0.719 ± 0.009	0.201TrpTrp: 0.201 ± 0.005	0.343TrpTyr: 0.343 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.392TyrAla: 1.392 ± 0.012	0.688TyrCys: 0.688 ± 0.009	1.271TyrAsp: 1.271 ± 0.014	1.725TyrGlu: 1.725 ± 0.017	1.239TyrPhe: 1.239 ± 0.012	1.673TyrGly: 1.673 ± 0.018	0.749TyrHis: 0.749 ± 0.008	1.374TyrIle: 1.374 ± 0.013	1.536TyrLys: 1.536 ± 0.017	2.69TyrLeu: 2.69 ± 0.018	0.606TyrMet: 0.606 ± 0.007	1.093TyrAsn: 1.093 ± 0.01	1.303TyrPro: 1.303 ± 0.012	1.259TyrGln: 1.259 ± 0.011	1.593TyrArg: 1.593 ± 0.012	2.183TyrSer: 2.183 ± 0.015	1.45TyrThr: 1.45 ± 0.014	1.594TyrVal: 1.594 ± 0.012	0.363TyrTrp: 0.363 ± 0.007	0.949TyrTyr: 0.949 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.004XaaLeu: 0.004 ± 0.001	0.005XaaMet: 0.005 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.003XaaArg: 0.003 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.215XaaXaa: 0.215 ± 0.018

Statistics based on 22970 proteins (11531378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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