Amino acid dipepetide frequency for Peromyscus maniculatus bairdii (Prairie deer mouse)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.538AlaAla: 6.538 ± 0.033	1.303AlaCys: 1.303 ± 0.009	2.91AlaAsp: 2.91 ± 0.012	5.044AlaGlu: 5.044 ± 0.025	2.513AlaPhe: 2.513 ± 0.016	4.544AlaGly: 4.544 ± 0.026	1.519AlaHis: 1.519 ± 0.011	2.679AlaIle: 2.679 ± 0.011	3.67AlaLys: 3.67 ± 0.033	6.872AlaLeu: 6.872 ± 0.041	1.468AlaMet: 1.468 ± 0.009	1.991AlaAsn: 1.991 ± 0.009	4.227AlaPro: 4.227 ± 0.023	3.338AlaGln: 3.338 ± 0.021	3.584AlaArg: 3.584 ± 0.015	5.968AlaSer: 5.968 ± 0.022	3.659AlaThr: 3.659 ± 0.017	4.654AlaVal: 4.654 ± 0.017	0.798AlaTrp: 0.798 ± 0.008	1.495AlaTyr: 1.495 ± 0.011	0.002AlaXaa: 0.002 ± 0.0
Cys	1.179CysAla: 1.179 ± 0.009	0.597CysCys: 0.597 ± 0.013	1.021CysAsp: 1.021 ± 0.009	1.282CysGlu: 1.282 ± 0.011	0.777CysPhe: 0.777 ± 0.008	1.628CysGly: 1.628 ± 0.017	0.647CysHis: 0.647 ± 0.007	0.871CysIle: 0.871 ± 0.007	1.179CysLys: 1.179 ± 0.011	1.958CysLeu: 1.958 ± 0.015	0.389CysMet: 0.389 ± 0.005	0.801CysAsn: 0.801 ± 0.008	1.256CysPro: 1.256 ± 0.013	1.059CysGln: 1.059 ± 0.01	1.206CysArg: 1.206 ± 0.008	1.939CysSer: 1.939 ± 0.013	1.065CysThr: 1.065 ± 0.009	1.25CysVal: 1.25 ± 0.01	0.261CysTrp: 0.261 ± 0.003	0.555CysTyr: 0.555 ± 0.005	0.001CysXaa: 0.001 ± 0.0
Asp	2.982AspAla: 2.982 ± 0.013	1.005AspCys: 1.005 ± 0.009	2.665AspAsp: 2.665 ± 0.015	3.34AspGlu: 3.34 ± 0.018	2.012AspPhe: 2.012 ± 0.011	3.437AspGly: 3.437 ± 0.03	1.135AspHis: 1.135 ± 0.007	2.596AspIle: 2.596 ± 0.016	2.554AspLys: 2.554 ± 0.013	5.021AspLeu: 5.021 ± 0.023	1.132AspMet: 1.132 ± 0.011	1.633AspAsn: 1.633 ± 0.008	2.975AspPro: 2.975 ± 0.013	1.893AspGln: 1.893 ± 0.01	2.507AspArg: 2.507 ± 0.013	4.392AspSer: 4.392 ± 0.017	2.629AspThr: 2.629 ± 0.016	3.242AspVal: 3.242 ± 0.028	0.587AspTrp: 0.587 ± 0.005	1.454AspTyr: 1.454 ± 0.011	0.001AspXaa: 0.001 ± 0.0
Glu	5.463GluAla: 5.463 ± 0.023	1.442GluCys: 1.442 ± 0.014	4.49GluAsp: 4.49 ± 0.02	8.281GluGlu: 8.281 ± 0.039	1.982GluPhe: 1.982 ± 0.011	4.239GluGly: 4.239 ± 0.023	1.536GluHis: 1.536 ± 0.01	3.19GluIle: 3.19 ± 0.026	5.694GluLys: 5.694 ± 0.032	6.509GluLeu: 6.509 ± 0.031	1.687GluMet: 1.687 ± 0.01	3.12GluAsn: 3.12 ± 0.018	3.655GluPro: 3.655 ± 0.042	3.24GluGln: 3.24 ± 0.024	4.128GluArg: 4.128 ± 0.021	4.535GluSer: 4.535 ± 0.02	3.49GluThr: 3.49 ± 0.014	4.43GluVal: 4.43 ± 0.033	0.705GluTrp: 0.705 ± 0.006	1.741GluTyr: 1.741 ± 0.029	0.002GluXaa: 0.002 ± 0.0
Phe	1.858PheAla: 1.858 ± 0.012	0.856PheCys: 0.856 ± 0.008	1.585PheAsp: 1.585 ± 0.008	1.954PheGlu: 1.954 ± 0.01	1.483PhePhe: 1.483 ± 0.012	2.033PheGly: 2.033 ± 0.015	0.976PheHis: 0.976 ± 0.008	1.725PheIle: 1.725 ± 0.012	1.771PheLys: 1.771 ± 0.013	3.786PheLeu: 3.786 ± 0.027	0.697PheMet: 0.697 ± 0.007	1.213PheAsn: 1.213 ± 0.009	1.894PhePro: 1.894 ± 0.015	1.705PheGln: 1.705 ± 0.01	2.037PheArg: 2.037 ± 0.022	3.264PheSer: 3.264 ± 0.019	1.961PheThr: 1.961 ± 0.01	2.069PheVal: 2.069 ± 0.013	0.442PheTrp: 0.442 ± 0.005	1.084PheTyr: 1.084 ± 0.009	0.002PheXaa: 0.002 ± 0.0
Gly	4.131GlyAla: 4.131 ± 0.024	1.187GlyCys: 1.187 ± 0.011	3.086GlyAsp: 3.086 ± 0.016	4.173GlyGlu: 4.173 ± 0.021	2.178GlyPhe: 2.178 ± 0.017	4.693GlyGly: 4.693 ± 0.029	1.646GlyHis: 1.646 ± 0.011	2.567GlyIle: 2.567 ± 0.012	3.833GlyLys: 3.833 ± 0.021	5.578GlyLeu: 5.578 ± 0.027	1.215GlyMet: 1.215 ± 0.01	2.25GlyAsn: 2.25 ± 0.012	4.36GlyPro: 4.36 ± 0.044	2.784GlyGln: 2.784 ± 0.014	3.64GlyArg: 3.64 ± 0.016	5.989GlySer: 5.989 ± 0.022	3.604GlyThr: 3.604 ± 0.016	3.453GlyVal: 3.453 ± 0.017	0.732GlyTrp: 0.732 ± 0.008	1.696GlyTyr: 1.696 ± 0.012	0.002GlyXaa: 0.002 ± 0.0
His	1.317HisAla: 1.317 ± 0.009	0.685HisCys: 0.685 ± 0.008	0.873HisAsp: 0.873 ± 0.007	1.379HisGlu: 1.379 ± 0.009	1.04HisPhe: 1.04 ± 0.008	1.463HisGly: 1.463 ± 0.011	0.885HisHis: 0.885 ± 0.01	1.25HisIle: 1.25 ± 0.009	1.281HisLys: 1.281 ± 0.009	2.858HisLeu: 2.858 ± 0.018	0.569HisMet: 0.569 ± 0.006	0.815HisAsn: 0.815 ± 0.006	1.644HisPro: 1.644 ± 0.011	1.367HisGln: 1.367 ± 0.013	1.582HisArg: 1.582 ± 0.013	2.346HisSer: 2.346 ± 0.016	1.615HisThr: 1.615 ± 0.015	1.528HisVal: 1.528 ± 0.009	0.317HisTrp: 0.317 ± 0.004	0.809HisTyr: 0.809 ± 0.006	0.001HisXaa: 0.001 ± 0.0
Ile	2.472IleAla: 2.472 ± 0.012	0.973IleCys: 0.973 ± 0.008	1.949IleAsp: 1.949 ± 0.011	2.663IleGlu: 2.663 ± 0.024	1.733IlePhe: 1.733 ± 0.012	2.122IleGly: 2.122 ± 0.014	1.36IleHis: 1.36 ± 0.012	2.295IleIle: 2.295 ± 0.014	2.675IleLys: 2.675 ± 0.023	4.372IleLeu: 4.372 ± 0.02	0.937IleMet: 0.937 ± 0.007	1.713IleAsn: 1.713 ± 0.01	2.656IlePro: 2.656 ± 0.012	2.262IleGln: 2.262 ± 0.013	2.324IleArg: 2.324 ± 0.011	3.737IleSer: 3.737 ± 0.017	2.679IleThr: 2.679 ± 0.033	2.518IleVal: 2.518 ± 0.025	0.456IleTrp: 0.456 ± 0.005	1.284IleTyr: 1.284 ± 0.008	0.001IleXaa: 0.001 ± 0.0
Lys	4.342LysAla: 4.342 ± 0.027	1.154LysCys: 1.154 ± 0.011	3.463LysAsp: 3.463 ± 0.031	5.307LysGlu: 5.307 ± 0.029	1.698LysPhe: 1.698 ± 0.012	3.388LysGly: 3.388 ± 0.03	1.395LysHis: 1.395 ± 0.01	2.727LysIle: 2.727 ± 0.018	4.823LysLys: 4.823 ± 0.035	5.127LysLeu: 5.127 ± 0.022	1.479LysMet: 1.479 ± 0.014	2.322LysAsn: 2.322 ± 0.015	3.501LysPro: 3.501 ± 0.034	2.603LysGln: 2.603 ± 0.018	3.359LysArg: 3.359 ± 0.016	4.07LysSer: 4.07 ± 0.017	3.207LysThr: 3.207 ± 0.017	3.793LysVal: 3.793 ± 0.045	0.648LysTrp: 0.648 ± 0.01	1.64LysTyr: 1.64 ± 0.023	0.002LysXaa: 0.002 ± 0.0
Leu	6.508LeuAla: 6.508 ± 0.037	1.994LeuCys: 1.994 ± 0.016	4.747LeuAsp: 4.747 ± 0.017	7.394LeuGlu: 7.394 ± 0.034	3.084LeuPhe: 3.084 ± 0.022	5.531LeuGly: 5.531 ± 0.029	2.685LeuHis: 2.685 ± 0.015	3.651LeuIle: 3.651 ± 0.017	5.862LeuLys: 5.862 ± 0.027	10.094LeuLeu: 10.094 ± 0.063	1.924LeuMet: 1.924 ± 0.014	3.284LeuAsn: 3.284 ± 0.018	5.93LeuPro: 5.93 ± 0.029	5.904LeuGln: 5.904 ± 0.037	5.88LeuArg: 5.88 ± 0.026	8.052LeuSer: 8.052 ± 0.034	5.069LeuThr: 5.069 ± 0.016	5.257LeuVal: 5.257 ± 0.02	1.034LeuTrp: 1.034 ± 0.008	2.418LeuTyr: 2.418 ± 0.015	0.003LeuXaa: 0.003 ± 0.0
Met	1.844MetAla: 1.844 ± 0.01	0.371MetCys: 0.371 ± 0.005	1.244MetAsp: 1.244 ± 0.01	1.849MetGlu: 1.849 ± 0.012	0.666MetPhe: 0.666 ± 0.006	1.183MetGly: 1.183 ± 0.009	0.483MetHis: 0.483 ± 0.005	0.797MetIle: 0.797 ± 0.006	1.434MetLys: 1.434 ± 0.008	1.936MetLeu: 1.936 ± 0.013	0.541MetMet: 0.541 ± 0.006	0.861MetAsn: 0.861 ± 0.007	1.16MetPro: 1.16 ± 0.019	0.925MetGln: 0.925 ± 0.008	1.024MetArg: 1.024 ± 0.008	1.628MetSer: 1.628 ± 0.008	1.125MetThr: 1.125 ± 0.006	1.36MetVal: 1.36 ± 0.009	0.229MetTrp: 0.229 ± 0.003	0.573MetTyr: 0.573 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	2.052AsnAla: 2.052 ± 0.011	0.753AsnCys: 0.753 ± 0.006	1.502AsnAsp: 1.502 ± 0.009	2.125AsnGlu: 2.125 ± 0.012	1.359AsnPhe: 1.359 ± 0.009	2.295AsnGly: 2.295 ± 0.015	0.907AsnHis: 0.907 ± 0.007	2.001AsnIle: 2.001 ± 0.01	2.146AsnLys: 2.146 ± 0.013	3.575AsnLeu: 3.575 ± 0.017	0.856AsnMet: 0.856 ± 0.008	1.404AsnAsn: 1.404 ± 0.01	2.117AsnPro: 2.117 ± 0.012	1.654AsnGln: 1.654 ± 0.012	1.753AsnArg: 1.753 ± 0.01	3.08AsnSer: 3.08 ± 0.015	1.926AsnThr: 1.926 ± 0.01	2.207AsnVal: 2.207 ± 0.017	0.417AsnTrp: 0.417 ± 0.003	1.135AsnTyr: 1.135 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	5.016ProAla: 5.016 ± 0.026	1.091ProCys: 1.091 ± 0.011	2.947ProAsp: 2.947 ± 0.026	4.899ProGlu: 4.899 ± 0.035	1.908ProPhe: 1.908 ± 0.01	5.282ProGly: 5.282 ± 0.05	1.442ProHis: 1.442 ± 0.012	2.007ProIle: 2.007 ± 0.025	3.161ProLys: 3.161 ± 0.036	5.257ProLeu: 5.257 ± 0.024	1.08ProMet: 1.08 ± 0.009	1.758ProAsn: 1.758 ± 0.011	6.675ProPro: 6.675 ± 0.058	2.887ProGln: 2.887 ± 0.021	3.292ProArg: 3.292 ± 0.018	6.047ProSer: 6.047 ± 0.031	3.263ProThr: 3.263 ± 0.016	4.181ProVal: 4.181 ± 0.031	0.628ProTrp: 0.628 ± 0.007	1.518ProTyr: 1.518 ± 0.013	0.003ProXaa: 0.003 ± 0.0
Gln	3.609GlnAla: 3.609 ± 0.022	0.963GlnCys: 0.963 ± 0.011	2.351GlnAsp: 2.351 ± 0.013	3.995GlnGlu: 3.995 ± 0.024	1.336GlnPhe: 1.336 ± 0.007	2.824GlnGly: 2.824 ± 0.017	1.292GlnHis: 1.292 ± 0.011	1.959GlnIle: 1.959 ± 0.01	2.983GlnLys: 2.983 ± 0.016	4.772GlnLeu: 4.772 ± 0.031	1.122GlnMet: 1.122 ± 0.009	1.808GlnAsn: 1.808 ± 0.01	2.911GlnPro: 2.911 ± 0.023	3.392GlnGln: 3.392 ± 0.042	3.027GlnArg: 3.027 ± 0.022	3.302GlnSer: 3.302 ± 0.022	2.379GlnThr: 2.379 ± 0.014	2.828GlnVal: 2.828 ± 0.013	0.551GlnTrp: 0.551 ± 0.005	1.144GlnTyr: 1.144 ± 0.007	0.001GlnXaa: 0.001 ± 0.0
Arg	3.78ArgAla: 3.78 ± 0.016	1.141ArgCys: 1.141 ± 0.01	2.794ArgAsp: 2.794 ± 0.014	4.13ArgGlu: 4.13 ± 0.019	1.768ArgPhe: 1.768 ± 0.011	3.396ArgGly: 3.396 ± 0.024	1.528ArgHis: 1.528 ± 0.012	2.415ArgIle: 2.415 ± 0.013	3.714ArgLys: 3.714 ± 0.017	5.329ArgLeu: 5.329 ± 0.023	1.162ArgMet: 1.162 ± 0.007	2.129ArgAsn: 2.129 ± 0.011	3.302ArgPro: 3.302 ± 0.017	2.667ArgGln: 2.667 ± 0.017	4.226ArgArg: 4.226 ± 0.03	4.374ArgSer: 4.374 ± 0.031	2.842ArgThr: 2.842 ± 0.016	3.344ArgVal: 3.344 ± 0.029	0.676ArgTrp: 0.676 ± 0.007	1.395ArgTyr: 1.395 ± 0.008	0.002ArgXaa: 0.002 ± 0.0
Ser	5.517SerAla: 5.517 ± 0.019	1.853SerCys: 1.853 ± 0.013	4.15SerAsp: 4.15 ± 0.027	5.424SerGlu: 5.424 ± 0.019	2.965SerPhe: 2.965 ± 0.013	5.638SerGly: 5.638 ± 0.02	2.202SerHis: 2.202 ± 0.015	3.245SerIle: 3.245 ± 0.013	4.22SerLys: 4.22 ± 0.018	8.24SerLeu: 8.24 ± 0.037	1.691SerMet: 1.691 ± 0.01	2.634SerAsn: 2.634 ± 0.012	6.462SerPro: 6.462 ± 0.044	4.011SerGln: 4.011 ± 0.026	4.648SerArg: 4.648 ± 0.027	9.798SerSer: 9.798 ± 0.058	4.62SerThr: 4.62 ± 0.02	5.11SerVal: 5.11 ± 0.017	1.099SerTrp: 1.099 ± 0.012	2.033SerTyr: 2.033 ± 0.013	0.003SerXaa: 0.003 ± 0.0
Thr	3.873ThrAla: 3.873 ± 0.018	1.292ThrCys: 1.292 ± 0.012	2.514ThrAsp: 2.514 ± 0.014	3.689ThrGlu: 3.689 ± 0.017	2.038ThrPhe: 2.038 ± 0.011	3.634ThrGly: 3.634 ± 0.018	1.369ThrHis: 1.369 ± 0.009	2.412ThrIle: 2.412 ± 0.017	2.864ThrLys: 2.864 ± 0.027	5.342ThrLeu: 5.342 ± 0.016	1.124ThrMet: 1.124 ± 0.007	1.707ThrAsn: 1.707 ± 0.012	3.868ThrPro: 3.868 ± 0.023	2.365ThrGln: 2.365 ± 0.012	2.545ThrArg: 2.545 ± 0.011	4.828ThrSer: 4.828 ± 0.017	3.135ThrThr: 3.135 ± 0.021	4.092ThrVal: 4.092 ± 0.033	0.74ThrTrp: 0.74 ± 0.014	1.382ThrTyr: 1.382 ± 0.008	0.002ThrXaa: 0.002 ± 0.0
Val	4.269ValAla: 4.269 ± 0.018	1.413ValCys: 1.413 ± 0.011	3.005ValAsp: 3.005 ± 0.02	4.031ValGlu: 4.031 ± 0.034	2.275ValPhe: 2.275 ± 0.011	3.266ValGly: 3.266 ± 0.016	1.575ValHis: 1.575 ± 0.01	2.901ValIle: 2.901 ± 0.022	3.706ValLys: 3.706 ± 0.037	6.06ValLeu: 6.06 ± 0.019	1.273ValMet: 1.273 ± 0.008	2.297ValAsn: 2.297 ± 0.014	4.037ValPro: 4.037 ± 0.039	2.766ValGln: 2.766 ± 0.011	3.06ValArg: 3.06 ± 0.014	5.156ValSer: 5.156 ± 0.03	4.249ValThr: 4.249 ± 0.054	4.066ValVal: 4.066 ± 0.029	0.695ValTrp: 0.695 ± 0.005	1.551ValTyr: 1.551 ± 0.009	0.001ValXaa: 0.001 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.006	0.227TrpCys: 0.227 ± 0.003	0.627TrpAsp: 0.627 ± 0.006	0.823TrpGlu: 0.823 ± 0.006	0.449TrpPhe: 0.449 ± 0.007	0.622TrpGly: 0.622 ± 0.007	0.294TrpHis: 0.294 ± 0.004	0.507TrpIle: 0.507 ± 0.006	0.803TrpLys: 0.803 ± 0.007	1.158TrpLeu: 1.158 ± 0.008	0.316TrpMet: 0.316 ± 0.004	0.505TrpAsn: 0.505 ± 0.005	0.486TrpPro: 0.486 ± 0.006	0.502TrpGln: 0.502 ± 0.005	0.673TrpArg: 0.673 ± 0.005	0.887TrpSer: 0.887 ± 0.008	0.722TrpThr: 0.722 ± 0.009	0.69TrpVal: 0.69 ± 0.006	0.157TrpTrp: 0.157 ± 0.003	0.345TrpTyr: 0.345 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.308TyrAla: 1.308 ± 0.007	0.618TyrCys: 0.618 ± 0.006	1.271TyrAsp: 1.271 ± 0.009	1.777TyrGlu: 1.777 ± 0.013	1.129TyrPhe: 1.129 ± 0.008	1.573TyrGly: 1.573 ± 0.009	0.745TyrHis: 0.745 ± 0.006	1.383TyrIle: 1.383 ± 0.013	1.673TyrLys: 1.673 ± 0.036	2.456TyrLeu: 2.456 ± 0.013	0.571TyrMet: 0.571 ± 0.005	1.019TyrAsn: 1.019 ± 0.008	1.227TyrPro: 1.227 ± 0.01	1.226TyrGln: 1.226 ± 0.008	1.616TyrArg: 1.616 ± 0.014	2.168TyrSer: 2.168 ± 0.012	1.572TyrThr: 1.572 ± 0.016	1.578TyrVal: 1.578 ± 0.012	0.342TyrTrp: 0.342 ± 0.004	0.876TyrTyr: 0.876 ± 0.007	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.003XaaLeu: 0.003 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.009XaaXaa: 0.009 ± 0.001

Statistics based on 37544 proteins (26604240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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