Amino acid dipepetide frequency for Nesterenkonia natronophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.759AlaAla: 16.759 ± 0.219
0.801AlaCys: 0.801 ± 0.03
6.892AlaAsp: 6.892 ± 0.105
9.941AlaGlu: 9.941 ± 0.136
3.283AlaPhe: 3.283 ± 0.07
10.655AlaGly: 10.655 ± 0.151
2.628AlaHis: 2.628 ± 0.055
4.353AlaIle: 4.353 ± 0.097
2.898AlaLys: 2.898 ± 0.075
12.051AlaLeu: 12.051 ± 0.152
2.577AlaMet: 2.577 ± 0.06
2.143AlaAsn: 2.143 ± 0.05
5.282AlaPro: 5.282 ± 0.082
4.812AlaGln: 4.812 ± 0.079
7.231AlaArg: 7.231 ± 0.105
6.274AlaSer: 6.274 ± 0.094
5.769AlaThr: 5.769 ± 0.095
10.356AlaVal: 10.356 ± 0.126
1.507AlaTrp: 1.507 ± 0.048
2.132AlaTyr: 2.132 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.8CysAla: 0.8 ± 0.037
0.071CysCys: 0.071 ± 0.009
0.323CysAsp: 0.323 ± 0.022
0.39CysGlu: 0.39 ± 0.027
0.197CysPhe: 0.197 ± 0.015
0.724CysGly: 0.724 ± 0.032
0.148CysHis: 0.148 ± 0.015
0.207CysIle: 0.207 ± 0.016
0.085CysLys: 0.085 ± 0.012
0.587CysLeu: 0.587 ± 0.029
0.133CysMet: 0.133 ± 0.013
0.116CysAsn: 0.116 ± 0.013
0.362CysPro: 0.362 ± 0.024
0.201CysGln: 0.201 ± 0.017
0.451CysArg: 0.451 ± 0.024
0.428CysSer: 0.428 ± 0.023
0.392CysThr: 0.392 ± 0.022
0.431CysVal: 0.431 ± 0.023
0.092CysTrp: 0.092 ± 0.011
0.133CysTyr: 0.133 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.875AspAla: 6.875 ± 0.112
0.294AspCys: 0.294 ± 0.021
3.74AspAsp: 3.74 ± 0.089
4.199AspGlu: 4.199 ± 0.081
1.918AspPhe: 1.918 ± 0.048
4.544AspGly: 4.544 ± 0.094
1.53AspHis: 1.53 ± 0.047
2.513AspIle: 2.513 ± 0.06
1.262AspLys: 1.262 ± 0.042
6.088AspLeu: 6.088 ± 0.094
1.084AspMet: 1.084 ± 0.036
0.975AspAsn: 0.975 ± 0.041
3.867AspPro: 3.867 ± 0.059
2.2AspGln: 2.2 ± 0.054
3.786AspArg: 3.786 ± 0.083
3.411AspSer: 3.411 ± 0.07
2.816AspThr: 2.816 ± 0.06
4.782AspVal: 4.782 ± 0.092
0.872AspTrp: 0.872 ± 0.032
1.452AspTyr: 1.452 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
8.1GluAla: 8.1 ± 0.11
0.312GluCys: 0.312 ± 0.021
4.331GluAsp: 4.331 ± 0.09
5.039GluGlu: 5.039 ± 0.118
2.0GluPhe: 2.0 ± 0.059
4.658GluGly: 4.658 ± 0.082
1.981GluHis: 1.981 ± 0.048
3.017GluIle: 3.017 ± 0.067
1.802GluLys: 1.802 ± 0.047
7.27GluLeu: 7.27 ± 0.112
1.226GluMet: 1.226 ± 0.041
1.599GluAsn: 1.599 ± 0.044
3.568GluPro: 3.568 ± 0.076
3.088GluGln: 3.088 ± 0.06
4.632GluArg: 4.632 ± 0.083
3.863GluSer: 3.863 ± 0.069
3.785GluThr: 3.785 ± 0.083
5.409GluVal: 5.409 ± 0.089
0.854GluTrp: 0.854 ± 0.039
1.394GluTyr: 1.394 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.751PheAla: 3.751 ± 0.083
0.264PheCys: 0.264 ± 0.019
2.196PheAsp: 2.196 ± 0.053
1.816PheGlu: 1.816 ± 0.052
1.114PhePhe: 1.114 ± 0.042
3.241PheGly: 3.241 ± 0.065
0.673PheHis: 0.673 ± 0.032
1.348PheIle: 1.348 ± 0.052
0.618PheLys: 0.618 ± 0.03
2.883PheLeu: 2.883 ± 0.065
0.574PheMet: 0.574 ± 0.031
0.835PheAsn: 0.835 ± 0.031
1.424PhePro: 1.424 ± 0.041
0.875PheGln: 0.875 ± 0.036
1.783PheArg: 1.783 ± 0.042
2.126PheSer: 2.126 ± 0.061
2.203PheThr: 2.203 ± 0.061
2.355PheVal: 2.355 ± 0.058
0.468PheTrp: 0.468 ± 0.03
0.705PheTyr: 0.705 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.117GlyAla: 9.117 ± 0.127
0.569GlyCys: 0.569 ± 0.027
4.355GlyAsp: 4.355 ± 0.083
5.338GlyGlu: 5.338 ± 0.089
3.14GlyPhe: 3.14 ± 0.08
6.738GlyGly: 6.738 ± 0.109
2.064GlyHis: 2.064 ± 0.056
4.242GlyIle: 4.242 ± 0.091
2.382GlyLys: 2.382 ± 0.065
8.587GlyLeu: 8.587 ± 0.12
2.094GlyMet: 2.094 ± 0.057
1.786GlyAsn: 1.786 ± 0.056
3.831GlyPro: 3.831 ± 0.08
2.921GlyGln: 2.921 ± 0.067
5.73GlyArg: 5.73 ± 0.082
5.293GlySer: 5.293 ± 0.088
5.143GlyThr: 5.143 ± 0.078
7.269GlyVal: 7.269 ± 0.099
1.447GlyTrp: 1.447 ± 0.048
2.126GlyTyr: 2.126 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.362HisAla: 2.362 ± 0.056
0.191HisCys: 0.191 ± 0.016
1.296HisAsp: 1.296 ± 0.04
1.382HisGlu: 1.382 ± 0.043
0.779HisPhe: 0.779 ± 0.034
2.119HisGly: 2.119 ± 0.056
0.808HisHis: 0.808 ± 0.032
0.999HisIle: 0.999 ± 0.033
0.52HisLys: 0.52 ± 0.025
2.494HisLeu: 2.494 ± 0.058
0.505HisMet: 0.505 ± 0.026
0.499HisAsn: 0.499 ± 0.029
1.628HisPro: 1.628 ± 0.047
1.05HisGln: 1.05 ± 0.04
2.056HisArg: 2.056 ± 0.062
1.377HisSer: 1.377 ± 0.037
1.369HisThr: 1.369 ± 0.043
1.722HisVal: 1.722 ± 0.045
0.383HisTrp: 0.383 ± 0.025
0.509HisTyr: 0.509 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.588IleAla: 5.588 ± 0.101
0.366IleCys: 0.366 ± 0.021
2.891IleAsp: 2.891 ± 0.072
2.708IleGlu: 2.708 ± 0.064
1.418IlePhe: 1.418 ± 0.051
4.193IleGly: 4.193 ± 0.088
0.922IleHis: 0.922 ± 0.036
2.178IleIle: 2.178 ± 0.059
0.936IleLys: 0.936 ± 0.035
3.828IleLeu: 3.828 ± 0.071
0.847IleMet: 0.847 ± 0.037
1.247IleAsn: 1.247 ± 0.043
2.332IlePro: 2.332 ± 0.057
1.167IleGln: 1.167 ± 0.038
2.761IleArg: 2.761 ± 0.064
2.936IleSer: 2.936 ± 0.063
2.968IleThr: 2.968 ± 0.056
3.536IleVal: 3.536 ± 0.077
0.522IleTrp: 0.522 ± 0.027
0.905IleTyr: 0.905 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
2.638LysAla: 2.638 ± 0.062
0.092LysCys: 0.092 ± 0.012
1.388LysAsp: 1.388 ± 0.041
1.483LysGlu: 1.483 ± 0.044
0.617LysPhe: 0.617 ± 0.031
1.683LysGly: 1.683 ± 0.051
0.69LysHis: 0.69 ± 0.029
1.158LysIle: 1.158 ± 0.039
1.08LysLys: 1.08 ± 0.054
2.504LysLeu: 2.504 ± 0.065
0.502LysMet: 0.502 ± 0.027
0.72LysAsn: 0.72 ± 0.03
1.452LysPro: 1.452 ± 0.045
0.893LysGln: 0.893 ± 0.037
1.837LysArg: 1.837 ± 0.055
1.506LysSer: 1.506 ± 0.05
1.534LysThr: 1.534 ± 0.047
2.049LysVal: 2.049 ± 0.056
0.319LysTrp: 0.319 ± 0.019
0.574LysTyr: 0.574 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
12.124LeuAla: 12.124 ± 0.143
0.707LeuCys: 0.707 ± 0.036
5.786LeuAsp: 5.786 ± 0.1
6.202LeuGlu: 6.202 ± 0.084
2.944LeuPhe: 2.944 ± 0.074
8.912LeuGly: 8.912 ± 0.125
2.241LeuHis: 2.241 ± 0.049
4.714LeuIle: 4.714 ± 0.094
2.432LeuLys: 2.432 ± 0.061
10.189LeuLeu: 10.189 ± 0.156
2.135LeuMet: 2.135 ± 0.063
2.585LeuAsn: 2.585 ± 0.06
5.492LeuPro: 5.492 ± 0.085
3.072LeuGln: 3.072 ± 0.062
7.415LeuArg: 7.415 ± 0.1
6.331LeuSer: 6.331 ± 0.102
6.679LeuThr: 6.679 ± 0.098
8.072LeuVal: 8.072 ± 0.146
1.31LeuTrp: 1.31 ± 0.05
1.747LeuTyr: 1.747 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.43MetAla: 2.43 ± 0.056
0.123MetCys: 0.123 ± 0.011
1.09MetAsp: 1.09 ± 0.039
1.092MetGlu: 1.092 ± 0.042
0.648MetPhe: 0.648 ± 0.031
1.658MetGly: 1.658 ± 0.043
0.414MetHis: 0.414 ± 0.025
1.089MetIle: 1.089 ± 0.041
0.553MetLys: 0.553 ± 0.028
2.226MetLeu: 2.226 ± 0.06
0.514MetMet: 0.514 ± 0.025
0.575MetAsn: 0.575 ± 0.03
1.201MetPro: 1.201 ± 0.041
0.685MetGln: 0.685 ± 0.03
1.484MetArg: 1.484 ± 0.043
1.654MetSer: 1.654 ± 0.046
1.659MetThr: 1.659 ± 0.049
1.775MetVal: 1.775 ± 0.045
0.272MetTrp: 0.272 ± 0.019
0.288MetTyr: 0.288 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.583AsnAla: 2.583 ± 0.056
0.128AsnCys: 0.128 ± 0.013
1.286AsnAsp: 1.286 ± 0.041
1.273AsnGlu: 1.273 ± 0.043
0.735AsnPhe: 0.735 ± 0.033
1.816AsnGly: 1.816 ± 0.058
0.501AsnHis: 0.501 ± 0.023
1.09AsnIle: 1.09 ± 0.042
0.512AsnLys: 0.512 ± 0.027
2.27AsnLeu: 2.27 ± 0.054
0.448AsnMet: 0.448 ± 0.026
0.563AsnAsn: 0.563 ± 0.03
1.68AsnPro: 1.68 ± 0.046
0.812AsnGln: 0.812 ± 0.032
1.505AsnArg: 1.505 ± 0.047
1.286AsnSer: 1.286 ± 0.044
1.381AsnThr: 1.381 ± 0.042
1.757AsnVal: 1.757 ± 0.044
0.337AsnTrp: 0.337 ± 0.02
0.586AsnTyr: 0.586 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
6.077ProAla: 6.077 ± 0.108
0.204ProCys: 0.204 ± 0.015
3.425ProAsp: 3.425 ± 0.073
5.037ProGlu: 5.037 ± 0.105
1.59ProPhe: 1.59 ± 0.051
4.889ProGly: 4.889 ± 0.089
1.349ProHis: 1.349 ± 0.046
1.8ProIle: 1.8 ± 0.051
1.324ProLys: 1.324 ± 0.043
4.782ProLeu: 4.782 ± 0.098
1.064ProMet: 1.064 ± 0.034
1.188ProAsn: 1.188 ± 0.039
2.386ProPro: 2.386 ± 0.073
2.102ProGln: 2.102 ± 0.06
3.155ProArg: 3.155 ± 0.056
3.011ProSer: 3.011 ± 0.082
3.094ProThr: 3.094 ± 0.079
4.48ProVal: 4.48 ± 0.078
0.803ProTrp: 0.803 ± 0.035
1.06ProTyr: 1.06 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.261GlnAla: 4.261 ± 0.086
0.183GlnCys: 0.183 ± 0.018
1.796GlnAsp: 1.796 ± 0.045
2.301GlnGlu: 2.301 ± 0.056
1.008GlnPhe: 1.008 ± 0.036
2.518GlnGly: 2.518 ± 0.058
0.966GlnHis: 0.966 ± 0.04
1.677GlnIle: 1.677 ± 0.043
0.981GlnLys: 0.981 ± 0.037
4.253GlnLeu: 4.253 ± 0.082
0.814GlnMet: 0.814 ± 0.032
0.786GlnAsn: 0.786 ± 0.032
1.794GlnPro: 1.794 ± 0.045
1.777GlnGln: 1.777 ± 0.045
3.036GlnArg: 3.036 ± 0.074
1.8GlnSer: 1.8 ± 0.044
1.887GlnThr: 1.887 ± 0.047
3.055GlnVal: 3.055 ± 0.065
0.621GlnTrp: 0.621 ± 0.036
0.727GlnTyr: 0.727 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
7.231ArgAla: 7.231 ± 0.095
0.426ArgCys: 0.426 ± 0.029
3.589ArgAsp: 3.589 ± 0.068
4.425ArgGlu: 4.425 ± 0.075
2.219ArgPhe: 2.219 ± 0.049
4.972ArgGly: 4.972 ± 0.086
1.73ArgHis: 1.73 ± 0.052
3.402ArgIle: 3.402 ± 0.065
1.918ArgLys: 1.918 ± 0.054
6.886ArgLeu: 6.886 ± 0.108
1.692ArgMet: 1.692 ± 0.047
1.536ArgAsn: 1.536 ± 0.046
3.234ArgPro: 3.234 ± 0.068
2.702ArgGln: 2.702 ± 0.07
6.128ArgArg: 6.128 ± 0.115
4.453ArgSer: 4.453 ± 0.082
4.072ArgThr: 4.072 ± 0.073
4.964ArgVal: 4.964 ± 0.08
1.169ArgTrp: 1.169 ± 0.043
1.625ArgTyr: 1.625 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
7.771SerAla: 7.771 ± 0.106
0.348SerCys: 0.348 ± 0.024
3.244SerAsp: 3.244 ± 0.059
3.823SerGlu: 3.823 ± 0.07
1.939SerPhe: 1.939 ± 0.046
5.981SerGly: 5.981 ± 0.104
1.29SerHis: 1.29 ± 0.037
2.424SerIle: 2.424 ± 0.055
1.401SerLys: 1.401 ± 0.05
5.616SerLeu: 5.616 ± 0.079
1.528SerMet: 1.528 ± 0.045
1.259SerAsn: 1.259 ± 0.037
3.461SerPro: 3.461 ± 0.073
2.102SerGln: 2.102 ± 0.049
3.982SerArg: 3.982 ± 0.078
4.254SerSer: 4.254 ± 0.12
3.637SerThr: 3.637 ± 0.079
4.704SerVal: 4.704 ± 0.078
0.924SerTrp: 0.924 ± 0.031
1.251SerTyr: 1.251 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
7.088ThrAla: 7.088 ± 0.103
0.337ThrCys: 0.337 ± 0.02
3.475ThrAsp: 3.475 ± 0.071
3.857ThrGlu: 3.857 ± 0.08
1.885ThrPhe: 1.885 ± 0.05
5.688ThrGly: 5.688 ± 0.081
1.383ThrHis: 1.383 ± 0.043
2.47ThrIle: 2.47 ± 0.059
1.302ThrLys: 1.302 ± 0.043
5.818ThrLeu: 5.818 ± 0.08
1.187ThrMet: 1.187 ± 0.041
1.288ThrAsn: 1.288 ± 0.04
3.572ThrPro: 3.572 ± 0.065
1.849ThrGln: 1.849 ± 0.052
3.493ThrArg: 3.493 ± 0.062
3.638ThrSer: 3.638 ± 0.067
3.514ThrThr: 3.514 ± 0.068
5.41ThrVal: 5.41 ± 0.086
0.791ThrTrp: 0.791 ± 0.033
1.398ThrTyr: 1.398 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
9.019ValAla: 9.019 ± 0.128
0.574ValCys: 0.574 ± 0.031
4.964ValAsp: 4.964 ± 0.078
5.503ValGlu: 5.503 ± 0.087
2.556ValPhe: 2.556 ± 0.071
6.295ValGly: 6.295 ± 0.107
1.932ValHis: 1.932 ± 0.051
4.118ValIle: 4.118 ± 0.078
1.909ValLys: 1.909 ± 0.045
8.976ValLeu: 8.976 ± 0.14
1.839ValMet: 1.839 ± 0.048
1.957ValAsn: 1.957 ± 0.047
4.411ValPro: 4.411 ± 0.078
2.551ValGln: 2.551 ± 0.06
5.282ValArg: 5.282 ± 0.101
5.117ValSer: 5.117 ± 0.073
5.449ValThr: 5.449 ± 0.075
7.72ValVal: 7.72 ± 0.118
1.0ValTrp: 1.0 ± 0.041
1.492ValTyr: 1.492 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.464TrpAla: 1.464 ± 0.045
0.123TrpCys: 0.123 ± 0.011
0.848TrpAsp: 0.848 ± 0.039
0.843TrpGlu: 0.843 ± 0.034
0.532TrpPhe: 0.532 ± 0.03
0.91TrpGly: 0.91 ± 0.037
0.371TrpHis: 0.371 ± 0.021
0.693TrpIle: 0.693 ± 0.031
0.363TrpLys: 0.363 ± 0.018
1.607TrpLeu: 1.607 ± 0.052
0.341TrpMet: 0.341 ± 0.022
0.448TrpAsn: 0.448 ± 0.027
0.688TrpPro: 0.688 ± 0.033
0.566TrpGln: 0.566 ± 0.026
1.065TrpArg: 1.065 ± 0.037
0.862TrpSer: 0.862 ± 0.037
0.847TrpThr: 0.847 ± 0.033
1.132TrpVal: 1.132 ± 0.04
0.367TrpTrp: 0.367 ± 0.025
0.311TrpTyr: 0.311 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.305TyrAla: 2.305 ± 0.052
0.158TyrCys: 0.158 ± 0.015
1.293TyrAsp: 1.293 ± 0.044
1.277TyrGlu: 1.277 ± 0.044
0.728TyrPhe: 0.728 ± 0.03
1.978TyrGly: 1.978 ± 0.048
0.426TyrHis: 0.426 ± 0.027
0.756TyrIle: 0.756 ± 0.035
0.439TyrLys: 0.439 ± 0.027
2.175TyrLeu: 2.175 ± 0.052
0.324TyrMet: 0.324 ± 0.02
0.443TyrAsn: 0.443 ± 0.028
1.158TyrPro: 1.158 ± 0.039
0.814TyrGln: 0.814 ± 0.034
1.56TyrArg: 1.56 ± 0.049
1.319TyrSer: 1.319 ± 0.041
1.245TyrThr: 1.245 ± 0.046
1.688TyrVal: 1.688 ± 0.047
0.326TyrTrp: 0.326 ± 0.02
0.46TyrTyr: 0.46 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2262 proteins (764907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski