Amino acid dipepetide frequency for Haladaptatus sp. R4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.206AlaAla: 9.206 ± 0.109	0.645AlaCys: 0.645 ± 0.025	7.311AlaAsp: 7.311 ± 0.081	7.12AlaGlu: 7.12 ± 0.096	3.648AlaPhe: 3.648 ± 0.074	7.593AlaGly: 7.593 ± 0.101	1.699AlaHis: 1.699 ± 0.042	5.027AlaIle: 5.027 ± 0.07	2.41AlaLys: 2.41 ± 0.054	8.855AlaLeu: 8.855 ± 0.108	2.105AlaMet: 2.105 ± 0.045	2.649AlaAsn: 2.649 ± 0.054	3.248AlaPro: 3.248 ± 0.056	2.068AlaGln: 2.068 ± 0.049	5.298AlaArg: 5.298 ± 0.086	5.05AlaSer: 5.05 ± 0.076	5.984AlaThr: 5.984 ± 0.086	8.412AlaVal: 8.412 ± 0.111	1.027AlaTrp: 1.027 ± 0.035	2.493AlaTyr: 2.493 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.567CysAla: 0.567 ± 0.023	0.094CysCys: 0.094 ± 0.01	0.57CysAsp: 0.57 ± 0.027	0.553CysGlu: 0.553 ± 0.022	0.232CysPhe: 0.232 ± 0.016	0.822CysGly: 0.822 ± 0.028	0.19CysHis: 0.19 ± 0.013	0.314CysIle: 0.314 ± 0.019	0.128CysLys: 0.128 ± 0.01	0.618CysLeu: 0.618 ± 0.025	0.122CysMet: 0.122 ± 0.011	0.193CysAsn: 0.193 ± 0.015	0.474CysPro: 0.474 ± 0.022	0.154CysGln: 0.154 ± 0.011	0.483CysArg: 0.483 ± 0.021	0.535CysSer: 0.535 ± 0.023	0.421CysThr: 0.421 ± 0.021	0.487CysVal: 0.487 ± 0.023	0.111CysTrp: 0.111 ± 0.011	0.23CysTyr: 0.23 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.951AspAla: 7.951 ± 0.109	0.683AspCys: 0.683 ± 0.03	6.841AspAsp: 6.841 ± 0.103	7.831AspGlu: 7.831 ± 0.102	2.312AspPhe: 2.312 ± 0.049	7.539AspGly: 7.539 ± 0.106	1.76AspHis: 1.76 ± 0.045	3.761AspIle: 3.761 ± 0.062	1.293AspLys: 1.293 ± 0.041	5.887AspLeu: 5.887 ± 0.08	1.372AspMet: 1.372 ± 0.032	1.478AspAsn: 1.478 ± 0.043	3.645AspPro: 3.645 ± 0.064	1.513AspGln: 1.513 ± 0.036	4.855AspArg: 4.855 ± 0.073	4.211AspSer: 4.211 ± 0.068	4.097AspThr: 4.097 ± 0.061	7.058AspVal: 7.058 ± 0.087	1.044AspTrp: 1.044 ± 0.032	1.93AspTyr: 1.93 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.449GluAla: 6.449 ± 0.094	0.487GluCys: 0.487 ± 0.021	5.193GluAsp: 5.193 ± 0.07	6.717GluGlu: 6.717 ± 0.116	3.206GluPhe: 3.206 ± 0.051	4.853GluGly: 4.853 ± 0.066	1.982GluHis: 1.982 ± 0.049	4.083GluIle: 4.083 ± 0.065	2.423GluLys: 2.423 ± 0.057	7.598GluLeu: 7.598 ± 0.101	2.095GluMet: 2.095 ± 0.044	2.838GluAsn: 2.838 ± 0.054	3.269GluPro: 3.269 ± 0.067	2.593GluGln: 2.593 ± 0.054	6.901GluArg: 6.901 ± 0.098	5.184GluSer: 5.184 ± 0.079	6.216GluThr: 6.216 ± 0.088	5.053GluVal: 5.053 ± 0.069	1.127GluTrp: 1.127 ± 0.032	2.705GluTyr: 2.705 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.604PheAla: 3.604 ± 0.062	0.317PheCys: 0.317 ± 0.015	3.538PheAsp: 3.538 ± 0.059	3.229PheGlu: 3.229 ± 0.059	1.324PhePhe: 1.324 ± 0.042	3.559PheGly: 3.559 ± 0.059	0.781PheHis: 0.781 ± 0.029	1.492PheIle: 1.492 ± 0.041	0.681PheLys: 0.681 ± 0.025	3.292PheLeu: 3.292 ± 0.073	0.647PheMet: 0.647 ± 0.026	0.827PheAsn: 0.827 ± 0.027	1.545PhePro: 1.545 ± 0.034	0.909PheGln: 0.909 ± 0.027	2.062PheArg: 2.062 ± 0.044	2.246PheSer: 2.246 ± 0.045	2.112PheThr: 2.112 ± 0.045	3.74PheVal: 3.74 ± 0.073	0.464PheTrp: 0.464 ± 0.021	0.955PheTyr: 0.955 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.778GlyAla: 6.778 ± 0.093	0.739GlyCys: 0.739 ± 0.028	5.74GlyAsp: 5.74 ± 0.078	6.479GlyGlu: 6.479 ± 0.085	3.42GlyPhe: 3.42 ± 0.063	7.01GlyGly: 7.01 ± 0.108	1.825GlyHis: 1.825 ± 0.057	4.974GlyIle: 4.974 ± 0.064	2.811GlyLys: 2.811 ± 0.053	7.079GlyLeu: 7.079 ± 0.096	1.955GlyMet: 1.955 ± 0.041	2.614GlyAsn: 2.614 ± 0.052	2.833GlyPro: 2.833 ± 0.048	1.981GlyGln: 1.981 ± 0.042	4.477GlyArg: 4.477 ± 0.07	5.339GlySer: 5.339 ± 0.081	6.154GlyThr: 6.154 ± 0.082	7.063GlyVal: 7.063 ± 0.093	1.191GlyTrp: 1.191 ± 0.037	2.893GlyTyr: 2.893 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.96HisAla: 1.96 ± 0.044	0.198HisCys: 0.198 ± 0.014	1.903HisAsp: 1.903 ± 0.048	1.82HisGlu: 1.82 ± 0.038	0.679HisPhe: 0.679 ± 0.024	2.061HisGly: 2.061 ± 0.052	0.613HisHis: 0.613 ± 0.029	0.942HisIle: 0.942 ± 0.032	0.376HisLys: 0.376 ± 0.019	1.844HisLeu: 1.844 ± 0.047	0.339HisMet: 0.339 ± 0.016	0.487HisAsn: 0.487 ± 0.022	1.332HisPro: 1.332 ± 0.034	0.494HisGln: 0.494 ± 0.024	1.425HisArg: 1.425 ± 0.041	1.065HisSer: 1.065 ± 0.027	1.118HisThr: 1.118 ± 0.035	1.895HisVal: 1.895 ± 0.038	0.285HisTrp: 0.285 ± 0.018	0.6HisTyr: 0.6 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.049IleAla: 5.049 ± 0.079	0.303IleCys: 0.303 ± 0.019	4.214IleAsp: 4.214 ± 0.073	4.487IleGlu: 4.487 ± 0.074	1.373IlePhe: 1.373 ± 0.041	4.434IleGly: 4.434 ± 0.076	1.038IleHis: 1.038 ± 0.031	2.081IleIle: 2.081 ± 0.055	0.883IleLys: 0.883 ± 0.032	3.859IleLeu: 3.859 ± 0.071	0.631IleMet: 0.631 ± 0.025	1.226IleAsn: 1.226 ± 0.039	2.644IlePro: 2.644 ± 0.042	1.245IleGln: 1.245 ± 0.036	3.049IleArg: 3.049 ± 0.054	2.861IleSer: 2.861 ± 0.054	2.801IleThr: 2.801 ± 0.054	4.214IleVal: 4.214 ± 0.072	0.416IleTrp: 0.416 ± 0.021	1.113IleTyr: 1.113 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.099LysAla: 2.099 ± 0.046	0.117LysCys: 0.117 ± 0.011	1.41LysAsp: 1.41 ± 0.042	1.835LysGlu: 1.835 ± 0.051	0.838LysPhe: 0.838 ± 0.03	1.821LysGly: 1.821 ± 0.043	0.626LysHis: 0.626 ± 0.026	1.202LysIle: 1.202 ± 0.035	1.016LysLys: 1.016 ± 0.041	2.268LysLeu: 2.268 ± 0.047	0.557LysMet: 0.557 ± 0.024	0.945LysAsn: 0.945 ± 0.032	1.281LysPro: 1.281 ± 0.034	1.023LysGln: 1.023 ± 0.04	2.129LysArg: 2.129 ± 0.047	1.77LysSer: 1.77 ± 0.044	1.954LysThr: 1.954 ± 0.048	1.627LysVal: 1.627 ± 0.045	0.371LysTrp: 0.371 ± 0.019	0.875LysTyr: 0.875 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	9.349LeuAla: 9.349 ± 0.108	0.624LeuCys: 0.624 ± 0.024	7.305LeuAsp: 7.305 ± 0.097	5.933LeuGlu: 5.933 ± 0.079	3.65LeuPhe: 3.65 ± 0.066	7.608LeuGly: 7.608 ± 0.098	1.657LeuHis: 1.657 ± 0.038	3.547LeuIle: 3.547 ± 0.071	1.946LeuLys: 1.946 ± 0.05	8.838LeuLeu: 8.838 ± 0.132	1.501LeuMet: 1.501 ± 0.038	2.162LeuAsn: 2.162 ± 0.044	4.163LeuPro: 4.163 ± 0.065	2.205LeuGln: 2.205 ± 0.05	5.265LeuArg: 5.265 ± 0.077	6.447LeuSer: 6.447 ± 0.08	5.471LeuThr: 5.471 ± 0.069	8.34LeuVal: 8.34 ± 0.126	1.007LeuTrp: 1.007 ± 0.034	2.406LeuTyr: 2.406 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.048	0.104MetCys: 0.104 ± 0.01	1.455MetAsp: 1.455 ± 0.038	1.296MetGlu: 1.296 ± 0.035	0.667MetPhe: 0.667 ± 0.025	1.642MetGly: 1.642 ± 0.042	0.392MetHis: 0.392 ± 0.018	0.796MetIle: 0.796 ± 0.029	0.66MetLys: 0.66 ± 0.027	1.804MetLeu: 1.804 ± 0.041	0.428MetMet: 0.428 ± 0.019	0.859MetAsn: 0.859 ± 0.03	0.868MetPro: 0.868 ± 0.028	0.59MetGln: 0.59 ± 0.026	1.214MetArg: 1.214 ± 0.033	1.658MetSer: 1.658 ± 0.037	1.7MetThr: 1.7 ± 0.038	1.495MetVal: 1.495 ± 0.035	0.183MetTrp: 0.183 ± 0.013	0.473MetTyr: 0.473 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.765AsnAla: 2.765 ± 0.051	0.276AsnCys: 0.276 ± 0.014	2.188AsnAsp: 2.188 ± 0.051	2.22AsnGlu: 2.22 ± 0.048	0.87AsnPhe: 0.87 ± 0.026	2.745AsnGly: 2.745 ± 0.061	0.684AsnHis: 0.684 ± 0.028	1.216AsnIle: 1.216 ± 0.03	0.625AsnLys: 0.625 ± 0.026	2.435AsnLeu: 2.435 ± 0.046	0.511AsnMet: 0.511 ± 0.023	0.759AsnAsn: 0.759 ± 0.031	1.873AsnPro: 1.873 ± 0.044	0.768AsnGln: 0.768 ± 0.026	2.074AsnArg: 2.074 ± 0.04	1.56AsnSer: 1.56 ± 0.045	1.584AsnThr: 1.584 ± 0.04	2.683AsnVal: 2.683 ± 0.055	0.406AsnTrp: 0.406 ± 0.018	0.844AsnTyr: 0.844 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.494ProAla: 3.494 ± 0.066	0.24ProCys: 0.24 ± 0.014	4.294ProAsp: 4.294 ± 0.067	4.127ProGlu: 4.127 ± 0.064	1.681ProPhe: 1.681 ± 0.039	3.28ProGly: 3.28 ± 0.056	0.886ProHis: 0.886 ± 0.028	2.135ProIle: 2.135 ± 0.045	1.356ProLys: 1.356 ± 0.038	3.73ProLeu: 3.73 ± 0.072	0.902ProMet: 0.902 ± 0.031	1.576ProAsn: 1.576 ± 0.038	1.996ProPro: 1.996 ± 0.043	1.036ProGln: 1.036 ± 0.033	2.125ProArg: 2.125 ± 0.046	2.87ProSer: 2.87 ± 0.049	3.217ProThr: 3.217 ± 0.053	3.721ProVal: 3.721 ± 0.065	0.546ProTrp: 0.546 ± 0.021	1.253ProTyr: 1.253 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.209GlnAla: 2.209 ± 0.051	0.163GlnCys: 0.163 ± 0.012	1.312GlnAsp: 1.312 ± 0.034	1.643GlnGlu: 1.643 ± 0.047	1.196GlnPhe: 1.196 ± 0.034	1.656GlnGly: 1.656 ± 0.04	0.62GlnHis: 0.62 ± 0.023	1.22GlnIle: 1.22 ± 0.036	0.822GlnLys: 0.822 ± 0.033	2.353GlnLeu: 2.353 ± 0.047	0.605GlnMet: 0.605 ± 0.027	0.854GlnAsn: 0.854 ± 0.029	1.172GlnPro: 1.172 ± 0.03	1.179GlnGln: 1.179 ± 0.047	2.012GlnArg: 2.012 ± 0.05	1.818GlnSer: 1.818 ± 0.039	1.67GlnThr: 1.67 ± 0.04	1.842GlnVal: 1.842 ± 0.039	0.395GlnTrp: 0.395 ± 0.018	0.961GlnTyr: 0.961 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.2ArgAla: 5.2 ± 0.085	0.5ArgCys: 0.5 ± 0.022	4.651ArgAsp: 4.651 ± 0.071	5.912ArgGlu: 5.912 ± 0.08	2.473ArgPhe: 2.473 ± 0.043	4.214ArgGly: 4.214 ± 0.064	1.287ArgHis: 1.287 ± 0.035	3.311ArgIle: 3.311 ± 0.053	1.918ArgLys: 1.918 ± 0.043	5.429ArgLeu: 5.429 ± 0.07	1.469ArgMet: 1.469 ± 0.035	2.083ArgAsn: 2.083 ± 0.048	2.356ArgPro: 2.356 ± 0.046	1.748ArgGln: 1.748 ± 0.047	4.762ArgArg: 4.762 ± 0.079	3.689ArgSer: 3.689 ± 0.056	4.292ArgThr: 4.292 ± 0.062	4.753ArgVal: 4.753 ± 0.069	0.846ArgTrp: 0.846 ± 0.031	2.017ArgTyr: 2.017 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.263SerAla: 5.263 ± 0.09	0.377SerCys: 0.377 ± 0.022	4.805SerAsp: 4.805 ± 0.076	4.465SerGlu: 4.465 ± 0.079	2.409SerPhe: 2.409 ± 0.05	5.996SerGly: 5.996 ± 0.076	1.22SerHis: 1.22 ± 0.036	3.057SerIle: 3.057 ± 0.057	1.851SerLys: 1.851 ± 0.046	5.675SerLeu: 5.675 ± 0.086	1.394SerMet: 1.394 ± 0.036	1.998SerAsn: 1.998 ± 0.047	2.772SerPro: 2.772 ± 0.053	1.503SerGln: 1.503 ± 0.032	3.379SerArg: 3.379 ± 0.066	3.925SerSer: 3.925 ± 0.073	3.904SerThr: 3.904 ± 0.069	5.356SerVal: 5.356 ± 0.072	0.786SerTrp: 0.786 ± 0.031	1.685SerTyr: 1.685 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.142ThrAla: 6.142 ± 0.092	0.376ThrCys: 0.376 ± 0.02	5.269ThrAsp: 5.269 ± 0.074	4.758ThrGlu: 4.758 ± 0.064	2.379ThrPhe: 2.379 ± 0.049	5.697ThrGly: 5.697 ± 0.083	1.333ThrHis: 1.333 ± 0.033	3.389ThrIle: 3.389 ± 0.06	1.688ThrLys: 1.688 ± 0.042	5.912ThrLeu: 5.912 ± 0.085	1.305ThrMet: 1.305 ± 0.037	1.972ThrAsn: 1.972 ± 0.048	3.26ThrPro: 3.26 ± 0.054	1.433ThrGln: 1.433 ± 0.038	3.303ThrArg: 3.303 ± 0.055	3.478ThrSer: 3.478 ± 0.065	5.133ThrThr: 5.133 ± 0.113	6.714ThrVal: 6.714 ± 0.079	0.725ThrTrp: 0.725 ± 0.026	1.916ThrTyr: 1.916 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	8.444ValAla: 8.444 ± 0.115	0.686ValCys: 0.686 ± 0.023	5.503ValAsp: 5.503 ± 0.071	7.23ValGlu: 7.23 ± 0.1	3.374ValPhe: 3.374 ± 0.057	7.437ValGly: 7.437 ± 0.105	1.754ValHis: 1.754 ± 0.042	3.74ValIle: 3.74 ± 0.066	1.879ValLys: 1.879 ± 0.049	7.987ValLeu: 7.987 ± 0.119	1.508ValMet: 1.508 ± 0.034	2.319ValAsn: 2.319 ± 0.051	3.973ValPro: 3.973 ± 0.061	2.025ValGln: 2.025 ± 0.045	5.138ValArg: 5.138 ± 0.082	5.73ValSer: 5.73 ± 0.075	5.838ValThr: 5.838 ± 0.079	8.127ValVal: 8.127 ± 0.115	0.904ValTrp: 0.904 ± 0.03	2.205ValTyr: 2.205 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.851TrpAla: 0.851 ± 0.032	0.107TrpCys: 0.107 ± 0.009	0.805TrpAsp: 0.805 ± 0.033	0.909TrpGlu: 0.909 ± 0.027	0.558TrpPhe: 0.558 ± 0.023	0.92TrpGly: 0.92 ± 0.031	0.294TrpHis: 0.294 ± 0.018	0.579TrpIle: 0.579 ± 0.024	0.466TrpLys: 0.466 ± 0.019	1.269TrpLeu: 1.269 ± 0.037	0.307TrpMet: 0.307 ± 0.016	0.505TrpAsn: 0.505 ± 0.021	0.463TrpPro: 0.463 ± 0.021	0.431TrpGln: 0.431 ± 0.022	0.838TrpArg: 0.838 ± 0.03	0.762TrpSer: 0.762 ± 0.025	0.874TrpThr: 0.874 ± 0.03	0.875TrpVal: 0.875 ± 0.029	0.242TrpTrp: 0.242 ± 0.015	0.42TrpTyr: 0.42 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.562TyrAla: 2.562 ± 0.055	0.261TyrCys: 0.261 ± 0.016	2.755TyrAsp: 2.755 ± 0.053	2.413TyrGlu: 2.413 ± 0.05	1.034TyrPhe: 1.034 ± 0.03	2.469TyrGly: 2.469 ± 0.054	0.794TyrHis: 0.794 ± 0.028	1.055TyrIle: 1.055 ± 0.032	0.53TyrLys: 0.53 ± 0.024	2.689TyrLeu: 2.689 ± 0.051	0.432TyrMet: 0.432 ± 0.02	0.742TyrAsn: 0.742 ± 0.024	1.297TyrPro: 1.297 ± 0.043	0.806TyrGln: 0.806 ± 0.028	2.122TyrArg: 2.122 ± 0.044	1.624TyrSer: 1.624 ± 0.042	1.642TyrThr: 1.642 ± 0.042	2.349TyrVal: 2.349 ± 0.043	0.4TyrTrp: 0.4 ± 0.02	0.988TyrTyr: 0.988 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4086 proteins (1085222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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