Amino acid dipepetide frequency for Phlebia centrifuga

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.002AlaAla: 8.002 ± 0.061	1.009AlaCys: 1.009 ± 0.016	4.223AlaAsp: 4.223 ± 0.028	4.99AlaGlu: 4.99 ± 0.045	3.192AlaPhe: 3.192 ± 0.026	5.202AlaGly: 5.202 ± 0.038	2.009AlaHis: 2.009 ± 0.018	4.17AlaIle: 4.17 ± 0.031	3.961AlaLys: 3.961 ± 0.034	8.088AlaLeu: 8.088 ± 0.048	1.901AlaMet: 1.901 ± 0.022	2.747AlaAsn: 2.747 ± 0.024	4.881AlaPro: 4.881 ± 0.045	3.269AlaGln: 3.269 ± 0.029	4.995AlaArg: 4.995 ± 0.034	7.501AlaSer: 7.501 ± 0.044	4.994AlaThr: 4.994 ± 0.034	5.438AlaVal: 5.438 ± 0.035	1.082AlaTrp: 1.082 ± 0.015	2.142AlaTyr: 2.142 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.014	0.204CysCys: 0.204 ± 0.007	0.619CysAsp: 0.619 ± 0.013	0.604CysGlu: 0.604 ± 0.012	0.442CysPhe: 0.442 ± 0.011	0.845CysGly: 0.845 ± 0.014	0.319CysHis: 0.319 ± 0.009	0.648CysIle: 0.648 ± 0.012	0.514CysLys: 0.514 ± 0.01	1.18CysLeu: 1.18 ± 0.018	0.254CysMet: 0.254 ± 0.007	0.402CysAsn: 0.402 ± 0.012	0.691CysPro: 0.691 ± 0.014	0.415CysGln: 0.415 ± 0.01	0.712CysArg: 0.712 ± 0.012	0.894CysSer: 0.894 ± 0.014	0.705CysThr: 0.705 ± 0.011	0.753CysVal: 0.753 ± 0.014	0.179CysTrp: 0.179 ± 0.006	0.323CysTyr: 0.323 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.737AspAla: 4.737 ± 0.033	0.627AspCys: 0.627 ± 0.012	4.451AspAsp: 4.451 ± 0.035	4.664AspGlu: 4.664 ± 0.042	2.168AspPhe: 2.168 ± 0.024	4.035AspGly: 4.035 ± 0.031	1.252AspHis: 1.252 ± 0.016	3.287AspIle: 3.287 ± 0.026	2.24AspLys: 2.24 ± 0.022	5.223AspLeu: 5.223 ± 0.038	1.329AspMet: 1.329 ± 0.016	1.835AspAsn: 1.835 ± 0.02	3.468AspPro: 3.468 ± 0.024	1.664AspGln: 1.664 ± 0.02	2.918AspArg: 2.918 ± 0.029	4.37AspSer: 4.37 ± 0.033	3.13AspThr: 3.13 ± 0.024	4.127AspVal: 4.127 ± 0.03	0.885AspTrp: 0.885 ± 0.013	1.477AspTyr: 1.477 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.076GluAla: 5.076 ± 0.038	0.634GluCys: 0.634 ± 0.012	4.724GluAsp: 4.724 ± 0.04	5.793GluGlu: 5.793 ± 0.056	1.897GluPhe: 1.897 ± 0.021	3.867GluGly: 3.867 ± 0.034	1.509GluHis: 1.509 ± 0.018	2.923GluIle: 2.923 ± 0.029	3.3GluLys: 3.3 ± 0.028	5.491GluLeu: 5.491 ± 0.039	1.513GluMet: 1.513 ± 0.018	2.028GluAsn: 2.028 ± 0.02	2.839GluPro: 2.839 ± 0.029	2.349GluGln: 2.349 ± 0.024	4.065GluArg: 4.065 ± 0.034	4.215GluSer: 4.215 ± 0.03	3.284GluThr: 3.284 ± 0.026	3.818GluVal: 3.818 ± 0.027	0.909GluTrp: 0.909 ± 0.016	1.606GluTyr: 1.606 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.954PheAla: 2.954 ± 0.024	0.511PheCys: 0.511 ± 0.012	2.253PheAsp: 2.253 ± 0.021	2.071PheGlu: 2.071 ± 0.02	1.458PhePhe: 1.458 ± 0.021	2.623PheGly: 2.623 ± 0.033	0.914PheHis: 0.914 ± 0.014	1.758PheIle: 1.758 ± 0.022	1.536PheLys: 1.536 ± 0.019	3.356PheLeu: 3.356 ± 0.03	0.78PheMet: 0.78 ± 0.012	1.34PheAsn: 1.34 ± 0.016	2.081PhePro: 2.081 ± 0.022	1.244PheGln: 1.244 ± 0.017	1.93PheArg: 1.93 ± 0.019	3.089PheSer: 3.089 ± 0.027	2.162PheThr: 2.162 ± 0.022	2.413PheVal: 2.413 ± 0.024	0.54PheTrp: 0.54 ± 0.009	0.97PheTyr: 0.97 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.76GlyAla: 4.76 ± 0.037	0.748GlyCys: 0.748 ± 0.013	3.514GlyAsp: 3.514 ± 0.029	3.61GlyGlu: 3.61 ± 0.032	2.448GlyPhe: 2.448 ± 0.023	5.091GlyGly: 5.091 ± 0.057	1.572GlyHis: 1.572 ± 0.02	3.236GlyIle: 3.236 ± 0.026	3.389GlyLys: 3.389 ± 0.033	5.484GlyLeu: 5.484 ± 0.038	1.539GlyMet: 1.539 ± 0.023	2.276GlyAsn: 2.276 ± 0.022	3.306GlyPro: 3.306 ± 0.032	2.291GlyGln: 2.291 ± 0.024	4.026GlyArg: 4.026 ± 0.031	5.669GlySer: 5.669 ± 0.048	3.915GlyThr: 3.915 ± 0.033	4.086GlyVal: 4.086 ± 0.033	1.108GlyTrp: 1.108 ± 0.017	1.823GlyTyr: 1.823 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.039HisAla: 2.039 ± 0.021	0.336HisCys: 0.336 ± 0.008	1.356HisAsp: 1.356 ± 0.018	1.315HisGlu: 1.315 ± 0.016	0.955HisPhe: 0.955 ± 0.014	1.614HisGly: 1.614 ± 0.019	0.813HisHis: 0.813 ± 0.014	1.449HisIle: 1.449 ± 0.017	0.938HisLys: 0.938 ± 0.013	2.48HisLeu: 2.48 ± 0.025	0.526HisMet: 0.526 ± 0.012	0.859HisAsn: 0.859 ± 0.014	1.893HisPro: 1.893 ± 0.02	0.901HisGln: 0.901 ± 0.015	1.646HisArg: 1.646 ± 0.019	2.128HisSer: 2.128 ± 0.026	1.498HisThr: 1.498 ± 0.02	1.564HisVal: 1.564 ± 0.017	0.346HisTrp: 0.346 ± 0.008	0.66HisTyr: 0.66 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.177IleAla: 4.177 ± 0.03	0.681IleCys: 0.681 ± 0.011	2.82IleAsp: 2.82 ± 0.022	2.745IleGlu: 2.745 ± 0.023	1.864IlePhe: 1.864 ± 0.022	2.914IleGly: 2.914 ± 0.028	1.283IleHis: 1.283 ± 0.017	2.412IleIle: 2.412 ± 0.025	2.044IleLys: 2.044 ± 0.021	4.616IleLeu: 4.616 ± 0.038	0.96IleMet: 0.96 ± 0.012	1.651IleAsn: 1.651 ± 0.02	3.453IlePro: 3.453 ± 0.03	1.888IleGln: 1.888 ± 0.022	2.915IleArg: 2.915 ± 0.024	4.096IleSer: 4.096 ± 0.027	2.811IleThr: 2.811 ± 0.024	3.287IleVal: 3.287 ± 0.031	0.695IleTrp: 0.695 ± 0.011	1.26IleTyr: 1.26 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.189LysAla: 4.189 ± 0.035	0.452LysCys: 0.452 ± 0.009	2.659LysAsp: 2.659 ± 0.026	3.308LysGlu: 3.308 ± 0.032	1.361LysPhe: 1.361 ± 0.018	2.904LysGly: 2.904 ± 0.026	1.126LysHis: 1.126 ± 0.016	2.074LysIle: 2.074 ± 0.023	3.069LysLys: 3.069 ± 0.037	4.077LysLeu: 4.077 ± 0.034	0.981LysMet: 0.981 ± 0.014	1.464LysAsn: 1.464 ± 0.019	2.547LysPro: 2.547 ± 0.025	1.734LysGln: 1.734 ± 0.019	3.487LysArg: 3.487 ± 0.03	3.267LysSer: 3.267 ± 0.031	2.637LysThr: 2.637 ± 0.024	2.858LysVal: 2.858 ± 0.027	0.682LysTrp: 0.682 ± 0.013	1.239LysTyr: 1.239 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.896LeuAla: 7.896 ± 0.046	1.175LeuCys: 1.175 ± 0.018	5.404LeuAsp: 5.404 ± 0.036	5.623LeuGlu: 5.623 ± 0.039	3.283LeuPhe: 3.283 ± 0.028	5.486LeuGly: 5.486 ± 0.037	2.551LeuHis: 2.551 ± 0.023	3.784LeuIle: 3.784 ± 0.035	4.127LeuLys: 4.127 ± 0.032	8.353LeuLeu: 8.353 ± 0.061	1.719LeuMet: 1.719 ± 0.019	3.106LeuAsn: 3.106 ± 0.028	6.423LeuPro: 6.423 ± 0.042	3.854LeuGln: 3.854 ± 0.031	6.116LeuArg: 6.116 ± 0.043	8.033LeuSer: 8.033 ± 0.052	5.059LeuThr: 5.059 ± 0.038	5.643LeuVal: 5.643 ± 0.039	1.234LeuTrp: 1.234 ± 0.018	2.265LeuTyr: 2.265 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.934MetAla: 1.934 ± 0.021	0.224MetCys: 0.224 ± 0.007	1.353MetAsp: 1.353 ± 0.018	1.324MetGlu: 1.324 ± 0.017	0.737MetPhe: 0.737 ± 0.012	1.287MetGly: 1.287 ± 0.021	0.584MetHis: 0.584 ± 0.011	0.894MetIle: 0.894 ± 0.014	1.059MetLys: 1.059 ± 0.014	1.868MetLeu: 1.868 ± 0.023	0.509MetMet: 0.509 ± 0.01	0.788MetAsn: 0.788 ± 0.012	1.338MetPro: 1.338 ± 0.017	0.902MetGln: 0.902 ± 0.014	1.319MetArg: 1.319 ± 0.019	2.122MetSer: 2.122 ± 0.022	1.21MetThr: 1.21 ± 0.017	1.208MetVal: 1.208 ± 0.017	0.267MetTrp: 0.267 ± 0.007	0.51MetTyr: 0.51 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.062AsnAla: 3.062 ± 0.026	0.378AsnCys: 0.378 ± 0.009	1.841AsnAsp: 1.841 ± 0.02	1.857AsnGlu: 1.857 ± 0.021	1.255AsnPhe: 1.255 ± 0.016	2.671AsnGly: 2.671 ± 0.029	0.795AsnHis: 0.795 ± 0.014	1.986AsnIle: 1.986 ± 0.02	1.401AsnLys: 1.401 ± 0.019	3.109AsnLeu: 3.109 ± 0.03	0.82AsnMet: 0.82 ± 0.014	1.309AsnAsn: 1.309 ± 0.021	2.309AsnPro: 2.309 ± 0.022	1.155AsnGln: 1.155 ± 0.015	1.749AsnArg: 1.749 ± 0.019	2.669AsnSer: 2.669 ± 0.025	2.11AsnThr: 2.11 ± 0.02	2.414AsnVal: 2.414 ± 0.023	0.494AsnTrp: 0.494 ± 0.008	0.826AsnTyr: 0.826 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.28ProAla: 5.28 ± 0.04	0.524ProCys: 0.524 ± 0.012	3.318ProAsp: 3.318 ± 0.028	3.785ProGlu: 3.785 ± 0.026	2.18ProPhe: 2.18 ± 0.019	3.697ProGly: 3.697 ± 0.032	1.582ProHis: 1.582 ± 0.021	2.836ProIle: 2.836 ± 0.024	2.506ProLys: 2.506 ± 0.026	5.468ProLeu: 5.468 ± 0.035	1.137ProMet: 1.137 ± 0.017	2.186ProAsn: 2.186 ± 0.023	6.542ProPro: 6.542 ± 0.08	2.463ProGln: 2.463 ± 0.029	3.598ProArg: 3.598 ± 0.031	7.611ProSer: 7.611 ± 0.059	4.581ProThr: 4.581 ± 0.036	4.008ProVal: 4.008 ± 0.036	0.704ProTrp: 0.704 ± 0.014	1.644ProTyr: 1.644 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.326GlnAla: 3.326 ± 0.028	0.431GlnCys: 0.431 ± 0.009	2.058GlnAsp: 2.058 ± 0.024	2.3GlnGlu: 2.3 ± 0.024	1.278GlnPhe: 1.278 ± 0.017	2.194GlnGly: 2.194 ± 0.023	1.053GlnHis: 1.053 ± 0.014	1.728GlnIle: 1.728 ± 0.019	1.665GlnLys: 1.665 ± 0.021	3.435GlnLeu: 3.435 ± 0.028	0.856GlnMet: 0.856 ± 0.013	1.343GlnAsn: 1.343 ± 0.017	2.417GlnPro: 2.417 ± 0.032	1.939GlnGln: 1.939 ± 0.031	2.482GlnArg: 2.482 ± 0.025	3.098GlnSer: 3.098 ± 0.026	2.315GlnThr: 2.315 ± 0.022	2.269GlnVal: 2.269 ± 0.019	0.592GlnTrp: 0.592 ± 0.011	1.101GlnTyr: 1.101 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.951ArgAla: 4.951 ± 0.037	0.731ArgCys: 0.731 ± 0.012	3.282ArgAsp: 3.282 ± 0.027	3.919ArgGlu: 3.919 ± 0.035	2.114ArgPhe: 2.114 ± 0.025	3.543ArgGly: 3.543 ± 0.034	1.546ArgHis: 1.546 ± 0.018	3.053ArgIle: 3.053 ± 0.029	3.47ArgLys: 3.47 ± 0.031	5.595ArgLeu: 5.595 ± 0.036	1.402ArgMet: 1.402 ± 0.019	2.135ArgAsn: 2.135 ± 0.022	3.623ArgPro: 3.623 ± 0.036	2.411ArgGln: 2.411 ± 0.023	5.183ArgArg: 5.183 ± 0.047	5.197ArgSer: 5.197 ± 0.045	3.748ArgThr: 3.748 ± 0.029	3.585ArgVal: 3.585 ± 0.028	0.94ArgTrp: 0.94 ± 0.014	1.665ArgTyr: 1.665 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.026SerAla: 7.026 ± 0.048	0.853SerCys: 0.853 ± 0.014	4.65SerAsp: 4.65 ± 0.041	4.462SerGlu: 4.462 ± 0.034	3.098SerPhe: 3.098 ± 0.028	5.592SerGly: 5.592 ± 0.039	2.2SerHis: 2.2 ± 0.023	4.073SerIle: 4.073 ± 0.03	3.611SerLys: 3.611 ± 0.03	7.966SerLeu: 7.966 ± 0.053	1.785SerMet: 1.785 ± 0.019	2.938SerAsn: 2.938 ± 0.027	6.699SerPro: 6.699 ± 0.061	3.341SerGln: 3.341 ± 0.029	5.293SerArg: 5.293 ± 0.042	10.501SerSer: 10.501 ± 0.098	6.194SerThr: 6.194 ± 0.045	5.128SerVal: 5.128 ± 0.036	1.051SerTrp: 1.051 ± 0.013	2.048SerTyr: 2.048 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.097ThrAla: 5.097 ± 0.034	0.702ThrCys: 0.702 ± 0.013	2.851ThrAsp: 2.851 ± 0.025	3.059ThrGlu: 3.059 ± 0.025	2.31ThrPhe: 2.31 ± 0.024	3.831ThrGly: 3.831 ± 0.034	1.455ThrHis: 1.455 ± 0.016	3.109ThrIle: 3.109 ± 0.025	2.463ThrLys: 2.463 ± 0.025	5.786ThrLeu: 5.786 ± 0.036	1.181ThrMet: 1.181 ± 0.016	2.013ThrAsn: 2.013 ± 0.019	4.855ThrPro: 4.855 ± 0.038	2.125ThrGln: 2.125 ± 0.02	3.392ThrArg: 3.392 ± 0.029	5.86ThrSer: 5.86 ± 0.042	4.068ThrThr: 4.068 ± 0.032	3.93ThrVal: 3.93 ± 0.031	0.805ThrTrp: 0.805 ± 0.015	1.546ThrTyr: 1.546 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.185ValAla: 5.185 ± 0.032	0.828ValCys: 0.828 ± 0.014	4.003ValAsp: 4.003 ± 0.028	4.042ValGlu: 4.042 ± 0.032	2.403ValPhe: 2.403 ± 0.021	3.861ValGly: 3.861 ± 0.03	1.69ValHis: 1.69 ± 0.019	3.042ValIle: 3.042 ± 0.029	2.957ValLys: 2.957 ± 0.03	5.854ValLeu: 5.854 ± 0.037	1.343ValMet: 1.343 ± 0.017	2.188ValAsn: 2.188 ± 0.024	4.119ValPro: 4.119 ± 0.033	2.488ValGln: 2.488 ± 0.021	3.793ValArg: 3.793 ± 0.028	5.107ValSer: 5.107 ± 0.032	3.566ValThr: 3.566 ± 0.027	4.525ValVal: 4.525 ± 0.034	0.89ValTrp: 0.89 ± 0.014	1.705ValTyr: 1.705 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.073TrpAla: 1.073 ± 0.015	0.201TrpCys: 0.201 ± 0.006	0.908TrpAsp: 0.908 ± 0.015	0.887TrpGlu: 0.887 ± 0.013	0.551TrpPhe: 0.551 ± 0.012	0.866TrpGly: 0.866 ± 0.013	0.337TrpHis: 0.337 ± 0.009	0.726TrpIle: 0.726 ± 0.012	0.819TrpLys: 0.819 ± 0.013	1.223TrpLeu: 1.223 ± 0.017	0.34TrpMet: 0.34 ± 0.008	0.598TrpAsn: 0.598 ± 0.011	0.572TrpPro: 0.572 ± 0.012	0.52TrpGln: 0.52 ± 0.01	0.942TrpArg: 0.942 ± 0.015	1.077TrpSer: 1.077 ± 0.016	0.871TrpThr: 0.871 ± 0.013	0.867TrpVal: 0.867 ± 0.014	0.262TrpTrp: 0.262 ± 0.008	0.396TrpTyr: 0.396 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.108TyrAla: 2.108 ± 0.025	0.379TyrCys: 0.379 ± 0.01	1.601TyrAsp: 1.601 ± 0.017	1.479TyrGlu: 1.479 ± 0.018	0.99TyrPhe: 0.99 ± 0.015	1.77TyrGly: 1.77 ± 0.02	0.727TyrHis: 0.727 ± 0.013	1.385TyrIle: 1.385 ± 0.017	1.048TyrLys: 1.048 ± 0.016	2.483TyrLeu: 2.483 ± 0.024	0.559TyrMet: 0.559 ± 0.01	1.001TyrAsn: 1.001 ± 0.015	1.593TyrPro: 1.593 ± 0.021	0.93TyrGln: 0.93 ± 0.015	1.532TyrArg: 1.532 ± 0.018	2.002TyrSer: 2.002 ± 0.02	1.579TyrThr: 1.579 ± 0.016	1.669TyrVal: 1.669 ± 0.018	0.37TyrTrp: 0.37 ± 0.01	0.793TyrTyr: 0.793 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13628 proteins (5081813 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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