Amino acid dipepetide frequency for Thermodesulforhabdus norvegica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.273AlaAla: 6.273 ± 0.127	1.113AlaCys: 1.113 ± 0.032	3.538AlaAsp: 3.538 ± 0.066	5.577AlaGlu: 5.577 ± 0.103	3.674AlaPhe: 3.674 ± 0.066	6.346AlaGly: 6.346 ± 0.103	1.542AlaHis: 1.542 ± 0.037	4.71AlaIle: 4.71 ± 0.078	3.149AlaLys: 3.149 ± 0.062	9.358AlaLeu: 9.358 ± 0.112	2.037AlaMet: 2.037 ± 0.048	1.682AlaAsn: 1.682 ± 0.043	2.496AlaPro: 2.496 ± 0.056	2.097AlaGln: 2.097 ± 0.058	5.807AlaArg: 5.807 ± 0.08	4.333AlaSer: 4.333 ± 0.078	3.247AlaThr: 3.247 ± 0.065	6.909AlaVal: 6.909 ± 0.091	0.804AlaTrp: 0.804 ± 0.032	2.501AlaTyr: 2.501 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.037	0.268CysCys: 0.268 ± 0.019	0.701CysAsp: 0.701 ± 0.03	0.824CysGlu: 0.824 ± 0.027	0.616CysPhe: 0.616 ± 0.026	1.405CysGly: 1.405 ± 0.044	0.38CysHis: 0.38 ± 0.027	0.758CysIle: 0.758 ± 0.026	0.544CysLys: 0.544 ± 0.027	1.242CysLeu: 1.242 ± 0.037	0.304CysMet: 0.304 ± 0.02	0.416CysAsn: 0.416 ± 0.023	0.878CysPro: 0.878 ± 0.038	0.289CysGln: 0.289 ± 0.02	1.077CysArg: 1.077 ± 0.044	0.863CysSer: 0.863 ± 0.035	0.618CysThr: 0.618 ± 0.027	1.014CysVal: 1.014 ± 0.043	0.155CysTrp: 0.155 ± 0.014	0.437CysTyr: 0.437 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.485AspAla: 3.485 ± 0.069	0.587AspCys: 0.587 ± 0.028	2.447AspAsp: 2.447 ± 0.054	4.078AspGlu: 4.078 ± 0.072	2.585AspPhe: 2.585 ± 0.052	3.636AspGly: 3.636 ± 0.064	0.994AspHis: 0.994 ± 0.035	3.523AspIle: 3.523 ± 0.064	1.932AspLys: 1.932 ± 0.052	5.6AspLeu: 5.6 ± 0.086	1.224AspMet: 1.224 ± 0.04	1.209AspAsn: 1.209 ± 0.04	3.101AspPro: 3.101 ± 0.058	1.211AspGln: 1.211 ± 0.036	3.987AspArg: 3.987 ± 0.079	2.119AspSer: 2.119 ± 0.055	1.947AspThr: 1.947 ± 0.05	4.258AspVal: 4.258 ± 0.083	0.631AspTrp: 0.631 ± 0.025	1.756AspTyr: 1.756 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.555GluAla: 6.555 ± 0.101	0.756GluCys: 0.756 ± 0.031	3.717GluAsp: 3.717 ± 0.068	6.838GluGlu: 6.838 ± 0.118	2.562GluPhe: 2.562 ± 0.052	5.004GluGly: 5.004 ± 0.07	1.315GluHis: 1.315 ± 0.035	5.429GluIle: 5.429 ± 0.083	5.885GluLys: 5.885 ± 0.098	7.391GluLeu: 7.391 ± 0.111	2.025GluMet: 2.025 ± 0.053	2.604GluAsn: 2.604 ± 0.051	2.523GluPro: 2.523 ± 0.065	2.051GluGln: 2.051 ± 0.054	5.434GluArg: 5.434 ± 0.093	3.328GluSer: 3.328 ± 0.066	3.129GluThr: 3.129 ± 0.064	5.685GluVal: 5.685 ± 0.092	0.91GluTrp: 0.91 ± 0.034	2.123GluTyr: 2.123 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.09PheAla: 3.09 ± 0.067	0.764PheCys: 0.764 ± 0.03	2.287PheAsp: 2.287 ± 0.05	2.723PheGlu: 2.723 ± 0.06	2.459PhePhe: 2.459 ± 0.065	3.322PheGly: 3.322 ± 0.072	0.954PheHis: 0.954 ± 0.03	2.622PheIle: 2.622 ± 0.061	1.597PheLys: 1.597 ± 0.043	4.907PheLeu: 4.907 ± 0.096	1.081PheMet: 1.081 ± 0.034	1.191PheAsn: 1.191 ± 0.04	2.125PhePro: 2.125 ± 0.053	1.13PheGln: 1.13 ± 0.038	3.173PheArg: 3.173 ± 0.059	2.981PheSer: 2.981 ± 0.059	2.022PheThr: 2.022 ± 0.047	3.439PheVal: 3.439 ± 0.061	0.631PheTrp: 0.631 ± 0.03	1.593PheTyr: 1.593 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.484GlyAla: 5.484 ± 0.095	1.216GlyCys: 1.216 ± 0.044	3.543GlyAsp: 3.543 ± 0.078	4.785GlyGlu: 4.785 ± 0.082	3.615GlyPhe: 3.615 ± 0.066	5.422GlyGly: 5.422 ± 0.098	1.588GlyHis: 1.588 ± 0.04	6.186GlyIle: 6.186 ± 0.093	4.631GlyLys: 4.631 ± 0.08	7.739GlyLeu: 7.739 ± 0.104	2.094GlyMet: 2.094 ± 0.056	2.357GlyAsn: 2.357 ± 0.047	2.597GlyPro: 2.597 ± 0.055	1.817GlyGln: 1.817 ± 0.051	5.269GlyArg: 5.269 ± 0.085	4.469GlySer: 4.469 ± 0.073	3.953GlyThr: 3.953 ± 0.073	5.811GlyVal: 5.811 ± 0.09	1.062GlyTrp: 1.062 ± 0.032	2.771GlyTyr: 2.771 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.373HisAla: 1.373 ± 0.043	0.308HisCys: 0.308 ± 0.019	0.91HisAsp: 0.91 ± 0.035	1.274HisGlu: 1.274 ± 0.037	0.995HisPhe: 0.995 ± 0.034	1.607HisGly: 1.607 ± 0.046	0.559HisHis: 0.559 ± 0.027	1.329HisIle: 1.329 ± 0.043	0.787HisLys: 0.787 ± 0.033	1.975HisLeu: 1.975 ± 0.056	0.423HisMet: 0.423 ± 0.023	0.623HisAsn: 0.623 ± 0.024	1.402HisPro: 1.402 ± 0.034	0.518HisGln: 0.518 ± 0.024	1.495HisArg: 1.495 ± 0.038	1.018HisSer: 1.018 ± 0.036	0.823HisThr: 0.823 ± 0.034	1.456HisVal: 1.456 ± 0.037	0.192HisTrp: 0.192 ± 0.014	0.728HisTyr: 0.728 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.412IleAla: 5.412 ± 0.089	0.937IleCys: 0.937 ± 0.036	3.419IleAsp: 3.419 ± 0.062	4.651IleGlu: 4.651 ± 0.07	2.944IlePhe: 2.944 ± 0.065	4.682IleGly: 4.682 ± 0.088	1.326IleHis: 1.326 ± 0.04	4.216IleIle: 4.216 ± 0.089	3.355IleLys: 3.355 ± 0.064	6.723IleLeu: 6.723 ± 0.101	1.467IleMet: 1.467 ± 0.053	2.076IleAsn: 2.076 ± 0.051	3.906IlePro: 3.906 ± 0.067	1.564IleGln: 1.564 ± 0.049	4.808IleArg: 4.808 ± 0.075	4.12IleSer: 4.12 ± 0.077	3.524IleThr: 3.524 ± 0.062	5.244IleVal: 5.244 ± 0.087	0.639IleTrp: 0.639 ± 0.031	1.918IleTyr: 1.918 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.584LysAla: 4.584 ± 0.09	0.548LysCys: 0.548 ± 0.029	2.749LysAsp: 2.749 ± 0.058	4.651LysGlu: 4.651 ± 0.087	1.604LysPhe: 1.604 ± 0.044	4.066LysGly: 4.066 ± 0.081	0.954LysHis: 0.954 ± 0.036	3.814LysIle: 3.814 ± 0.064	4.187LysLys: 4.187 ± 0.082	4.521LysLeu: 4.521 ± 0.069	1.235LysMet: 1.235 ± 0.036	1.943LysAsn: 1.943 ± 0.058	2.564LysPro: 2.564 ± 0.057	1.246LysGln: 1.246 ± 0.041	3.516LysArg: 3.516 ± 0.075	2.798LysSer: 2.798 ± 0.056	2.645LysThr: 2.645 ± 0.049	3.801LysVal: 3.801 ± 0.077	0.656LysTrp: 0.656 ± 0.032	1.525LysTyr: 1.525 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.991LeuAla: 7.991 ± 0.098	1.585LeuCys: 1.585 ± 0.049	5.071LeuAsp: 5.071 ± 0.091	7.749LeuGlu: 7.749 ± 0.101	4.376LeuPhe: 4.376 ± 0.085	7.532LeuGly: 7.532 ± 0.104	1.876LeuHis: 1.876 ± 0.049	6.519LeuIle: 6.519 ± 0.09	6.581LeuLys: 6.581 ± 0.096	10.051LeuLeu: 10.051 ± 0.145	2.41LeuMet: 2.41 ± 0.052	3.098LeuAsn: 3.098 ± 0.06	4.892LeuPro: 4.892 ± 0.078	2.877LeuGln: 2.877 ± 0.059	6.652LeuArg: 6.652 ± 0.098	6.529LeuSer: 6.529 ± 0.087	4.699LeuThr: 4.699 ± 0.087	7.261LeuVal: 7.261 ± 0.098	1.277LeuTrp: 1.277 ± 0.042	2.973LeuTyr: 2.973 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.277MetAla: 2.277 ± 0.048	0.254MetCys: 0.254 ± 0.018	1.233MetAsp: 1.233 ± 0.037	1.871MetGlu: 1.871 ± 0.045	0.738MetPhe: 0.738 ± 0.031	2.065MetGly: 2.065 ± 0.055	0.357MetHis: 0.357 ± 0.02	1.605MetIle: 1.605 ± 0.047	1.867MetLys: 1.867 ± 0.045	2.072MetLeu: 2.072 ± 0.05	0.602MetMet: 0.602 ± 0.03	0.846MetAsn: 0.846 ± 0.03	1.1MetPro: 1.1 ± 0.042	0.559MetGln: 0.559 ± 0.025	1.311MetArg: 1.311 ± 0.041	1.441MetSer: 1.441 ± 0.046	1.231MetThr: 1.231 ± 0.036	1.948MetVal: 1.948 ± 0.05	0.208MetTrp: 0.208 ± 0.016	0.506MetTyr: 0.506 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.155AsnAla: 2.155 ± 0.054	0.414AsnCys: 0.414 ± 0.023	1.209AsnAsp: 1.209 ± 0.041	1.665AsnGlu: 1.665 ± 0.042	1.271AsnPhe: 1.271 ± 0.043	2.024AsnGly: 2.024 ± 0.054	0.585AsnHis: 0.585 ± 0.025	2.222AsnIle: 2.222 ± 0.048	1.159AsnLys: 1.159 ± 0.042	3.433AsnLeu: 3.433 ± 0.059	0.659AsnMet: 0.659 ± 0.026	0.879AsnAsn: 0.879 ± 0.032	2.322AsnPro: 2.322 ± 0.063	0.631AsnGln: 0.631 ± 0.027	2.326AsnArg: 2.326 ± 0.061	1.444AsnSer: 1.444 ± 0.043	1.227AsnThr: 1.227 ± 0.039	2.373AsnVal: 2.373 ± 0.052	0.387AsnTrp: 0.387 ± 0.024	1.013AsnTyr: 1.013 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.179ProAla: 3.179 ± 0.062	0.612ProCys: 0.612 ± 0.034	3.217ProAsp: 3.217 ± 0.06	4.924ProGlu: 4.924 ± 0.075	2.285ProPhe: 2.285 ± 0.051	4.291ProGly: 4.291 ± 0.078	1.041ProHis: 1.041 ± 0.04	2.359ProIle: 2.359 ± 0.051	1.614ProLys: 1.614 ± 0.044	4.488ProLeu: 4.488 ± 0.075	0.943ProMet: 0.943 ± 0.032	1.095ProAsn: 1.095 ± 0.03	2.363ProPro: 2.363 ± 0.056	1.25ProGln: 1.25 ± 0.033	2.519ProArg: 2.519 ± 0.052	2.614ProSer: 2.614 ± 0.06	1.742ProThr: 1.742 ± 0.045	4.517ProVal: 4.517 ± 0.065	0.619ProTrp: 0.619 ± 0.03	1.747ProTyr: 1.747 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.22GlnAla: 2.22 ± 0.055	0.311GlnCys: 0.311 ± 0.02	1.258GlnAsp: 1.258 ± 0.038	2.068GlnGlu: 2.068 ± 0.047	0.89GlnPhe: 0.89 ± 0.035	1.807GlnGly: 1.807 ± 0.043	0.438GlnHis: 0.438 ± 0.025	1.819GlnIle: 1.819 ± 0.048	2.052GlnLys: 2.052 ± 0.048	2.14GlnLeu: 2.14 ± 0.056	0.69GlnMet: 0.69 ± 0.03	0.914GlnAsn: 0.914 ± 0.033	0.952GlnPro: 0.952 ± 0.036	0.823GlnGln: 0.823 ± 0.033	1.717GlnArg: 1.717 ± 0.051	1.266GlnSer: 1.266 ± 0.039	1.068GlnThr: 1.068 ± 0.033	1.965GlnVal: 1.965 ± 0.044	0.306GlnTrp: 0.306 ± 0.019	0.722GlnTyr: 0.722 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.933ArgAla: 4.933 ± 0.08	0.959ArgCys: 0.959 ± 0.037	3.57ArgAsp: 3.57 ± 0.073	5.731ArgGlu: 5.731 ± 0.096	3.113ArgPhe: 3.113 ± 0.067	4.274ArgGly: 4.274 ± 0.077	1.352ArgHis: 1.352 ± 0.04	5.291ArgIle: 5.291 ± 0.07	4.192ArgLys: 4.192 ± 0.077	7.054ArgLeu: 7.054 ± 0.096	1.697ArgMet: 1.697 ± 0.04	2.296ArgAsn: 2.296 ± 0.055	2.924ArgPro: 2.924 ± 0.064	1.885ArgGln: 1.885 ± 0.05	5.101ArgArg: 5.101 ± 0.089	3.684ArgSer: 3.684 ± 0.071	2.828ArgThr: 2.828 ± 0.059	5.323ArgVal: 5.323 ± 0.075	1.025ArgTrp: 1.025 ± 0.045	2.35ArgTyr: 2.35 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.887SerAla: 3.887 ± 0.072	0.794SerCys: 0.794 ± 0.033	2.671SerAsp: 2.671 ± 0.057	3.838SerGlu: 3.838 ± 0.072	2.771SerPhe: 2.771 ± 0.062	5.161SerGly: 5.161 ± 0.093	1.116SerHis: 1.116 ± 0.04	3.508SerIle: 3.508 ± 0.065	2.192SerLys: 2.192 ± 0.052	6.053SerLeu: 6.053 ± 0.083	1.389SerMet: 1.389 ± 0.043	1.279SerAsn: 1.279 ± 0.034	2.88SerPro: 2.88 ± 0.053	1.454SerGln: 1.454 ± 0.051	4.079SerArg: 4.079 ± 0.067	3.357SerSer: 3.357 ± 0.075	2.398SerThr: 2.398 ± 0.055	4.365SerVal: 4.365 ± 0.073	0.798SerTrp: 0.798 ± 0.032	1.778SerTyr: 1.778 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.764ThrAla: 3.764 ± 0.07	0.615ThrCys: 0.615 ± 0.026	2.222ThrAsp: 2.222 ± 0.062	2.93ThrGlu: 2.93 ± 0.062	2.051ThrPhe: 2.051 ± 0.055	4.567ThrGly: 4.567 ± 0.077	0.861ThrHis: 0.861 ± 0.032	2.775ThrIle: 2.775 ± 0.065	1.636ThrLys: 1.636 ± 0.043	4.683ThrLeu: 4.683 ± 0.086	0.988ThrMet: 0.988 ± 0.034	1.108ThrAsn: 1.108 ± 0.038	2.499ThrPro: 2.499 ± 0.055	0.934ThrGln: 0.934 ± 0.037	2.711ThrArg: 2.711 ± 0.051	2.312ThrSer: 2.312 ± 0.061	2.289ThrThr: 2.289 ± 0.056	4.165ThrVal: 4.165 ± 0.064	0.54ThrTrp: 0.54 ± 0.027	1.419ThrTyr: 1.419 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	6.288ValAla: 6.288 ± 0.085	1.127ValCys: 1.127 ± 0.039	4.217ValAsp: 4.217 ± 0.075	5.954ValGlu: 5.954 ± 0.101	3.459ValPhe: 3.459 ± 0.072	5.532ValGly: 5.532 ± 0.077	1.563ValHis: 1.563 ± 0.043	5.638ValIle: 5.638 ± 0.086	4.339ValLys: 4.339 ± 0.074	7.9ValLeu: 7.9 ± 0.096	1.92ValMet: 1.92 ± 0.046	2.365ValAsn: 2.365 ± 0.052	3.755ValPro: 3.755 ± 0.066	1.86ValGln: 1.86 ± 0.045	5.104ValArg: 5.104 ± 0.079	4.758ValSer: 4.758 ± 0.073	3.851ValThr: 3.851 ± 0.065	7.199ValVal: 7.199 ± 0.105	0.787ValTrp: 0.787 ± 0.033	2.294ValTyr: 2.294 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.834TrpAla: 0.834 ± 0.034	0.191TrpCys: 0.191 ± 0.016	0.634TrpAsp: 0.634 ± 0.026	0.878TrpGlu: 0.878 ± 0.034	0.552TrpPhe: 0.552 ± 0.024	0.9TrpGly: 0.9 ± 0.033	0.265TrpHis: 0.265 ± 0.018	0.904TrpIle: 0.904 ± 0.035	0.849TrpLys: 0.849 ± 0.03	1.207TrpLeu: 1.207 ± 0.035	0.292TrpMet: 0.292 ± 0.02	0.528TrpAsn: 0.528 ± 0.026	0.453TrpPro: 0.453 ± 0.026	0.441TrpGln: 0.441 ± 0.022	0.735TrpArg: 0.735 ± 0.03	0.646TrpSer: 0.646 ± 0.029	0.516TrpThr: 0.516 ± 0.029	0.838TrpVal: 0.838 ± 0.035	0.2TrpTrp: 0.2 ± 0.018	0.371TrpTyr: 0.371 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.049	0.491TyrCys: 0.491 ± 0.022	1.695TyrAsp: 1.695 ± 0.047	2.254TyrGlu: 2.254 ± 0.054	1.531TyrPhe: 1.531 ± 0.045	2.763TyrGly: 2.763 ± 0.062	0.727TyrHis: 0.727 ± 0.029	1.708TyrIle: 1.708 ± 0.047	1.06TyrLys: 1.06 ± 0.035	3.463TyrLeu: 3.463 ± 0.067	0.609TyrMet: 0.609 ± 0.029	0.887TyrAsn: 0.887 ± 0.037	1.686TyrPro: 1.686 ± 0.048	0.789TyrGln: 0.789 ± 0.03	2.761TyrArg: 2.761 ± 0.053	1.688TyrSer: 1.688 ± 0.051	1.313TyrThr: 1.313 ± 0.039	2.339TyrVal: 2.339 ± 0.05	0.409TyrTrp: 0.409 ± 0.023	1.135TyrTyr: 1.135 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2661 proteins (865482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---