Amino acid dipepetide frequency for Gossypium mustelinum (Cotton)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.101AlaAla: 6.101 ± 0.016	1.263AlaCys: 1.263 ± 0.006	3.042AlaAsp: 3.042 ± 0.009	4.135AlaGlu: 4.135 ± 0.014	2.761AlaPhe: 2.761 ± 0.011	3.881AlaGly: 3.881 ± 0.013	1.215AlaHis: 1.215 ± 0.005	3.776AlaIle: 3.776 ± 0.013	3.921AlaLys: 3.921 ± 0.012	6.502AlaLeu: 6.502 ± 0.018	1.78AlaMet: 1.78 ± 0.007	2.632AlaAsn: 2.632 ± 0.009	2.749AlaPro: 2.749 ± 0.01	2.051AlaGln: 2.051 ± 0.01	3.181AlaArg: 3.181 ± 0.01	5.966AlaSer: 5.966 ± 0.014	3.567AlaThr: 3.567 ± 0.009	4.663AlaVal: 4.663 ± 0.012	0.746AlaTrp: 0.746 ± 0.005	1.773AlaTyr: 1.773 ± 0.008	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.006	0.574CysCys: 0.574 ± 0.005	0.894CysAsp: 0.894 ± 0.005	0.921CysGlu: 0.921 ± 0.005	0.965CysPhe: 0.965 ± 0.005	1.384CysGly: 1.384 ± 0.007	0.484CysHis: 0.484 ± 0.004	1.03CysIle: 1.03 ± 0.006	1.221CysLys: 1.221 ± 0.007	2.009CysLeu: 2.009 ± 0.008	0.464CysMet: 0.464 ± 0.004	0.949CysAsn: 0.949 ± 0.006	0.962CysPro: 0.962 ± 0.006	0.627CysGln: 0.627 ± 0.004	1.067CysArg: 1.067 ± 0.005	1.933CysSer: 1.933 ± 0.009	0.84CysThr: 0.84 ± 0.006	1.023CysVal: 1.023 ± 0.006	0.262CysTrp: 0.262 ± 0.002	0.575CysTyr: 0.575 ± 0.004	0.0CysXaa: 0.0 ± 0.0
Asp	3.351AspAla: 3.351 ± 0.011	1.009AspCys: 1.009 ± 0.006	3.675AspAsp: 3.675 ± 0.015	4.001AspGlu: 4.001 ± 0.013	2.323AspPhe: 2.323 ± 0.008	3.723AspGly: 3.723 ± 0.011	1.212AspHis: 1.212 ± 0.006	3.062AspIle: 3.062 ± 0.009	2.781AspLys: 2.781 ± 0.009	5.047AspLeu: 5.047 ± 0.015	1.312AspMet: 1.312 ± 0.006	2.175AspAsn: 2.175 ± 0.008	2.581AspPro: 2.581 ± 0.01	1.735AspGln: 1.735 ± 0.007	2.288AspArg: 2.288 ± 0.009	4.213AspSer: 4.213 ± 0.011	2.159AspThr: 2.159 ± 0.008	3.533AspVal: 3.533 ± 0.01	0.703AspTrp: 0.703 ± 0.005	1.529AspTyr: 1.529 ± 0.006	0.0AspXaa: 0.0 ± 0.0
Glu	4.686GluAla: 4.686 ± 0.016	0.937GluCys: 0.937 ± 0.005	3.922GluAsp: 3.922 ± 0.015	6.138GluGlu: 6.138 ± 0.028	2.364GluPhe: 2.364 ± 0.008	3.648GluGly: 3.648 ± 0.01	1.247GluHis: 1.247 ± 0.007	3.769GluIle: 3.769 ± 0.012	4.868GluLys: 4.868 ± 0.019	6.016GluLeu: 6.016 ± 0.016	1.796GluMet: 1.796 ± 0.009	3.318GluAsn: 3.318 ± 0.012	2.177GluPro: 2.177 ± 0.009	2.224GluGln: 2.224 ± 0.008	3.337GluArg: 3.337 ± 0.011	4.61GluSer: 4.61 ± 0.014	3.239GluThr: 3.239 ± 0.014	4.096GluVal: 4.096 ± 0.013	0.728GluTrp: 0.728 ± 0.004	1.619GluTyr: 1.619 ± 0.007	0.0GluXaa: 0.0 ± 0.0
Phe	2.443PheAla: 2.443 ± 0.009	0.928PheCys: 0.928 ± 0.005	2.347PheAsp: 2.347 ± 0.009	2.306PheGlu: 2.306 ± 0.009	2.052PhePhe: 2.052 ± 0.008	3.082PheGly: 3.082 ± 0.013	1.153PheHis: 1.153 ± 0.006	2.186PheIle: 2.186 ± 0.007	2.225PheLys: 2.225 ± 0.008	4.351PheLeu: 4.351 ± 0.013	1.002PheMet: 1.002 ± 0.005	1.909PheAsn: 1.909 ± 0.008	2.199PhePro: 2.199 ± 0.008	1.613PheGln: 1.613 ± 0.006	2.031PheArg: 2.031 ± 0.009	4.209PheSer: 4.209 ± 0.011	2.015PheThr: 2.015 ± 0.009	2.66PheVal: 2.66 ± 0.008	0.586PheTrp: 0.586 ± 0.004	1.307PheTyr: 1.307 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	3.708GlyAla: 3.708 ± 0.013	1.346GlyCys: 1.346 ± 0.008	3.33GlyAsp: 3.33 ± 0.009	3.586GlyGlu: 3.586 ± 0.011	3.188GlyPhe: 3.188 ± 0.01	5.127GlyGly: 5.127 ± 0.028	1.509GlyHis: 1.509 ± 0.006	3.648GlyIle: 3.648 ± 0.011	4.161GlyLys: 4.161 ± 0.013	5.855GlyLeu: 5.855 ± 0.015	1.502GlyMet: 1.502 ± 0.007	3.345GlyAsn: 3.345 ± 0.011	2.406GlyPro: 2.406 ± 0.009	2.072GlyGln: 2.072 ± 0.01	3.427GlyArg: 3.427 ± 0.012	6.161GlySer: 6.161 ± 0.016	3.293GlyThr: 3.293 ± 0.011	4.02GlyVal: 4.02 ± 0.012	0.878GlyTrp: 0.878 ± 0.005	2.042GlyTyr: 2.042 ± 0.009	0.0GlyXaa: 0.0 ± 0.0
His	1.357HisAla: 1.357 ± 0.006	0.55HisCys: 0.55 ± 0.004	1.131HisAsp: 1.131 ± 0.006	1.286HisGlu: 1.286 ± 0.006	1.107HisPhe: 1.107 ± 0.005	1.723HisGly: 1.723 ± 0.008	1.009HisHis: 1.009 ± 0.008	1.209HisIle: 1.209 ± 0.006	1.186HisLys: 1.186 ± 0.006	2.473HisLeu: 2.473 ± 0.009	0.531HisMet: 0.531 ± 0.004	0.982HisAsn: 0.982 ± 0.006	1.408HisPro: 1.408 ± 0.006	1.058HisGln: 1.058 ± 0.005	1.365HisArg: 1.365 ± 0.006	1.949HisSer: 1.949 ± 0.008	0.905HisThr: 0.905 ± 0.005	1.513HisVal: 1.513 ± 0.007	0.317HisTrp: 0.317 ± 0.003	0.703HisTyr: 0.703 ± 0.004	0.0HisXaa: 0.0 ± 0.0
Ile	3.561IleAla: 3.561 ± 0.011	1.176IleCys: 1.176 ± 0.006	2.921IleAsp: 2.921 ± 0.009	3.314IleGlu: 3.314 ± 0.012	2.34IlePhe: 2.34 ± 0.009	3.43IleGly: 3.43 ± 0.014	1.298IleHis: 1.298 ± 0.005	2.872IleIle: 2.872 ± 0.008	3.071IleLys: 3.071 ± 0.01	5.19IleLeu: 5.19 ± 0.014	1.147IleMet: 1.147 ± 0.005	2.321IleAsn: 2.321 ± 0.008	3.014IlePro: 3.014 ± 0.011	2.016IleGln: 2.016 ± 0.008	2.607IleArg: 2.607 ± 0.01	4.981IleSer: 4.981 ± 0.012	2.588IleThr: 2.588 ± 0.009	3.426IleVal: 3.426 ± 0.012	0.713IleTrp: 0.713 ± 0.005	1.487IleTyr: 1.487 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	4.168LysAla: 4.168 ± 0.013	1.023LysCys: 1.023 ± 0.007	3.333LysAsp: 3.333 ± 0.012	4.822LysGlu: 4.822 ± 0.023	2.217LysPhe: 2.217 ± 0.008	3.783LysGly: 3.783 ± 0.011	1.429LysHis: 1.429 ± 0.006	3.274LysIle: 3.274 ± 0.01	4.826LysLys: 4.826 ± 0.018	6.237LysLeu: 6.237 ± 0.015	1.539LysMet: 1.539 ± 0.007	2.762LysAsn: 2.762 ± 0.009	2.91LysPro: 2.91 ± 0.012	2.48LysGln: 2.48 ± 0.008	3.661LysArg: 3.661 ± 0.012	4.744LysSer: 4.744 ± 0.013	2.97LysThr: 2.97 ± 0.009	3.938LysVal: 3.938 ± 0.011	0.802LysTrp: 0.802 ± 0.005	1.642LysTyr: 1.642 ± 0.007	0.0LysXaa: 0.0 ± 0.0
Leu	6.345LeuAla: 6.345 ± 0.015	1.853LeuCys: 1.853 ± 0.007	5.059LeuAsp: 5.059 ± 0.014	6.479LeuGlu: 6.479 ± 0.018	3.925LeuPhe: 3.925 ± 0.012	5.685LeuGly: 5.685 ± 0.015	2.611LeuHis: 2.611 ± 0.009	4.646LeuIle: 4.646 ± 0.014	6.497LeuLys: 6.497 ± 0.018	9.912LeuLeu: 9.912 ± 0.024	2.171LeuMet: 2.171 ± 0.007	4.221LeuAsn: 4.221 ± 0.012	5.24LeuPro: 5.24 ± 0.013	4.496LeuGln: 4.496 ± 0.014	5.351LeuArg: 5.351 ± 0.015	8.848LeuSer: 8.848 ± 0.021	4.521LeuThr: 4.521 ± 0.013	6.244LeuVal: 6.244 ± 0.016	1.151LeuTrp: 1.151 ± 0.006	2.537LeuTyr: 2.537 ± 0.009	0.0LeuXaa: 0.0 ± 0.0
Met	2.151MetAla: 2.151 ± 0.009	0.318MetCys: 0.318 ± 0.003	1.432MetAsp: 1.432 ± 0.006	2.071MetGlu: 2.071 ± 0.009	0.845MetPhe: 0.845 ± 0.005	1.644MetGly: 1.644 ± 0.007	0.547MetHis: 0.547 ± 0.004	1.18MetIle: 1.18 ± 0.006	1.704MetLys: 1.704 ± 0.007	2.241MetLeu: 2.241 ± 0.008	0.69MetMet: 0.69 ± 0.004	1.073MetAsn: 1.073 ± 0.006	1.075MetPro: 1.075 ± 0.006	0.967MetGln: 0.967 ± 0.005	1.143MetArg: 1.143 ± 0.006	1.782MetSer: 1.782 ± 0.007	1.011MetThr: 1.011 ± 0.005	1.711MetVal: 1.711 ± 0.007	0.245MetTrp: 0.245 ± 0.003	0.549MetTyr: 0.549 ± 0.004	0.0MetXaa: 0.0 ± 0.0
Asn	2.731AsnAla: 2.731 ± 0.009	0.947AsnCys: 0.947 ± 0.006	2.203AsnAsp: 2.203 ± 0.007	2.727AsnGlu: 2.727 ± 0.012	1.991AsnPhe: 1.991 ± 0.008	3.54AsnGly: 3.54 ± 0.012	1.164AsnHis: 1.164 ± 0.006	2.562AsnIle: 2.562 ± 0.009	2.586AsnLys: 2.586 ± 0.009	4.901AsnLeu: 4.901 ± 0.018	1.165AsnMet: 1.165 ± 0.006	2.536AsnAsn: 2.536 ± 0.012	2.458AsnPro: 2.458 ± 0.009	1.877AsnGln: 1.877 ± 0.008	2.093AsnArg: 2.093 ± 0.008	4.035AsnSer: 4.035 ± 0.013	1.999AsnThr: 1.999 ± 0.007	2.824AsnVal: 2.824 ± 0.01	0.578AsnTrp: 0.578 ± 0.004	1.314AsnTyr: 1.314 ± 0.006	0.0AsnXaa: 0.0 ± 0.0
Pro	2.93ProAla: 2.93 ± 0.011	0.84ProCys: 0.84 ± 0.006	2.403ProAsp: 2.403 ± 0.009	3.089ProGlu: 3.089 ± 0.012	2.113ProPhe: 2.113 ± 0.008	2.667ProGly: 2.667 ± 0.01	1.098ProHis: 1.098 ± 0.006	2.366ProIle: 2.366 ± 0.008	2.906ProLys: 2.906 ± 0.013	4.434ProLeu: 4.434 ± 0.013	1.025ProMet: 1.025 ± 0.005	2.374ProAsn: 2.374 ± 0.009	3.855ProPro: 3.855 ± 0.035	1.885ProGln: 1.885 ± 0.007	2.363ProArg: 2.363 ± 0.01	5.298ProSer: 5.298 ± 0.016	2.672ProThr: 2.672 ± 0.01	3.072ProVal: 3.072 ± 0.01	0.598ProTrp: 0.598 ± 0.004	1.319ProTyr: 1.319 ± 0.007	0.0ProXaa: 0.0 ± 0.0
Gln	2.429GlnAla: 2.429 ± 0.008	0.618GlnCys: 0.618 ± 0.004	1.654GlnAsp: 1.654 ± 0.007	2.378GlnGlu: 2.378 ± 0.009	1.416GlnPhe: 1.416 ± 0.006	2.177GlnGly: 2.177 ± 0.008	1.009GlnHis: 1.009 ± 0.006	2.058GlnIle: 2.058 ± 0.009	2.356GlnLys: 2.356 ± 0.01	3.798GlnLeu: 3.798 ± 0.011	1.009GlnMet: 1.009 ± 0.005	1.861GlnAsn: 1.861 ± 0.008	1.826GlnPro: 1.826 ± 0.009	2.368GlnGln: 2.368 ± 0.022	2.141GlnArg: 2.141 ± 0.008	2.999GlnSer: 2.999 ± 0.011	1.769GlnThr: 1.769 ± 0.007	2.388GlnVal: 2.388 ± 0.009	0.478GlnTrp: 0.478 ± 0.004	0.956GlnTyr: 0.956 ± 0.005	0.0GlnXaa: 0.0 ± 0.0
Arg	3.037ArgAla: 3.037 ± 0.01	1.007ArgCys: 1.007 ± 0.007	2.58ArgAsp: 2.58 ± 0.009	3.212ArgGlu: 3.212 ± 0.01	2.236ArgPhe: 2.236 ± 0.009	3.05ArgGly: 3.05 ± 0.011	1.262ArgHis: 1.262 ± 0.006	2.822ArgIle: 2.822 ± 0.01	3.836ArgLys: 3.836 ± 0.012	5.008ArgLeu: 5.008 ± 0.015	1.271ArgMet: 1.271 ± 0.006	2.521ArgAsn: 2.521 ± 0.009	2.263ArgPro: 2.263 ± 0.009	1.869ArgGln: 1.869 ± 0.008	3.757ArgArg: 3.757 ± 0.015	4.289ArgSer: 4.289 ± 0.014	2.426ArgThr: 2.426 ± 0.008	3.15ArgVal: 3.15 ± 0.011	0.721ArgTrp: 0.721 ± 0.005	1.451ArgTyr: 1.451 ± 0.007	0.0ArgXaa: 0.0 ± 0.0
Ser	5.287SerAla: 5.287 ± 0.014	1.777SerCys: 1.777 ± 0.008	4.381SerAsp: 4.381 ± 0.011	4.831SerGlu: 4.831 ± 0.017	4.194SerPhe: 4.194 ± 0.013	5.943SerGly: 5.943 ± 0.018	2.005SerHis: 2.005 ± 0.008	4.699SerIle: 4.699 ± 0.012	5.218SerLys: 5.218 ± 0.015	8.957SerLeu: 8.957 ± 0.02	2.187SerMet: 2.187 ± 0.008	4.393SerAsn: 4.393 ± 0.014	4.653SerPro: 4.653 ± 0.019	3.122SerGln: 3.122 ± 0.011	4.396SerArg: 4.396 ± 0.013	11.417SerSer: 11.417 ± 0.032	4.817SerThr: 4.817 ± 0.014	5.107SerVal: 5.107 ± 0.012	1.129SerTrp: 1.129 ± 0.006	2.35SerTyr: 2.35 ± 0.008	0.0SerXaa: 0.0 ± 0.0
Thr	3.433ThrAla: 3.433 ± 0.011	0.955ThrCys: 0.955 ± 0.006	2.301ThrAsp: 2.301 ± 0.009	2.773ThrGlu: 2.773 ± 0.012	2.038ThrPhe: 2.038 ± 0.008	3.256ThrGly: 3.256 ± 0.01	1.008ThrHis: 1.008 ± 0.005	2.773ThrIle: 2.773 ± 0.01	2.788ThrLys: 2.788 ± 0.01	4.651ThrLeu: 4.651 ± 0.013	1.193ThrMet: 1.193 ± 0.005	2.156ThrAsn: 2.156 ± 0.008	2.58ThrPro: 2.58 ± 0.009	1.541ThrGln: 1.541 ± 0.007	2.325ThrArg: 2.325 ± 0.008	4.729ThrSer: 4.729 ± 0.014	3.002ThrThr: 3.002 ± 0.012	3.319ThrVal: 3.319 ± 0.009	0.627ThrTrp: 0.627 ± 0.005	1.331ThrTyr: 1.331 ± 0.007	0.0ThrXaa: 0.0 ± 0.0
Val	4.629ValAla: 4.629 ± 0.013	1.132ValCys: 1.132 ± 0.007	3.614ValAsp: 3.614 ± 0.01	4.337ValGlu: 4.337 ± 0.015	2.671ValPhe: 2.671 ± 0.009	4.029ValGly: 4.029 ± 0.011	1.467ValHis: 1.467 ± 0.007	3.375ValIle: 3.375 ± 0.01	3.919ValLys: 3.919 ± 0.012	6.189ValLeu: 6.189 ± 0.016	1.496ValMet: 1.496 ± 0.007	2.674ValAsn: 2.674 ± 0.009	3.191ValPro: 3.191 ± 0.011	2.273ValGln: 2.273 ± 0.007	2.944ValArg: 2.944 ± 0.01	5.467ValSer: 5.467 ± 0.013	3.141ValThr: 3.141 ± 0.012	4.649ValVal: 4.649 ± 0.013	0.736ValTrp: 0.736 ± 0.005	1.895ValTyr: 1.895 ± 0.008	0.0ValXaa: 0.0 ± 0.0
Trp	0.726TrpAla: 0.726 ± 0.004	0.245TrpCys: 0.245 ± 0.003	0.693TrpAsp: 0.693 ± 0.005	0.763TrpGlu: 0.763 ± 0.004	0.547TrpPhe: 0.547 ± 0.004	0.726TrpGly: 0.726 ± 0.005	0.301TrpHis: 0.301 ± 0.003	0.701TrpIle: 0.701 ± 0.004	0.946TrpLys: 0.946 ± 0.005	1.235TrpLeu: 1.235 ± 0.006	0.342TrpMet: 0.342 ± 0.003	0.696TrpAsn: 0.696 ± 0.005	0.499TrpPro: 0.499 ± 0.004	0.455TrpGln: 0.455 ± 0.003	0.828TrpArg: 0.828 ± 0.005	0.96TrpSer: 0.96 ± 0.006	0.609TrpThr: 0.609 ± 0.004	0.795TrpVal: 0.795 ± 0.005	0.247TrpTrp: 0.247 ± 0.003	0.336TrpTyr: 0.336 ± 0.003	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.666TyrAla: 1.666 ± 0.007	0.649TyrCys: 0.649 ± 0.004	1.498TyrAsp: 1.498 ± 0.007	1.569TyrGlu: 1.569 ± 0.007	1.313TyrPhe: 1.313 ± 0.006	2.107TyrGly: 2.107 ± 0.009	0.733TyrHis: 0.733 ± 0.004	1.464TyrIle: 1.464 ± 0.006	1.541TyrLys: 1.541 ± 0.008	2.788TyrLeu: 2.788 ± 0.011	0.756TyrMet: 0.756 ± 0.005	1.333TyrAsn: 1.333 ± 0.007	1.263TyrPro: 1.263 ± 0.007	0.96TyrGln: 0.96 ± 0.006	1.463TyrArg: 1.463 ± 0.007	2.273TyrSer: 2.273 ± 0.009	1.238TyrThr: 1.238 ± 0.006	1.696TyrVal: 1.696 ± 0.008	0.405TyrTrp: 0.405 ± 0.004	0.981TyrTyr: 0.981 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 91033 proteins (37160271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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