Amino acid dipepetide frequency for Janthinobacterium sp. HH01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.208AlaAla: 19.208 ± 0.221
1.194AlaCys: 1.194 ± 0.027
6.87AlaAsp: 6.87 ± 0.062
6.237AlaGlu: 6.237 ± 0.068
3.738AlaPhe: 3.738 ± 0.046
10.756AlaGly: 10.756 ± 0.1
2.456AlaHis: 2.456 ± 0.046
5.662AlaIle: 5.662 ± 0.059
4.156AlaLys: 4.156 ± 0.058
14.401AlaLeu: 14.401 ± 0.192
3.6AlaMet: 3.6 ± 0.043
3.503AlaAsn: 3.503 ± 0.049
6.25AlaPro: 6.25 ± 0.08
5.682AlaGln: 5.682 ± 0.088
7.654AlaArg: 7.654 ± 0.08
7.129AlaSer: 7.129 ± 0.078
6.282AlaThr: 6.282 ± 0.065
8.496AlaVal: 8.496 ± 0.078
1.676AlaTrp: 1.676 ± 0.031
2.947AlaTyr: 2.947 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.143CysAla: 1.143 ± 0.022
0.126CysCys: 0.126 ± 0.009
0.485CysAsp: 0.485 ± 0.015
0.399CysGlu: 0.399 ± 0.014
0.268CysPhe: 0.268 ± 0.011
0.849CysGly: 0.849 ± 0.02
0.234CysHis: 0.234 ± 0.01
0.398CysIle: 0.398 ± 0.015
0.256CysLys: 0.256 ± 0.013
0.772CysLeu: 0.772 ± 0.018
0.195CysMet: 0.195 ± 0.01
0.216CysAsn: 0.216 ± 0.011
0.369CysPro: 0.369 ± 0.016
0.244CysGln: 0.244 ± 0.012
0.474CysArg: 0.474 ± 0.015
0.493CysSer: 0.493 ± 0.019
0.435CysThr: 0.435 ± 0.015
0.633CysVal: 0.633 ± 0.019
0.126CysTrp: 0.126 ± 0.007
0.24CysTyr: 0.24 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.862AspAla: 6.862 ± 0.079
0.459AspCys: 0.459 ± 0.017
2.946AspAsp: 2.946 ± 0.042
2.913AspGlu: 2.913 ± 0.041
2.123AspPhe: 2.123 ± 0.035
5.091AspGly: 5.091 ± 0.049
1.104AspHis: 1.104 ± 0.025
2.779AspIle: 2.779 ± 0.04
2.118AspLys: 2.118 ± 0.034
5.238AspLeu: 5.238 ± 0.058
1.351AspMet: 1.351 ± 0.028
1.597AspAsn: 1.597 ± 0.029
2.625AspPro: 2.625 ± 0.038
2.079AspGln: 2.079 ± 0.058
2.855AspArg: 2.855 ± 0.039
2.642AspSer: 2.642 ± 0.046
2.722AspThr: 2.722 ± 0.039
3.808AspVal: 3.808 ± 0.058
0.909AspTrp: 0.909 ± 0.023
1.708AspTyr: 1.708 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.044GluAla: 6.044 ± 0.056
0.338GluCys: 0.338 ± 0.013
2.067GluAsp: 2.067 ± 0.035
2.522GluGlu: 2.522 ± 0.046
1.779GluPhe: 1.779 ± 0.033
3.177GluGly: 3.177 ± 0.048
1.335GluHis: 1.335 ± 0.029
2.719GluIle: 2.719 ± 0.04
1.992GluLys: 1.992 ± 0.04
6.0GluLeu: 6.0 ± 0.07
1.292GluMet: 1.292 ± 0.028
1.391GluAsn: 1.391 ± 0.024
2.107GluPro: 2.107 ± 0.035
3.073GluGln: 3.073 ± 0.044
4.065GluArg: 4.065 ± 0.057
2.328GluSer: 2.328 ± 0.04
2.493GluThr: 2.493 ± 0.035
3.505GluVal: 3.505 ± 0.05
0.698GluTrp: 0.698 ± 0.017
1.196GluTyr: 1.196 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.954PheAla: 3.954 ± 0.046
0.361PheCys: 0.361 ± 0.014
2.542PheAsp: 2.542 ± 0.037
1.853PheGlu: 1.853 ± 0.032
1.369PhePhe: 1.369 ± 0.033
3.285PheGly: 3.285 ± 0.038
0.729PheHis: 0.729 ± 0.02
1.629PheIle: 1.629 ± 0.028
1.346PheLys: 1.346 ± 0.025
2.921PheLeu: 2.921 ± 0.041
0.825PheMet: 0.825 ± 0.02
1.391PheAsn: 1.391 ± 0.028
1.406PhePro: 1.406 ± 0.031
1.151PheGln: 1.151 ± 0.027
1.796PheArg: 1.796 ± 0.032
2.384PheSer: 2.384 ± 0.038
1.961PheThr: 1.961 ± 0.038
2.517PheVal: 2.517 ± 0.035
0.45PheTrp: 0.45 ± 0.018
1.02PheTyr: 1.02 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
9.388GlyAla: 9.388 ± 0.081
0.736GlyCys: 0.736 ± 0.02
4.14GlyAsp: 4.14 ± 0.051
4.023GlyGlu: 4.023 ± 0.054
3.056GlyPhe: 3.056 ± 0.041
6.907GlyGly: 6.907 ± 0.085
1.761GlyHis: 1.761 ± 0.032
3.897GlyIle: 3.897 ± 0.052
3.944GlyLys: 3.944 ± 0.053
8.138GlyLeu: 8.138 ± 0.074
2.364GlyMet: 2.364 ± 0.036
2.515GlyAsn: 2.515 ± 0.045
2.653GlyPro: 2.653 ± 0.037
3.269GlyGln: 3.269 ± 0.047
4.693GlyArg: 4.693 ± 0.049
4.738GlySer: 4.738 ± 0.061
4.187GlyThr: 4.187 ± 0.055
6.411GlyVal: 6.411 ± 0.058
1.32GlyTrp: 1.32 ± 0.027
2.594GlyTyr: 2.594 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.687HisAla: 2.687 ± 0.042
0.251HisCys: 0.251 ± 0.011
1.209HisAsp: 1.209 ± 0.026
1.07HisGlu: 1.07 ± 0.025
0.921HisPhe: 0.921 ± 0.02
2.014HisGly: 2.014 ± 0.032
0.65HisHis: 0.65 ± 0.024
1.014HisIle: 1.014 ± 0.023
0.642HisLys: 0.642 ± 0.019
2.112HisLeu: 2.112 ± 0.031
0.507HisMet: 0.507 ± 0.015
0.598HisAsn: 0.598 ± 0.018
1.262HisPro: 1.262 ± 0.025
0.836HisGln: 0.836 ± 0.024
1.278HisArg: 1.278 ± 0.029
1.111HisSer: 1.111 ± 0.026
1.044HisThr: 1.044 ± 0.021
1.383HisVal: 1.383 ± 0.027
0.358HisTrp: 0.358 ± 0.014
0.715HisTyr: 0.715 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.569IleAla: 6.569 ± 0.085
0.421IleCys: 0.421 ± 0.015
3.314IleAsp: 3.314 ± 0.048
2.952IleGlu: 2.952 ± 0.044
1.381IlePhe: 1.381 ± 0.031
4.366IleGly: 4.366 ± 0.053
0.862IleHis: 0.862 ± 0.02
1.883IleIle: 1.883 ± 0.033
1.836IleLys: 1.836 ± 0.042
3.615IleLeu: 3.615 ± 0.048
0.9IleMet: 0.9 ± 0.022
1.755IleAsn: 1.755 ± 0.034
2.075IlePro: 2.075 ± 0.032
1.318IleGln: 1.318 ± 0.028
2.48IleArg: 2.48 ± 0.034
2.921IleSer: 2.921 ± 0.043
2.611IleThr: 2.611 ± 0.037
3.668IleVal: 3.668 ± 0.048
0.512IleTrp: 0.512 ± 0.017
1.147IleTyr: 1.147 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.238LysAla: 4.238 ± 0.053
0.163LysCys: 0.163 ± 0.008
1.887LysAsp: 1.887 ± 0.043
1.808LysGlu: 1.808 ± 0.037
1.131LysPhe: 1.131 ± 0.025
2.458LysGly: 2.458 ± 0.038
0.745LysHis: 0.745 ± 0.019
1.909LysIle: 1.909 ± 0.036
1.584LysLys: 1.584 ± 0.035
4.269LysLeu: 4.269 ± 0.051
1.034LysMet: 1.034 ± 0.026
1.266LysAsn: 1.266 ± 0.028
2.219LysPro: 2.219 ± 0.039
1.662LysGln: 1.662 ± 0.035
2.237LysArg: 2.237 ± 0.039
1.993LysSer: 1.993 ± 0.033
2.103LysThr: 2.103 ± 0.042
2.724LysVal: 2.724 ± 0.034
0.387LysTrp: 0.387 ± 0.015
0.835LysTyr: 0.835 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.537LeuAla: 14.537 ± 0.116
0.977LeuCys: 0.977 ± 0.024
5.841LeuAsp: 5.841 ± 0.063
5.161LeuGlu: 5.161 ± 0.064
3.508LeuPhe: 3.508 ± 0.045
7.889LeuGly: 7.889 ± 0.079
2.312LeuHis: 2.312 ± 0.036
4.476LeuIle: 4.476 ± 0.042
3.947LeuLys: 3.947 ± 0.053
11.281LeuLeu: 11.281 ± 0.117
2.541LeuMet: 2.541 ± 0.039
3.405LeuAsn: 3.405 ± 0.049
6.011LeuPro: 6.011 ± 0.072
4.204LeuGln: 4.204 ± 0.061
7.184LeuArg: 7.184 ± 0.074
7.088LeuSer: 7.088 ± 0.113
5.883LeuThr: 5.883 ± 0.093
7.026LeuVal: 7.026 ± 0.066
1.186LeuTrp: 1.186 ± 0.029
2.377LeuTyr: 2.377 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.062MetAla: 3.062 ± 0.043
0.162MetCys: 0.162 ± 0.009
1.213MetAsp: 1.213 ± 0.023
1.195MetGlu: 1.195 ± 0.022
0.782MetPhe: 0.782 ± 0.018
1.697MetGly: 1.697 ± 0.029
0.588MetHis: 0.588 ± 0.02
1.044MetIle: 1.044 ± 0.023
1.121MetLys: 1.121 ± 0.026
2.982MetLeu: 2.982 ± 0.043
0.731MetMet: 0.731 ± 0.02
0.99MetAsn: 0.99 ± 0.02
1.432MetPro: 1.432 ± 0.029
1.23MetGln: 1.23 ± 0.026
1.661MetArg: 1.661 ± 0.026
1.675MetSer: 1.675 ± 0.027
1.582MetThr: 1.582 ± 0.032
1.741MetVal: 1.741 ± 0.03
0.236MetTrp: 0.236 ± 0.011
0.481MetTyr: 0.481 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.714AsnAla: 3.714 ± 0.05
0.24AsnCys: 0.24 ± 0.01
1.684AsnAsp: 1.684 ± 0.029
1.321AsnGlu: 1.321 ± 0.026
1.186AsnPhe: 1.186 ± 0.023
2.944AsnGly: 2.944 ± 0.053
0.613AsnHis: 0.613 ± 0.02
1.584AsnIle: 1.584 ± 0.028
1.106AsnLys: 1.106 ± 0.026
3.141AsnLeu: 3.141 ± 0.045
0.728AsnMet: 0.728 ± 0.019
1.13AsnAsn: 1.13 ± 0.029
1.81AsnPro: 1.81 ± 0.034
1.201AsnGln: 1.201 ± 0.029
1.722AsnArg: 1.722 ± 0.03
1.643AsnSer: 1.643 ± 0.036
1.798AsnThr: 1.798 ± 0.032
2.21AsnVal: 2.21 ± 0.037
0.475AsnTrp: 0.475 ± 0.015
0.984AsnTyr: 0.984 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
7.028ProAla: 7.028 ± 0.081
0.287ProCys: 0.287 ± 0.013
2.958ProAsp: 2.958 ± 0.042
3.026ProGlu: 3.026 ± 0.043
1.671ProPhe: 1.671 ± 0.03
4.059ProGly: 4.059 ± 0.053
1.044ProHis: 1.044 ± 0.024
1.742ProIle: 1.742 ± 0.03
1.52ProLys: 1.52 ± 0.032
5.154ProLeu: 5.154 ± 0.056
1.176ProMet: 1.176 ± 0.028
1.394ProAsn: 1.394 ± 0.028
2.452ProPro: 2.452 ± 0.052
2.182ProGln: 2.182 ± 0.037
2.42ProArg: 2.42 ± 0.045
2.699ProSer: 2.699 ± 0.037
2.365ProThr: 2.365 ± 0.041
3.967ProVal: 3.967 ± 0.048
0.61ProTrp: 0.61 ± 0.02
1.157ProTyr: 1.157 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.6GlnAla: 5.6 ± 0.063
0.275GlnCys: 0.275 ± 0.012
1.743GlnAsp: 1.743 ± 0.029
1.714GlnGlu: 1.714 ± 0.031
1.514GlnPhe: 1.514 ± 0.029
2.825GlnGly: 2.825 ± 0.039
1.012GlnHis: 1.012 ± 0.022
2.136GlnIle: 2.136 ± 0.07
1.321GlnLys: 1.321 ± 0.026
4.964GlnLeu: 4.964 ± 0.085
1.096GlnMet: 1.096 ± 0.025
1.109GlnAsn: 1.109 ± 0.024
2.176GlnPro: 2.176 ± 0.037
2.482GlnGln: 2.482 ± 0.044
3.252GlnArg: 3.252 ± 0.048
2.173GlnSer: 2.173 ± 0.037
2.084GlnThr: 2.084 ± 0.028
3.177GlnVal: 3.177 ± 0.065
0.615GlnTrp: 0.615 ± 0.017
1.007GlnTyr: 1.007 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.882ArgAla: 6.882 ± 0.065
0.488ArgCys: 0.488 ± 0.017
3.338ArgAsp: 3.338 ± 0.044
3.395ArgGlu: 3.395 ± 0.045
2.379ArgPhe: 2.379 ± 0.038
3.934ArgGly: 3.934 ± 0.046
1.685ArgHis: 1.685 ± 0.031
3.252ArgIle: 3.252 ± 0.041
2.207ArgLys: 2.207 ± 0.034
6.957ArgLeu: 6.957 ± 0.066
1.775ArgMet: 1.775 ± 0.032
1.982ArgAsn: 1.982 ± 0.031
2.617ArgPro: 2.617 ± 0.038
2.954ArgGln: 2.954 ± 0.044
4.254ArgArg: 4.254 ± 0.068
3.399ArgSer: 3.399 ± 0.048
2.977ArgThr: 2.977 ± 0.038
4.156ArgVal: 4.156 ± 0.048
0.938ArgTrp: 0.938 ± 0.025
2.009ArgTyr: 2.009 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
7.326SerAla: 7.326 ± 0.079
0.468SerCys: 0.468 ± 0.015
2.964SerAsp: 2.964 ± 0.044
2.578SerGlu: 2.578 ± 0.04
2.249SerPhe: 2.249 ± 0.039
5.596SerGly: 5.596 ± 0.067
1.182SerHis: 1.182 ± 0.022
2.716SerIle: 2.716 ± 0.034
2.002SerLys: 2.002 ± 0.036
5.946SerLeu: 5.946 ± 0.058
1.425SerMet: 1.425 ± 0.025
1.773SerAsn: 1.773 ± 0.033
2.63SerPro: 2.63 ± 0.036
2.059SerGln: 2.059 ± 0.034
3.21SerArg: 3.21 ± 0.041
3.677SerSer: 3.677 ± 0.065
3.27SerThr: 3.27 ± 0.081
4.207SerVal: 4.207 ± 0.048
0.829SerTrp: 0.829 ± 0.021
1.731SerTyr: 1.731 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.453ThrAla: 6.453 ± 0.103
0.349ThrCys: 0.349 ± 0.012
2.672ThrAsp: 2.672 ± 0.048
2.398ThrGlu: 2.398 ± 0.035
1.718ThrPhe: 1.718 ± 0.036
4.576ThrGly: 4.576 ± 0.062
1.02ThrHis: 1.02 ± 0.024
2.638ThrIle: 2.638 ± 0.036
1.45ThrLys: 1.45 ± 0.033
6.443ThrLeu: 6.443 ± 0.074
1.265ThrMet: 1.265 ± 0.026
1.476ThrAsn: 1.476 ± 0.038
3.498ThrPro: 3.498 ± 0.046
1.97ThrGln: 1.97 ± 0.037
2.911ThrArg: 2.911 ± 0.039
2.973ThrSer: 2.973 ± 0.052
3.057ThrThr: 3.057 ± 0.082
4.273ThrVal: 4.273 ± 0.053
0.624ThrTrp: 0.624 ± 0.018
1.309ThrTyr: 1.309 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.098ValAla: 9.098 ± 0.095
0.653ValCys: 0.653 ± 0.018
3.944ValAsp: 3.944 ± 0.044
3.797ValGlu: 3.797 ± 0.049
2.496ValPhe: 2.496 ± 0.034
5.251ValGly: 5.251 ± 0.057
1.411ValHis: 1.411 ± 0.024
3.441ValIle: 3.441 ± 0.046
2.65ValLys: 2.65 ± 0.041
7.889ValLeu: 7.889 ± 0.072
1.811ValMet: 1.811 ± 0.03
2.359ValAsn: 2.359 ± 0.041
3.455ValPro: 3.455 ± 0.05
2.789ValGln: 2.789 ± 0.04
4.51ValArg: 4.51 ± 0.05
4.312ValSer: 4.312 ± 0.054
4.003ValThr: 4.003 ± 0.059
5.567ValVal: 5.567 ± 0.066
0.879ValTrp: 0.879 ± 0.021
1.751ValTyr: 1.751 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.116TrpAla: 1.116 ± 0.025
0.14TrpCys: 0.14 ± 0.01
0.643TrpAsp: 0.643 ± 0.021
0.558TrpGlu: 0.558 ± 0.02
0.528TrpPhe: 0.528 ± 0.015
0.818TrpGly: 0.818 ± 0.02
0.351TrpHis: 0.351 ± 0.015
0.642TrpIle: 0.642 ± 0.017
0.519TrpLys: 0.519 ± 0.017
1.818TrpLeu: 1.818 ± 0.034
0.426TrpMet: 0.426 ± 0.017
0.498TrpAsn: 0.498 ± 0.015
0.596TrpPro: 0.596 ± 0.018
0.767TrpGln: 0.767 ± 0.021
1.085TrpArg: 1.085 ± 0.027
0.876TrpSer: 0.876 ± 0.022
0.691TrpThr: 0.691 ± 0.022
0.808TrpVal: 0.808 ± 0.022
0.234TrpTrp: 0.234 ± 0.01
0.34TrpTyr: 0.34 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.99TyrAla: 2.99 ± 0.043
0.265TyrCys: 0.265 ± 0.01
1.471TyrAsp: 1.471 ± 0.031
1.2TyrGlu: 1.2 ± 0.025
1.095TyrPhe: 1.095 ± 0.025
2.244TyrGly: 2.244 ± 0.041
0.571TyrHis: 0.571 ± 0.016
1.024TyrIle: 1.024 ± 0.023
0.933TyrLys: 0.933 ± 0.023
2.794TyrLeu: 2.794 ± 0.038
0.561TyrMet: 0.561 ± 0.022
0.883TyrAsn: 0.883 ± 0.024
1.268TyrPro: 1.268 ± 0.025
1.123TyrGln: 1.123 ± 0.027
1.835TyrArg: 1.835 ± 0.028
1.581TyrSer: 1.581 ± 0.037
1.526TyrThr: 1.526 ± 0.036
1.791TyrVal: 1.791 ± 0.034
0.394TyrTrp: 0.394 ± 0.015
0.758TyrTyr: 0.758 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5974 proteins (2157853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski