Amino acid dipepetide frequency for Ferroglobus placidus (strain DSM 10642 / AEDII12DO)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.372AlaAla: 5.372 ± 0.117	0.84AlaCys: 0.84 ± 0.044	2.807AlaAsp: 2.807 ± 0.08	6.755AlaGlu: 6.755 ± 0.129	3.545AlaPhe: 3.545 ± 0.078	5.03AlaGly: 5.03 ± 0.107	0.892AlaHis: 0.892 ± 0.041	5.87AlaIle: 5.87 ± 0.096	6.178AlaLys: 6.178 ± 0.096	7.277AlaLeu: 7.277 ± 0.12	1.767AlaMet: 1.767 ± 0.057	1.998AlaAsn: 1.998 ± 0.059	1.818AlaPro: 1.818 ± 0.062	1.037AlaGln: 1.037 ± 0.043	3.276AlaArg: 3.276 ± 0.08	3.606AlaSer: 3.606 ± 0.08	2.891AlaThr: 2.891 ± 0.079	6.52AlaVal: 6.52 ± 0.111	0.655AlaTrp: 0.655 ± 0.033	2.611AlaTyr: 2.611 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.587CysAla: 0.587 ± 0.027	0.148CysCys: 0.148 ± 0.016	0.543CysAsp: 0.543 ± 0.028	0.945CysGlu: 0.945 ± 0.045	0.404CysPhe: 0.404 ± 0.027	1.225CysGly: 1.225 ± 0.049	0.563CysHis: 0.563 ± 0.086	0.627CysIle: 0.627 ± 0.03	0.781CysLys: 0.781 ± 0.043	0.781CysLeu: 0.781 ± 0.04	0.271CysMet: 0.271 ± 0.022	0.35CysAsn: 0.35 ± 0.024	0.73CysPro: 0.73 ± 0.042	0.167CysGln: 0.167 ± 0.017	0.59CysArg: 0.59 ± 0.032	0.692CysSer: 0.692 ± 0.034	0.409CysThr: 0.409 ± 0.025	0.852CysVal: 0.852 ± 0.043	0.151CysTrp: 0.151 ± 0.022	0.468CysTyr: 0.468 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	3.096AspAla: 3.096 ± 0.074	0.598AspCys: 0.598 ± 0.04	1.935AspAsp: 1.935 ± 0.053	4.965AspGlu: 4.965 ± 0.092	2.919AspPhe: 2.919 ± 0.073	3.135AspGly: 3.135 ± 0.079	0.669AspHis: 0.669 ± 0.03	3.173AspIle: 3.173 ± 0.062	3.043AspLys: 3.043 ± 0.069	4.926AspLeu: 4.926 ± 0.083	0.905AspMet: 0.905 ± 0.035	1.188AspAsn: 1.188 ± 0.05	2.13AspPro: 2.13 ± 0.057	0.543AspGln: 0.543 ± 0.031	2.305AspArg: 2.305 ± 0.06	2.192AspSer: 2.192 ± 0.065	1.632AspThr: 1.632 ± 0.053	5.2AspVal: 5.2 ± 0.099	0.668AspTrp: 0.668 ± 0.034	2.355AspTyr: 2.355 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.04GluAla: 6.04 ± 0.101	0.692GluCys: 0.692 ± 0.035	4.703GluAsp: 4.703 ± 0.083	11.113GluGlu: 11.113 ± 0.175	4.422GluPhe: 4.422 ± 0.089	5.265GluGly: 5.265 ± 0.114	1.117GluHis: 1.117 ± 0.041	8.824GluIle: 8.824 ± 0.128	10.472GluLys: 10.472 ± 0.176	8.588GluLeu: 8.588 ± 0.134	2.277GluMet: 2.277 ± 0.064	3.986GluAsn: 3.986 ± 0.084	1.9GluPro: 1.9 ± 0.052	1.117GluGln: 1.117 ± 0.041	5.775GluArg: 5.775 ± 0.109	3.834GluSer: 3.834 ± 0.091	2.772GluThr: 2.772 ± 0.071	8.554GluVal: 8.554 ± 0.135	0.948GluTrp: 0.948 ± 0.041	2.878GluTyr: 2.878 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.412PheAla: 3.412 ± 0.094	0.587PheCys: 0.587 ± 0.03	2.593PheAsp: 2.593 ± 0.068	4.502PheGlu: 4.502 ± 0.09	2.374PhePhe: 2.374 ± 0.075	3.695PheGly: 3.695 ± 0.086	0.639PheHis: 0.639 ± 0.029	2.838PheIle: 2.838 ± 0.07	3.1PheLys: 3.1 ± 0.068	4.796PheLeu: 4.796 ± 0.111	0.878PheMet: 0.878 ± 0.039	1.396PheAsn: 1.396 ± 0.046	1.729PhePro: 1.729 ± 0.057	0.746PheGln: 0.746 ± 0.03	2.209PheArg: 2.209 ± 0.054	3.289PheSer: 3.289 ± 0.074	1.926PheThr: 1.926 ± 0.053	4.488PheVal: 4.488 ± 0.089	0.536PheTrp: 0.536 ± 0.03	1.907PheTyr: 1.907 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.181GlyAla: 4.181 ± 0.091	0.942GlyCys: 0.942 ± 0.049	3.276GlyAsp: 3.276 ± 0.082	6.158GlyGlu: 6.158 ± 0.092	3.37GlyPhe: 3.37 ± 0.073	4.675GlyGly: 4.675 ± 0.095	0.958GlyHis: 0.958 ± 0.038	5.905GlyIle: 5.905 ± 0.091	6.456GlyLys: 6.456 ± 0.117	5.25GlyLeu: 5.25 ± 0.099	1.792GlyMet: 1.792 ± 0.05	2.239GlyAsn: 2.239 ± 0.07	1.229GlyPro: 1.229 ± 0.043	0.819GlyGln: 0.819 ± 0.037	3.651GlyArg: 3.651 ± 0.088	3.45GlySer: 3.45 ± 0.081	2.751GlyThr: 2.751 ± 0.08	6.27GlyVal: 6.27 ± 0.093	0.858GlyTrp: 0.858 ± 0.04	3.065GlyTyr: 3.065 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.185HisAla: 1.185 ± 0.046	0.218HisCys: 0.218 ± 0.019	0.692HisAsp: 0.692 ± 0.031	1.07HisGlu: 1.07 ± 0.044	0.707HisPhe: 0.707 ± 0.034	1.206HisGly: 1.206 ± 0.052	0.328HisHis: 0.328 ± 0.024	0.964HisIle: 0.964 ± 0.04	0.804HisLys: 0.804 ± 0.034	1.385HisLeu: 1.385 ± 0.04	0.292HisMet: 0.292 ± 0.024	0.421HisAsn: 0.421 ± 0.026	1.032HisPro: 1.032 ± 0.041	0.283HisGln: 0.283 ± 0.024	0.719HisArg: 0.719 ± 0.037	0.857HisSer: 0.857 ± 0.038	0.602HisThr: 0.602 ± 0.035	1.264HisVal: 1.264 ± 0.043	0.136HisTrp: 0.136 ± 0.017	0.698HisTyr: 0.698 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.397IleAla: 6.397 ± 0.111	0.869IleCys: 0.869 ± 0.043	3.954IleAsp: 3.954 ± 0.083	6.835IleGlu: 6.835 ± 0.12	3.727IlePhe: 3.727 ± 0.096	5.008IleGly: 5.008 ± 0.098	1.169IleHis: 1.169 ± 0.043	5.098IleIle: 5.098 ± 0.091	5.359IleLys: 5.359 ± 0.086	7.698IleLeu: 7.698 ± 0.118	1.399IleMet: 1.399 ± 0.045	2.445IleAsn: 2.445 ± 0.068	3.503IlePro: 3.503 ± 0.074	1.187IleGln: 1.187 ± 0.045	3.718IleArg: 3.718 ± 0.087	4.973IleSer: 4.973 ± 0.091	3.317IleThr: 3.317 ± 0.073	6.692IleVal: 6.692 ± 0.118	0.596IleTrp: 0.596 ± 0.03	3.032IleTyr: 3.032 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	6.213LysAla: 6.213 ± 0.096	0.884LysCys: 0.884 ± 0.047	4.007LysAsp: 4.007 ± 0.082	8.554LysGlu: 8.554 ± 0.143	3.638LysPhe: 3.638 ± 0.076	4.812LysGly: 4.812 ± 0.095	1.193LysHis: 1.193 ± 0.043	7.636LysIle: 7.636 ± 0.107	7.681LysLys: 7.681 ± 0.124	8.07LysLeu: 8.07 ± 0.117	1.75LysMet: 1.75 ± 0.051	3.177LysAsn: 3.177 ± 0.064	3.099LysPro: 3.099 ± 0.07	1.094LysGln: 1.094 ± 0.042	4.644LysArg: 4.644 ± 0.098	4.004LysSer: 4.004 ± 0.089	3.109LysThr: 3.109 ± 0.064	7.051LysVal: 7.051 ± 0.115	0.73LysTrp: 0.73 ± 0.035	3.037LysTyr: 3.037 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.421LeuAla: 7.421 ± 0.124	0.819LeuCys: 0.819 ± 0.035	4.263LeuAsp: 4.263 ± 0.07	8.339LeuGlu: 8.339 ± 0.129	3.859LeuPhe: 3.859 ± 0.099	6.17LeuGly: 6.17 ± 0.11	1.337LeuHis: 1.337 ± 0.045	7.085LeuIle: 7.085 ± 0.11	9.164LeuLys: 9.164 ± 0.124	9.051LeuLeu: 9.051 ± 0.154	2.175LeuMet: 2.175 ± 0.057	3.517LeuAsn: 3.517 ± 0.079	3.573LeuPro: 3.573 ± 0.077	1.538LeuGln: 1.538 ± 0.051	5.238LeuArg: 5.238 ± 0.094	6.446LeuSer: 6.446 ± 0.116	4.175LeuThr: 4.175 ± 0.091	6.358LeuVal: 6.358 ± 0.115	0.849LeuTrp: 0.849 ± 0.037	3.085LeuTyr: 3.085 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.458MetAla: 1.458 ± 0.054	0.212MetCys: 0.212 ± 0.02	0.976MetAsp: 0.976 ± 0.039	1.807MetGlu: 1.807 ± 0.054	0.852MetPhe: 0.852 ± 0.036	1.456MetGly: 1.456 ± 0.043	0.388MetHis: 0.388 ± 0.022	1.691MetIle: 1.691 ± 0.051	2.324MetLys: 2.324 ± 0.053	2.189MetLeu: 2.189 ± 0.069	0.49MetMet: 0.49 ± 0.027	0.875MetAsn: 0.875 ± 0.039	0.854MetPro: 0.854 ± 0.035	0.45MetGln: 0.45 ± 0.025	1.62MetArg: 1.62 ± 0.055	1.287MetSer: 1.287 ± 0.043	0.78MetThr: 0.78 ± 0.033	1.446MetVal: 1.446 ± 0.049	0.207MetTrp: 0.207 ± 0.016	0.64MetTyr: 0.64 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.543AsnAla: 2.543 ± 0.069	0.527AsnCys: 0.527 ± 0.032	1.37AsnAsp: 1.37 ± 0.051	2.631AsnGlu: 2.631 ± 0.075	1.991AsnPhe: 1.991 ± 0.053	2.374AsnGly: 2.374 ± 0.071	0.483AsnHis: 0.483 ± 0.029	2.15AsnIle: 2.15 ± 0.064	1.948AsnLys: 1.948 ± 0.054	3.839AsnLeu: 3.839 ± 0.085	0.539AsnMet: 0.539 ± 0.023	1.011AsnAsn: 1.011 ± 0.046	2.195AsnPro: 2.195 ± 0.061	0.497AsnGln: 0.497 ± 0.026	1.381AsnArg: 1.381 ± 0.047	1.879AsnSer: 1.879 ± 0.055	1.241AsnThr: 1.241 ± 0.046	3.352AsnVal: 3.352 ± 0.083	0.431AsnTrp: 0.431 ± 0.029	1.493AsnTyr: 1.493 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.293ProAla: 2.293 ± 0.062	0.372ProCys: 0.372 ± 0.024	1.947ProAsp: 1.947 ± 0.064	4.17ProGlu: 4.17 ± 0.076	1.844ProPhe: 1.844 ± 0.053	2.133ProGly: 2.133 ± 0.064	0.705ProHis: 0.705 ± 0.038	2.48ProIle: 2.48 ± 0.067	2.917ProLys: 2.917 ± 0.07	3.206ProLeu: 3.206 ± 0.075	0.752ProMet: 0.752 ± 0.031	1.331ProAsn: 1.331 ± 0.046	1.762ProPro: 1.762 ± 0.061	0.701ProGln: 0.701 ± 0.029	1.505ProArg: 1.505 ± 0.051	2.013ProSer: 2.013 ± 0.061	1.814ProThr: 1.814 ± 0.099	2.99ProVal: 2.99 ± 0.071	0.444ProTrp: 0.444 ± 0.027	1.487ProTyr: 1.487 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	1.091GlnAla: 1.091 ± 0.05	0.159GlnCys: 0.159 ± 0.018	0.566GlnAsp: 0.566 ± 0.028	1.146GlnGlu: 1.146 ± 0.048	0.569GlnPhe: 0.569 ± 0.027	0.804GlnGly: 0.804 ± 0.033	0.286GlnHis: 0.286 ± 0.021	1.424GlnIle: 1.424 ± 0.048	1.281GlnLys: 1.281 ± 0.046	1.54GlnLeu: 1.54 ± 0.048	0.465GlnMet: 0.465 ± 0.026	0.613GlnAsn: 0.613 ± 0.031	0.645GlnPro: 0.645 ± 0.031	0.4GlnGln: 0.4 ± 0.027	0.867GlnArg: 0.867 ± 0.034	0.76GlnSer: 0.76 ± 0.038	0.73GlnThr: 0.73 ± 0.037	0.955GlnVal: 0.955 ± 0.041	0.201GlnTrp: 0.201 ± 0.019	0.493GlnTyr: 0.493 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.27ArgAla: 3.27 ± 0.076	0.586ArgCys: 0.586 ± 0.033	2.658ArgAsp: 2.658 ± 0.066	5.559ArgGlu: 5.559 ± 0.123	2.197ArgPhe: 2.197 ± 0.063	3.747ArgGly: 3.747 ± 0.074	0.657ArgHis: 0.657 ± 0.034	4.924ArgIle: 4.924 ± 0.1	5.195ArgLys: 5.195 ± 0.102	4.048ArgLeu: 4.048 ± 0.083	1.37ArgMet: 1.37 ± 0.046	1.912ArgAsn: 1.912 ± 0.056	1.132ArgPro: 1.132 ± 0.046	0.814ArgGln: 0.814 ± 0.032	3.497ArgArg: 3.497 ± 0.087	2.348ArgSer: 2.348 ± 0.056	1.677ArgThr: 1.677 ± 0.043	4.556ArgVal: 4.556 ± 0.096	0.556ArgTrp: 0.556 ± 0.03	1.817ArgTyr: 1.817 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.562SerAla: 3.562 ± 0.08	0.749SerCys: 0.749 ± 0.042	2.502SerAsp: 2.502 ± 0.067	4.883SerGlu: 4.883 ± 0.102	2.964SerPhe: 2.964 ± 0.076	4.444SerGly: 4.444 ± 0.099	0.805SerHis: 0.805 ± 0.037	3.88SerIle: 3.88 ± 0.076	4.234SerLys: 4.234 ± 0.082	5.619SerLeu: 5.619 ± 0.098	1.303SerMet: 1.303 ± 0.049	1.661SerAsn: 1.661 ± 0.058	2.166SerPro: 2.166 ± 0.062	0.951SerGln: 0.951 ± 0.041	2.578SerArg: 2.578 ± 0.067	3.448SerSer: 3.448 ± 0.093	2.274SerThr: 2.274 ± 0.063	4.193SerVal: 4.193 ± 0.068	0.609SerTrp: 0.609 ± 0.036	2.424SerTyr: 2.424 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	3.091ThrAla: 3.091 ± 0.081	0.406ThrCys: 0.406 ± 0.027	1.662ThrAsp: 1.662 ± 0.056	2.56ThrGlu: 2.56 ± 0.068	1.997ThrPhe: 1.997 ± 0.056	3.217ThrGly: 3.217 ± 0.073	0.733ThrHis: 0.733 ± 0.034	3.041ThrIle: 3.041 ± 0.071	2.545ThrLys: 2.545 ± 0.065	4.187ThrLeu: 4.187 ± 0.088	0.76ThrMet: 0.76 ± 0.037	1.285ThrAsn: 1.285 ± 0.05	2.525ThrPro: 2.525 ± 0.12	0.696ThrGln: 0.696 ± 0.036	1.698ThrArg: 1.698 ± 0.043	2.305ThrSer: 2.305 ± 0.071	2.134ThrThr: 2.134 ± 0.069	2.994ThrVal: 2.994 ± 0.085	0.333ThrTrp: 0.333 ± 0.023	1.476ThrTyr: 1.476 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	6.238ValAla: 6.238 ± 0.107	1.034ValCys: 1.034 ± 0.039	4.504ValAsp: 4.504 ± 0.1	8.927ValGlu: 8.927 ± 0.129	3.889ValPhe: 3.889 ± 0.083	5.406ValGly: 5.406 ± 0.097	1.117ValHis: 1.117 ± 0.046	6.164ValIle: 6.164 ± 0.098	7.511ValLys: 7.511 ± 0.104	7.383ValLeu: 7.383 ± 0.117	1.842ValMet: 1.842 ± 0.055	2.788ValAsn: 2.788 ± 0.074	2.817ValPro: 2.817 ± 0.062	1.163ValGln: 1.163 ± 0.044	4.609ValArg: 4.609 ± 0.094	4.871ValSer: 4.871 ± 0.095	3.429ValThr: 3.429 ± 0.087	8.193ValVal: 8.193 ± 0.112	0.778ValTrp: 0.778 ± 0.034	3.127ValTyr: 3.127 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.027	0.123TrpCys: 0.123 ± 0.015	0.545TrpAsp: 0.545 ± 0.026	0.869TrpGlu: 0.869 ± 0.036	0.442TrpPhe: 0.442 ± 0.028	0.666TrpGly: 0.666 ± 0.034	0.159TrpHis: 0.159 ± 0.015	0.931TrpIle: 0.931 ± 0.042	1.025TrpLys: 1.025 ± 0.035	0.984TrpLeu: 0.984 ± 0.039	0.31TrpMet: 0.31 ± 0.025	0.457TrpAsn: 0.457 ± 0.028	0.195TrpPro: 0.195 ± 0.016	0.192TrpGln: 0.192 ± 0.018	0.68TrpArg: 0.68 ± 0.036	0.531TrpSer: 0.531 ± 0.034	0.354TrpThr: 0.354 ± 0.023	0.742TrpVal: 0.742 ± 0.038	0.189TrpTrp: 0.189 ± 0.017	0.383TrpTyr: 0.383 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.722TyrAla: 2.722 ± 0.071	0.519TyrCys: 0.519 ± 0.032	2.074TyrAsp: 2.074 ± 0.053	3.488TyrGlu: 3.488 ± 0.076	1.933TyrPhe: 1.933 ± 0.059	2.828TyrGly: 2.828 ± 0.066	0.668TyrHis: 0.668 ± 0.03	2.269TyrIle: 2.269 ± 0.059	2.365TyrLys: 2.365 ± 0.061	3.645TyrLeu: 3.645 ± 0.078	0.662TyrMet: 0.662 ± 0.033	1.223TyrAsn: 1.223 ± 0.046	1.832TyrPro: 1.832 ± 0.058	0.601TyrGln: 0.601 ± 0.031	1.959TyrArg: 1.959 ± 0.056	2.466TyrSer: 2.466 ± 0.074	1.63TyrThr: 1.63 ± 0.053	3.12TyrVal: 3.12 ± 0.076	0.474TyrTrp: 0.474 ± 0.03	1.733TyrTyr: 1.733 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2463 proteins (660597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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