Amino acid dipepetide frequency for Halobiforma nitratireducens JCM 10879

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.348AlaAla: 12.348 ± 0.173	0.694AlaCys: 0.694 ± 0.026	10.193AlaAsp: 10.193 ± 0.124	8.525AlaGlu: 8.525 ± 0.115	3.644AlaPhe: 3.644 ± 0.064	9.038AlaGly: 9.038 ± 0.108	1.718AlaHis: 1.718 ± 0.04	5.163AlaIle: 5.163 ± 0.088	1.624AlaLys: 1.624 ± 0.045	9.578AlaLeu: 9.578 ± 0.123	1.88AlaMet: 1.88 ± 0.047	2.212AlaAsn: 2.212 ± 0.046	3.537AlaPro: 3.537 ± 0.062	1.919AlaGln: 1.919 ± 0.049	5.749AlaArg: 5.749 ± 0.091	5.345AlaSer: 5.345 ± 0.087	7.173AlaThr: 7.173 ± 0.106	10.371AlaVal: 10.371 ± 0.14	0.995AlaTrp: 0.995 ± 0.032	2.597AlaTyr: 2.597 ± 0.051	0.006AlaXaa: 0.006 ± 0.003
Cys	0.541CysAla: 0.541 ± 0.025	0.113CysCys: 0.113 ± 0.011	0.624CysAsp: 0.624 ± 0.026	0.651CysGlu: 0.651 ± 0.027	0.197CysPhe: 0.197 ± 0.013	0.833CysGly: 0.833 ± 0.032	0.218CysHis: 0.218 ± 0.014	0.258CysIle: 0.258 ± 0.018	0.111CysLys: 0.111 ± 0.01	0.656CysLeu: 0.656 ± 0.027	0.109CysMet: 0.109 ± 0.009	0.2CysAsn: 0.2 ± 0.013	0.539CysPro: 0.539 ± 0.023	0.165CysGln: 0.165 ± 0.013	0.545CysArg: 0.545 ± 0.023	0.451CysSer: 0.451 ± 0.021	0.396CysThr: 0.396 ± 0.021	0.462CysVal: 0.462 ± 0.022	0.09CysTrp: 0.09 ± 0.009	0.228CysTyr: 0.228 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	10.291AspAla: 10.291 ± 0.118	0.718AspCys: 0.718 ± 0.028	9.82AspAsp: 9.82 ± 0.169	9.616AspGlu: 9.616 ± 0.116	1.767AspPhe: 1.767 ± 0.047	9.465AspGly: 9.465 ± 0.14	2.086AspHis: 2.086 ± 0.051	2.842AspIle: 2.842 ± 0.055	0.779AspLys: 0.779 ± 0.028	7.272AspLeu: 7.272 ± 0.105	1.069AspMet: 1.069 ± 0.032	1.218AspAsn: 1.218 ± 0.034	5.225AspPro: 5.225 ± 0.077	1.733AspGln: 1.733 ± 0.04	7.596AspArg: 7.596 ± 0.09	4.135AspSer: 4.135 ± 0.066	4.092AspThr: 4.092 ± 0.074	7.76AspVal: 7.76 ± 0.096	0.999AspTrp: 0.999 ± 0.037	1.819AspTyr: 1.819 ± 0.05	0.003AspXaa: 0.003 ± 0.002
Glu	8.78GluAla: 8.78 ± 0.097	0.561GluCys: 0.561 ± 0.023	7.164GluAsp: 7.164 ± 0.102	7.842GluGlu: 7.842 ± 0.132	3.298GluPhe: 3.298 ± 0.056	6.014GluGly: 6.014 ± 0.089	2.162GluHis: 2.162 ± 0.051	4.586GluIle: 4.586 ± 0.085	1.851GluLys: 1.851 ± 0.047	8.155GluLeu: 8.155 ± 0.087	1.864GluMet: 1.864 ± 0.047	2.602GluAsn: 2.602 ± 0.061	5.206GluPro: 5.206 ± 0.081	2.865GluGln: 2.865 ± 0.062	8.401GluArg: 8.401 ± 0.129	5.968GluSer: 5.968 ± 0.084	7.902GluThr: 7.902 ± 0.101	5.979GluVal: 5.979 ± 0.097	1.17GluTrp: 1.17 ± 0.032	3.049GluTyr: 3.049 ± 0.052	0.005GluXaa: 0.005 ± 0.002
Phe	3.5PheAla: 3.5 ± 0.063	0.254PheCys: 0.254 ± 0.016	3.354PheAsp: 3.354 ± 0.063	3.273PheGlu: 3.273 ± 0.065	0.933PhePhe: 0.933 ± 0.034	2.982PheGly: 2.982 ± 0.063	0.629PheHis: 0.629 ± 0.023	0.877PheIle: 0.877 ± 0.036	0.38PheLys: 0.38 ± 0.02	2.721PheLeu: 2.721 ± 0.065	0.481PheMet: 0.481 ± 0.025	0.575PheAsn: 0.575 ± 0.024	1.301PhePro: 1.301 ± 0.038	0.706PheGln: 0.706 ± 0.027	1.741PheArg: 1.741 ± 0.044	1.488PheSer: 1.488 ± 0.04	1.672PheThr: 1.672 ± 0.046	3.311PheVal: 3.311 ± 0.054	0.415PheTrp: 0.415 ± 0.022	0.802PheTyr: 0.802 ± 0.026	0.002PheXaa: 0.002 ± 0.001
Gly	7.289GlyAla: 7.289 ± 0.107	0.801GlyCys: 0.801 ± 0.033	7.636GlyAsp: 7.636 ± 0.101	7.271GlyGlu: 7.271 ± 0.1	2.967GlyPhe: 2.967 ± 0.054	7.027GlyGly: 7.027 ± 0.108	1.631GlyHis: 1.631 ± 0.047	4.312GlyIle: 4.312 ± 0.07	1.716GlyLys: 1.716 ± 0.053	7.079GlyLeu: 7.079 ± 0.104	1.614GlyMet: 1.614 ± 0.039	1.907GlyAsn: 1.907 ± 0.047	3.553GlyPro: 3.553 ± 0.063	1.968GlyGln: 1.968 ± 0.051	5.06GlyArg: 5.06 ± 0.082	5.445GlySer: 5.445 ± 0.084	6.329GlyThr: 6.329 ± 0.093	7.131GlyVal: 7.131 ± 0.085	1.119GlyTrp: 1.119 ± 0.035	2.622GlyTyr: 2.622 ± 0.045	0.002GlyXaa: 0.002 ± 0.002
His	1.935HisAla: 1.935 ± 0.041	0.203HisCys: 0.203 ± 0.016	2.017HisAsp: 2.017 ± 0.057	1.937HisGlu: 1.937 ± 0.046	0.492HisPhe: 0.492 ± 0.022	1.995HisGly: 1.995 ± 0.055	0.503HisHis: 0.503 ± 0.026	0.539HisIle: 0.539 ± 0.023	0.256HisLys: 0.256 ± 0.017	1.65HisLeu: 1.65 ± 0.041	0.264HisMet: 0.264 ± 0.015	0.39HisAsn: 0.39 ± 0.02	1.218HisPro: 1.218 ± 0.038	0.483HisGln: 0.483 ± 0.033	1.294HisArg: 1.294 ± 0.042	0.871HisSer: 0.871 ± 0.03	1.05HisThr: 1.05 ± 0.033	2.012HisVal: 2.012 ± 0.048	0.224HisTrp: 0.224 ± 0.015	0.564HisTyr: 0.564 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.005IleAla: 5.005 ± 0.088	0.255IleCys: 0.255 ± 0.014	4.672IleAsp: 4.672 ± 0.075	4.589IleGlu: 4.589 ± 0.069	0.931IlePhe: 0.931 ± 0.037	3.961IleGly: 3.961 ± 0.066	0.722IleHis: 0.722 ± 0.024	1.143IleIle: 1.143 ± 0.038	0.624IleLys: 0.624 ± 0.024	2.699IleLeu: 2.699 ± 0.06	0.48IleMet: 0.48 ± 0.023	0.866IleAsn: 0.866 ± 0.028	1.875IlePro: 1.875 ± 0.045	0.935IleGln: 0.935 ± 0.033	2.322IleArg: 2.322 ± 0.042	2.071IleSer: 2.071 ± 0.049	2.333IleThr: 2.333 ± 0.051	4.278IleVal: 4.278 ± 0.081	0.322IleTrp: 0.322 ± 0.017	0.93IleTyr: 0.93 ± 0.035	0.001IleXaa: 0.001 ± 0.001
Lys	1.524LysAla: 1.524 ± 0.04	0.096LysCys: 0.096 ± 0.012	0.962LysAsp: 0.962 ± 0.038	1.22LysGlu: 1.22 ± 0.041	0.423LysPhe: 0.423 ± 0.018	1.16LysGly: 1.16 ± 0.038	0.455LysHis: 0.455 ± 0.022	0.696LysIle: 0.696 ± 0.03	0.474LysLys: 0.474 ± 0.028	1.538LysLeu: 1.538 ± 0.039	0.332LysMet: 0.332 ± 0.018	0.509LysAsn: 0.509 ± 0.027	0.852LysPro: 0.852 ± 0.03	0.624LysGln: 0.624 ± 0.027	1.633LysArg: 1.633 ± 0.043	0.976LysSer: 0.976 ± 0.033	1.158LysThr: 1.158 ± 0.042	0.959LysVal: 0.959 ± 0.033	0.189LysTrp: 0.189 ± 0.015	0.463LysTyr: 0.463 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	10.436LeuAla: 10.436 ± 0.144	0.616LeuCys: 0.616 ± 0.025	5.593LeuAsp: 5.593 ± 0.073	12.607LeuGlu: 12.607 ± 0.127	3.005LeuPhe: 3.005 ± 0.068	7.013LeuGly: 7.013 ± 0.102	1.382LeuHis: 1.382 ± 0.041	2.88LeuIle: 2.88 ± 0.067	1.233LeuLys: 1.233 ± 0.038	8.409LeuLeu: 8.409 ± 0.135	1.123LeuMet: 1.123 ± 0.033	1.453LeuAsn: 1.453 ± 0.036	3.921LeuPro: 3.921 ± 0.067	1.822LeuGln: 1.822 ± 0.045	4.953LeuArg: 4.953 ± 0.063	5.144LeuSer: 5.144 ± 0.075	4.878LeuThr: 4.878 ± 0.062	8.034LeuVal: 8.034 ± 0.122	0.849LeuTrp: 0.849 ± 0.028	2.108LeuTyr: 2.108 ± 0.049	0.004LeuXaa: 0.004 ± 0.002
Met	1.742MetAla: 1.742 ± 0.041	0.118MetCys: 0.118 ± 0.01	1.138MetAsp: 1.138 ± 0.035	1.102MetGlu: 1.102 ± 0.037	0.484MetPhe: 0.484 ± 0.023	1.364MetGly: 1.364 ± 0.037	0.322MetHis: 0.322 ± 0.019	0.714MetIle: 0.714 ± 0.026	0.387MetLys: 0.387 ± 0.022	1.385MetLeu: 1.385 ± 0.039	0.293MetMet: 0.293 ± 0.017	0.548MetAsn: 0.548 ± 0.026	0.764MetPro: 0.764 ± 0.028	0.457MetGln: 0.457 ± 0.023	0.904MetArg: 0.904 ± 0.031	1.342MetSer: 1.342 ± 0.037	1.486MetThr: 1.486 ± 0.038	1.187MetVal: 1.187 ± 0.039	0.16MetTrp: 0.16 ± 0.011	0.397MetTyr: 0.397 ± 0.019	0.002MetXaa: 0.002 ± 0.001
Asn	2.513AsnAla: 2.513 ± 0.044	0.199AsnCys: 0.199 ± 0.014	1.768AsnAsp: 1.768 ± 0.044	1.956AsnGlu: 1.956 ± 0.051	0.532AsnPhe: 0.532 ± 0.026	2.006AsnGly: 2.006 ± 0.044	0.475AsnHis: 0.475 ± 0.022	0.658AsnIle: 0.658 ± 0.025	0.384AsnLys: 0.384 ± 0.023	1.724AsnLeu: 1.724 ± 0.041	0.35AsnMet: 0.35 ± 0.018	0.42AsnAsn: 0.42 ± 0.023	1.4AsnPro: 1.4 ± 0.037	0.522AsnGln: 0.522 ± 0.024	1.681AsnArg: 1.681 ± 0.046	0.841AsnSer: 0.841 ± 0.026	1.124AsnThr: 1.124 ± 0.039	2.237AsnVal: 2.237 ± 0.047	0.315AsnTrp: 0.315 ± 0.019	0.605AsnTyr: 0.605 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	4.765ProAla: 4.765 ± 0.07	0.259ProCys: 0.259 ± 0.018	5.415ProAsp: 5.415 ± 0.085	4.855ProGlu: 4.855 ± 0.077	1.52ProPhe: 1.52 ± 0.042	3.926ProGly: 3.926 ± 0.07	0.858ProHis: 0.858 ± 0.033	2.133ProIle: 2.133 ± 0.049	0.794ProLys: 0.794 ± 0.03	3.675ProLeu: 3.675 ± 0.072	0.808ProMet: 0.808 ± 0.03	1.197ProAsn: 1.197 ± 0.034	2.224ProPro: 2.224 ± 0.049	0.923ProGln: 0.923 ± 0.037	2.342ProArg: 2.342 ± 0.053	2.78ProSer: 2.78 ± 0.063	3.346ProThr: 3.346 ± 0.062	4.039ProVal: 4.039 ± 0.074	0.527ProTrp: 0.527 ± 0.021	1.114ProTyr: 1.114 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	2.261GlnAla: 2.261 ± 0.054	0.152GlnCys: 0.152 ± 0.01	1.29GlnAsp: 1.29 ± 0.04	1.915GlnGlu: 1.915 ± 0.056	0.975GlnPhe: 0.975 ± 0.028	1.505GlnGly: 1.505 ± 0.043	0.534GlnHis: 0.534 ± 0.034	0.942GlnIle: 0.942 ± 0.029	0.459GlnLys: 0.459 ± 0.022	2.497GlnLeu: 2.497 ± 0.051	0.464GlnMet: 0.464 ± 0.022	0.572GlnAsn: 0.572 ± 0.027	1.152GlnPro: 1.152 ± 0.035	0.987GlnGln: 0.987 ± 0.041	1.99GlnArg: 1.99 ± 0.048	1.433GlnSer: 1.433 ± 0.042	1.338GlnThr: 1.338 ± 0.034	1.669GlnVal: 1.669 ± 0.045	0.357GlnTrp: 0.357 ± 0.021	0.807GlnTyr: 0.807 ± 0.032	0.001GlnXaa: 0.001 ± 0.001
Arg	5.913ArgAla: 5.913 ± 0.088	0.525ArgCys: 0.525 ± 0.026	5.355ArgAsp: 5.355 ± 0.071	7.009ArgGlu: 7.009 ± 0.089	2.238ArgPhe: 2.238 ± 0.05	4.35ArgGly: 4.35 ± 0.075	1.312ArgHis: 1.312 ± 0.04	3.221ArgIle: 3.221 ± 0.053	1.415ArgLys: 1.415 ± 0.039	6.228ArgLeu: 6.228 ± 0.076	1.237ArgMet: 1.237 ± 0.035	1.667ArgAsn: 1.667 ± 0.05	2.763ArgPro: 2.763 ± 0.061	1.775ArgGln: 1.775 ± 0.047	5.372ArgArg: 5.372 ± 0.102	4.039ArgSer: 4.039 ± 0.083	4.449ArgThr: 4.449 ± 0.071	5.049ArgVal: 5.049 ± 0.076	0.77ArgTrp: 0.77 ± 0.031	1.98ArgTyr: 1.98 ± 0.046	0.003ArgXaa: 0.003 ± 0.002
Ser	5.071SerAla: 5.071 ± 0.083	0.37SerCys: 0.37 ± 0.019	4.988SerAsp: 4.988 ± 0.086	4.776SerGlu: 4.776 ± 0.087	1.802SerPhe: 1.802 ± 0.043	5.207SerGly: 5.207 ± 0.08	1.087SerHis: 1.087 ± 0.036	2.488SerIle: 2.488 ± 0.052	1.029SerLys: 1.029 ± 0.027	4.715SerLeu: 4.715 ± 0.076	1.048SerMet: 1.048 ± 0.03	1.306SerAsn: 1.306 ± 0.037	2.729SerPro: 2.729 ± 0.059	1.309SerGln: 1.309 ± 0.035	3.538SerArg: 3.538 ± 0.075	3.519SerSer: 3.519 ± 0.086	3.536SerThr: 3.536 ± 0.073	4.894SerVal: 4.894 ± 0.075	0.609SerTrp: 0.609 ± 0.026	1.396SerTyr: 1.396 ± 0.042	0.001SerXaa: 0.001 ± 0.001
Thr	7.023ThrAla: 7.023 ± 0.109	0.408ThrCys: 0.408 ± 0.023	6.425ThrAsp: 6.425 ± 0.097	5.227ThrGlu: 5.227 ± 0.066	2.039ThrPhe: 2.039 ± 0.043	5.858ThrGly: 5.858 ± 0.081	1.223ThrHis: 1.223 ± 0.037	3.31ThrIle: 3.31 ± 0.062	0.95ThrLys: 0.95 ± 0.033	5.572ThrLeu: 5.572 ± 0.074	1.084ThrMet: 1.084 ± 0.033	1.488ThrAsn: 1.488 ± 0.041	3.112ThrPro: 3.112 ± 0.062	1.311ThrGln: 1.311 ± 0.041	3.295ThrArg: 3.295 ± 0.066	2.869ThrSer: 2.869 ± 0.063	4.345ThrThr: 4.345 ± 0.082	7.088ThrVal: 7.088 ± 0.098	0.59ThrTrp: 0.59 ± 0.02	1.6ThrTyr: 1.6 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.781ValAla: 9.781 ± 0.126	0.691ValCys: 0.691 ± 0.025	8.246ValAsp: 8.246 ± 0.095	7.491ValGlu: 7.491 ± 0.102	2.868ValPhe: 2.868 ± 0.063	7.687ValGly: 7.687 ± 0.119	1.669ValHis: 1.669 ± 0.039	3.087ValIle: 3.087 ± 0.058	1.169ValLys: 1.169 ± 0.035	8.216ValLeu: 8.216 ± 0.116	1.257ValMet: 1.257 ± 0.039	1.712ValAsn: 1.712 ± 0.045	4.447ValPro: 4.447 ± 0.081	1.83ValGln: 1.83 ± 0.038	5.502ValArg: 5.502 ± 0.07	5.021ValSer: 5.021 ± 0.084	6.047ValThr: 6.047 ± 0.085	9.107ValVal: 9.107 ± 0.135	0.836ValTrp: 0.836 ± 0.028	2.159ValTyr: 2.159 ± 0.046	0.002ValXaa: 0.002 ± 0.002
Trp	0.847TrpAla: 0.847 ± 0.03	0.102TrpCys: 0.102 ± 0.01	0.812TrpAsp: 0.812 ± 0.033	0.868TrpGlu: 0.868 ± 0.028	0.456TrpPhe: 0.456 ± 0.024	0.847TrpGly: 0.847 ± 0.032	0.28TrpHis: 0.28 ± 0.016	0.545TrpIle: 0.545 ± 0.023	0.235TrpLys: 0.235 ± 0.017	1.261TrpLeu: 1.261 ± 0.04	0.21TrpMet: 0.21 ± 0.013	0.347TrpAsn: 0.347 ± 0.017	0.421TrpPro: 0.421 ± 0.022	0.338TrpGln: 0.338 ± 0.016	0.767TrpArg: 0.767 ± 0.034	0.587TrpSer: 0.587 ± 0.026	0.79TrpThr: 0.79 ± 0.027	0.813TrpVal: 0.813 ± 0.032	0.203TrpTrp: 0.203 ± 0.014	0.366TrpTyr: 0.366 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.054	0.252TyrCys: 0.252 ± 0.016	2.829TyrAsp: 2.829 ± 0.056	2.692TyrGlu: 2.692 ± 0.066	0.826TyrPhe: 0.826 ± 0.032	2.24TyrGly: 2.24 ± 0.049	0.629TyrHis: 0.629 ± 0.026	0.618TyrIle: 0.618 ± 0.024	0.375TyrLys: 0.375 ± 0.017	2.427TyrLeu: 2.427 ± 0.047	0.331TyrMet: 0.331 ± 0.018	0.523TyrAsn: 0.523 ± 0.024	1.255TyrPro: 1.255 ± 0.037	0.627TyrGln: 0.627 ± 0.028	1.981TyrArg: 1.981 ± 0.044	1.088TyrSer: 1.088 ± 0.033	1.369TyrThr: 1.369 ± 0.04	2.441TyrVal: 2.441 ± 0.051	0.355TyrTrp: 0.355 ± 0.019	0.82TyrTyr: 0.82 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.003XaaAsp: 0.003 ± 0.002	0.002XaaGlu: 0.002 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.004XaaLeu: 0.004 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.005XaaPro: 0.005 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.005XaaSer: 0.005 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3534 proteins (1004006 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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