Amino acid dipepetide frequency for Rutstroemia sp. NJR-2017a BVV2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.298AlaAla: 8.298 ± 0.063	0.971AlaCys: 0.971 ± 0.014	3.964AlaAsp: 3.964 ± 0.035	5.064AlaGlu: 5.064 ± 0.045	2.995AlaPhe: 2.995 ± 0.028	5.623AlaGly: 5.623 ± 0.044	1.605AlaHis: 1.605 ± 0.019	4.305AlaIle: 4.305 ± 0.042	4.243AlaLys: 4.243 ± 0.044	7.288AlaLeu: 7.288 ± 0.057	1.927AlaMet: 1.927 ± 0.021	3.068AlaAsn: 3.068 ± 0.031	4.453AlaPro: 4.453 ± 0.048	3.135AlaGln: 3.135 ± 0.031	4.388AlaArg: 4.388 ± 0.036	7.039AlaSer: 7.039 ± 0.05	5.153AlaThr: 5.153 ± 0.04	4.976AlaVal: 4.976 ± 0.039	1.077AlaTrp: 1.077 ± 0.017	2.123AlaTyr: 2.123 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.887CysAla: 0.887 ± 0.014	0.228CysCys: 0.228 ± 0.009	0.603CysAsp: 0.603 ± 0.013	0.599CysGlu: 0.599 ± 0.011	0.519CysPhe: 0.519 ± 0.013	0.91CysGly: 0.91 ± 0.017	0.278CysHis: 0.278 ± 0.009	0.735CysIle: 0.735 ± 0.014	0.544CysLys: 0.544 ± 0.011	1.187CysLeu: 1.187 ± 0.019	0.267CysMet: 0.267 ± 0.008	0.401CysAsn: 0.401 ± 0.009	0.604CysPro: 0.604 ± 0.014	0.396CysGln: 0.396 ± 0.01	0.646CysArg: 0.646 ± 0.014	0.903CysSer: 0.903 ± 0.017	0.711CysThr: 0.711 ± 0.015	0.742CysVal: 0.742 ± 0.014	0.207CysTrp: 0.207 ± 0.007	0.356CysTyr: 0.356 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.325AspAla: 4.325 ± 0.04	0.589AspCys: 0.589 ± 0.013	3.976AspAsp: 3.976 ± 0.047	4.469AspGlu: 4.469 ± 0.046	2.163AspPhe: 2.163 ± 0.024	3.996AspGly: 3.996 ± 0.032	1.125AspHis: 1.125 ± 0.02	3.247AspIle: 3.247 ± 0.029	2.372AspLys: 2.372 ± 0.029	4.884AspLeu: 4.884 ± 0.035	1.232AspMet: 1.232 ± 0.02	1.877AspAsn: 1.877 ± 0.023	3.043AspPro: 3.043 ± 0.028	1.684AspGln: 1.684 ± 0.019	2.81AspArg: 2.81 ± 0.035	4.158AspSer: 4.158 ± 0.039	2.94AspThr: 2.94 ± 0.031	3.524AspVal: 3.524 ± 0.031	0.859AspTrp: 0.859 ± 0.015	1.603AspTyr: 1.603 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.222GluAla: 5.222 ± 0.046	0.611GluCys: 0.611 ± 0.013	4.309GluAsp: 4.309 ± 0.042	6.065GluGlu: 6.065 ± 0.072	2.045GluPhe: 2.045 ± 0.021	4.221GluGly: 4.221 ± 0.038	1.325GluHis: 1.325 ± 0.021	3.406GluIle: 3.406 ± 0.03	4.336GluLys: 4.336 ± 0.044	5.174GluLeu: 5.174 ± 0.048	1.593GluMet: 1.593 ± 0.023	2.565GluAsn: 2.565 ± 0.025	2.65GluPro: 2.65 ± 0.042	2.35GluGln: 2.35 ± 0.028	3.963GluArg: 3.963 ± 0.041	4.36GluSer: 4.36 ± 0.04	3.436GluThr: 3.436 ± 0.032	3.807GluVal: 3.807 ± 0.034	0.925GluTrp: 0.925 ± 0.014	1.728GluTyr: 1.728 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.933PheAla: 2.933 ± 0.03	0.543PheCys: 0.543 ± 0.013	2.196PheAsp: 2.196 ± 0.024	2.234PheGlu: 2.234 ± 0.023	1.57PhePhe: 1.57 ± 0.022	2.912PheGly: 2.912 ± 0.032	0.868PheHis: 0.868 ± 0.015	1.889PheIle: 1.889 ± 0.023	1.608PheLys: 1.608 ± 0.024	3.5PheLeu: 3.5 ± 0.034	0.803PheMet: 0.803 ± 0.013	1.488PheAsn: 1.488 ± 0.019	1.935PhePro: 1.935 ± 0.022	1.356PheGln: 1.356 ± 0.02	1.858PheArg: 1.858 ± 0.021	3.105PheSer: 3.105 ± 0.026	2.287PheThr: 2.287 ± 0.027	2.339PheVal: 2.339 ± 0.026	0.629PheTrp: 0.629 ± 0.014	1.106PheTyr: 1.106 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.311GlyAla: 5.311 ± 0.045	0.847GlyCys: 0.847 ± 0.015	3.532GlyAsp: 3.532 ± 0.032	4.051GlyGlu: 4.051 ± 0.042	2.823GlyPhe: 2.823 ± 0.026	6.245GlyGly: 6.245 ± 0.066	1.623GlyHis: 1.623 ± 0.025	3.741GlyIle: 3.741 ± 0.04	3.966GlyLys: 3.966 ± 0.037	5.977GlyLeu: 5.977 ± 0.047	1.779GlyMet: 1.779 ± 0.021	2.782GlyAsn: 2.782 ± 0.031	3.017GlyPro: 3.017 ± 0.033	2.308GlyGln: 2.308 ± 0.029	4.117GlyArg: 4.117 ± 0.039	5.824GlySer: 5.824 ± 0.051	4.151GlyThr: 4.151 ± 0.033	4.521GlyVal: 4.521 ± 0.041	1.215GlyTrp: 1.215 ± 0.017	2.201GlyTyr: 2.201 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.646HisAla: 1.646 ± 0.019	0.311HisCys: 0.311 ± 0.009	1.215HisAsp: 1.215 ± 0.018	1.31HisGlu: 1.31 ± 0.018	0.892HisPhe: 0.892 ± 0.015	1.591HisGly: 1.591 ± 0.023	0.763HisHis: 0.763 ± 0.016	1.247HisIle: 1.247 ± 0.018	0.963HisLys: 0.963 ± 0.017	2.116HisLeu: 2.116 ± 0.027	0.458HisMet: 0.458 ± 0.01	0.9HisAsn: 0.9 ± 0.016	1.566HisPro: 1.566 ± 0.024	0.89HisGln: 0.89 ± 0.016	1.321HisArg: 1.321 ± 0.019	1.871HisSer: 1.871 ± 0.023	1.332HisThr: 1.332 ± 0.018	1.258HisVal: 1.258 ± 0.018	0.306HisTrp: 0.306 ± 0.009	0.678HisTyr: 0.678 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.265IleAla: 4.265 ± 0.034	0.789IleCys: 0.789 ± 0.016	2.992IleAsp: 2.992 ± 0.029	3.191IleGlu: 3.191 ± 0.032	2.169IlePhe: 2.169 ± 0.026	3.378IleGly: 3.378 ± 0.035	1.23IleHis: 1.23 ± 0.016	2.812IleIle: 2.812 ± 0.032	2.429IleLys: 2.429 ± 0.026	4.921IleLeu: 4.921 ± 0.046	1.115IleMet: 1.115 ± 0.016	2.057IleAsn: 2.057 ± 0.024	3.241IlePro: 3.241 ± 0.031	1.938IleGln: 1.938 ± 0.019	2.844IleArg: 2.844 ± 0.03	4.376IleSer: 4.376 ± 0.039	3.172IleThr: 3.172 ± 0.03	3.305IleVal: 3.305 ± 0.034	0.788IleTrp: 0.788 ± 0.014	1.592IleTyr: 1.592 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.358LysAla: 4.358 ± 0.042	0.522LysCys: 0.522 ± 0.011	3.033LysAsp: 3.033 ± 0.034	3.948LysGlu: 3.948 ± 0.043	1.605LysPhe: 1.605 ± 0.023	3.42LysGly: 3.42 ± 0.033	1.153LysHis: 1.153 ± 0.016	2.625LysIle: 2.625 ± 0.029	3.796LysLys: 3.796 ± 0.053	4.358LysLeu: 4.358 ± 0.04	1.206LysMet: 1.206 ± 0.017	2.034LysAsn: 2.034 ± 0.023	2.767LysPro: 2.767 ± 0.032	1.86LysGln: 1.86 ± 0.02	3.393LysArg: 3.393 ± 0.033	4.047LysSer: 4.047 ± 0.041	3.045LysThr: 3.045 ± 0.029	3.111LysVal: 3.111 ± 0.03	0.741LysTrp: 0.741 ± 0.014	1.55LysTyr: 1.55 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	7.246LeuAla: 7.246 ± 0.056	1.133LeuCys: 1.133 ± 0.02	4.928LeuAsp: 4.928 ± 0.037	5.527LeuGlu: 5.527 ± 0.043	3.251LeuPhe: 3.251 ± 0.033	5.949LeuGly: 5.949 ± 0.046	2.149LeuHis: 2.149 ± 0.026	4.139LeuIle: 4.139 ± 0.038	4.485LeuLys: 4.485 ± 0.039	8.411LeuLeu: 8.411 ± 0.08	1.795LeuMet: 1.795 ± 0.022	3.298LeuAsn: 3.298 ± 0.033	5.382LeuPro: 5.382 ± 0.037	3.733LeuGln: 3.733 ± 0.039	5.322LeuArg: 5.322 ± 0.043	7.448LeuSer: 7.448 ± 0.044	4.888LeuThr: 4.888 ± 0.042	5.191LeuVal: 5.191 ± 0.043	1.185LeuTrp: 1.185 ± 0.02	2.397LeuTyr: 2.397 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.063MetAla: 2.063 ± 0.022	0.249MetCys: 0.249 ± 0.009	1.298MetAsp: 1.298 ± 0.018	1.395MetGlu: 1.395 ± 0.018	0.775MetPhe: 0.775 ± 0.017	1.581MetGly: 1.581 ± 0.02	0.494MetHis: 0.494 ± 0.01	1.123MetIle: 1.123 ± 0.019	1.198MetLys: 1.198 ± 0.017	1.832MetLeu: 1.832 ± 0.023	0.602MetMet: 0.602 ± 0.014	0.916MetAsn: 0.916 ± 0.017	1.173MetPro: 1.173 ± 0.017	0.855MetGln: 0.855 ± 0.014	1.268MetArg: 1.268 ± 0.019	1.899MetSer: 1.899 ± 0.024	1.319MetThr: 1.319 ± 0.018	1.371MetVal: 1.371 ± 0.017	0.267MetTrp: 0.267 ± 0.007	0.553MetTyr: 0.553 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.286AsnAla: 3.286 ± 0.033	0.459AsnCys: 0.459 ± 0.011	2.049AsnAsp: 2.049 ± 0.025	2.196AsnGlu: 2.196 ± 0.021	1.529AsnPhe: 1.529 ± 0.019	3.309AsnGly: 3.309 ± 0.031	0.92AsnHis: 0.92 ± 0.015	2.336AsnIle: 2.336 ± 0.026	1.688AsnLys: 1.688 ± 0.019	3.475AsnLeu: 3.475 ± 0.033	0.902AsnMet: 0.902 ± 0.015	1.709AsnAsn: 1.709 ± 0.024	2.496AsnPro: 2.496 ± 0.024	1.368AsnGln: 1.368 ± 0.018	1.905AsnArg: 1.905 ± 0.018	3.245AsnSer: 3.245 ± 0.032	2.492AsnThr: 2.492 ± 0.029	2.358AsnVal: 2.358 ± 0.025	0.582AsnTrp: 0.582 ± 0.014	1.216AsnTyr: 1.216 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	4.688ProAla: 4.688 ± 0.046	0.447ProCys: 0.447 ± 0.011	2.81ProAsp: 2.81 ± 0.025	3.653ProGlu: 3.653 ± 0.039	1.997ProPhe: 1.997 ± 0.023	3.53ProGly: 3.53 ± 0.034	1.25ProHis: 1.25 ± 0.02	2.736ProIle: 2.736 ± 0.029	2.831ProLys: 2.831 ± 0.032	4.626ProLeu: 4.626 ± 0.031	1.038ProMet: 1.038 ± 0.017	2.351ProAsn: 2.351 ± 0.027	4.755ProPro: 4.755 ± 0.063	2.353ProGln: 2.353 ± 0.036	3.129ProArg: 3.129 ± 0.036	5.998ProSer: 5.998 ± 0.058	4.099ProThr: 4.099 ± 0.04	3.311ProVal: 3.311 ± 0.034	0.665ProTrp: 0.665 ± 0.015	1.521ProTyr: 1.521 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.143GlnAla: 3.143 ± 0.03	0.385GlnCys: 0.385 ± 0.012	1.875GlnAsp: 1.875 ± 0.021	2.341GlnGlu: 2.341 ± 0.03	1.256GlnPhe: 1.256 ± 0.019	2.266GlnGly: 2.266 ± 0.025	0.936GlnHis: 0.936 ± 0.015	1.963GlnIle: 1.963 ± 0.025	2.108GlnLys: 2.108 ± 0.023	3.203GlnLeu: 3.203 ± 0.034	0.833GlnMet: 0.833 ± 0.016	1.671GlnAsn: 1.671 ± 0.023	2.206GlnPro: 2.206 ± 0.033	2.055GlnGln: 2.055 ± 0.043	2.314GlnArg: 2.314 ± 0.023	3.115GlnSer: 3.115 ± 0.033	2.297GlnThr: 2.297 ± 0.026	2.038GlnVal: 2.038 ± 0.023	0.522GlnTrp: 0.522 ± 0.012	1.169GlnTyr: 1.169 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.204ArgAla: 4.204 ± 0.034	0.636ArgCys: 0.636 ± 0.013	3.133ArgAsp: 3.133 ± 0.037	3.931ArgGlu: 3.931 ± 0.045	1.97ArgPhe: 1.97 ± 0.021	3.764ArgGly: 3.764 ± 0.038	1.333ArgHis: 1.333 ± 0.019	2.9ArgIle: 2.9 ± 0.029	3.673ArgLys: 3.673 ± 0.033	4.899ArgLeu: 4.899 ± 0.038	1.299ArgMet: 1.299 ± 0.017	2.337ArgAsn: 2.337 ± 0.027	3.054ArgPro: 3.054 ± 0.036	2.256ArgGln: 2.256 ± 0.024	4.554ArgArg: 4.554 ± 0.045	4.583ArgSer: 4.583 ± 0.043	3.175ArgThr: 3.175 ± 0.03	3.104ArgVal: 3.104 ± 0.029	0.868ArgTrp: 0.868 ± 0.013	1.592ArgTyr: 1.592 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.668SerAla: 6.668 ± 0.051	0.875SerCys: 0.875 ± 0.016	4.106SerAsp: 4.106 ± 0.038	4.325SerGlu: 4.325 ± 0.046	3.143SerPhe: 3.143 ± 0.028	5.742SerGly: 5.742 ± 0.047	1.942SerHis: 1.942 ± 0.026	4.575SerIle: 4.575 ± 0.037	4.208SerLys: 4.208 ± 0.04	7.215SerLeu: 7.215 ± 0.046	1.791SerMet: 1.791 ± 0.021	3.461SerAsn: 3.461 ± 0.031	5.577SerPro: 5.577 ± 0.058	3.183SerGln: 3.183 ± 0.033	4.775SerArg: 4.775 ± 0.048	9.739SerSer: 9.739 ± 0.124	6.275SerThr: 6.275 ± 0.066	4.6SerVal: 4.6 ± 0.039	1.122SerTrp: 1.122 ± 0.017	2.264SerTyr: 2.264 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.044ThrAla: 5.044 ± 0.04	0.733ThrCys: 0.733 ± 0.014	2.765ThrAsp: 2.765 ± 0.024	3.158ThrGlu: 3.158 ± 0.031	2.361ThrPhe: 2.361 ± 0.022	4.263ThrGly: 4.263 ± 0.039	1.308ThrHis: 1.308 ± 0.018	3.443ThrIle: 3.443 ± 0.029	2.899ThrLys: 2.899 ± 0.028	5.324ThrLeu: 5.324 ± 0.044	1.256ThrMet: 1.256 ± 0.016	2.455ThrAsn: 2.455 ± 0.024	4.423ThrPro: 4.423 ± 0.056	2.101ThrGln: 2.101 ± 0.022	2.993ThrArg: 2.993 ± 0.028	6.072ThrSer: 6.072 ± 0.063	4.785ThrThr: 4.785 ± 0.054	3.663ThrVal: 3.663 ± 0.033	0.833ThrTrp: 0.833 ± 0.016	1.773ThrTyr: 1.773 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	4.913ValAla: 4.913 ± 0.039	0.768ValCys: 0.768 ± 0.013	3.574ValAsp: 3.574 ± 0.033	4.107ValGlu: 4.107 ± 0.037	2.357ValPhe: 2.357 ± 0.027	4.188ValGly: 4.188 ± 0.036	1.262ValHis: 1.262 ± 0.018	3.003ValIle: 3.003 ± 0.028	3.132ValLys: 3.132 ± 0.033	5.432ValLeu: 5.432 ± 0.048	1.334ValMet: 1.334 ± 0.017	2.277ValAsn: 2.277 ± 0.024	3.371ValPro: 3.371 ± 0.03	2.243ValGln: 2.243 ± 0.021	3.231ValArg: 3.231 ± 0.032	4.561ValSer: 4.561 ± 0.042	3.391ValThr: 3.391 ± 0.035	4.34ValVal: 4.34 ± 0.041	0.866ValTrp: 0.866 ± 0.016	1.727ValTyr: 1.727 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.062TrpAla: 1.062 ± 0.017	0.196TrpCys: 0.196 ± 0.007	0.872TrpAsp: 0.872 ± 0.016	0.896TrpGlu: 0.896 ± 0.015	0.516TrpPhe: 0.516 ± 0.011	1.01TrpGly: 1.01 ± 0.018	0.324TrpHis: 0.324 ± 0.008	0.82TrpIle: 0.82 ± 0.013	0.866TrpLys: 0.866 ± 0.015	1.282TrpLeu: 1.282 ± 0.018	0.379TrpMet: 0.379 ± 0.009	0.645TrpAsn: 0.645 ± 0.013	0.551TrpPro: 0.551 ± 0.011	0.526TrpGln: 0.526 ± 0.013	0.899TrpArg: 0.899 ± 0.017	1.039TrpSer: 1.039 ± 0.018	0.903TrpThr: 0.903 ± 0.015	0.907TrpVal: 0.907 ± 0.016	0.274TrpTrp: 0.274 ± 0.009	0.422TrpTyr: 0.422 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.136TyrAla: 2.136 ± 0.025	0.431TyrCys: 0.431 ± 0.012	1.646TyrAsp: 1.646 ± 0.021	1.631TyrGlu: 1.631 ± 0.019	1.226TyrPhe: 1.226 ± 0.02	2.136TyrGly: 2.136 ± 0.026	0.742TyrHis: 0.742 ± 0.014	1.559TyrIle: 1.559 ± 0.022	1.226TyrLys: 1.226 ± 0.018	2.753TyrLeu: 2.753 ± 0.025	0.621TyrMet: 0.621 ± 0.011	1.226TyrAsn: 1.226 ± 0.018	1.521TyrPro: 1.521 ± 0.023	1.103TyrGln: 1.103 ± 0.016	1.537TyrArg: 1.537 ± 0.019	2.205TyrSer: 2.205 ± 0.033	1.8TyrThr: 1.8 ± 0.024	1.612TyrVal: 1.612 ± 0.02	0.46TyrTrp: 0.46 ± 0.01	0.978TyrTyr: 0.978 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8646 proteins (4317793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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