Amino acid dipepetide frequency for Acidomyces richmondensis BFW

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.033AlaAla: 9.033 ± 0.057	1.205AlaCys: 1.205 ± 0.017	4.171AlaAsp: 4.171 ± 0.036	5.271AlaGlu: 5.271 ± 0.041	3.281AlaPhe: 3.281 ± 0.032	5.998AlaGly: 5.998 ± 0.04	1.886AlaHis: 1.886 ± 0.02	4.453AlaIle: 4.453 ± 0.034	4.134AlaLys: 4.134 ± 0.037	7.833AlaLeu: 7.833 ± 0.04	2.058AlaMet: 2.058 ± 0.024	3.041AlaAsn: 3.041 ± 0.027	4.295AlaPro: 4.295 ± 0.039	3.446AlaGln: 3.446 ± 0.03	5.214AlaArg: 5.214 ± 0.036	6.965AlaSer: 6.965 ± 0.044	5.078AlaThr: 5.078 ± 0.039	5.42AlaVal: 5.42 ± 0.04	1.197AlaTrp: 1.197 ± 0.018	2.319AlaTyr: 2.319 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.076CysAla: 1.076 ± 0.017	0.305CysCys: 0.305 ± 0.015	0.702CysAsp: 0.702 ± 0.015	0.694CysGlu: 0.694 ± 0.013	0.596CysPhe: 0.596 ± 0.012	1.031CysGly: 1.031 ± 0.015	0.369CysHis: 0.369 ± 0.009	0.8CysIle: 0.8 ± 0.014	0.559CysLys: 0.559 ± 0.013	1.372CysLeu: 1.372 ± 0.019	0.319CysMet: 0.319 ± 0.009	0.479CysAsn: 0.479 ± 0.01	0.7CysPro: 0.7 ± 0.015	0.463CysGln: 0.463 ± 0.01	0.865CysArg: 0.865 ± 0.014	1.028CysSer: 1.028 ± 0.018	0.744CysThr: 0.744 ± 0.012	0.871CysVal: 0.871 ± 0.015	0.221CysTrp: 0.221 ± 0.007	0.392CysTyr: 0.392 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.551AspAla: 4.551 ± 0.038	0.681AspCys: 0.681 ± 0.013	3.822AspAsp: 3.822 ± 0.043	4.429AspGlu: 4.429 ± 0.04	2.174AspPhe: 2.174 ± 0.022	4.237AspGly: 4.237 ± 0.039	1.223AspHis: 1.223 ± 0.016	3.007AspIle: 3.007 ± 0.027	2.176AspLys: 2.176 ± 0.022	4.899AspLeu: 4.899 ± 0.035	1.286AspMet: 1.286 ± 0.02	1.725AspAsn: 1.725 ± 0.018	3.11AspPro: 3.11 ± 0.027	1.823AspGln: 1.823 ± 0.022	3.108AspArg: 3.108 ± 0.033	3.675AspSer: 3.675 ± 0.035	2.638AspThr: 2.638 ± 0.024	3.675AspVal: 3.675 ± 0.035	0.872AspTrp: 0.872 ± 0.014	1.525AspTyr: 1.525 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.292GluAla: 5.292 ± 0.039	0.706GluCys: 0.706 ± 0.013	4.121GluAsp: 4.121 ± 0.038	5.605GluGlu: 5.605 ± 0.067	1.85GluPhe: 1.85 ± 0.022	3.93GluGly: 3.93 ± 0.037	1.486GluHis: 1.486 ± 0.021	3.173GluIle: 3.173 ± 0.03	3.698GluLys: 3.698 ± 0.036	5.091GluLeu: 5.091 ± 0.043	1.582GluMet: 1.582 ± 0.019	2.359GluAsn: 2.359 ± 0.024	2.447GluPro: 2.447 ± 0.023	2.706GluGln: 2.706 ± 0.025	4.489GluArg: 4.489 ± 0.047	4.04GluSer: 4.04 ± 0.035	3.232GluThr: 3.232 ± 0.027	3.639GluVal: 3.639 ± 0.036	0.9GluTrp: 0.9 ± 0.014	1.715GluTyr: 1.715 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.199PheAla: 3.199 ± 0.028	0.61PheCys: 0.61 ± 0.013	2.24PheAsp: 2.24 ± 0.021	2.151PheGlu: 2.151 ± 0.025	1.646PhePhe: 1.646 ± 0.022	2.912PheGly: 2.912 ± 0.032	0.939PheHis: 0.939 ± 0.015	1.778PheIle: 1.778 ± 0.022	1.439PheLys: 1.439 ± 0.018	3.35PheLeu: 3.35 ± 0.029	0.796PheMet: 0.796 ± 0.013	1.43PheAsn: 1.43 ± 0.021	1.891PhePro: 1.891 ± 0.02	1.319PheGln: 1.319 ± 0.017	1.979PheArg: 1.979 ± 0.021	2.865PheSer: 2.865 ± 0.027	2.141PheThr: 2.141 ± 0.022	2.359PheVal: 2.359 ± 0.027	0.64PheTrp: 0.64 ± 0.012	1.107PheTyr: 1.107 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.2GlyAla: 5.2 ± 0.038	0.94GlyCys: 0.94 ± 0.015	3.568GlyAsp: 3.568 ± 0.031	3.893GlyGlu: 3.893 ± 0.035	2.802GlyPhe: 2.802 ± 0.034	6.233GlyGly: 6.233 ± 0.066	1.713GlyHis: 1.713 ± 0.022	3.673GlyIle: 3.673 ± 0.035	3.602GlyLys: 3.602 ± 0.033	6.075GlyLeu: 6.075 ± 0.04	1.81GlyMet: 1.81 ± 0.022	2.564GlyAsn: 2.564 ± 0.026	3.212GlyPro: 3.212 ± 0.03	2.608GlyGln: 2.608 ± 0.026	4.502GlyArg: 4.502 ± 0.034	5.507GlySer: 5.507 ± 0.044	3.965GlyThr: 3.965 ± 0.033	4.421GlyVal: 4.421 ± 0.032	1.286GlyTrp: 1.286 ± 0.019	2.179GlyTyr: 2.179 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.023HisAla: 2.023 ± 0.025	0.369HisCys: 0.369 ± 0.01	1.333HisAsp: 1.333 ± 0.018	1.407HisGlu: 1.407 ± 0.018	0.971HisPhe: 0.971 ± 0.014	1.782HisGly: 1.782 ± 0.022	0.939HisHis: 0.939 ± 0.02	1.282HisIle: 1.282 ± 0.019	0.96HisLys: 0.96 ± 0.013	2.322HisLeu: 2.322 ± 0.024	0.529HisMet: 0.529 ± 0.011	0.89HisAsn: 0.89 ± 0.015	1.762HisPro: 1.762 ± 0.019	1.038HisGln: 1.038 ± 0.018	1.665HisArg: 1.665 ± 0.021	1.857HisSer: 1.857 ± 0.022	1.364HisThr: 1.364 ± 0.017	1.537HisVal: 1.537 ± 0.02	0.36HisTrp: 0.36 ± 0.01	0.702HisTyr: 0.702 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.385IleAla: 4.385 ± 0.036	0.843IleCys: 0.843 ± 0.014	2.859IleAsp: 2.859 ± 0.026	3.024IleGlu: 3.024 ± 0.029	2.119IlePhe: 2.119 ± 0.025	3.445IleGly: 3.445 ± 0.035	1.229IleHis: 1.229 ± 0.017	2.612IleIle: 2.612 ± 0.029	2.167IleLys: 2.167 ± 0.022	4.601IleLeu: 4.601 ± 0.042	1.084IleMet: 1.084 ± 0.018	1.869IleAsn: 1.869 ± 0.023	2.946IlePro: 2.946 ± 0.025	1.913IleGln: 1.913 ± 0.02	2.937IleArg: 2.937 ± 0.027	4.005IleSer: 4.005 ± 0.034	2.895IleThr: 2.895 ± 0.029	3.249IleVal: 3.249 ± 0.03	0.776IleTrp: 0.776 ± 0.014	1.512IleTyr: 1.512 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.27LysAla: 4.27 ± 0.042	0.552LysCys: 0.552 ± 0.011	2.706LysAsp: 2.706 ± 0.031	3.332LysGlu: 3.332 ± 0.04	1.379LysPhe: 1.379 ± 0.018	2.984LysGly: 2.984 ± 0.027	1.205LysHis: 1.205 ± 0.019	2.35LysIle: 2.35 ± 0.023	3.147LysLys: 3.147 ± 0.037	4.048LysLeu: 4.048 ± 0.033	1.132LysMet: 1.132 ± 0.019	1.734LysAsn: 1.734 ± 0.021	2.489LysPro: 2.489 ± 0.024	1.987LysGln: 1.987 ± 0.022	3.741LysArg: 3.741 ± 0.036	3.309LysSer: 3.309 ± 0.03	2.701LysThr: 2.701 ± 0.026	2.809LysVal: 2.809 ± 0.026	0.69LysTrp: 0.69 ± 0.012	1.41LysTyr: 1.41 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.93LeuAla: 7.93 ± 0.051	1.308LeuCys: 1.308 ± 0.017	4.927LeuAsp: 4.927 ± 0.038	5.395LeuGlu: 5.395 ± 0.043	3.24LeuPhe: 3.24 ± 0.029	5.759LeuGly: 5.759 ± 0.041	2.387LeuHis: 2.387 ± 0.024	4.088LeuIle: 4.088 ± 0.036	4.23LeuLys: 4.23 ± 0.035	8.292LeuLeu: 8.292 ± 0.057	1.847LeuMet: 1.847 ± 0.021	3.211LeuAsn: 3.211 ± 0.026	5.563LeuPro: 5.563 ± 0.041	3.974LeuGln: 3.974 ± 0.036	6.005LeuArg: 6.005 ± 0.044	7.04LeuSer: 7.04 ± 0.043	4.796LeuThr: 4.796 ± 0.031	5.161LeuVal: 5.161 ± 0.044	1.195LeuTrp: 1.195 ± 0.019	2.39LeuTyr: 2.39 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.305MetAla: 2.305 ± 0.023	0.287MetCys: 0.287 ± 0.009	1.252MetAsp: 1.252 ± 0.017	1.383MetGlu: 1.383 ± 0.019	0.753MetPhe: 0.753 ± 0.013	1.498MetGly: 1.498 ± 0.018	0.567MetHis: 0.567 ± 0.011	1.077MetIle: 1.077 ± 0.017	1.096MetLys: 1.096 ± 0.015	2.064MetLeu: 2.064 ± 0.019	0.62MetMet: 0.62 ± 0.012	0.869MetAsn: 0.869 ± 0.014	1.376MetPro: 1.376 ± 0.021	0.998MetGln: 0.998 ± 0.015	1.475MetArg: 1.475 ± 0.018	1.887MetSer: 1.887 ± 0.02	1.322MetThr: 1.322 ± 0.018	1.319MetVal: 1.319 ± 0.018	0.293MetTrp: 0.293 ± 0.009	0.588MetTyr: 0.588 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.27AsnAla: 3.27 ± 0.028	0.484AsnCys: 0.484 ± 0.011	1.95AsnAsp: 1.95 ± 0.021	2.144AsnGlu: 2.144 ± 0.019	1.435AsnPhe: 1.435 ± 0.021	3.172AsnGly: 3.172 ± 0.029	0.862AsnHis: 0.862 ± 0.014	2.114AsnIle: 2.114 ± 0.023	1.551AsnLys: 1.551 ± 0.019	3.255AsnLeu: 3.255 ± 0.029	0.868AsnMet: 0.868 ± 0.015	1.441AsnAsn: 1.441 ± 0.024	2.287AsnPro: 2.287 ± 0.023	1.305AsnGln: 1.305 ± 0.016	1.983AsnArg: 1.983 ± 0.023	2.737AsnSer: 2.737 ± 0.025	2.14AsnThr: 2.14 ± 0.026	2.401AsnVal: 2.401 ± 0.026	0.565AsnTrp: 0.565 ± 0.011	1.056AsnTyr: 1.056 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.848ProAla: 4.848 ± 0.046	0.586ProCys: 0.586 ± 0.014	2.988ProAsp: 2.988 ± 0.024	3.463ProGlu: 3.463 ± 0.032	1.99ProPhe: 1.99 ± 0.023	3.735ProGly: 3.735 ± 0.037	1.429ProHis: 1.429 ± 0.018	2.61ProIle: 2.61 ± 0.028	2.558ProLys: 2.558 ± 0.03	4.657ProLeu: 4.657 ± 0.036	1.123ProMet: 1.123 ± 0.016	2.244ProAsn: 2.244 ± 0.025	5.28ProPro: 5.28 ± 0.069	2.429ProGln: 2.429 ± 0.028	3.279ProArg: 3.279 ± 0.031	5.742ProSer: 5.742 ± 0.045	3.782ProThr: 3.782 ± 0.032	3.22ProVal: 3.22 ± 0.024	0.728ProTrp: 0.728 ± 0.015	1.55ProTyr: 1.55 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.469GlnAla: 3.469 ± 0.032	0.501GlnCys: 0.501 ± 0.01	1.977GlnAsp: 1.977 ± 0.019	2.37GlnGlu: 2.37 ± 0.025	1.218GlnPhe: 1.218 ± 0.016	2.316GlnGly: 2.316 ± 0.024	1.233GlnHis: 1.233 ± 0.019	2.064GlnIle: 2.064 ± 0.023	2.04GlnLys: 2.04 ± 0.026	3.509GlnLeu: 3.509 ± 0.03	1.006GlnMet: 1.006 ± 0.017	1.647GlnAsn: 1.647 ± 0.021	2.512GlnPro: 2.512 ± 0.028	2.795GlnGln: 2.795 ± 0.054	2.917GlnArg: 2.917 ± 0.027	3.162GlnSer: 3.162 ± 0.03	2.41GlnThr: 2.41 ± 0.025	2.098GlnVal: 2.098 ± 0.023	0.598GlnTrp: 0.598 ± 0.011	1.214GlnTyr: 1.214 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.034ArgAla: 5.034 ± 0.039	0.844ArgCys: 0.844 ± 0.015	3.314ArgAsp: 3.314 ± 0.031	4.159ArgGlu: 4.159 ± 0.038	2.194ArgPhe: 2.194 ± 0.023	3.834ArgGly: 3.834 ± 0.04	1.733ArgHis: 1.733 ± 0.022	3.072ArgIle: 3.072 ± 0.025	3.821ArgLys: 3.821 ± 0.033	5.789ArgLeu: 5.789 ± 0.037	1.53ArgMet: 1.53 ± 0.015	2.301ArgAsn: 2.301 ± 0.025	3.659ArgPro: 3.659 ± 0.032	2.888ArgGln: 2.888 ± 0.026	5.713ArgArg: 5.713 ± 0.06	4.816ArgSer: 4.816 ± 0.048	3.482ArgThr: 3.482 ± 0.033	3.424ArgVal: 3.424 ± 0.029	1.023ArgTrp: 1.023 ± 0.016	1.727ArgTyr: 1.727 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.579SerAla: 6.579 ± 0.043	0.952SerCys: 0.952 ± 0.017	3.981SerAsp: 3.981 ± 0.031	4.072SerGlu: 4.072 ± 0.032	2.795SerPhe: 2.795 ± 0.028	5.652SerGly: 5.652 ± 0.042	1.947SerHis: 1.947 ± 0.024	3.966SerIle: 3.966 ± 0.034	3.571SerLys: 3.571 ± 0.033	6.834SerLeu: 6.834 ± 0.045	1.807SerMet: 1.807 ± 0.02	3.051SerAsn: 3.051 ± 0.025	5.202SerPro: 5.202 ± 0.051	3.146SerGln: 3.146 ± 0.03	4.938SerArg: 4.938 ± 0.04	8.199SerSer: 8.199 ± 0.076	5.32SerThr: 5.32 ± 0.043	4.473SerVal: 4.473 ± 0.038	1.098SerTrp: 1.098 ± 0.018	2.002SerTyr: 2.002 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.271ThrAla: 5.271 ± 0.039	0.805ThrCys: 0.805 ± 0.014	2.642ThrAsp: 2.642 ± 0.025	2.926ThrGlu: 2.926 ± 0.028	2.249ThrPhe: 2.249 ± 0.022	4.069ThrGly: 4.069 ± 0.036	1.343ThrHis: 1.343 ± 0.019	3.086ThrIle: 3.086 ± 0.028	2.47ThrLys: 2.47 ± 0.028	5.201ThrLeu: 5.201 ± 0.032	1.231ThrMet: 1.231 ± 0.017	2.121ThrAsn: 2.121 ± 0.025	3.941ThrPro: 3.941 ± 0.04	2.028ThrGln: 2.028 ± 0.022	3.092ThrArg: 3.092 ± 0.027	5.285ThrSer: 5.285 ± 0.043	3.965ThrThr: 3.965 ± 0.036	3.679ThrVal: 3.679 ± 0.029	0.816ThrTrp: 0.816 ± 0.014	1.651ThrTyr: 1.651 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.158ValAla: 5.158 ± 0.034	0.916ValCys: 0.916 ± 0.017	3.572ValAsp: 3.572 ± 0.032	3.893ValGlu: 3.893 ± 0.035	2.339ValPhe: 2.339 ± 0.027	4.116ValGly: 4.116 ± 0.037	1.448ValHis: 1.448 ± 0.021	2.935ValIle: 2.935 ± 0.03	2.864ValLys: 2.864 ± 0.029	5.504ValLeu: 5.504 ± 0.038	1.37ValMet: 1.37 ± 0.017	2.24ValAsn: 2.24 ± 0.024	3.418ValPro: 3.418 ± 0.032	2.449ValGln: 2.449 ± 0.025	3.699ValArg: 3.699 ± 0.029	4.415ValSer: 4.415 ± 0.037	3.346ValThr: 3.346 ± 0.031	4.098ValVal: 4.098 ± 0.038	0.91ValTrp: 0.91 ± 0.015	1.704ValTyr: 1.704 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.143TrpAla: 1.143 ± 0.017	0.234TrpCys: 0.234 ± 0.007	0.846TrpAsp: 0.846 ± 0.014	0.828TrpGlu: 0.828 ± 0.013	0.546TrpPhe: 0.546 ± 0.011	0.877TrpGly: 0.877 ± 0.015	0.394TrpHis: 0.394 ± 0.01	0.822TrpIle: 0.822 ± 0.015	0.794TrpLys: 0.794 ± 0.014	1.411TrpLeu: 1.411 ± 0.021	0.396TrpMet: 0.396 ± 0.009	0.628TrpAsn: 0.628 ± 0.012	0.671TrpPro: 0.671 ± 0.014	0.646TrpGln: 0.646 ± 0.012	1.079TrpArg: 1.079 ± 0.016	1.066TrpSer: 1.066 ± 0.018	0.937TrpThr: 0.937 ± 0.014	0.843TrpVal: 0.843 ± 0.013	0.294TrpTrp: 0.294 ± 0.009	0.439TrpTyr: 0.439 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.022	0.46TyrCys: 0.46 ± 0.011	1.664TyrAsp: 1.664 ± 0.02	1.622TyrGlu: 1.622 ± 0.02	1.213TyrPhe: 1.213 ± 0.016	2.175TyrGly: 2.175 ± 0.023	0.759TyrHis: 0.759 ± 0.013	1.509TyrIle: 1.509 ± 0.02	1.097TyrLys: 1.097 ± 0.017	2.632TyrLeu: 2.632 ± 0.024	0.634TyrMet: 0.634 ± 0.014	1.174TyrAsn: 1.174 ± 0.017	1.477TyrPro: 1.477 ± 0.018	1.094TyrGln: 1.094 ± 0.016	1.677TyrArg: 1.677 ± 0.019	1.985TyrSer: 1.985 ± 0.025	1.613TyrThr: 1.613 ± 0.021	1.699TyrVal: 1.699 ± 0.021	0.433TyrTrp: 0.433 ± 0.011	0.975TyrTyr: 0.975 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11098 proteins (4519851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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