Amino acid dipepetide frequency for Tolypocladium capitatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.128AlaAla: 12.128 ± 0.094	1.192AlaCys: 1.192 ± 0.016	5.3AlaAsp: 5.3 ± 0.044	5.625AlaGlu: 5.625 ± 0.049	3.141AlaPhe: 3.141 ± 0.031	7.024AlaGly: 7.024 ± 0.051	2.08AlaHis: 2.08 ± 0.027	3.845AlaIle: 3.845 ± 0.037	4.203AlaLys: 4.203 ± 0.04	8.246AlaLeu: 8.246 ± 0.053	2.338AlaMet: 2.338 ± 0.026	3.011AlaAsn: 3.011 ± 0.03	5.767AlaPro: 5.767 ± 0.053	3.714AlaGln: 3.714 ± 0.035	6.495AlaArg: 6.495 ± 0.04	8.162AlaSer: 8.162 ± 0.056	5.648AlaThr: 5.648 ± 0.042	6.285AlaVal: 6.285 ± 0.049	1.243AlaTrp: 1.243 ± 0.017	2.098AlaTyr: 2.098 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.054CysAla: 1.054 ± 0.017	0.275CysCys: 0.275 ± 0.009	0.678CysAsp: 0.678 ± 0.014	0.573CysGlu: 0.573 ± 0.012	0.525CysPhe: 0.525 ± 0.014	0.987CysGly: 0.987 ± 0.02	0.359CysHis: 0.359 ± 0.011	0.627CysIle: 0.627 ± 0.014	0.461CysLys: 0.461 ± 0.012	1.29CysLeu: 1.29 ± 0.021	0.261CysMet: 0.261 ± 0.008	0.404CysAsn: 0.404 ± 0.011	0.763CysPro: 0.763 ± 0.015	0.434CysGln: 0.434 ± 0.01	0.933CysArg: 0.933 ± 0.016	0.925CysSer: 0.925 ± 0.016	0.672CysThr: 0.672 ± 0.012	0.827CysVal: 0.827 ± 0.014	0.195CysTrp: 0.195 ± 0.009	0.335CysTyr: 0.335 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.971AspAla: 5.971 ± 0.045	0.637AspCys: 0.637 ± 0.012	5.223AspAsp: 5.223 ± 0.066	4.864AspGlu: 4.864 ± 0.046	2.128AspPhe: 2.128 ± 0.024	5.255AspGly: 5.255 ± 0.044	1.265AspHis: 1.265 ± 0.019	2.548AspIle: 2.548 ± 0.029	2.493AspLys: 2.493 ± 0.027	4.918AspLeu: 4.918 ± 0.042	1.478AspMet: 1.478 ± 0.018	1.698AspAsn: 1.698 ± 0.023	3.279AspPro: 3.279 ± 0.034	1.806AspGln: 1.806 ± 0.022	3.423AspArg: 3.423 ± 0.035	3.966AspSer: 3.966 ± 0.036	2.602AspThr: 2.602 ± 0.026	4.164AspVal: 4.164 ± 0.035	0.858AspTrp: 0.858 ± 0.015	1.387AspTyr: 1.387 ± 0.018	0.001AspXaa: 0.001 ± 0.0
Glu	5.97GluAla: 5.97 ± 0.049	0.607GluCys: 0.607 ± 0.013	4.112GluAsp: 4.112 ± 0.041	4.8GluGlu: 4.8 ± 0.06	1.798GluPhe: 1.798 ± 0.022	3.67GluGly: 3.67 ± 0.034	1.408GluHis: 1.408 ± 0.019	2.361GluIle: 2.361 ± 0.025	2.987GluLys: 2.987 ± 0.033	5.193GluLeu: 5.193 ± 0.043	1.47GluMet: 1.47 ± 0.015	1.783GluAsn: 1.783 ± 0.024	3.064GluPro: 3.064 ± 0.033	2.427GluGln: 2.427 ± 0.03	4.214GluArg: 4.214 ± 0.049	3.997GluSer: 3.997 ± 0.038	3.219GluThr: 3.219 ± 0.029	3.359GluVal: 3.359 ± 0.033	0.832GluTrp: 0.832 ± 0.015	1.472GluTyr: 1.472 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.135PheAla: 3.135 ± 0.032	0.544PheCys: 0.544 ± 0.013	2.205PheAsp: 2.205 ± 0.026	1.919PheGlu: 1.919 ± 0.022	1.432PhePhe: 1.432 ± 0.024	2.766PheGly: 2.766 ± 0.033	0.842PheHis: 0.842 ± 0.014	1.469PheIle: 1.469 ± 0.023	1.326PheLys: 1.326 ± 0.019	3.169PheLeu: 3.169 ± 0.032	0.738PheMet: 0.738 ± 0.014	1.257PheAsn: 1.257 ± 0.016	1.809PhePro: 1.809 ± 0.021	1.233PheGln: 1.233 ± 0.018	2.037PheArg: 2.037 ± 0.026	2.654PheSer: 2.654 ± 0.027	1.857PheThr: 1.857 ± 0.025	2.387PheVal: 2.387 ± 0.025	0.571PheTrp: 0.571 ± 0.011	0.974PheTyr: 0.974 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.46GlyAla: 6.46 ± 0.055	0.935GlyCys: 0.935 ± 0.017	4.368GlyAsp: 4.368 ± 0.04	4.0GlyGlu: 4.0 ± 0.032	2.704GlyPhe: 2.704 ± 0.034	6.861GlyGly: 6.861 ± 0.074	1.957GlyHis: 1.957 ± 0.026	3.255GlyIle: 3.255 ± 0.03	3.357GlyLys: 3.357 ± 0.034	6.259GlyLeu: 6.259 ± 0.053	1.701GlyMet: 1.701 ± 0.023	2.467GlyAsn: 2.467 ± 0.029	3.899GlyPro: 3.899 ± 0.04	2.857GlyGln: 2.857 ± 0.032	5.319GlyArg: 5.319 ± 0.045	6.112GlySer: 6.112 ± 0.046	3.936GlyThr: 3.936 ± 0.035	4.554GlyVal: 4.554 ± 0.035	1.176GlyTrp: 1.176 ± 0.02	1.963GlyTyr: 1.963 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.196HisAla: 2.196 ± 0.025	0.336HisCys: 0.336 ± 0.01	1.495HisAsp: 1.495 ± 0.022	1.313HisGlu: 1.313 ± 0.018	0.827HisPhe: 0.827 ± 0.016	2.157HisGly: 2.157 ± 0.026	1.027HisHis: 1.027 ± 0.022	1.016HisIle: 1.016 ± 0.018	0.838HisLys: 0.838 ± 0.013	2.289HisLeu: 2.289 ± 0.025	0.536HisMet: 0.536 ± 0.013	0.72HisAsn: 0.72 ± 0.014	1.724HisPro: 1.724 ± 0.022	1.057HisGln: 1.057 ± 0.017	1.831HisArg: 1.831 ± 0.029	1.707HisSer: 1.707 ± 0.022	1.109HisThr: 1.109 ± 0.015	1.69HisVal: 1.69 ± 0.02	0.311HisTrp: 0.311 ± 0.009	0.617HisTyr: 0.617 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.631IleAla: 3.631 ± 0.035	0.634IleCys: 0.634 ± 0.01	2.426IleAsp: 2.426 ± 0.032	2.265IleGlu: 2.265 ± 0.023	1.561IlePhe: 1.561 ± 0.023	2.75IleGly: 2.75 ± 0.032	1.03IleHis: 1.03 ± 0.016	1.869IleIle: 1.869 ± 0.027	1.873IleLys: 1.873 ± 0.023	3.793IleLeu: 3.793 ± 0.04	0.922IleMet: 0.922 ± 0.015	1.44IleAsn: 1.44 ± 0.019	2.535IlePro: 2.535 ± 0.028	1.54IleGln: 1.54 ± 0.02	2.636IleArg: 2.636 ± 0.028	3.085IleSer: 3.085 ± 0.03	2.197IleThr: 2.197 ± 0.023	2.763IleVal: 2.763 ± 0.03	0.599IleTrp: 0.599 ± 0.012	1.096IleTyr: 1.096 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.33LysAla: 4.33 ± 0.043	0.454LysCys: 0.454 ± 0.012	2.531LysAsp: 2.531 ± 0.027	2.797LysGlu: 2.797 ± 0.036	1.272LysPhe: 1.272 ± 0.018	2.811LysGly: 2.811 ± 0.028	1.064LysHis: 1.064 ± 0.016	1.806LysIle: 1.806 ± 0.025	2.929LysLys: 2.929 ± 0.051	3.794LysLeu: 3.794 ± 0.037	1.033LysMet: 1.033 ± 0.018	1.413LysAsn: 1.413 ± 0.019	2.699LysPro: 2.699 ± 0.03	1.729LysGln: 1.729 ± 0.024	3.383LysArg: 3.383 ± 0.037	3.006LysSer: 3.006 ± 0.031	2.585LysThr: 2.585 ± 0.028	2.556LysVal: 2.556 ± 0.027	0.564LysTrp: 0.564 ± 0.013	1.117LysTyr: 1.117 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.652LeuAla: 8.652 ± 0.065	1.245LeuCys: 1.245 ± 0.018	5.391LeuAsp: 5.391 ± 0.036	5.191LeuGlu: 5.191 ± 0.046	3.054LeuPhe: 3.054 ± 0.036	6.263LeuGly: 6.263 ± 0.045	2.201LeuHis: 2.201 ± 0.027	3.206LeuIle: 3.206 ± 0.034	3.697LeuLys: 3.697 ± 0.039	8.337LeuLeu: 8.337 ± 0.077	1.741LeuMet: 1.741 ± 0.026	2.714LeuAsn: 2.714 ± 0.03	5.655LeuPro: 5.655 ± 0.041	3.616LeuGln: 3.616 ± 0.033	6.52LeuArg: 6.52 ± 0.046	6.901LeuSer: 6.901 ± 0.053	4.498LeuThr: 4.498 ± 0.036	5.837LeuVal: 5.837 ± 0.043	1.133LeuTrp: 1.133 ± 0.019	2.113LeuTyr: 2.113 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.643MetAla: 2.643 ± 0.025	0.239MetCys: 0.239 ± 0.008	1.421MetAsp: 1.421 ± 0.021	1.304MetGlu: 1.304 ± 0.021	0.717MetPhe: 0.717 ± 0.014	1.579MetGly: 1.579 ± 0.021	0.492MetHis: 0.492 ± 0.012	0.828MetIle: 0.828 ± 0.015	0.937MetLys: 0.937 ± 0.016	1.939MetLeu: 1.939 ± 0.025	0.617MetMet: 0.617 ± 0.015	0.693MetAsn: 0.693 ± 0.016	1.503MetPro: 1.503 ± 0.021	0.889MetGln: 0.889 ± 0.017	1.42MetArg: 1.42 ± 0.019	1.882MetSer: 1.882 ± 0.024	1.318MetThr: 1.318 ± 0.019	1.401MetVal: 1.401 ± 0.022	0.266MetTrp: 0.266 ± 0.009	0.509MetTyr: 0.509 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.961AsnAla: 2.961 ± 0.03	0.414AsnCys: 0.414 ± 0.012	1.727AsnAsp: 1.727 ± 0.026	1.664AsnGlu: 1.664 ± 0.02	1.152AsnPhe: 1.152 ± 0.02	2.797AsnGly: 2.797 ± 0.032	0.76AsnHis: 0.76 ± 0.014	1.557AsnIle: 1.557 ± 0.018	1.387AsnLys: 1.387 ± 0.022	2.879AsnLeu: 2.879 ± 0.029	0.843AsnMet: 0.843 ± 0.015	1.139AsnAsn: 1.139 ± 0.021	2.199AsnPro: 2.199 ± 0.025	1.142AsnGln: 1.142 ± 0.019	1.911AsnArg: 1.911 ± 0.023	2.257AsnSer: 2.257 ± 0.029	1.715AsnThr: 1.715 ± 0.023	2.149AsnVal: 2.149 ± 0.026	0.47AsnTrp: 0.47 ± 0.011	0.843AsnTyr: 0.843 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.472ProAla: 6.472 ± 0.052	0.657ProCys: 0.657 ± 0.015	3.484ProAsp: 3.484 ± 0.03	3.657ProGlu: 3.657 ± 0.035	1.96ProPhe: 1.96 ± 0.021	4.68ProGly: 4.68 ± 0.045	1.469ProHis: 1.469 ± 0.022	2.105ProIle: 2.105 ± 0.022	2.493ProLys: 2.493 ± 0.029	4.853ProLeu: 4.853 ± 0.042	1.214ProMet: 1.214 ± 0.019	2.002ProAsn: 2.002 ± 0.024	6.241ProPro: 6.241 ± 0.077	2.544ProGln: 2.544 ± 0.04	4.564ProArg: 4.564 ± 0.038	6.29ProSer: 6.29 ± 0.057	3.86ProThr: 3.86 ± 0.04	3.809ProVal: 3.809 ± 0.033	0.782ProTrp: 0.782 ± 0.014	1.388ProTyr: 1.388 ± 0.019	0.001ProXaa: 0.001 ± 0.0
Gln	3.757GlnAla: 3.757 ± 0.033	0.41GlnCys: 0.41 ± 0.01	2.152GlnAsp: 2.152 ± 0.026	2.177GlnGlu: 2.177 ± 0.029	1.18GlnPhe: 1.18 ± 0.017	2.632GlnGly: 2.632 ± 0.032	1.173GlnHis: 1.173 ± 0.019	1.499GlnIle: 1.499 ± 0.021	1.67GlnLys: 1.67 ± 0.023	3.462GlnLeu: 3.462 ± 0.036	0.922GlnMet: 0.922 ± 0.019	1.239GlnAsn: 1.239 ± 0.018	2.832GlnPro: 2.832 ± 0.04	2.679GlnGln: 2.679 ± 0.066	3.004GlnArg: 3.004 ± 0.03	2.873GlnSer: 2.873 ± 0.03	2.15GlnThr: 2.15 ± 0.027	2.226GlnVal: 2.226 ± 0.027	0.523GlnTrp: 0.523 ± 0.012	1.0GlnTyr: 1.0 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	6.012ArgAla: 6.012 ± 0.038	0.896ArgCys: 0.896 ± 0.017	4.093ArgAsp: 4.093 ± 0.037	4.178ArgGlu: 4.178 ± 0.037	2.273ArgPhe: 2.273 ± 0.023	4.835ArgGly: 4.835 ± 0.048	2.055ArgHis: 2.055 ± 0.025	2.775ArgIle: 2.775 ± 0.024	3.385ArgLys: 3.385 ± 0.034	6.31ArgLeu: 6.31 ± 0.048	1.457ArgMet: 1.457 ± 0.021	2.247ArgAsn: 2.247 ± 0.022	4.617ArgPro: 4.617 ± 0.047	3.082ArgGln: 3.082 ± 0.032	7.113ArgArg: 7.113 ± 0.077	5.285ArgSer: 5.285 ± 0.048	3.513ArgThr: 3.513 ± 0.031	3.888ArgVal: 3.888 ± 0.035	1.01ArgTrp: 1.01 ± 0.017	1.623ArgTyr: 1.623 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.22SerAla: 7.22 ± 0.053	0.948SerCys: 0.948 ± 0.018	4.068SerAsp: 4.068 ± 0.038	3.629SerGlu: 3.629 ± 0.036	2.772SerPhe: 2.772 ± 0.029	5.681SerGly: 5.681 ± 0.046	1.906SerHis: 1.906 ± 0.022	3.298SerIle: 3.298 ± 0.03	3.288SerLys: 3.288 ± 0.029	6.96SerLeu: 6.96 ± 0.05	1.747SerMet: 1.747 ± 0.022	2.528SerAsn: 2.528 ± 0.022	5.902SerPro: 5.902 ± 0.064	3.043SerGln: 3.043 ± 0.033	5.763SerArg: 5.763 ± 0.046	8.313SerSer: 8.313 ± 0.071	4.963SerThr: 4.963 ± 0.043	4.508SerVal: 4.508 ± 0.036	1.062SerTrp: 1.062 ± 0.017	1.768SerTyr: 1.768 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.518ThrAla: 5.518 ± 0.037	0.728ThrCys: 0.728 ± 0.014	2.694ThrAsp: 2.694 ± 0.026	2.725ThrGlu: 2.725 ± 0.027	1.895ThrPhe: 1.895 ± 0.023	4.08ThrGly: 4.08 ± 0.036	1.197ThrHis: 1.197 ± 0.018	2.42ThrIle: 2.42 ± 0.031	2.258ThrLys: 2.258 ± 0.026	4.81ThrLeu: 4.81 ± 0.036	1.262ThrMet: 1.262 ± 0.019	1.783ThrAsn: 1.783 ± 0.025	4.246ThrPro: 4.246 ± 0.036	1.921ThrGln: 1.921 ± 0.026	3.413ThrArg: 3.413 ± 0.032	4.715ThrSer: 4.715 ± 0.044	3.779ThrThr: 3.779 ± 0.043	3.561ThrVal: 3.561 ± 0.04	0.768ThrTrp: 0.768 ± 0.014	1.381ThrTyr: 1.381 ± 0.021	0.001ThrXaa: 0.001 ± 0.0
Val	6.214ValAla: 6.214 ± 0.046	0.873ValCys: 0.873 ± 0.017	4.167ValAsp: 4.167 ± 0.034	3.89ValGlu: 3.89 ± 0.033	2.421ValPhe: 2.421 ± 0.026	4.436ValGly: 4.436 ± 0.04	1.464ValHis: 1.464 ± 0.02	2.494ValIle: 2.494 ± 0.03	2.708ValLys: 2.708 ± 0.03	5.805ValLeu: 5.805 ± 0.044	1.392ValMet: 1.392 ± 0.021	2.009ValAsn: 2.009 ± 0.021	3.823ValPro: 3.823 ± 0.034	2.36ValGln: 2.36 ± 0.023	3.988ValArg: 3.988 ± 0.035	4.534ValSer: 4.534 ± 0.034	3.351ValThr: 3.351 ± 0.037	4.797ValVal: 4.797 ± 0.045	0.849ValTrp: 0.849 ± 0.016	1.622ValTyr: 1.622 ± 0.023	0.001ValXaa: 0.001 ± 0.0
Trp	1.142TrpAla: 1.142 ± 0.018	0.188TrpCys: 0.188 ± 0.007	0.884TrpAsp: 0.884 ± 0.018	0.799TrpGlu: 0.799 ± 0.014	0.495TrpPhe: 0.495 ± 0.012	0.905TrpGly: 0.905 ± 0.019	0.365TrpHis: 0.365 ± 0.009	0.617TrpIle: 0.617 ± 0.012	0.664TrpLys: 0.664 ± 0.012	1.298TrpLeu: 1.298 ± 0.02	0.351TrpMet: 0.351 ± 0.009	0.548TrpAsn: 0.548 ± 0.012	0.646TrpPro: 0.646 ± 0.013	0.552TrpGln: 0.552 ± 0.012	1.073TrpArg: 1.073 ± 0.018	0.978TrpSer: 0.978 ± 0.016	0.88TrpThr: 0.88 ± 0.017	0.845TrpVal: 0.845 ± 0.014	0.274TrpTrp: 0.274 ± 0.008	0.367TrpTyr: 0.367 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.081TyrAla: 2.081 ± 0.027	0.367TyrCys: 0.367 ± 0.011	1.544TyrAsp: 1.544 ± 0.024	1.372TyrGlu: 1.372 ± 0.019	1.014TyrPhe: 1.014 ± 0.017	1.971TyrGly: 1.971 ± 0.029	0.682TyrHis: 0.682 ± 0.013	1.051TyrIle: 1.051 ± 0.016	0.921TyrLys: 0.921 ± 0.017	2.359TyrLeu: 2.359 ± 0.027	0.576TyrMet: 0.576 ± 0.012	0.87TyrAsn: 0.87 ± 0.016	1.318TyrPro: 1.318 ± 0.021	0.94TyrGln: 0.94 ± 0.016	1.604TyrArg: 1.604 ± 0.021	1.727TyrSer: 1.727 ± 0.024	1.305TyrThr: 1.305 ± 0.021	1.588TyrVal: 1.588 ± 0.023	0.386TyrTrp: 0.386 ± 0.01	0.757TyrTyr: 0.757 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.099XaaXaa: 0.099 ± 0.03

Statistics based on 7634 proteins (3983078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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